NADAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4H9_LEIBR

TriTrypDb:

LbrM.06.0110 , LBRM2903_060006500

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.315
CLV_PCSK_SKI1_1	113	117	PF00082	0.327
CLV_PCSK_SKI1_1	143	147	PF00082	0.341
CLV_PCSK_SKI1_1	75	79	PF00082	0.361
DEG_SPOP_SBC_1	5	9	PF00917	0.445
DOC_ANK_TNKS_1	166	173	PF00023	0.465
DOC_CKS1_1	126	131	PF01111	0.453
DOC_MAPK_gen_1	10	17	PF00069	0.610
DOC_MAPK_gen_1	92	100	PF00069	0.308
DOC_MAPK_MEF2A_6	92	99	PF00069	0.327
DOC_USP7_MATH_1	179	183	PF00917	0.730
DOC_USP7_MATH_1	5	9	PF00917	0.685
DOC_WW_Pin1_4	125	130	PF00397	0.453
DOC_WW_Pin1_4	26	31	PF00397	0.311
DOC_WW_Pin1_4	55	60	PF00397	0.351
LIG_APCC_ABBAyCdc20_2	154	160	PF00400	0.414
LIG_FHA_2	126	132	PF00498	0.327
LIG_FHA_2	14	20	PF00498	0.420
LIG_LIR_Gen_1	102	111	PF02991	0.322
LIG_LIR_Gen_1	88	98	PF02991	0.210
LIG_LIR_LC3C_4	34	38	PF02991	0.420
LIG_LIR_Nem_3	102	106	PF02991	0.388
LIG_LIR_Nem_3	22	28	PF02991	0.309
LIG_LIR_Nem_3	88	93	PF02991	0.197
LIG_LYPXL_yS_3	43	46	PF13949	0.327
LIG_SH2_CRK	126	130	PF00017	0.453
LIG_SH2_CRK	25	29	PF00017	0.420
LIG_SH2_STAT5	103	106	PF00017	0.381
LIG_SH2_STAT5	49	52	PF00017	0.308
LIG_SH3_3	24	30	PF00018	0.289
LIG_SH3_3	38	44	PF00018	0.297
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.309
LIG_TRAF2_1	159	162	PF00917	0.559
LIG_TYR_ITIM	41	46	PF00017	0.420
LIG_WRC_WIRS_1	14	19	PF05994	0.551
MOD_CDK_SPK_2	125	130	PF00069	0.200
MOD_CK1_1	29	35	PF00069	0.323
MOD_CK1_1	3	9	PF00069	0.553
MOD_CK2_1	13	19	PF00069	0.524
MOD_CK2_1	156	162	PF00069	0.587
MOD_CK2_1	55	61	PF00069	0.350
MOD_GlcNHglycan	181	184	PF01048	0.608
MOD_GSK3_1	115	122	PF00069	0.444
MOD_GSK3_1	175	182	PF00069	0.765
MOD_GSK3_1	62	69	PF00069	0.359
MOD_NEK2_1	116	121	PF00069	0.165
MOD_NEK2_1	99	104	PF00069	0.415
MOD_PKB_1	154	162	PF00069	0.552
MOD_Plk_1	65	71	PF00069	0.420
MOD_Plk_4	119	125	PF00069	0.405
MOD_Plk_4	66	72	PF00069	0.293
MOD_Plk_4	99	105	PF00069	0.403
MOD_ProDKin_1	125	131	PF00069	0.453
MOD_ProDKin_1	26	32	PF00069	0.311
MOD_ProDKin_1	55	61	PF00069	0.351
TRG_ENDOCYTIC_2	103	106	PF00928	0.292
TRG_ENDOCYTIC_2	25	28	PF00928	0.335
TRG_ENDOCYTIC_2	43	46	PF00928	0.223
TRG_ER_diArg_1	154	157	PF00400	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I812	Leptomonas seymouri	79%	100%
A0A0S4IYE8	Bodo saltans	50%	100%
A0A0S4JDI7	Bodo saltans	28%	88%
A0A1X0NJB1	Trypanosomatidae	58%	100%
A0A3R7KBB5	Trypanosoma rangeli	59%	100%
A0A3S5H5N3	Leishmania donovani	84%	100%
A4HSQ4	Leishmania infantum	84%	100%
B2J4E5	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	27%	100%
C9ZTA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AKP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P30176	Escherichia coli (strain K12)	31%	100%
Q0T6G3	Shigella flexneri serotype 5b (strain 8401)	31%	100%
Q323Z6	Shigella boydii serotype 4 (strain Sb227)	31%	100%
Q3Z3Y7	Shigella sonnei (strain Ss046)	31%	100%
Q4QJ66	Leishmania major	84%	100%
Q83LU8	Shigella flexneri	31%	100%