Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4H4_LEIBR

TriTrypDb:

LbrM.06.0060 , LBRM2903_060006000

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	86	92	PF00089	0.419
CLV_NRD_NRD_1	157	159	PF00675	0.524
CLV_NRD_NRD_1	168	170	PF00675	0.598
CLV_NRD_NRD_1	197	199	PF00675	0.576
CLV_NRD_NRD_1	212	214	PF00675	0.394
CLV_NRD_NRD_1	240	242	PF00675	0.589
CLV_NRD_NRD_1	68	70	PF00675	0.643
CLV_NRD_NRD_1	88	90	PF00675	0.524
CLV_PCSK_KEX2_1	155	157	PF00082	0.636
CLV_PCSK_KEX2_1	168	170	PF00082	0.451
CLV_PCSK_KEX2_1	197	199	PF00082	0.576
CLV_PCSK_KEX2_1	212	214	PF00082	0.394
CLV_PCSK_KEX2_1	87	89	PF00082	0.575
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.622
CLV_PCSK_SKI1_1	158	162	PF00082	0.411
DEG_Nend_UBRbox_3	1	3	PF02207	0.805
DOC_CYCLIN_RxL_1	155	165	PF00134	0.407
DOC_CYCLIN_RxL_1	288	301	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.561
DOC_PP2B_LxvP_1	278	281	PF13499	0.581
DOC_PP2B_LxvP_1	295	298	PF13499	0.736
DOC_USP7_MATH_1	134	138	PF00917	0.543
DOC_USP7_MATH_1	226	230	PF00917	0.656
DOC_USP7_MATH_1	289	293	PF00917	0.835
DOC_USP7_MATH_1	315	319	PF00917	0.675
DOC_USP7_MATH_1	386	390	PF00917	0.597
DOC_USP7_MATH_1	401	405	PF00917	0.476
DOC_USP7_MATH_1	423	427	PF00917	0.578
DOC_USP7_MATH_1	68	72	PF00917	0.488
DOC_USP7_UBL2_3	155	159	PF12436	0.411
DOC_WW_Pin1_4	13	18	PF00397	0.505
DOC_WW_Pin1_4	233	238	PF00397	0.776
DOC_WW_Pin1_4	276	281	PF00397	0.558
DOC_WW_Pin1_4	307	312	PF00397	0.835
DOC_WW_Pin1_4	325	330	PF00397	0.506
DOC_WW_Pin1_4	335	340	PF00397	0.494
DOC_WW_Pin1_4	350	355	PF00397	0.495
DOC_WW_Pin1_4	419	424	PF00397	0.562
LIG_14-3-3_CanoR_1	197	207	PF00244	0.409
LIG_14-3-3_CanoR_1	218	223	PF00244	0.506
LIG_14-3-3_CanoR_1	293	298	PF00244	0.624
LIG_14-3-3_CanoR_1	320	326	PF00244	0.579
LIG_14-3-3_CanoR_1	69	74	PF00244	0.554
LIG_BRCT_BRCA1_1	317	321	PF00533	0.595
LIG_eIF4E_1	359	365	PF01652	0.538
LIG_FHA_1	336	342	PF00498	0.565
LIG_FHA_1	346	352	PF00498	0.527
LIG_FHA_2	111	117	PF00498	0.444
LIG_FHA_2	172	178	PF00498	0.390
LIG_FHA_2	234	240	PF00498	0.765
LIG_FHA_2	26	32	PF00498	0.477
LIG_FHA_2	43	49	PF00498	0.540
LIG_LIR_Apic_2	273	277	PF02991	0.637
LIG_LIR_Gen_1	357	365	PF02991	0.535
LIG_LIR_Gen_1	412	423	PF02991	0.561
LIG_LIR_Nem_3	330	335	PF02991	0.566
LIG_LIR_Nem_3	357	362	PF02991	0.517
LIG_LIR_Nem_3	412	418	PF02991	0.562
LIG_MYND_1	276	280	PF01753	0.539
LIG_PDZ_Class_3	422	427	PF00595	0.565
LIG_Pex14_2	411	415	PF04695	0.561
LIG_SH2_NCK_1	176	180	PF00017	0.539
LIG_SH2_STAP1	119	123	PF00017	0.548
LIG_SH2_STAP1	80	84	PF00017	0.417
LIG_SH2_STAT3	119	122	PF00017	0.511
LIG_SH2_STAT5	359	362	PF00017	0.536
LIG_SH3_1	274	280	PF00018	0.540
