Putative pumillio protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 5, putative

Species:

Leishmania braziliensis

UniProt:

A4H4H3_LEIBR

TriTrypDb:

LbrM.06.0050 , LBRM2903_060005900

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003723	RNA binding	4	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.549
CLV_NRD_NRD_1	269	271	PF00675	0.389
CLV_PCSK_KEX2_1	269	271	PF00082	0.389
CLV_PCSK_KEX2_1	320	322	PF00082	0.409
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.448
CLV_PCSK_SKI1_1	195	199	PF00082	0.394
CLV_PCSK_SKI1_1	269	273	PF00082	0.413
DEG_APCC_DBOX_1	194	202	PF00400	0.371
DEG_APCC_DBOX_1	268	276	PF00400	0.414
DEG_MDM2_SWIB_1	364	371	PF02201	0.335
DEG_SCF_FBW7_2	241	247	PF00400	0.391
DEG_SPOP_SBC_1	23	27	PF00917	0.716
DOC_CKS1_1	241	246	PF01111	0.391
DOC_CKS1_1	472	477	PF01111	0.610
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.667
DOC_MAPK_gen_1	193	201	PF00069	0.472
DOC_MAPK_gen_1	393	402	PF00069	0.448
DOC_MAPK_MEF2A_6	193	201	PF00069	0.472
DOC_PP2B_LxvP_1	60	63	PF13499	0.484
DOC_PP4_FxxP_1	128	131	PF00568	0.658
DOC_USP7_MATH_1	105	109	PF00917	0.555
DOC_USP7_MATH_1	138	142	PF00917	0.557
DOC_USP7_MATH_1	146	150	PF00917	0.742
DOC_USP7_MATH_1	189	193	PF00917	0.465
DOC_USP7_MATH_1	23	27	PF00917	0.777
DOC_USP7_MATH_1	37	41	PF00917	0.472
DOC_USP7_MATH_1	48	52	PF00917	0.493
DOC_USP7_MATH_1	84	88	PF00917	0.671
DOC_USP7_UBL2_3	316	320	PF12436	0.391
DOC_USP7_UBL2_3	95	99	PF12436	0.757
DOC_WW_Pin1_4	109	114	PF00397	0.642
DOC_WW_Pin1_4	127	132	PF00397	0.450
DOC_WW_Pin1_4	240	245	PF00397	0.453
DOC_WW_Pin1_4	438	443	PF00397	0.411
DOC_WW_Pin1_4	444	449	PF00397	0.373
DOC_WW_Pin1_4	471	476	PF00397	0.654
DOC_WW_Pin1_4	65	70	PF00397	0.711
LIG_14-3-3_CanoR_1	139	146	PF00244	0.745
LIG_14-3-3_CanoR_1	321	331	PF00244	0.410
LIG_Actin_WH2_2	336	351	PF00022	0.209
LIG_APCC_ABBA_1	249	254	PF00400	0.455
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_2	20	24	PF00653	0.686
LIG_BRCT_BRCA1_1	124	128	PF00533	0.763
LIG_BRCT_BRCA1_1	4	8	PF00533	0.746
LIG_EH1_1	341	349	PF00400	0.354
LIG_FHA_1	138	144	PF00498	0.702
LIG_FHA_1	151	157	PF00498	0.687
LIG_FHA_1	266	272	PF00498	0.404
LIG_FHA_1	439	445	PF00498	0.546
LIG_FHA_1	55	61	PF00498	0.641
LIG_FHA_1	78	84	PF00498	0.747
LIG_FHA_2	119	125	PF00498	0.756
LIG_FHA_2	234	240	PF00498	0.383
LIG_FHA_2	472	478	PF00498	0.623
LIG_GBD_Chelix_1	384	392	PF00786	0.391
LIG_IBAR_NPY_1	104	106	PF08397	0.536
LIG_LIR_Apic_2	125	131	PF02991	0.657
