Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4H5_LEIBR

TriTrypDb:

LbrM.06.0070 , LBRM2903_060006100

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.511
CLV_NRD_NRD_1	306	308	PF00675	0.437
CLV_NRD_NRD_1	405	407	PF00675	0.513
CLV_NRD_NRD_1	47	49	PF00675	0.481
CLV_PCSK_FUR_1	112	116	PF00082	0.330
CLV_PCSK_KEX2_1	114	116	PF00082	0.489
CLV_PCSK_KEX2_1	306	308	PF00082	0.437
CLV_PCSK_KEX2_1	405	407	PF00082	0.476
CLV_PCSK_KEX2_1	47	49	PF00082	0.481
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.339
CLV_PCSK_PC7_1	302	308	PF00082	0.277
CLV_PCSK_SKI1_1	316	320	PF00082	0.389
CLV_PCSK_SKI1_1	336	340	PF00082	0.386
CLV_PCSK_SKI1_1	357	361	PF00082	0.385
CLV_PCSK_SKI1_1	408	412	PF00082	0.511
DEG_APCC_DBOX_1	308	316	PF00400	0.420
DOC_CDC14_PxL_1	278	286	PF14671	0.432
DOC_CDC14_PxL_1	294	302	PF14671	0.379
DOC_MAPK_gen_1	306	314	PF00069	0.371
DOC_MAPK_gen_1	366	376	PF00069	0.323
DOC_MAPK_MEF2A_6	134	142	PF00069	0.407
DOC_PP1_RVXF_1	367	373	PF00149	0.294
DOC_PP1_RVXF_1	403	410	PF00149	0.455
DOC_PP2B_LxvP_1	163	166	PF13499	0.533
DOC_PP2B_LxvP_1	338	341	PF13499	0.512
DOC_PP2B_LxvP_1	347	350	PF13499	0.563
DOC_PP4_FxxP_1	178	181	PF00568	0.497
DOC_PP4_FxxP_1	325	328	PF00568	0.326
DOC_USP7_MATH_1	12	16	PF00917	0.525
DOC_USP7_MATH_1	264	268	PF00917	0.507
DOC_USP7_MATH_1	401	405	PF00917	0.524
DOC_USP7_MATH_1	75	79	PF00917	0.567
DOC_USP7_MATH_1	96	100	PF00917	0.549
DOC_USP7_UBL2_3	186	190	PF12436	0.323
DOC_WW_Pin1_4	134	139	PF00397	0.416
DOC_WW_Pin1_4	324	329	PF00397	0.460
DOC_WW_Pin1_4	349	354	PF00397	0.482
DOC_WW_Pin1_4	409	414	PF00397	0.564
LIG_14-3-3_CanoR_1	235	239	PF00244	0.429
LIG_14-3-3_CanoR_1	283	287	PF00244	0.481
LIG_14-3-3_CanoR_1	336	341	PF00244	0.594
LIG_14-3-3_CanoR_1	357	362	PF00244	0.387
LIG_14-3-3_CanoR_1	430	434	PF00244	0.385
LIG_CaM_IQ_9	39	55	PF13499	0.438
LIG_EVH1_1	347	351	PF00568	0.510
LIG_FHA_1	165	171	PF00498	0.496
LIG_FHA_1	177	183	PF00498	0.340
LIG_FHA_1	231	237	PF00498	0.450
LIG_FHA_1	358	364	PF00498	0.455
LIG_FHA_1	365	371	PF00498	0.439
LIG_FHA_2	215	221	PF00498	0.504
LIG_FHA_2	59	65	PF00498	0.727
LIG_LIR_Apic_2	177	181	PF02991	0.514
LIG_LIR_Apic_2	324	328	PF02991	0.340
LIG_LIR_Apic_2	380	385	PF02991	0.409
LIG_LIR_Gen_1	143	151	PF02991	0.436
LIG_LIR_Gen_1	358	365	PF02991	0.399
LIG_LIR_Gen_1	420	431	PF02991	0.443
LIG_LIR_Gen_1	88	96	PF02991	0.437
LIG_LIR_LC3C_4	7	11	PF02991	0.518
LIG_LIR_Nem_3	118	124	PF02991	0.340
LIG_LIR_Nem_3	143	147	PF02991	0.327
LIG_LIR_Nem_3	20	24	PF02991	0.472
LIG_LIR_Nem_3	358	364	PF02991	0.399
LIG_LIR_Nem_3	420	426	PF02991	0.464
LIG_LIR_Nem_3	69	73	PF02991	0.486
LIG_LIR_Nem_3	88	92	PF02991	0.435
LIG_Pex14_1	210	214	PF04695	0.421
LIG_SH2_CRK	144	148	PF00017	0.468
LIG_SH2_CRK	202	206	PF00017	0.283
LIG_SH2_CRK	305	309	PF00017	0.388
LIG_SH2_CRK	382	386	PF00017	0.371
LIG_SH2_CRK	89	93	PF00017	0.498
LIG_SH2_NCK_1	144	148	PF00017	0.281
LIG_SH2_NCK_1	382	386	PF00017	0.292
LIG_SH2_SRC	394	397	PF00017	0.514
LIG_SH2_STAP1	121	125	PF00017	0.450
LIG_SH2_STAP1	73	77	PF00017	0.428