LIG_SH3_2	378	383	PF14604	0.594
LIG_SH3_3	274	280	PF00018	0.620
LIG_SH3_3	281	287	PF00018	0.660
LIG_SH3_3	306	312	PF00018	0.631
LIG_SH3_3	348	354	PF00018	0.562
LIG_SH3_3	375	381	PF00018	0.592
LIG_SUMO_SIM_par_1	22	28	PF11976	0.439
LIG_TRAF2_1	206	209	PF00917	0.650
LIG_TRAF2_1	236	239	PF00917	0.765
LIG_TRAF2_1	261	264	PF00917	0.566
LIG_UBA3_1	149	155	PF00899	0.459
LIG_UBA3_1	160	166	PF00899	0.478
LIG_WRC_WIRS_1	408	413	PF05994	0.549
MOD_CK1_1	112	118	PF00069	0.620
MOD_CK1_1	296	302	PF00069	0.633
MOD_CK1_1	328	334	PF00069	0.559
MOD_CK1_1	387	393	PF00069	0.587
MOD_CK1_1	419	425	PF00069	0.563
MOD_CK1_1	71	77	PF00069	0.602
MOD_CK1_1	79	85	PF00069	0.613
MOD_CK2_1	110	116	PF00069	0.439
MOD_CK2_1	134	140	PF00069	0.456
MOD_CK2_1	171	177	PF00069	0.641
MOD_CK2_1	203	209	PF00069	0.653
MOD_CK2_1	233	239	PF00069	0.675
MOD_CK2_1	25	31	PF00069	0.622
MOD_CK2_1	363	369	PF00069	0.544
MOD_CK2_1	386	392	PF00069	0.594
MOD_CK2_1	419	425	PF00069	0.601
MOD_CK2_1	42	48	PF00069	0.405
MOD_GlcNHglycan	11	14	PF01048	0.647
MOD_GlcNHglycan	226	229	PF01048	0.774
MOD_GlcNHglycan	246	249	PF01048	0.692
MOD_GlcNHglycan	7	10	PF01048	0.662
MOD_GSK3_1	1	8	PF00069	0.754
MOD_GSK3_1	180	187	PF00069	0.616
MOD_GSK3_1	224	231	PF00069	0.652
MOD_GSK3_1	289	296	PF00069	0.745
MOD_GSK3_1	321	328	PF00069	0.586
MOD_GSK3_1	345	352	PF00069	0.567
MOD_GSK3_1	386	393	PF00069	0.588
MOD_GSK3_1	419	426	PF00069	0.564
MOD_GSK3_1	9	16	PF00069	0.583
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	184	189	PF00069	0.474
MOD_NEK2_1	270	275	PF00069	0.792
MOD_NEK2_1	321	326	PF00069	0.575
MOD_NEK2_1	42	47	PF00069	0.649
MOD_NEK2_2	315	320	PF00069	0.592
MOD_PK_1	69	75	PF00069	0.501
MOD_PKA_1	69	75	PF00069	0.638
MOD_PKA_2	217	223	PF00069	0.448
MOD_PKA_2	68	74	PF00069	0.564
MOD_PKB_1	87	95	PF00069	0.630
MOD_Plk_1	171	177	PF00069	0.641
MOD_Plk_1	387	393	PF00069	0.587
MOD_Plk_4	265	271	PF00069	0.633
MOD_ProDKin_1	13	19	PF00069	0.505
MOD_ProDKin_1	233	239	PF00069	0.777
MOD_ProDKin_1	276	282	PF00069	0.563
MOD_ProDKin_1	307	313	PF00069	0.833
MOD_ProDKin_1	325	331	PF00069	0.506
MOD_ProDKin_1	335	341	PF00069	0.492
MOD_ProDKin_1	350	356	PF00069	0.491
MOD_ProDKin_1	419	425	PF00069	0.563
MOD_SUMO_rev_2	137	144	PF00179	0.538
MOD_SUMO_rev_2	55	65	PF00179	0.476
TRG_ENDOCYTIC_2	359	362	PF00928	0.536
TRG_ER_diArg_1	167	169	PF00400	0.648
TRG_ER_diArg_1	197	199	PF00400	0.576
TRG_ER_diArg_1	211	213	PF00400	0.468
TRG_ER_diArg_1	86	89	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5M8	Leishmania donovani	68%	100%
A4HSP9	Leishmania infantum	68%	100%
E9AKN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QJ73	Leishmania major	67%	100%