LIG_LIR_Apic_2	313	317	PF02991	0.448
LIG_LIR_Apic_2	462	468	PF02991	0.355
LIG_LIR_Gen_1	130	138	PF02991	0.493
LIG_LIR_Gen_1	175	186	PF02991	0.495
LIG_LIR_Gen_1	352	361	PF02991	0.521
LIG_LIR_Nem_3	130	135	PF02991	0.498
LIG_LIR_Nem_3	152	157	PF02991	0.726
LIG_LIR_Nem_3	175	181	PF02991	0.421
LIG_LIR_Nem_3	352	357	PF02991	0.554
LIG_LIR_Nem_3	414	418	PF02991	0.344
LIG_LIR_Nem_3	432	436	PF02991	0.300
LIG_LIR_Nem_3	51	56	PF02991	0.651
LIG_PCNA_yPIPBox_3	389	401	PF02747	0.435
LIG_Pex14_2	364	368	PF04695	0.403
LIG_SH2_CRK	132	136	PF00017	0.499
LIG_SH2_CRK	314	318	PF00017	0.448
LIG_SH2_CRK	433	437	PF00017	0.506
LIG_SH2_CRK	461	465	PF00017	0.461
LIG_SH2_NCK_1	132	136	PF00017	0.499
LIG_SH2_NCK_1	314	318	PF00017	0.448
LIG_SH2_NCK_1	43	47	PF00017	0.683
LIG_SH2_NCK_1	437	441	PF00017	0.445
LIG_SH2_PTP2	252	255	PF00017	0.470
LIG_SH2_PTP2	354	357	PF00017	0.511
LIG_SH2_SRC	252	255	PF00017	0.428
LIG_SH2_SRC	431	434	PF00017	0.522
LIG_SH2_STAP1	214	218	PF00017	0.495
LIG_SH2_STAP1	376	380	PF00017	0.448
LIG_SH2_STAP1	461	465	PF00017	0.471
LIG_SH2_STAP1	9	13	PF00017	0.649
LIG_SH2_STAT3	116	119	PF00017	0.653
LIG_SH2_STAT3	342	345	PF00017	0.336
LIG_SH2_STAT3	418	421	PF00017	0.448
LIG_SH2_STAT5	101	104	PF00017	0.577
LIG_SH2_STAT5	116	119	PF00017	0.623
LIG_SH2_STAT5	240	243	PF00017	0.409
LIG_SH2_STAT5	252	255	PF00017	0.485
LIG_SH2_STAT5	342	345	PF00017	0.306
LIG_SH2_STAT5	354	357	PF00017	0.386
LIG_SH2_STAT5	418	421	PF00017	0.448
LIG_SH3_3	132	138	PF00018	0.511
LIG_SH3_3	73	79	PF00018	0.765
LIG_SH3_4	316	323	PF00018	0.391
LIG_SUMO_SIM_par_1	286	294	PF11976	0.436
LIG_SUMO_SIM_par_1	296	301	PF11976	0.272
LIG_SUMO_SIM_par_1	79	85	PF11976	0.511
LIG_TYR_ITIM	435	440	PF00017	0.440
LIG_UBA3_1	308	316	PF00899	0.391
LIG_UBA3_1	330	336	PF00899	0.391
LIG_WRC_WIRS_1	361	366	PF05994	0.516
MOD_CK1_1	108	114	PF00069	0.624
MOD_CK1_1	118	124	PF00069	0.595
MOD_CK1_1	141	147	PF00069	0.648
MOD_CK1_1	149	155	PF00069	0.711
MOD_CK1_1	160	166	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.693
MOD_CK1_1	41	47	PF00069	0.631
MOD_CK1_1	68	74	PF00069	0.558
MOD_CK1_1	87	93	PF00069	0.673
MOD_CK1_1	94	100	PF00069	0.724
MOD_CK2_1	118	124	PF00069	0.770
MOD_CK2_1	160	166	PF00069	0.597
MOD_CK2_1	233	239	PF00069	0.383
MOD_GlcNHglycan	1	4	PF01048	0.698
MOD_GlcNHglycan	124	127	PF01048	0.605
MOD_GlcNHglycan	140	143	PF01048	0.439
MOD_GlcNHglycan	148	151	PF01048	0.591
MOD_GlcNHglycan	324	327	PF01048	0.448
MOD_GlcNHglycan	425	428	PF01048	0.462
