HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4I2_LEIBR

TriTrypDb:

LbrM.06.0140 , LBRM2903_060006800

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006203	dGTP catabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009143	nucleoside triphosphate catabolic process	6	2
GO:0009144	purine nucleoside triphosphate metabolic process	6	2
GO:0009146	purine nucleoside triphosphate catabolic process	7	2
GO:0009151	purine deoxyribonucleotide metabolic process	6	2
GO:0009155	purine deoxyribonucleotide catabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009200	deoxyribonucleoside triphosphate metabolic process	6	2
GO:0009204	deoxyribonucleoside triphosphate catabolic process	7	2
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	7	2
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	8	2
GO:0009262	deoxyribonucleotide metabolic process	4	2
GO:0009264	deoxyribonucleotide catabolic process	5	2
GO:0009394	2'-deoxyribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019692	deoxyribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046070	dGTP metabolic process	7	2
GO:0046386	deoxyribose phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008832	dGTPase activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016793	triphosphoric monoester hydrolase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.430
CLV_NRD_NRD_1	134	136	PF00675	0.305
CLV_NRD_NRD_1	2	4	PF00675	0.550
CLV_NRD_NRD_1	420	422	PF00675	0.421
CLV_PCSK_KEX2_1	117	119	PF00082	0.324
CLV_PCSK_KEX2_1	134	136	PF00082	0.309
CLV_PCSK_KEX2_1	170	172	PF00082	0.311
CLV_PCSK_KEX2_1	420	422	PF00082	0.421
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.311
CLV_PCSK_SKI1_1	134	138	PF00082	0.280
CLV_PCSK_SKI1_1	222	226	PF00082	0.337
CLV_PCSK_SKI1_1	228	232	PF00082	0.298
CLV_PCSK_SKI1_1	70	74	PF00082	0.280
DEG_APCC_DBOX_1	133	141	PF00400	0.299
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DOC_CKS1_1	30	35	PF01111	0.403
DOC_CKS1_1	404	409	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.402
DOC_MAPK_FxFP_2	49	52	PF00069	0.371
DOC_MAPK_gen_1	117	123	PF00069	0.406
DOC_MAPK_gen_1	170	176	PF00069	0.311
DOC_MAPK_gen_1	3	13	PF00069	0.528
DOC_MAPK_MEF2A_6	143	152	PF00069	0.275
DOC_MAPK_MEF2A_6	192	199	PF00069	0.368
DOC_PP4_FxxP_1	190	193	PF00568	0.347
DOC_PP4_FxxP_1	379	382	PF00568	0.417
DOC_PP4_FxxP_1	49	52	PF00568	0.371
DOC_USP7_MATH_1	320	324	PF00917	0.424
DOC_USP7_MATH_1	346	350	PF00917	0.388
DOC_USP7_MATH_1	373	377	PF00917	0.380
DOC_WW_Pin1_4	29	34	PF00397	0.424
DOC_WW_Pin1_4	399	404	PF00397	0.470
LIG_14-3-3_CanoR_1	134	142	PF00244	0.303
LIG_14-3-3_CanoR_1	201	209	PF00244	0.311
LIG_14-3-3_CanoR_1	318	327	PF00244	0.444
LIG_14-3-3_CanoR_1	37	42	PF00244	0.348
LIG_14-3-3_CanoR_1	433	440	PF00244	0.438
LIG_Actin_WH2_2	385	401	PF00022	0.485
LIG_BRCT_BRCA1_1	107	111	PF00533	0.311
LIG_BRCT_BRCA1_1	375	379	PF00533	0.359
LIG_BRCT_BRCA1_1	401	405	PF00533	0.441
LIG_BRCT_BRCA1_1	446	450	PF00533	0.508
LIG_Clathr_ClatBox_1	10	14	PF01394	0.238
LIG_Clathr_ClatBox_1	415	419	PF01394	0.346
LIG_DLG_GKlike_1	37	44	PF00625	0.345
LIG_FHA_1	136	142	PF00498	0.308
LIG_FHA_1	192	198	PF00498	0.358
LIG_FHA_1	245	251	PF00498	0.424
LIG_FHA_1	278	284	PF00498	0.346
LIG_FHA_1	311	317	PF00498	0.464
LIG_FHA_1	412	418	PF00498	0.364
LIG_FHA_1	443	449	PF00498	0.545
LIG_FHA_1	5	11	PF00498	0.338
LIG_FHA_2	142	148	PF00498	0.438
LIG_FHA_2	160	166	PF00498	0.406
LIG_FHA_2	269	275	PF00498	0.332
LIG_FHA_2	326	332	PF00498	0.263
LIG_FHA_2	55	61	PF00498	0.265
LIG_LIR_Apic_2	376	382	PF02991	0.409
LIG_LIR_Apic_2	47	52	PF02991	0.371
LIG_LIR_Gen_1	108	115	PF02991	0.324
