Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 2

Species:

Leishmania braziliensis

UniProt:

A4H4H8_LEIBR

TriTrypDb:

LbrM.06.0100 , LBRM2903_060006400

Length:

187

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H8

PDB structure(s): 4s1j_A , 4s1j_B

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	11
GO:0006457	protein folding	2	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018208	peptidyl-proline modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0016853	isomerase activity	2	11
GO:0016859	cis-trans isomerase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	174	178	PF00082	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DOC_CKS1_1	139	144	PF01111	0.247
DOC_MAPK_HePTP_8	150	162	PF00069	0.500
DOC_MAPK_MEF2A_6	153	162	PF00069	0.500
DOC_MAPK_MEF2A_6	2	11	PF00069	0.659
DOC_PP1_RVXF_1	145	152	PF00149	0.374
DOC_WW_Pin1_4	138	143	PF00397	0.374
LIG_14-3-3_CanoR_1	174	180	PF00244	0.361
LIG_14-3-3_CanoR_1	54	62	PF00244	0.247
LIG_BRCT_BRCA1_1	131	135	PF00533	0.355
LIG_FHA_1	139	145	PF00498	0.359
LIG_FHA_1	14	20	PF00498	0.541
LIG_FHA_1	176	182	PF00498	0.369
LIG_FHA_1	24	30	PF00498	0.411
LIG_FHA_2	32	38	PF00498	0.259
LIG_FHA_2	89	95	PF00498	0.355
LIG_HCF-1_HBM_1	66	69	PF13415	0.247
LIG_LIR_Gen_1	74	84	PF02991	0.339
LIG_LIR_Gen_1	89	94	PF02991	0.340
LIG_LIR_Nem_3	27	33	PF02991	0.340
LIG_LIR_Nem_3	56	62	PF02991	0.418
LIG_LIR_Nem_3	74	79	PF02991	0.339
LIG_LIR_Nem_3	89	93	PF02991	0.340
LIG_MLH1_MIPbox_1	131	135	PF16413	0.355
LIG_SH2_STAT5	30	33	PF00017	0.394
LIG_SH3_3	136	142	PF00018	0.247
LIG_TYR_ITSM	26	33	PF00017	0.292
LIG_UBA3_1	43	50	PF00899	0.286
MOD_CK2_1	31	37	PF00069	0.383
MOD_GSK3_1	134	141	PF00069	0.355
MOD_GSK3_1	93	100	PF00069	0.355
MOD_N-GLC_1	129	134	PF02516	0.355
MOD_NEK2_1	134	139	PF00069	0.350
MOD_NEK2_1	31	36	PF00069	0.242
MOD_NEK2_1	93	98	PF00069	0.355
MOD_NEK2_2	175	180	PF00069	0.369
MOD_NEK2_2	71	76	PF00069	0.355
MOD_NEK2_2	97	102	PF00069	0.355
MOD_PIKK_1	129	135	PF00454	0.343
MOD_PKA_2	53	59	PF00069	0.332
MOD_Plk_1	31	37	PF00069	0.243
MOD_Plk_4	25	31	PF00069	0.525
MOD_Plk_4	71	77	PF00069	0.352
MOD_Plk_4	97	103	PF00069	0.362
MOD_ProDKin_1	138	144	PF00069	0.374
MOD_SUMO_for_1	106	109	PF00179	0.247
TRG_ENDOCYTIC_2	30	33	PF00928	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075B759	Homo sapiens	54%	100%
A0A075B767	Homo sapiens	54%	100%
A0A0B4J2A2	Homo sapiens	55%	100%
A0A0N0P364	Leptomonas seymouri	41%	82%
A0A0N0P523	Leptomonas seymouri	56%	68%
A0A0N0P839	Leptomonas seymouri	50%	95%
A0A0N1I0P5	Leptomonas seymouri	61%	100%
A0A0N1I6E6	Leptomonas seymouri	73%	98%
A0A0N1PC19	Leptomonas seymouri	36%	94%
A0A0N1PDY0	Leptomonas seymouri	32%	76%
A0A0S4J0W0	Bodo saltans	49%	76%
A0A0S4J351	Bodo saltans	33%	70%
A0A0S4J378	Bodo saltans	69%	100%
A0A0S4J465	Bodo saltans	27%	77%
A0A0S4J4A4	Bodo saltans	55%	100%
A0A0S4J7K8	Bodo saltans	62%	100%
A0A0S4J8W7	Bodo saltans	43%	81%
A0A0S4J9U9	Bodo saltans	34%	89%
A0A0S4JID7	Bodo saltans	50%	83%
A0A0S4KDV3	Bodo saltans	35%	99%
A0A0S4KGS8	Bodo saltans	36%	76%
A0A0S4KLH0	Bodo saltans	58%	94%
A0A1X0ND98	Trypanosomatidae	29%	96%
A0A1X0NGT2	Trypanosomatidae	33%	95%
A0A1X0NJS0	Trypanosomatidae	75%	98%
A0A1X0NTQ9	Trypanosomatidae	52%	82%
A0A1X0NTS4	Trypanosomatidae	44%	81%
A0A1X0NXG7	Trypanosomatidae	54%	72%
A0A1X0P184	Trypanosomatidae	56%	95%
A0A1X0P2K2	Trypanosomatidae	32%	71%
A0A1X0P4X3	Trypanosomatidae	36%	100%
A0A1X0P5F9	Trypanosomatidae	63%	100%
A0A3Q8ICB3	Leishmania donovani	44%	82%
A0A3R7MP70	Trypanosoma rangeli	37%	100%
A0A3R7NMR3	Trypanosoma rangeli	61%	100%
A0A3R7RC31	Trypanosoma rangeli	52%	95%
A0A3R7RE54	Trypanosoma rangeli	52%	73%
A0A3R7RI88	Trypanosoma rangeli	73%	98%
A0A3S5H5N2	Leishmania donovani	81%	100%
A0A3S5H7U6	Leishmania donovani	53%	72%