LIG_SH2_STAT5	202	205	PF00017	0.383
LIG_SH2_STAT5	296	299	PF00017	0.292
LIG_SH2_STAT5	394	397	PF00017	0.544
LIG_SH2_STAT5	89	92	PF00017	0.522
LIG_SH3_3	345	351	PF00018	0.625
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.259
LIG_SUMO_SIM_anti_2	7	12	PF11976	0.523
LIG_SUMO_SIM_par_1	166	171	PF11976	0.573
LIG_SUMO_SIM_par_1	179	185	PF11976	0.325
LIG_SUMO_SIM_par_1	327	332	PF11976	0.444
LIG_TYR_ITIM	142	147	PF00017	0.283
LIG_TYR_ITIM	200	205	PF00017	0.301
LIG_TYR_ITIM	87	92	PF00017	0.533
LIG_WRC_WIRS_1	175	180	PF05994	0.395
MOD_CK1_1	386	392	PF00069	0.466
MOD_CK1_1	412	418	PF00069	0.485
MOD_CK2_1	214	220	PF00069	0.375
MOD_CK2_1	58	64	PF00069	0.546
MOD_DYRK1A_RPxSP_1	134	138	PF00069	0.418
MOD_GlcNHglycan	134	137	PF01048	0.549
MOD_GlcNHglycan	169	173	PF01048	0.445
MOD_GlcNHglycan	32	35	PF01048	0.534
MOD_GlcNHglycan	379	382	PF01048	0.459
MOD_GlcNHglycan	441	444	PF01048	0.409
MOD_GlcNHglycan	77	80	PF01048	0.640
MOD_GSK3_1	164	171	PF00069	0.470
MOD_GSK3_1	210	217	PF00069	0.427
MOD_GSK3_1	226	233	PF00069	0.329
MOD_GSK3_1	364	371	PF00069	0.510
MOD_GSK3_1	383	390	PF00069	0.365
MOD_GSK3_1	411	418	PF00069	0.493
MOD_N-GLC_1	17	22	PF02516	0.395
MOD_NEK2_1	182	187	PF00069	0.427
MOD_NEK2_1	271	276	PF00069	0.356
MOD_NEK2_1	30	35	PF00069	0.536
MOD_NEK2_1	370	375	PF00069	0.418
MOD_NEK2_1	429	434	PF00069	0.479
MOD_NEK2_1	441	446	PF00069	0.431
MOD_PIKK_1	96	102	PF00454	0.381
MOD_PKA_2	210	216	PF00069	0.564
MOD_PKA_2	234	240	PF00069	0.436
MOD_PKA_2	282	288	PF00069	0.406
MOD_PKA_2	365	371	PF00069	0.374
MOD_PKA_2	429	435	PF00069	0.408
MOD_PKA_2	96	102	PF00069	0.381
MOD_Plk_1	17	23	PF00069	0.397
MOD_Plk_1	329	335	PF00069	0.299
MOD_Plk_1	87	93	PF00069	0.441
MOD_Plk_2-3	383	389	PF00069	0.397
MOD_Plk_4	120	126	PF00069	0.336
MOD_Plk_4	17	23	PF00069	0.481
MOD_Plk_4	239	245	PF00069	0.421
MOD_Plk_4	25	31	PF00069	0.419
MOD_Plk_4	264	270	PF00069	0.491
MOD_Plk_4	429	435	PF00069	0.365
MOD_Plk_4	87	93	PF00069	0.442
MOD_ProDKin_1	134	140	PF00069	0.408
MOD_ProDKin_1	324	330	PF00069	0.465
MOD_ProDKin_1	349	355	PF00069	0.471
MOD_ProDKin_1	409	415	PF00069	0.564
MOD_SUMO_for_1	258	261	PF00179	0.475
MOD_SUMO_rev_2	255	260	PF00179	0.634
MOD_SUMO_rev_2	69	78	PF00179	0.387
TRG_DiLeu_BaEn_1	25	30	PF01217	0.383
TRG_DiLeu_BaEn_2	309	315	PF01217	0.307
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.297
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.288
TRG_ENDOCYTIC_2	144	147	PF00928	0.466
TRG_ENDOCYTIC_2	202	205	PF00928	0.320
TRG_ENDOCYTIC_2	305	308	PF00928	0.472
TRG_ENDOCYTIC_2	89	92	PF00928	0.428
TRG_ER_diArg_1	245	248	PF00400	0.404
TRG_ER_diArg_1	305	307	PF00400	0.469
TRG_ER_diArg_1	405	408	PF00400	0.522
TRG_NES_CRM1_1	266	279	PF08389	0.285
TRG_NES_CRM1_1	310	324	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NL12	Trypanosomatidae	31%	100%
C9ZT97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AKN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QJ72	Leishmania major	74%	100%
V5B4P7	Trypanosoma cruzi	31%	100%