Putative 20S proteasome beta 6 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome beta 6 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H4I0_LEIBR

TriTrypDb:

LbrM.06.0120 , LBRM2903_060006600

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0005839	proteasome core complex	3	11
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H4I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I0

PDB structure(s): 6qm7_a , 6qm7_M , 6qm8_a , 6qm8_M , 6tcz_m , 6td5_m

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0019538	protein metabolic process	3	11
GO:0030163	protein catabolic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.259
CLV_NRD_NRD_1	330	332	PF00675	0.401
CLV_NRD_NRD_1	45	47	PF00675	0.456
CLV_PCSK_FUR_1	42	46	PF00082	0.458
CLV_PCSK_KEX2_1	219	221	PF00082	0.259
CLV_PCSK_KEX2_1	44	46	PF00082	0.461
CLV_PCSK_SKI1_1	219	223	PF00082	0.261
CLV_PCSK_SKI1_1	296	300	PF00082	0.259
DEG_APCC_DBOX_1	179	187	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DEG_SPOP_SBC_1	48	52	PF00917	0.463
DOC_AGCK_PIF_1	222	227	PF00069	0.459
DOC_CKS1_1	164	169	PF01111	0.554
DOC_MAPK_MEF2A_6	17	24	PF00069	0.400
DOC_PP1_RVXF_1	188	194	PF00149	0.459
DOC_PP2B_LxvP_1	108	111	PF13499	0.505
DOC_PP4_FxxP_1	264	267	PF00568	0.459
DOC_PP4_FxxP_1	75	78	PF00568	0.454
DOC_USP7_MATH_1	246	250	PF00917	0.472
DOC_USP7_MATH_1	57	61	PF00917	0.489
DOC_USP7_UBL2_3	188	192	PF12436	0.540
DOC_WW_Pin1_4	118	123	PF00397	0.454
DOC_WW_Pin1_4	163	168	PF00397	0.554
DOC_WW_Pin1_4	8	13	PF00397	0.451
LIG_14-3-3_CanoR_1	275	283	PF00244	0.521
LIG_14-3-3_CanoR_1	45	54	PF00244	0.465
LIG_14-3-3_CanoR_1	56	65	PF00244	0.465
LIG_BIR_III_4	245	249	PF00653	0.515
LIG_BRCT_BRCA1_1	159	163	PF00533	0.459
LIG_BRCT_BRCA1_1	311	315	PF00533	0.515
LIG_CtBP_PxDLS_1	78	82	PF00389	0.442
LIG_FHA_1	128	134	PF00498	0.554
LIG_FHA_1	203	209	PF00498	0.474
LIG_FHA_1	248	254	PF00498	0.479
LIG_FHA_1	48	54	PF00498	0.469
LIG_FHA_2	153	159	PF00498	0.400
LIG_GBD_Chelix_1	208	216	PF00786	0.268
LIG_LIR_Apic_2	263	267	PF02991	0.461
LIG_LIR_Apic_2	51	57	PF02991	0.481
LIG_LIR_Gen_1	137	142	PF02991	0.477
LIG_LIR_Gen_1	226	233	PF02991	0.459
LIG_LIR_Gen_1	243	252	PF02991	0.459
LIG_LIR_Gen_1	312	323	PF02991	0.467
LIG_LIR_Nem_3	137	141	PF02991	0.488
LIG_LIR_Nem_3	226	230	PF02991	0.459
LIG_LIR_Nem_3	243	247	PF02991	0.459
LIG_LIR_Nem_3	312	318	PF02991	0.479
LIG_NRBOX	182	188	PF00104	0.404
LIG_Pex14_2	24	28	PF04695	0.398
LIG_SH2_CRK	244	248	PF00017	0.459
LIG_SH2_CRK	54	58	PF00017	0.571
LIG_SH2_NCK_1	244	248	PF00017	0.459
LIG_SH2_STAP1	225	229	PF00017	0.459
LIG_SH2_STAP1	242	246	PF00017	0.459
LIG_SH2_STAT5	225	228	PF00017	0.459