A0A3S5IQL2	Trypanosoma rangeli	28%	72%
A0A3S7WYY5	Leishmania donovani	56%	100%
A0A3S7X325	Leishmania donovani	31%	76%
A0A3S7X410	Leishmania donovani	51%	82%
A0A3S7XB52	Leishmania donovani	35%	70%
A0A422N1Z9	Trypanosoma rangeli	51%	83%
A0A422N490	Trypanosoma rangeli	45%	81%
A4HCI8	Leishmania braziliensis	43%	82%
A4HE26	Leishmania braziliensis	57%	100%
A4HHU7	Leishmania braziliensis	31%	76%
A4HIW9	Leishmania braziliensis	51%	82%
A4HLM4	Leishmania braziliensis	49%	95%
A4HPH9	Leishmania braziliensis	34%	94%
A4HSQ3	Leishmania infantum	81%	100%
A4I004	Leishmania infantum	44%	82%
A4I1D2	Leishmania infantum	56%	100%
A4I4Z7	Leishmania infantum	31%	76%
A4I698	Leishmania infantum	51%	82%
A4I935	Leishmania infantum	53%	72%
A4IDA1	Leishmania infantum	35%	70%
B3A0R0	Lottia gigantea	68%	91%
C9ZIV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	95%
C9ZNS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	79%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	72%
C9ZRQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	83%
C9ZSQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	81%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	94%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	66%
C9ZYX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A5M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A8E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
D4AY02	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	62%	83%
E9AKP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	85%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	82%
E9AXG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	76%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	82%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	73%
F5H284	Homo sapiens	54%	100%
O00060	Uromyces fabae	63%	100%
O00845	Paramecium primaurelia	58%	100%
O02614	Leishmania major	56%	100%
O25982	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	100%
O43447	Homo sapiens	55%	100%
O49605	Arabidopsis thaliana	52%	83%
O49886	Lupinus luteus	60%	100%
O53021	Dickeya dadantii (strain 3937)	35%	98%
O66105	Treponema pallidum (strain Nichols)	53%	87%
O74729	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
O93826	Arthroderma benhamiae	62%	83%
O94273	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	93%
P0AFL3	Escherichia coli (strain K12)	33%	98%
P0AFL4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	33%	98%
P0AFL5	Escherichia coli O157:H7	33%	98%
P0C1H7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	62%	100%
P0C1H8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	62%	100%
P0C1H9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	64%	89%
P0C1I0	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	63%	89%
P0C1I3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	54%	100%
P0C1I4	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	54%	100%
P0C1I5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	47%	100%
P0C1I7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	56%	100%
P0C1I8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	55%	100%
P0CP78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	60%	81%
P0CP79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	60%	81%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	58%	100%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	58%	100%
P0CP84	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	52%	100%
P0CP85	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	52%	100%
P0CP86	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	100%
P0CP87	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	100%
P0DN26	Homo sapiens	54%	100%
P0DN37	Homo sapiens	54%	100%
P10111	Rattus norvegicus	60%	100%
