Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4H0_LEIBR

TriTrypDb:

LbrM.06.0020 , LBRM2903_060005500

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	25
GO:0042995	cell projection	2	25
GO:0043226	organelle	2	25
GO:0043227	membrane-bounded organelle	3	25
GO:0110165	cellular anatomical entity	1	25
GO:0120025	plasma membrane bounded cell projection	3	25
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H4H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4H0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	4
GO:0044237	cellular metabolic process	2	5
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.294
CLV_NRD_NRD_1	187	189	PF00675	0.440
CLV_NRD_NRD_1	190	192	PF00675	0.391
CLV_NRD_NRD_1	443	445	PF00675	0.529
CLV_NRD_NRD_1	91	93	PF00675	0.445
CLV_PCSK_FUR_1	89	93	PF00082	0.595
CLV_PCSK_KEX2_1	379	381	PF00082	0.342
CLV_PCSK_KEX2_1	91	93	PF00082	0.443
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.217
CLV_PCSK_SKI1_1	427	431	PF00082	0.491
DEG_SCF_FBW7_1	56	62	PF00400	0.510
DOC_CDC14_PxL_1	206	214	PF14671	0.518
DOC_CDC14_PxL_1	325	333	PF14671	0.453
DOC_CKS1_1	178	183	PF01111	0.280
DOC_CKS1_1	56	61	PF01111	0.715
DOC_CYCLIN_RxL_1	1	12	PF00134	0.460
DOC_CYCLIN_RxL_1	199	208	PF00134	0.547
DOC_CYCLIN_RxL_1	279	291	PF00134	0.430
DOC_CYCLIN_RxL_1	352	362	PF00134	0.245
DOC_CYCLIN_RxL_1	374	385	PF00134	0.293
DOC_MAPK_gen_1	188	195	PF00069	0.465
DOC_MAPK_gen_1	521	531	PF00069	0.539
DOC_PP1_RVXF_1	102	109	PF00149	0.510
DOC_PP4_FxxP_1	17	20	PF00568	0.651
DOC_PP4_FxxP_1	43	46	PF00568	0.461
DOC_USP7_MATH_1	102	106	PF00917	0.456
DOC_USP7_MATH_1	229	233	PF00917	0.285
DOC_USP7_MATH_1	26	30	PF00917	0.704
DOC_USP7_MATH_1	288	292	PF00917	0.431
DOC_WW_Pin1_4	177	182	PF00397	0.302
DOC_WW_Pin1_4	28	33	PF00397	0.697
DOC_WW_Pin1_4	296	301	PF00397	0.420
DOC_WW_Pin1_4	343	348	PF00397	0.478
DOC_WW_Pin1_4	390	395	PF00397	0.390
DOC_WW_Pin1_4	406	411	PF00397	0.498
DOC_WW_Pin1_4	438	443	PF00397	0.298
DOC_WW_Pin1_4	485	490	PF00397	0.417
DOC_WW_Pin1_4	52	57	PF00397	0.724
LIG_14-3-3_CanoR_1	235	240	PF00244	0.433
LIG_14-3-3_CanoR_1	279	287	PF00244	0.381
LIG_14-3-3_CanoR_1	316	325	PF00244	0.409
LIG_14-3-3_CanoR_1	380	389	PF00244	0.430
LIG_14-3-3_CanoR_1	435	443	PF00244	0.533
LIG_14-3-3_CanoR_1	444	450	PF00244	0.485
LIG_14-3-3_CanoR_1	524	531	PF00244	0.371
LIG_Actin_WH2_2	344	362	PF00022	0.287
LIG_Actin_WH2_2	412	429	PF00022	0.365
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.365
LIG_BRCT_BRCA1_1	104	108	PF00533	0.515
LIG_FHA_1	128	134	PF00498	0.497
LIG_FHA_1	164	170	PF00498	0.470
LIG_FHA_1	178	184	PF00498	0.386
LIG_FHA_1	221	227	PF00498	0.454
LIG_FHA_1	236	242	PF00498	0.457
LIG_FHA_1	31	37	PF00498	0.616
LIG_FHA_1	317	323	PF00498	0.337
LIG_FHA_1	351	357	PF00498	0.170
