MRP-L46 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

39S mitochondrial ribosomal protein L46, putative

Species:

Leishmania braziliensis

UniProt:

A4H4H2_LEIBR

TriTrypDb:

LbrM.06.0040 , LBRM2903_060005700

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4H4H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H2

PDB structure(s): 7aih_Ac , 7ane_Ac

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.345
CLV_NRD_NRD_1	188	190	PF00675	0.472
CLV_PCSK_KEX2_1	138	140	PF00082	0.245
CLV_PCSK_KEX2_1	188	190	PF00082	0.289
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.300
CLV_PCSK_SKI1_1	138	142	PF00082	0.316
CLV_PCSK_SKI1_1	278	282	PF00082	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SPOP_SBC_1	12	16	PF00917	0.424
DEG_SPOP_SBC_1	18	22	PF00917	0.486
DOC_CYCLIN_RxL_1	272	284	PF00134	0.450
DOC_MAPK_DCC_7	61	69	PF00069	0.175
DOC_MAPK_gen_1	163	171	PF00069	0.349
DOC_MAPK_HePTP_8	161	173	PF00069	0.327
DOC_MAPK_MEF2A_6	164	173	PF00069	0.317
DOC_USP7_MATH_1	13	17	PF00917	0.632
DOC_WW_Pin1_4	132	137	PF00397	0.297
DOC_WW_Pin1_4	28	33	PF00397	0.412
LIG_14-3-3_CanoR_1	139	146	PF00244	0.337
LIG_14-3-3_CanoR_1	158	162	PF00244	0.409
LIG_14-3-3_CanoR_1	195	202	PF00244	0.444
LIG_14-3-3_CanoR_1	23	33	PF00244	0.423
LIG_14-3-3_CanoR_1	98	103	PF00244	0.215
LIG_BIR_III_2	153	157	PF00653	0.477
LIG_BRCT_BRCA1_1	21	25	PF00533	0.480
LIG_BRCT_BRCA1_1	267	271	PF00533	0.454
LIG_FHA_1	13	19	PF00498	0.429
LIG_FHA_1	202	208	PF00498	0.322
LIG_FHA_1	220	226	PF00498	0.412
LIG_FHA_1	29	35	PF00498	0.470
LIG_FHA_1	99	105	PF00498	0.428
LIG_FHA_2	139	145	PF00498	0.241
LIG_FHA_2	258	264	PF00498	0.324
LIG_IRF3_LxIS_1	277	284	PF10401	0.305
LIG_LIR_Gen_1	166	173	PF02991	0.277
LIG_LIR_Nem_3	166	171	PF02991	0.282
LIG_NRBOX	276	282	PF00104	0.349
LIG_PDZ_Class_2	286	291	PF00595	0.418
LIG_REV1ctd_RIR_1	92	102	PF16727	0.386
LIG_SH2_CRK	235	239	PF00017	0.187
LIG_SH2_NCK_1	235	239	PF00017	0.187
LIG_SH2_SRC	123	126	PF00017	0.241
LIG_SH2_SRC	170	173	PF00017	0.298
LIG_SH2_STAP1	235	239	PF00017	0.319
LIG_SH2_STAP1	267	271	PF00017	0.403
LIG_SH2_STAT5	134	137	PF00017	0.283
LIG_SH2_STAT5	170	173	PF00017	0.270
LIG_SH2_STAT5	213	216	PF00017	0.329
LIG_SH2_STAT5	239	242	PF00017	0.312
LIG_SH2_STAT5	3	6	PF00017	0.486
LIG_SH2_STAT5	53	56	PF00017	0.244
LIG_SH2_STAT5	73	76	PF00017	0.300
LIG_SH3_1	3	9	PF00018	0.659
LIG_SH3_3	29	35	PF00018	0.412
LIG_SH3_3	3	9	PF00018	0.688
LIG_SUMO_SIM_par_1	279	284	PF11976	0.303
LIG_SUMO_SIM_par_1	65	70	PF11976	0.302
LIG_WW_3	155	159	PF00397	0.469
MOD_CDK_SPxK_1	132	138	PF00069	0.386
MOD_CDK_SPxxK_3	132	139	PF00069	0.386
MOD_CK1_1	21	27	PF00069	0.490
MOD_CK1_1	270	276	PF00069	0.276
MOD_CK1_1	87	93	PF00069	0.300
MOD_CK2_1	257	263	PF00069	0.349
MOD_CK2_1	80	86	PF00069	0.328
MOD_GlcNHglycan	148	151	PF01048	0.573
MOD_GlcNHglycan	235	238	PF01048	0.231
MOD_GlcNHglycan	272	275	PF01048	0.354
MOD_GlcNHglycan	282	286	PF01048	0.292
MOD_GlcNHglycan	86	89	PF01048	0.270
MOD_GSK3_1	13	20	PF00069	0.651
MOD_GSK3_1	179	186	PF00069	0.363
MOD_GSK3_1	190	197	PF00069	0.454
MOD_GSK3_1	24	31	PF00069	0.447
MOD_GSK3_1	281	288	PF00069	0.311
MOD_GSK3_1	80	87	PF00069	0.252
MOD_GSK3_1	90	97	PF00069	0.224
MOD_NEK2_1	17	22	PF00069	0.621
MOD_NEK2_1	233	238	PF00069	0.235
MOD_NEK2_1	94	99	PF00069	0.335
MOD_NEK2_2	157	162	PF00069	0.505
MOD_NEK2_2	219	224	PF00069	0.371
MOD_NEK2_2	267	272	PF00069	0.450
MOD_PIKK_1	201	207	PF00454	0.381
MOD_PIKK_1	24	30	PF00454	0.415
MOD_PKA_1	138	144	PF00069	0.300
MOD_PKA_2	138	144	PF00069	0.300
MOD_PKA_2	157	163	PF00069	0.398
MOD_PKA_2	194	200	PF00069	0.369
MOD_PKA_2	41	47	PF00069	0.380
MOD_PKA_2	80	86	PF00069	0.300
MOD_Plk_1	227	233	PF00069	0.344
MOD_Plk_4	13	19	PF00069	0.564
MOD_Plk_4	219	225	PF00069	0.354
MOD_Plk_4	90	96	PF00069	0.164
MOD_ProDKin_1	132	138	PF00069	0.297
MOD_ProDKin_1	28	34	PF00069	0.415
MOD_SUMO_rev_2	248	253	PF00179	0.445
TRG_DiLeu_BaEn_1	70	75	PF01217	0.256
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.332
TRG_ENDOCYTIC_2	170	173	PF00928	0.270
TRG_ENDOCYTIC_2	235	238	PF00928	0.183
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH67	Leptomonas seymouri	73%	100%
A0A0S4J242	Bodo saltans	50%	100%
A0A1X0NJC0	Trypanosomatidae	62%	100%
A0A3S7WPC6	Leishmania donovani	87%	100%
A0A422NCS2	Trypanosoma rangeli	61%	100%
A4HSP7	Leishmania infantum	86%	100%
C9ZT91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
E9AKN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q3SZ22	Bos taurus	25%	100%
Q4QJ75	Leishmania major	87%	100%
Q5RBU2	Pongo abelii	26%	100%
Q5RK00	Rattus norvegicus	26%	100%
Q9EQI8	Mus musculus	27%	100%
Q9H2W6	Homo sapiens	27%	100%
V5AP90	Trypanosoma cruzi	63%	100%