P10255	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	61%	84%
P14088	Echinococcus granulosus	61%	100%
P14832	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
P14851	Cricetulus griseus	59%	100%
P15425	Drosophila melanogaster	50%	79%
P17742	Mus musculus	59%	100%
P18253	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	100%
P20753	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	98%
P21568	Solanum lycopersicum	59%	100%
P21569	Zea mays	62%	100%
P22011	Candida albicans (strain SC5314 / ATCC MYA-2876)	64%	100%
P23284	Homo sapiens	60%	87%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	91%
P23869	Escherichia coli (strain K12)	37%	100%
P24367	Gallus gallus	67%	90%
P24368	Rattus norvegicus	61%	87%
P24369	Mus musculus	61%	87%
P24525	Brassica napus	61%	100%
P25007	Drosophila melanogaster	67%	82%
P25719	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P28517	Calliphora vicina	56%	80%
P29117	Rattus norvegicus	62%	91%
P29820	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	40%	100%
P30404	Bos taurus	62%	90%
P30405	Homo sapiens	62%	90%
P30412	Mus musculus	64%	88%
P34790	Arabidopsis thaliana	62%	100%
P34791	Arabidopsis thaliana	64%	72%
P34887	Allium cepa	66%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	83%
P35627	Unspecified eudicot DB-1992	64%	100%
P42693	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	37%	99%
P44499	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
P45877	Homo sapiens	59%	88%
P52009	Caenorhabditis elegans	63%	97%
P52010	Caenorhabditis elegans	61%	100%
P52011	Caenorhabditis elegans	59%	100%
P52013	Caenorhabditis elegans	64%	92%
P52014	Caenorhabditis elegans	58%	93%
P52015	Caenorhabditis elegans	57%	100%
P52017	Caenorhabditis elegans	45%	100%
P52018	Caenorhabditis elegans	55%	100%
P54985	Blattella germanica	61%	100%
P62935	Bos taurus	59%	100%
P62936	Sus scrofa	59%	100%
P62937	Homo sapiens	59%	100%
P62938	Chlorocebus aethiops	59%	100%
P62940	Macaca mulatta	59%	100%
P62941	Papio anubis	59%	100%
P65763	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	100%
P73789	Synechocystis sp. (strain PCC 6803 / Kazusa)	54%	100%
P77949	Streptomyces anulatus	42%	100%
P80311	Bos taurus	61%	87%
P83221	Streptomyces antibioticus	35%	100%
P84343	Neospora caninum	52%	100%
P87051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
P91791	Hemicentrotus pulcherrimus	58%	100%
P9WHW2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	100%
P9WHW3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	100%
Q01490	Orpinomyces sp. (strain PC-2)	65%	92%
Q06118	Streptomyces anulatus	60%	100%
Q08E11	Bos taurus	60%	88%
Q0P5D0	Bos taurus	55%	100%
Q0ZQK3	Saguinus oedipus	60%	100%
Q0ZQK6	Symphalangus syndactylus	59%	100%
Q0ZQK7	Nomascus leucogenys	59%	100%
Q0ZQK8	Hylobates lar	59%	100%
Q0ZQL0	Gorilla gorilla gorilla	59%	100%
Q0ZQL1	Pan troglodytes	59%	100%
Q0ZQL2	Pan paniscus	59%	100%
Q26516	Schistosoma japonicum	57%	100%
Q26548	Schistosoma mansoni	58%	68%
Q26551	Schistosoma mansoni	61%	88%
Q26565	Schistosoma mansoni	63%	100%
Q27774	Schistosoma japonicum	61%	88%
Q2FIC1	Staphylococcus aureus (strain USA300)	42%	95%
Q2FZU9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	42%	95%
Q2TZ33	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	60%	100%
Q2U6U0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	52%	100%
Q2UGK2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	69%	97%
Q2YPY5	Brucella abortus (strain 2308)	35%	95%
Q2YWT2	Staphylococcus aureus (strain bovine RF122 / ET3-1)	42%	95%
Q38867	Arabidopsis thaliana	57%	100%
Q38900	Arabidopsis thaliana	62%	100%
Q39613	Catharanthus roseus	61%	100%
Q41651	Vicia faba	61%	75%
Q42406	Arabidopsis thaliana	60%	100%
Q49W93	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	42%	95%