LIG_FHA_1	56	62	PF00498	0.664
LIG_FHA_1	75	81	PF00498	0.391
LIG_FHA_2	265	271	PF00498	0.501
LIG_FHA_2	360	366	PF00498	0.363
LIG_LIR_Apic_2	96	102	PF02991	0.390
LIG_LIR_Gen_1	308	317	PF02991	0.319
LIG_LIR_Nem_3	105	110	PF02991	0.386
LIG_LIR_Nem_3	197	201	PF02991	0.465
LIG_LIR_Nem_3	248	253	PF02991	0.422
LIG_LIR_Nem_3	296	301	PF02991	0.454
LIG_LIR_Nem_3	308	312	PF02991	0.421
LIG_LIR_Nem_3	343	348	PF02991	0.402
LIG_LIR_Nem_3	390	395	PF02991	0.439
LIG_LIR_Nem_3	438	443	PF02991	0.463
LIG_LIR_Nem_3	84	88	PF02991	0.605
LIG_MLH1_MIPbox_1	104	108	PF16413	0.328
LIG_MYND_3	209	213	PF01753	0.298
LIG_MYND_3	328	332	PF01753	0.547
LIG_PDZ_Class_1	530	535	PF00595	0.600
LIG_PTB_Apo_2	303	310	PF02174	0.213
LIG_PTB_Phospho_1	303	309	PF10480	0.217
LIG_SH2_SRC	309	312	PF00017	0.262
LIG_SH2_STAT5	107	110	PF00017	0.517
LIG_SH2_STAT5	199	202	PF00017	0.456
LIG_SH2_STAT5	309	312	PF00017	0.410
LIG_SH2_STAT5	498	501	PF00017	0.427
LIG_SH3_3	175	181	PF00018	0.315
LIG_SH3_3	53	59	PF00018	0.688
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.527
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.465
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.525
LIG_SUMO_SIM_anti_2	69	77	PF11976	0.444
LIG_SUMO_SIM_par_1	223	232	PF11976	0.334
LIG_SUMO_SIM_par_1	237	242	PF11976	0.412
LIG_SUMO_SIM_par_1	299	305	PF11976	0.486
LIG_SUMO_SIM_par_1	355	362	PF11976	0.448
LIG_TRAF2_1	448	451	PF00917	0.285
LIG_TRAF2_1	517	520	PF00917	0.350
LIG_TYR_ITIM	307	312	PF00017	0.263
LIG_TYR_ITIM	496	501	PF00017	0.454
LIG_WRC_WIRS_1	342	347	PF05994	0.225
MOD_CDK_SPxK_1	438	444	PF00069	0.346
MOD_CDK_SPxxK_3	28	35	PF00069	0.474
MOD_CDK_SPxxK_3	438	445	PF00069	0.241
MOD_CK1_1	129	135	PF00069	0.511
MOD_CK1_1	409	415	PF00069	0.459
MOD_CK1_1	438	444	PF00069	0.424
MOD_CK1_1	507	513	PF00069	0.530
MOD_CK1_1	55	61	PF00069	0.510
MOD_CK2_1	109	115	PF00069	0.595
MOD_CK2_1	317	323	PF00069	0.362
MOD_CK2_1	444	450	PF00069	0.486
MOD_CK2_1	508	514	PF00069	0.556
MOD_CK2_1	63	69	PF00069	0.691
MOD_GlcNHglycan	111	114	PF01048	0.650
MOD_GlcNHglycan	241	244	PF01048	0.362
MOD_GlcNHglycan	28	31	PF01048	0.585
MOD_GSK3_1	164	171	PF00069	0.582
MOD_GSK3_1	217	224	PF00069	0.415
MOD_GSK3_1	235	242	PF00069	0.410
MOD_GSK3_1	26	33	PF00069	0.597
MOD_GSK3_1	312	319	PF00069	0.331
MOD_GSK3_1	479	486	PF00069	0.467
MOD_GSK3_1	501	508	PF00069	0.414
MOD_GSK3_1	510	517	PF00069	0.368
MOD_GSK3_1	55	62	PF00069	0.569
MOD_N-GLC_1	164	169	PF02516	0.475
MOD_N-GLC_1	305	310	PF02516	0.304
MOD_N-GLC_1	381	386	PF02516	0.379
MOD_N-GLC_1	404	409	PF02516	0.478
MOD_N-GLC_1	508	513	PF02516	0.555
MOD_N-GLC_2	290	292	PF02516	0.413
MOD_NEK2_1	108	113	PF00069	0.642
MOD_NEK2_1	126	131	PF00069	0.405
MOD_NEK2_1	163	168	PF00069	0.410
MOD_NEK2_1	169	174	PF00069	0.520