MOD_GlcNHglycan	44	47	PF01048	0.634
MOD_GlcNHglycan	50	53	PF01048	0.602
MOD_GlcNHglycan	96	99	PF01048	0.680
MOD_GSK3_1	105	112	PF00069	0.573
MOD_GSK3_1	115	122	PF00069	0.610
MOD_GSK3_1	127	134	PF00069	0.624
MOD_GSK3_1	137	144	PF00069	0.644
MOD_GSK3_1	145	152	PF00069	0.716
MOD_GSK3_1	184	191	PF00069	0.479
MOD_GSK3_1	261	268	PF00069	0.443
MOD_GSK3_1	37	44	PF00069	0.639
MOD_GSK3_1	84	91	PF00069	0.708
MOD_NEK2_1	117	122	PF00069	0.666
MOD_NEK2_1	24	29	PF00069	0.675
MOD_NEK2_1	261	266	PF00069	0.490
MOD_NEK2_1	298	303	PF00069	0.349
MOD_NEK2_1	330	335	PF00069	0.503
MOD_NEK2_1	360	365	PF00069	0.458
MOD_NEK2_1	388	393	PF00069	0.473
MOD_NEK2_1	402	407	PF00069	0.323
MOD_NEK2_1	411	416	PF00069	0.397
MOD_NEK2_1	423	428	PF00069	0.485
MOD_NEK2_1	443	448	PF00069	0.422
MOD_NEK2_1	8	13	PF00069	0.693
MOD_PIKK_1	115	121	PF00454	0.730
MOD_PIKK_1	262	268	PF00454	0.422
MOD_PIKK_1	298	304	PF00454	0.341
MOD_PIKK_1	54	60	PF00454	0.695
MOD_PKA_2	138	144	PF00069	0.698
MOD_PKA_2	38	44	PF00069	0.541
MOD_PKA_2	77	83	PF00069	0.791
MOD_Plk_1	402	408	PF00069	0.273
MOD_Plk_4	112	118	PF00069	0.507
MOD_Plk_4	177	183	PF00069	0.503
MOD_Plk_4	77	83	PF00069	0.691
MOD_Plk_4	8	14	PF00069	0.607
MOD_ProDKin_1	109	115	PF00069	0.643
MOD_ProDKin_1	127	133	PF00069	0.449
MOD_ProDKin_1	240	246	PF00069	0.453
MOD_ProDKin_1	438	444	PF00069	0.409
MOD_ProDKin_1	471	477	PF00069	0.691
MOD_ProDKin_1	65	71	PF00069	0.710
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.502
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.400
TRG_ENDOCYTIC_2	132	135	PF00928	0.499
TRG_ENDOCYTIC_2	214	217	PF00928	0.497
TRG_ENDOCYTIC_2	354	357	PF00928	0.511
TRG_ENDOCYTIC_2	433	436	PF00928	0.494
TRG_ENDOCYTIC_2	437	440	PF00928	0.480
TRG_ENDOCYTIC_2	461	464	PF00928	0.374
TRG_ENDOCYTIC_2	9	12	PF00928	0.617
TRG_ER_diArg_1	269	271	PF00400	0.377
TRG_ER_diArg_1	392	395	PF00400	0.419
TRG_NES_CRM1_1	215	227	PF08389	0.295
TRG_NES_CRM1_1	345	359	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSE0	Leptomonas seymouri	62%	100%
A0A0N1ILR0	Leptomonas seymouri	33%	73%
A0A0S4J2F9	Bodo saltans	46%	100%
A0A1X0NJM4	Trypanosomatidae	47%	100%
A0A3S5IQY1	Trypanosoma rangeli	44%	100%
A0A3S7WPA1	Leishmania donovani	86%	100%
A4HSP8	Leishmania infantum	86%	100%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AKN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QCQ8	Leishmania major	33%	100%
Q4QJ74	Leishmania major	85%	100%
V5B968	Trypanosoma cruzi	48%	100%