LIG_SH2_STAT5	308	311	PF00017	0.576
LIG_SH2_STAT5	54	57	PF00017	0.486
LIG_SH3_2	12	17	PF14604	0.426
LIG_SH3_3	61	67	PF00018	0.558
LIG_SH3_3	9	15	PF00018	0.440
LIG_SUMO_SIM_par_1	77	82	PF11976	0.445
LIG_TRAF2_1	287	290	PF00917	0.498
LIG_TRFH_1	163	167	PF08558	0.554
LIG_WRC_WIRS_1	224	229	PF05994	0.459
LIG_WW_3	14	18	PF00397	0.414
MOD_CDC14_SPxK_1	14	17	PF00782	0.419
MOD_CDK_SPxK_1	11	17	PF00069	0.428
MOD_CK1_1	11	17	PF00069	0.458
MOD_CK1_1	204	210	PF00069	0.404
MOD_CK1_1	260	266	PF00069	0.472
MOD_CK1_1	284	290	PF00069	0.404
MOD_CK1_1	314	320	PF00069	0.468
MOD_CK1_1	49	55	PF00069	0.494
MOD_CK2_1	260	266	PF00069	0.481
MOD_CK2_1	284	290	PF00069	0.467
MOD_GlcNHglycan	259	262	PF01048	0.274
MOD_GSK3_1	166	173	PF00069	0.515
MOD_N-GLC_2	150	152	PF02516	0.204
MOD_NEK2_1	1	6	PF00069	0.447
MOD_NEK2_1	103	108	PF00069	0.496
MOD_NEK2_1	211	216	PF00069	0.459
MOD_NEK2_1	254	259	PF00069	0.505
MOD_NEK2_1	28	33	PF00069	0.395
MOD_NEK2_1	47	52	PF00069	0.429
MOD_NEK2_1	79	84	PF00069	0.445
MOD_PIKK_1	57	63	PF00454	0.487
MOD_PKA_2	257	263	PF00069	0.544
MOD_PKB_1	44	52	PF00069	0.460
MOD_Plk_4	103	109	PF00069	0.484
MOD_Plk_4	166	172	PF00069	0.517
MOD_Plk_4	211	217	PF00069	0.492
MOD_Plk_4	260	266	PF00069	0.459
MOD_Plk_4	311	317	PF00069	0.554
MOD_Plk_4	49	55	PF00069	0.473
MOD_ProDKin_1	118	124	PF00069	0.448
MOD_ProDKin_1	163	169	PF00069	0.554
MOD_ProDKin_1	8	14	PF00069	0.446
MOD_SUMO_rev_2	158	163	PF00179	0.432
TRG_DiLeu_BaEn_3	289	295	PF01217	0.468
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.511
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.390
TRG_ENDOCYTIC_2	224	227	PF00928	0.459
TRG_ENDOCYTIC_2	244	247	PF00928	0.372
TRG_ER_diArg_1	219	221	PF00400	0.459
TRG_ER_diArg_1	34	37	PF00400	0.399
TRG_ER_diArg_1	42	45	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILF0	Leptomonas seymouri	88%	100%
A0A0S4J7A1	Bodo saltans	69%	100%
A0A0S4KNR5	Bodo saltans	24%	100%
A0A1X0NK57	Trypanosomatidae	74%	100%
A0A3R7KX47	Trypanosoma rangeli	73%	100%
A0A3S7WPD8	Leishmania donovani	87%	100%
A4HSQ5	Leishmania infantum	87%	100%
C9ZTA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AKP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O82531	Petunia hybrida	42%	100%
P23724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P40304	Drosophila melanogaster	42%	100%
P42742	Arabidopsis thaliana	43%	100%
Q4QJ65	Leishmania major	85%	100%
Q5V1D5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	27%	100%
Q86A21	Dictyostelium discoideum	42%	100%
Q9U794	Trypanosoma brucei brucei	70%	100%
Q9UQY2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%