MOD_NEK2_1	217	222	PF00069	0.427
MOD_NEK2_1	228	233	PF00069	0.363
MOD_NEK2_1	239	244	PF00069	0.343
MOD_NEK2_1	25	30	PF00069	0.630
MOD_NEK2_1	262	267	PF00069	0.329
MOD_NEK2_1	277	282	PF00069	0.368
MOD_NEK2_1	359	364	PF00069	0.213
MOD_NEK2_1	381	386	PF00069	0.326
MOD_NEK2_1	404	409	PF00069	0.393
MOD_NEK2_1	422	427	PF00069	0.386
MOD_NEK2_1	87	92	PF00069	0.584
MOD_NEK2_2	102	107	PF00069	0.504
MOD_NEK2_2	229	234	PF00069	0.307
MOD_OFUCOSY	408	415	PF10250	0.291
MOD_PIKK_1	279	285	PF00454	0.357
MOD_PIKK_1	74	80	PF00454	0.619
MOD_PKA_1	444	450	PF00069	0.459
MOD_PKA_2	317	323	PF00069	0.439
MOD_PKA_2	359	365	PF00069	0.367
MOD_PKA_2	504	510	PF00069	0.555
MOD_PKA_2	523	529	PF00069	0.355
MOD_PKB_1	314	322	PF00069	0.229
MOD_Plk_1	114	120	PF00069	0.577
MOD_Plk_1	164	170	PF00069	0.472
MOD_Plk_1	305	311	PF00069	0.403
MOD_Plk_1	513	519	PF00069	0.428
MOD_Plk_2-3	514	520	PF00069	0.481
MOD_Plk_4	129	135	PF00069	0.434
MOD_Plk_4	164	170	PF00069	0.465
MOD_Plk_4	305	311	PF00069	0.459
MOD_Plk_4	359	365	PF00069	0.330
MOD_Plk_4	396	402	PF00069	0.446
MOD_Plk_4	63	69	PF00069	0.696
MOD_ProDKin_1	177	183	PF00069	0.292
MOD_ProDKin_1	28	34	PF00069	0.698
MOD_ProDKin_1	296	302	PF00069	0.425
MOD_ProDKin_1	343	349	PF00069	0.475
MOD_ProDKin_1	390	396	PF00069	0.391
MOD_ProDKin_1	406	412	PF00069	0.502
MOD_ProDKin_1	438	444	PF00069	0.304
MOD_ProDKin_1	485	491	PF00069	0.431
MOD_ProDKin_1	52	58	PF00069	0.725
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.350
TRG_ENDOCYTIC_2	107	110	PF00928	0.335
TRG_ENDOCYTIC_2	309	312	PF00928	0.265
TRG_ENDOCYTIC_2	498	501	PF00928	0.448
TRG_ER_diArg_1	314	317	PF00400	0.491
TRG_ER_diArg_1	88	91	PF00400	0.544
TRG_NES_CRM1_1	350	361	PF08389	0.392
TRG_NLS_MonoExtC_3	187	192	PF00514	0.294
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	25%	81%
A0A0N1IHY9	Leptomonas seymouri	56%	100%
A0A0S4IJS8	Bodo saltans	27%	100%
A0A0S4IK76	Bodo saltans	26%	98%
A0A0S4IRN7	Bodo saltans	26%	100%
A0A0S4KN43	Bodo saltans	27%	91%
A0A3S5H5M6	Leishmania donovani	87%	100%
A0A3S7X2V4	Leishmania donovani	25%	69%
A0A3S7X7D2	Leishmania donovani	26%	100%
A4H7G0	Leishmania braziliensis	23%	100%
A4HSP5	Leishmania infantum	87%	100%
A4I9H0	Leishmania infantum	26%	100%
C9ZRQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZUA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	72%
C9ZXN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZZI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	88%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	79%
E9AEF0	Leishmania major	24%	69%
E9AHJ6	Leishmania infantum	25%	69%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
P23799	Trypanosoma brucei brucei	25%	85%
P26337	Trypanosoma equiperdum	23%	85%
Q4QJ77	Leishmania major	85%	100%
V5BMQ2	Trypanosoma cruzi	23%	95%