Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4H7_LEIBR

TriTrypDb:

LbrM.06.0090 , LBRM2903_060006300

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H4H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.526
CLV_NRD_NRD_1	183	185	PF00675	0.174
CLV_NRD_NRD_1	213	215	PF00675	0.346
CLV_NRD_NRD_1	317	319	PF00675	0.283
CLV_NRD_NRD_1	56	58	PF00675	0.492
CLV_NRD_NRD_1	589	591	PF00675	0.436
CLV_PCSK_KEX2_1	154	156	PF00082	0.525
CLV_PCSK_KEX2_1	183	185	PF00082	0.174
CLV_PCSK_KEX2_1	213	215	PF00082	0.299
CLV_PCSK_KEX2_1	261	263	PF00082	0.316
CLV_PCSK_KEX2_1	317	319	PF00082	0.345
CLV_PCSK_KEX2_1	56	58	PF00082	0.492
CLV_PCSK_KEX2_1	589	591	PF00082	0.436
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.236
CLV_PCSK_SKI1_1	261	265	PF00082	0.236
CLV_PCSK_SKI1_1	28	32	PF00082	0.187
CLV_PCSK_SKI1_1	583	587	PF00082	0.442
CLV_PCSK_SKI1_1	7	11	PF00082	0.396
CLV_PCSK_SKI1_1	91	95	PF00082	0.418
DEG_APCC_DBOX_1	90	98	PF00400	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DEG_SPOP_SBC_1	127	131	PF00917	0.593
DEG_SPOP_SBC_1	284	288	PF00917	0.379
DOC_CKS1_1	348	353	PF01111	0.458
DOC_CYCLIN_RxL_1	2	13	PF00134	0.581
DOC_MAPK_gen_1	50	60	PF00069	0.367
DOC_PP1_RVXF_1	195	202	PF00149	0.470
DOC_PP1_RVXF_1	26	33	PF00149	0.540
DOC_USP7_MATH_1	114	118	PF00917	0.612
DOC_USP7_MATH_1	125	129	PF00917	0.669
DOC_USP7_MATH_1	204	208	PF00917	0.476
DOC_USP7_MATH_1	284	288	PF00917	0.478
DOC_USP7_MATH_1	359	363	PF00917	0.457
DOC_USP7_MATH_1	373	377	PF00917	0.556
DOC_USP7_MATH_1	430	434	PF00917	0.478
DOC_USP7_MATH_1	592	596	PF00917	0.675
DOC_WW_Pin1_4	280	285	PF00397	0.590
DOC_WW_Pin1_4	347	352	PF00397	0.479
LIG_14-3-3_CanoR_1	154	161	PF00244	0.672
LIG_14-3-3_CanoR_1	183	188	PF00244	0.472
LIG_14-3-3_CanoR_1	191	201	PF00244	0.511
LIG_14-3-3_CanoR_1	2	10	PF00244	0.552
LIG_14-3-3_CanoR_1	213	220	PF00244	0.507
LIG_14-3-3_CanoR_1	252	258	PF00244	0.538
LIG_14-3-3_CanoR_1	267	275	PF00244	0.508
LIG_14-3-3_CanoR_1	28	33	PF00244	0.551
LIG_14-3-3_CanoR_1	416	420	PF00244	0.431
LIG_14-3-3_CanoR_1	452	457	PF00244	0.443
LIG_14-3-3_CanoR_1	460	466	PF00244	0.446
LIG_14-3-3_CanoR_1	491	495	PF00244	0.587
LIG_14-3-3_CanoR_1	531	539	PF00244	0.614
LIG_14-3-3_CanoR_1	571	575	PF00244	0.548
LIG_Actin_WH2_2	567	585	PF00022	0.590
LIG_BRCT_BRCA1_1	425	429	PF00533	0.495
LIG_Clathr_ClatBox_1	9	13	PF01394	0.553
LIG_deltaCOP1_diTrp_1	473	479	PF00928	0.462
LIG_deltaCOP1_diTrp_1	69	79	PF00928	0.361
LIG_EVH1_1	348	352	PF00568	0.389
LIG_FHA_1	111	117	PF00498	0.782
LIG_FHA_1	144	150	PF00498	0.704
LIG_FHA_1	221	227	PF00498	0.475