Q4I1Y1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	54%	100%
Q4I5R9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	66%	75%
Q4IPB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	45%	100%
Q4IPH4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	62%	100%
Q4L4W9	Staphylococcus haemolyticus (strain JCSC1435)	43%	94%
Q4P6X6	Ustilago maydis (strain 521 / FGSC 9021)	58%	100%
Q4PCH8	Ustilago maydis (strain 521 / FGSC 9021)	37%	100%
Q4Q1A6	Leishmania major	35%	100%
Q4Q424	Leishmania major	53%	100%
Q4Q6Q9	Leishmania major	46%	100%
Q4Q7V7	Leishmania major	31%	100%
Q4QAK0	Leishmania major	32%	77%
Q4QBK2	Leishmania major	43%	100%
Q4QJ67	Leishmania major	83%	100%
Q4WCM6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	58%	100%
Q4WCR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	53%	100%
Q4WMB6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	88%
Q4WP12	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	66%	89%
Q54E95	Dictyostelium discoideum	47%	100%
Q54SM3	Dictyostelium discoideum	59%	100%
Q57D43	Brucella abortus biovar 1 (strain 9-941)	35%	95%
Q59641	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	32%	100%
Q5AQL0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	58%	100%
Q5ASQ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	52%	100%
Q5B4R3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	64%	87%
Q5BAH7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	89%
Q5E992	Bos taurus	51%	100%
Q5HHD1	Staphylococcus aureus (strain COL)	42%	95%
Q5HQK8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	43%	95%
Q5R8S7	Pongo pygmaeus	59%	100%
Q5UP71	Acanthamoeba polyphaga mimivirus	30%	80%
Q5ZLV2	Gallus gallus	45%	100%
Q6C4W6	Yarrowia lipolytica (strain CLIB 122 / E 150)	60%	82%
Q6DTV9	Aotus trivirgatus	60%	100%
Q6GAX2	Staphylococcus aureus (strain MSSA476)	42%	95%
Q6GID4	Staphylococcus aureus (strain MRSA252)	42%	95%
Q6MWS8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	100%
Q7A1C0	Staphylococcus aureus (strain MW2)	42%	95%
Q7A6I1	Staphylococcus aureus (strain N315)	42%	95%
Q7SF72	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	51%	100%
Q7SG06	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	63%	100%
Q812D3	Rattus norvegicus	45%	100%
Q8CT84	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	43%	95%
Q8G0J9	Brucella suis biovar 1 (strain 1330)	34%	95%
Q8HXS3	Felis catus	57%	100%
Q8L8W5	Arabidopsis thaliana	60%	82%
Q8LDP4	Arabidopsis thaliana	59%	93%
Q8SRE1	Encephalitozoon cuniculi (strain GB-M1)	58%	100%
Q8W171	Glycine max	62%	100%
Q8X166	Aspergillus niger	67%	88%
Q8X191	Aspergillus niger	53%	100%
Q8YHB5	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	34%	95%
Q94A16	Arabidopsis thaliana	31%	81%
Q99KR7	Mus musculus	61%	91%
Q99VD4	Staphylococcus aureus (strain Mu50 / ATCC 700699)	42%	95%
Q9ASS6	Arabidopsis thaliana	63%	72%
Q9C835	Arabidopsis thaliana	31%	79%
Q9CDE9	Mycobacterium leprae (strain TN)	41%	100%
Q9D0W5	Mus musculus	51%	100%
Q9D6L8	Mus musculus	45%	100%
Q9D868	Mus musculus	57%	99%
Q9H2H8	Homo sapiens	46%	100%
Q9LIK6	Arabidopsis thaliana	44%	81%
Q9LPC7	Arabidopsis thaliana	50%	100%
Q9NI62	Dictyostelium discoideum	47%	100%
Q9SIH1	Arabidopsis thaliana	48%	100%
Q9SKQ0	Arabidopsis thaliana	59%	100%
Q9SP02	Arabidopsis thaliana	62%	92%
Q9TTC6	Oryctolagus cuniculus	59%	100%
Q9TW32	Dictyostelium discoideum	59%	95%
Q9UA41	Dictyostelium discoideum	55%	100%
Q9Y3C6	Homo sapiens	51%	100%
Q9Y536	Homo sapiens	54%	100%
Q9ZJH5	Helicobacter pylori (strain J99 / ATCC 700824)	39%	100%
Q9ZVJ4	Arabidopsis thaliana	51%	94%
V5B2A0	Trypanosoma cruzi	56%	72%
V5BGX2	Trypanosoma cruzi	29%	71%
V5BHF5	Trypanosoma cruzi	54%	95%
V5BM49	Trypanosoma cruzi	43%	76%
V5D532	Trypanosoma cruzi	71%	96%