LIG_LIR_Gen_1	14	25	PF02991	0.393
LIG_LIR_Gen_1	279	290	PF02991	0.394
LIG_LIR_Gen_1	32	41	PF02991	0.207
LIG_LIR_Gen_1	437	448	PF02991	0.555
LIG_LIR_Nem_3	108	114	PF02991	0.324
LIG_LIR_Nem_3	14	20	PF02991	0.431
LIG_LIR_Nem_3	162	166	PF02991	0.292
LIG_LIR_Nem_3	279	285	PF02991	0.393
LIG_LIR_Nem_3	32	38	PF02991	0.225
LIG_LIR_Nem_3	402	408	PF02991	0.450
LIG_LIR_Nem_3	437	443	PF02991	0.427
LIG_Pex14_1	215	219	PF04695	0.298
LIG_Pex14_2	107	111	PF04695	0.265
LIG_SH2_NCK_1	17	21	PF00017	0.461
LIG_SH2_SRC	17	20	PF00017	0.417
LIG_SH2_STAP1	321	325	PF00017	0.463
LIG_SH2_STAP1	440	444	PF00017	0.471
LIG_SH2_STAT3	242	245	PF00017	0.442
LIG_SH2_STAT5	181	184	PF00017	0.323
LIG_SH2_STAT5	264	267	PF00017	0.332
LIG_SH3_3	333	339	PF00018	0.487
LIG_SH3_3	345	351	PF00018	0.436
LIG_SH3_3	367	373	PF00018	0.416
LIG_SH3_3	379	385	PF00018	0.370
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.342
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.349
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.478
LIG_SUMO_SIM_par_1	411	419	PF11976	0.355
LIG_SUMO_SIM_par_1	9	14	PF11976	0.241
LIG_TYR_ITIM	161	166	PF00017	0.358
LIG_UBA3_1	230	236	PF00899	0.306
MOD_CK2_1	159	165	PF00069	0.406
MOD_CK2_1	223	229	PF00069	0.338
MOD_CK2_1	268	274	PF00069	0.330
MOD_CK2_1	325	331	PF00069	0.465
MOD_CK2_1	54	60	PF00069	0.350
MOD_GlcNHglycan	204	207	PF01048	0.329
MOD_GlcNHglycan	322	325	PF01048	0.437
MOD_GlcNHglycan	434	437	PF01048	0.235
MOD_GSK3_1	383	390	PF00069	0.475
MOD_GSK3_1	399	406	PF00069	0.489
MOD_NEK2_1	202	207	PF00069	0.302
MOD_NEK2_1	223	228	PF00069	0.373
MOD_NEK2_1	325	330	PF00069	0.428
MOD_NEK2_1	44	49	PF00069	0.347
MOD_NEK2_1	444	449	PF00069	0.461
MOD_NEK2_1	59	64	PF00069	0.311
MOD_NEK2_1	68	73	PF00069	0.311
MOD_PIKK_1	383	389	PF00454	0.429
MOD_PKA_1	383	389	PF00069	0.429
MOD_PKA_1	420	426	PF00069	0.401
MOD_PKA_2	183	189	PF00069	0.334
MOD_PKA_2	420	426	PF00069	0.413
MOD_PKA_2	432	438	PF00069	0.443
MOD_Plk_1	277	283	PF00069	0.349
MOD_Plk_1	325	331	PF00069	0.494
MOD_Plk_1	411	417	PF00069	0.338
MOD_Plk_1	59	65	PF00069	0.311
MOD_Plk_4	268	274	PF00069	0.382
MOD_Plk_4	277	283	PF00069	0.399
MOD_Plk_4	373	379	PF00069	0.397
MOD_Plk_4	45	51	PF00069	0.351
MOD_ProDKin_1	29	35	PF00069	0.421
MOD_ProDKin_1	399	405	PF00069	0.464
TRG_DiLeu_BaEn_1	411	416	PF01217	0.360
TRG_DiLeu_BaEn_3	411	417	PF01217	0.338
TRG_ENDOCYTIC_2	163	166	PF00928	0.280
TRG_ENDOCYTIC_2	17	20	PF00928	0.439
TRG_ENDOCYTIC_2	264	267	PF00928	0.333
TRG_ENDOCYTIC_2	440	443	PF00928	0.474
TRG_ER_diArg_1	134	136	PF00400	0.333
TRG_ER_diArg_1	311	314	PF00400	0.357
TRG_ER_diArg_1	420	422	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL39	Leptomonas seymouri	83%	99%
A0A0N1PD02	Leptomonas seymouri	36%	73%
A0A0S4J2F4	Bodo saltans	52%	100%
A0A1X0NJC9	Trypanosomatidae	66%	100%
A0A3Q8IGB9	Leishmania donovani	36%	67%
A0A3R7NIH1	Trypanosoma rangeli	67%	100%
A0A3S7WPC5	Leishmania donovani	93%	100%
A4HKP4	Leishmania braziliensis	35%	67%
A4HSQ7	Leishmania infantum	93%	100%
A4I875	Leishmania infantum	36%	67%
B0G107	Dictyostelium discoideum	33%	88%
C9ZTA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AKP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B333	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	67%
Q09374	Caenorhabditis elegans	31%	77%
Q0VCA5	Bos taurus	31%	77%
Q4Q521	Leishmania major	35%	67%
Q4QJ63	Leishmania major	93%	100%
Q502K2	Danio rerio	31%	73%
Q5UQ48	Acanthamoeba polyphaga mimivirus	29%	99%
Q5ZJL9	Gallus gallus	32%	74%
Q60710	Mus musculus	29%	69%
Q6INN8	Xenopus laevis	31%	72%
Q9Y3Z3	Homo sapiens	31%	73%
V5B971	Trypanosoma cruzi	66%	100%