Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H4H1_LEIBR

TriTrypDb:

LbrM.06.0030 , LBRM2903_060005600

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	24
GO:0032991	protein-containing complex	1	24
GO:0043226	organelle	2	24
GO:0043228	non-membrane-bounded organelle	3	24
GO:0043229	intracellular organelle	3	24
GO:0043232	intracellular non-membrane-bounded organelle	4	24
GO:0110165	cellular anatomical entity	1	24
GO:1990904	ribonucleoprotein complex	2	24
GO:0005730	nucleolus	5	6
GO:0097361	CIA complex	3	1
GO:0140535	intracellular protein-containing complex	2	1
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H4H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	4
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	4
GO:0000398	mRNA splicing, via spliceosome	8	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	5
GO:0008380	RNA splicing	7	4
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:0006790	sulfur compound metabolic process	3	1
GO:0016043	cellular component organization	3	2
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	2
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	2
GO:0000027	ribosomal large subunit assembly	7	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.475
CLV_C14_Caspase3-7	516	520	PF00656	0.468
CLV_NRD_NRD_1	170	172	PF00675	0.497
CLV_NRD_NRD_1	23	25	PF00675	0.495
CLV_NRD_NRD_1	247	249	PF00675	0.748
CLV_PCSK_KEX2_1	123	125	PF00082	0.568
CLV_PCSK_KEX2_1	170	172	PF00082	0.539
CLV_PCSK_KEX2_1	23	25	PF00082	0.555
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.568
CLV_PCSK_SKI1_1	104	108	PF00082	0.424
CLV_PCSK_SKI1_1	171	175	PF00082	0.465
CLV_PCSK_SKI1_1	213	217	PF00082	0.450
CLV_PCSK_SKI1_1	445	449	PF00082	0.257
CLV_PCSK_SKI1_1	457	461	PF00082	0.385
CLV_PCSK_SKI1_1	499	503	PF00082	0.257
CLV_PCSK_SKI1_1	531	535	PF00082	0.254
CLV_PCSK_SKI1_1	542	546	PF00082	0.304
CLV_PCSK_SKI1_1	606	610	PF00082	0.263
CLV_PCSK_SKI1_1	647	651	PF00082	0.403
CLV_PCSK_SKI1_1	66	70	PF00082	0.376
DEG_SPOP_SBC_1	438	442	PF00917	0.508
DOC_MAPK_gen_1	123	130	PF00069	0.569
DOC_MAPK_gen_1	23	33	PF00069	0.393
DOC_MAPK_gen_1	248	257	PF00069	0.402
DOC_MAPK_gen_1	285	293	PF00069	0.425
DOC_MAPK_gen_1	3	10	PF00069	0.427
DOC_MAPK_HePTP_8	283	295	PF00069	0.484
DOC_MAPK_MEF2A_6	24	33	PF00069	0.416
DOC_MAPK_MEF2A_6	248	257	PF00069	0.610
DOC_MAPK_MEF2A_6	286	295	PF00069	0.486
DOC_MAPK_MEF2A_6	3	10	PF00069	0.433
DOC_USP7_MATH_1	181	185	PF00917	0.730
DOC_USP7_MATH_1	228	232	PF00917	0.581
DOC_USP7_MATH_1	247	251	PF00917	0.708
DOC_USP7_MATH_1	581	585	PF00917	0.445
DOC_USP7_MATH_1	94	98	PF00917	0.634
DOC_USP7_MATH_2	151	157	PF00917	0.406
DOC_USP7_UBL2_3	168	172	PF12436	0.467
DOC_USP7_UBL2_3	174	178	PF12436	0.565
DOC_USP7_UBL2_3	5	9	PF12436	0.439
DOC_USP7_UBL2_3	75	79	PF12436	0.541
DOC_WW_Pin1_4	237	242	PF00397	0.802
DOC_WW_Pin1_4	387	392	PF00397	0.521
DOC_WW_Pin1_4	429	434	PF00397	0.481
LIG_14-3-3_CanoR_1	347	356	PF00244	0.623
LIG_14-3-3_CanoR_1	437	447	PF00244	0.488
LIG_14-3-3_CanoR_1	585	590	PF00244	0.563
LIG_APCC_ABBA_1	310	315	PF00400	0.385
LIG_APCC_ABBA_1	62	67	PF00400	0.551
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_BRCT_BRCA1_1	427	431	PF00533	0.411