LIG_FHA_1	32	38	PF00498	0.298
LIG_FHA_1	571	577	PF00498	0.522
LIG_FHA_1	589	595	PF00498	0.529
LIG_FHA_1	87	93	PF00498	0.254
LIG_FHA_2	193	199	PF00498	0.508
LIG_FHA_2	594	600	PF00498	0.645
LIG_FHA_2	6	12	PF00498	0.649
LIG_Integrin_RGD_1	17	19	PF01839	0.331
LIG_LIR_Apic_2	365	371	PF02991	0.542
LIG_LIR_Apic_2	47	52	PF02991	0.413
LIG_LIR_Gen_1	290	301	PF02991	0.470
LIG_LIR_Gen_1	498	505	PF02991	0.551
LIG_LIR_Nem_3	290	296	PF02991	0.428
LIG_LIR_Nem_3	4	9	PF02991	0.555
LIG_LIR_Nem_3	498	503	PF02991	0.489
LIG_LIR_Nem_3	523	528	PF02991	0.513
LIG_LIR_Nem_3	565	570	PF02991	0.596
LIG_NRBOX	89	95	PF00104	0.323
LIG_Pex14_1	475	479	PF04695	0.438
LIG_SH2_CRK	567	571	PF00017	0.556
LIG_SH2_CRK	6	10	PF00017	0.554
LIG_SH2_CRK	82	86	PF00017	0.248
LIG_SH2_PTP2	527	530	PF00017	0.412
LIG_SH2_SRC	461	464	PF00017	0.470
LIG_SH2_STAP1	259	263	PF00017	0.374
LIG_SH2_STAT3	396	399	PF00017	0.473
LIG_SH2_STAT5	396	399	PF00017	0.527
LIG_SH2_STAT5	41	44	PF00017	0.264
LIG_SH2_STAT5	448	451	PF00017	0.461
LIG_SH2_STAT5	461	464	PF00017	0.438
LIG_SH2_STAT5	500	503	PF00017	0.517
LIG_SH2_STAT5	517	520	PF00017	0.570
LIG_SH2_STAT5	525	528	PF00017	0.479
LIG_SH3_2	189	194	PF14604	0.470
LIG_SH3_3	186	192	PF00018	0.501
LIG_SH3_3	346	352	PF00018	0.494
LIG_SH3_3	367	373	PF00018	0.502
LIG_SH3_3	431	437	PF00018	0.483
LIG_SH3_3	97	103	PF00018	0.699
LIG_SUMO_SIM_par_1	572	578	PF11976	0.583
LIG_SUMO_SIM_par_1	63	70	PF11976	0.346
LIG_SUMO_SIM_par_1	8	13	PF11976	0.572
LIG_TRAF2_1	343	346	PF00917	0.495
LIG_TYR_ITIM	561	566	PF00017	0.524
LIG_TYR_ITIM	80	85	PF00017	0.368
LIG_UBA3_1	486	495	PF00899	0.565
MOD_CK1_1	128	134	PF00069	0.776
MOD_CK1_1	136	142	PF00069	0.717
MOD_CK1_1	221	227	PF00069	0.407
MOD_CK1_1	277	283	PF00069	0.551
MOD_CK1_1	286	292	PF00069	0.498
MOD_CK1_1	362	368	PF00069	0.573
MOD_CK1_1	432	438	PF00069	0.466
MOD_CK1_1	464	470	PF00069	0.461
MOD_CK1_1	534	540	PF00069	0.633
MOD_CK2_1	340	346	PF00069	0.475
MOD_CK2_1	435	441	PF00069	0.443
MOD_CK2_1	544	550	PF00069	0.499
MOD_CK2_1	593	599	PF00069	0.642
MOD_Cter_Amidation	587	590	PF01082	0.402
MOD_GlcNHglycan	164	167	PF01048	0.279
MOD_GlcNHglycan	168	171	PF01048	0.236
MOD_GlcNHglycan	206	209	PF01048	0.318
MOD_GlcNHglycan	214	217	PF01048	0.309
MOD_GlcNHglycan	220	223	PF01048	0.260
MOD_GlcNHglycan	230	234	PF01048	0.193
MOD_GlcNHglycan	243	246	PF01048	0.262
MOD_GlcNHglycan	375	378	PF01048	0.354
MOD_GlcNHglycan	424	428	PF01048	0.259
MOD_GlcNHglycan	467	470	PF01048	0.332
MOD_GSK3_1	1	8	PF00069	0.667
MOD_GSK3_1	110	117	PF00069	0.659
MOD_GSK3_1	128	135	PF00069	0.653
MOD_GSK3_1	162	169	PF00069	0.453
MOD_GSK3_1	183	190	PF00069	0.482
MOD_GSK3_1	274	281	PF00069	0.512
MOD_GSK3_1	283	290	PF00069	0.420
MOD_GSK3_1	358	365	PF00069	0.551
MOD_GSK3_1	425	432	PF00069	0.480
MOD_GSK3_1	461	468	PF00069	0.475
MOD_GSK3_1	534	541	PF00069	0.615
MOD_GSK3_1	588	595	PF00069	0.686
MOD_N-GLC_1	132	137	PF02516	0.474
MOD_N-GLC_1	465	470	PF02516	0.303
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	220	225	PF00069	0.527
MOD_NEK2_1	278	283	PF00069	0.431
MOD_NEK2_1	423	428	PF00069	0.472
MOD_NEK2_1	44	49	PF00069	0.327
MOD_NEK2_1	490	495	PF00069	0.593
MOD_NEK2_1	538	543	PF00069	0.617
MOD_NEK2_1	81	86	PF00069	0.312
MOD_NEK2_2	86	91	PF00069	0.186
MOD_PIKK_1	352	358	PF00454	0.512
MOD_PKA_1	154	160	PF00069	0.672
MOD_PKA_1	183	189	PF00069	0.374
MOD_PKA_2	1	7	PF00069	0.564
MOD_PKA_2	125	131	PF00069	0.704
MOD_PKA_2	154	160	PF00069	0.792
MOD_PKA_2	182	188	PF00069	0.379
MOD_PKA_2	212	218	PF00069	0.550
MOD_PKA_2	268	274	PF00069	0.514
MOD_PKA_2	415	421	PF00069	0.470
MOD_PKA_2	435	441	PF00069	0.491
MOD_PKA_2	490	496	PF00069	0.578
MOD_PKA_2	570	576	PF00069	0.595
MOD_PKA_2	588	594	PF00069	0.652
MOD_PKB_1	124	132	PF00069	0.689
MOD_PKB_1	26	34	PF00069	0.448
MOD_PKB_1	529	537	PF00069	0.612
MOD_Plk_1	132	138	PF00069	0.749
MOD_Plk_1	142	148	PF00069	0.716
MOD_Plk_4	136	142	PF00069	0.713
MOD_Plk_4	28	34	PF00069	0.477
MOD_Plk_4	44	50	PF00069	0.215
MOD_Plk_4	534	540	PF00069	0.576
MOD_Plk_4	544	550	PF00069	0.482
MOD_ProDKin_1	280	286	PF00069	0.590
MOD_ProDKin_1	347	353	PF00069	0.479
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.374
TRG_ENDOCYTIC_2	41	44	PF00928	0.290
TRG_ENDOCYTIC_2	500	503	PF00928	0.470
TRG_ENDOCYTIC_2	525	528	PF00928	0.487
TRG_ENDOCYTIC_2	563	566	PF00928	0.505
TRG_ENDOCYTIC_2	567	570	PF00928	0.508
TRG_ENDOCYTIC_2	6	9	PF00928	0.555
TRG_ENDOCYTIC_2	82	85	PF00928	0.407
TRG_ER_diArg_1	154	156	PF00400	0.727
TRG_ER_diArg_1	317	319	PF00400	0.559
TRG_ER_diArg_1	528	531	PF00400	0.505
TRG_ER_diArg_1	55	57	PF00400	0.293
TRG_ER_diArg_1	75	78	PF00400	0.321
TRG_NES_CRM1_1	550	565	PF08389	0.568
TRG_NES_CRM1_1	575	587	PF08389	0.582
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.174
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR5	Leptomonas seymouri	56%	99%
A0A0S4J1D5	Bodo saltans	33%	94%
A0A1X0NL56	Trypanosomatidae	36%	100%
A0A3R7NA89	Trypanosoma rangeli	35%	100%
A0A3S5H5N1	Leishmania donovani	82%	100%
A4HSQ2	Leishmania infantum	82%	100%
C9ZT98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QJ68	Leishmania major	82%	100%
V5AP94	Trypanosoma cruzi	33%	100%