LIG_BRCT_BRCA1_1	511	515	PF00533	0.457
LIG_BRCT_BRCA1_1	555	559	PF00533	0.414
LIG_deltaCOP1_diTrp_1	614	620	PF00928	0.449
LIG_FHA_1	136	142	PF00498	0.602
LIG_FHA_1	252	258	PF00498	0.492
LIG_FHA_1	263	269	PF00498	0.563
LIG_FHA_1	379	385	PF00498	0.491
LIG_FHA_1	402	408	PF00498	0.583
LIG_FHA_1	444	450	PF00498	0.471
LIG_FHA_1	486	492	PF00498	0.507
LIG_FHA_1	5	11	PF00498	0.614
LIG_FHA_1	530	536	PF00498	0.612
LIG_FHA_1	648	654	PF00498	0.333
LIG_FHA_2	152	158	PF00498	0.489
LIG_FHA_2	328	334	PF00498	0.374
LIG_FHA_2	368	374	PF00498	0.346
LIG_FHA_2	43	49	PF00498	0.460
LIG_Integrin_RGD_1	392	394	PF01839	0.233
LIG_LIR_Gen_1	275	283	PF02991	0.370
LIG_LIR_Gen_1	553	559	PF02991	0.598
LIG_LIR_Gen_1	570	581	PF02991	0.445
LIG_LIR_Gen_1	612	619	PF02991	0.410
LIG_LIR_Nem_3	115	119	PF02991	0.431
LIG_LIR_Nem_3	158	164	PF02991	0.439
LIG_LIR_Nem_3	275	279	PF02991	0.374
LIG_LIR_Nem_3	553	558	PF02991	0.612
LIG_LIR_Nem_3	570	576	PF02991	0.405
LIG_Pex14_1	555	559	PF04695	0.449
LIG_Pex14_1	660	664	PF04695	0.263
LIG_Pex14_2	511	515	PF04695	0.449
LIG_PTB_Apo_2	308	315	PF02174	0.337
LIG_SH2_CRK	116	120	PF00017	0.408
LIG_SH2_GRB2like	364	367	PF00017	0.501
LIG_SH2_STAP1	573	577	PF00017	0.550
LIG_SH2_STAT3	352	355	PF00017	0.480
LIG_SH2_STAT5	109	112	PF00017	0.577
LIG_SH2_STAT5	256	259	PF00017	0.387
LIG_SH2_STAT5	313	316	PF00017	0.535
LIG_SH2_STAT5	377	380	PF00017	0.446
LIG_SH2_STAT5	385	388	PF00017	0.452
LIG_SH2_STAT5	469	472	PF00017	0.488
LIG_SH2_STAT5	479	482	PF00017	0.515
LIG_SH2_STAT5	523	526	PF00017	0.446
LIG_SH2_STAT5	565	568	PF00017	0.550
LIG_SH2_STAT5	607	610	PF00017	0.449
LIG_SH3_3	134	140	PF00018	0.568
LIG_SH3_5	475	479	PF00018	0.410
LIG_SUMO_SIM_par_1	138	145	PF11976	0.381
LIG_SUMO_SIM_par_1	299	308	PF11976	0.501
LIG_TRAF2_1	97	100	PF00917	0.519
LIG_TYR_ITIM	114	119	PF00017	0.559
LIG_UBA3_1	28	34	PF00899	0.384
LIG_WRC_WIRS_1	143	148	PF05994	0.464
LIG_WRC_WIRS_1	292	297	PF05994	0.361
LIG_WRC_WIRS_1	43	48	PF05994	0.535
LIG_WRC_WIRS_1	458	463	PF05994	0.406
MOD_CDC14_SPxK_1	240	243	PF00782	0.541
MOD_CDK_SPK_2	387	392	PF00069	0.508
MOD_CDK_SPK_2	429	434	PF00069	0.457
MOD_CDK_SPxK_1	237	243	PF00069	0.544
MOD_CK1_1	277	283	PF00069	0.456
MOD_CK1_1	451	457	PF00069	0.509
MOD_CK2_1	153	159	PF00069	0.467
MOD_CK2_1	198	204	PF00069	0.498
MOD_CK2_1	272	278	PF00069	0.406
MOD_CK2_1	327	333	PF00069	0.484
MOD_CK2_1	362	368	PF00069	0.557
MOD_CK2_1	42	48	PF00069	0.472
MOD_CK2_1	80	86	PF00069	0.843
MOD_CK2_1	94	100	PF00069	0.686
MOD_Cter_Amidation	121	124	PF01082	0.435
MOD_GlcNHglycan	120	123	PF01048	0.482
MOD_GlcNHglycan	124	127	PF01048	0.444
MOD_GlcNHglycan	178	181	PF01048	0.567
MOD_GlcNHglycan	183	186	PF01048	0.645
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	268	271	PF01048	0.510
MOD_GlcNHglycan	349	352	PF01048	0.536
MOD_GlcNHglycan	39	42	PF01048	0.399
MOD_GlcNHglycan	475	478	PF01048	0.280
MOD_GlcNHglycan	481	484	PF01048	0.295
MOD_GlcNHglycan	525	528	PF01048	0.287
MOD_GlcNHglycan	539	542	PF01048	0.476
MOD_GlcNHglycan	567	570	PF01048	0.332
MOD_GlcNHglycan	83	86	PF01048	0.688
MOD_GlcNHglycan	91	94	PF01048	0.678
MOD_GSK3_1	118	125	PF00069	0.491
MOD_GSK3_1	243	250	PF00069	0.605
MOD_GSK3_1	258	265	PF00069	0.620
MOD_GSK3_1	268	275	PF00069	0.438
MOD_GSK3_1	369	376	PF00069	0.423
MOD_GSK3_1	397	404	PF00069	0.448
MOD_GSK3_1	409	416	PF00069	0.386
MOD_GSK3_1	425	432	PF00069	0.570
MOD_GSK3_1	439	446	PF00069	0.479
MOD_GSK3_1	481	488	PF00069	0.502
MOD_GSK3_1	495	502	PF00069	0.441
MOD_GSK3_1	509	516	PF00069	0.548
MOD_GSK3_1	525	532	PF00069	0.543
MOD_GSK3_1	553	560	PF00069	0.477
MOD_GSK3_1	577	584	PF00069	0.589
MOD_GSK3_1	609	616	PF00069	0.587
MOD_GSK3_1	75	82	PF00069	0.491
MOD_N-GLC_1	228	233	PF02516	0.757
MOD_N-GLC_1	262	267	PF02516	0.519
MOD_NEK2_1	272	277	PF00069	0.372
MOD_NEK2_1	291	296	PF00069	0.389
MOD_NEK2_1	327	332	PF00069	0.456
MOD_NEK2_1	395	400	PF00069	0.537
MOD_NEK2_1	449	454	PF00069	0.607
MOD_NEK2_1	577	582	PF00069	0.604
MOD_NEK2_1	648	653	PF00069	0.309
MOD_NEK2_2	142	147	PF00069	0.509
MOD_NEK2_2	251	256	PF00069	0.406
MOD_NEK2_2	485	490	PF00069	0.447
MOD_PIKK_1	135	141	PF00454	0.396
MOD_PIKK_1	356	362	PF00454	0.599
MOD_PIKK_1	493	499	PF00454	0.510
MOD_PK_1	11	17	PF00069	0.399
MOD_PK_1	613	619	PF00069	0.508
MOD_PKA_2	247	253	PF00069	0.592
MOD_Plk_1	277	283	PF00069	0.355
MOD_Plk_1	367	373	PF00069	0.355
MOD_Plk_1	401	407	PF00069	0.469
MOD_Plk_1	443	449	PF00069	0.483
MOD_Plk_1	485	491	PF00069	0.499
MOD_Plk_1	529	535	PF00069	0.563
MOD_Plk_1	613	619	PF00069	0.496
MOD_Plk_2-3	153	159	PF00069	0.591
MOD_Plk_2-3	278	284	PF00069	0.438
MOD_Plk_4	222	228	PF00069	0.660
MOD_Plk_4	251	257	PF00069	0.591
MOD_Plk_4	278	284	PF00069	0.497
MOD_Plk_4	413	419	PF00069	0.406
MOD_Plk_4	543	549	PF00069	0.482
MOD_Plk_4	550	556	PF00069	0.460
MOD_Plk_4	60	66	PF00069	0.597
MOD_Plk_4	627	633	PF00069	0.397
MOD_Plk_4	634	640	PF00069	0.296
MOD_ProDKin_1	237	243	PF00069	0.802
MOD_ProDKin_1	387	393	PF00069	0.521
MOD_ProDKin_1	429	435	PF00069	0.481
MOD_SUMO_for_1	322	325	PF00179	0.385
MOD_SUMO_rev_2	278	287	PF00179	0.400
MOD_SUMO_rev_2	537	547	PF00179	0.252
MOD_SUMO_rev_2	602	608	PF00179	0.410
MOD_SUMO_rev_2	63	71	PF00179	0.458
MOD_SUMO_rev_2	651	657	PF00179	0.364
MOD_SUMO_rev_2	97	102	PF00179	0.585
TRG_DiLeu_BaEn_1	159	164	PF01217	0.423
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.503
TRG_ENDOCYTIC_2	116	119	PF00928	0.418
TRG_ENDOCYTIC_2	573	576	PF00928	0.550
TRG_ER_diArg_1	23	26	PF00400	0.429
TRG_NES_CRM1_1	27	39	PF08389	0.415
TRG_NLS_MonoExtN_4	168	175	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF5	Leptomonas seymouri	63%	96%
A0A0S4JTE0	Bodo saltans	42%	88%
A0A0S4KJ87	Bodo saltans	24%	100%
A0A1X0NK47	Trypanosomatidae	47%	95%
A0A3Q8IGC4	Leishmania donovani	27%	100%
A0A3R7K7N9	Trypanosoma rangeli	46%	95%
A0A3S5H5M7	Leishmania donovani	67%	99%
A0A3S7XBP3	Leishmania donovani	27%	100%
A4HDT7	Leishmania braziliensis	27%	100%
A4HL42	Leishmania braziliensis	25%	100%
A4HPZ9	Leishmania braziliensis	26%	100%
A4HSP6	Leishmania infantum	67%	99%
A4I135	Leishmania infantum	27%	100%
A4IDR0	Leishmania infantum	27%	100%
C9ZT89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	95%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P53699	Candida albicans	23%	97%
Q4Q0T1	Leishmania major	27%	100%
Q4QAA4	Leishmania major	27%	100%
Q4QJ76	Leishmania major	65%	100%
V5BDR9	Trypanosoma cruzi	47%	97%