LeishMANIAdb
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Putative ABC transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ABC transporter
Gene product:
ABC transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4H4G9_LEIBR
TriTrypDb:
LbrM.06.0010 , LBRM2903_060005300 * , LBRM2903_060006200 *
Length:
658

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 14
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
TermNameLevelCount
GO:0005635 nuclear envelope 4 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 32
GO:0020016 ciliary pocket 2 1
GO:0030139 endocytic vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
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Expansion

Sequence features

A4H4G9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G9

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 3
GO:0009987 cellular process 1 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 30
GO:0003824 catalytic activity 1 2
GO:0005215 transporter activity 1 32
GO:0005319 lipid transporter activity 2 1
GO:0005488 binding 1 30
GO:0005524 ATP binding 5 30
GO:0005548 phospholipid transporter activity 3 1
GO:0015399 primary active transmembrane transporter activity 4 32
GO:0016787 hydrolase activity 2 2
GO:0017076 purine nucleotide binding 4 30
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 233 237 PF00656 0.576
CLV_C14_Caspase3-7 56 60 PF00656 0.565
CLV_NRD_NRD_1 125 127 PF00675 0.392
CLV_NRD_NRD_1 137 139 PF00675 0.343
CLV_NRD_NRD_1 167 169 PF00675 0.349
CLV_NRD_NRD_1 209 211 PF00675 0.322
CLV_NRD_NRD_1 352 354 PF00675 0.418
CLV_NRD_NRD_1 381 383 PF00675 0.332
CLV_PCSK_FUR_1 165 169 PF00082 0.341
CLV_PCSK_KEX2_1 125 127 PF00082 0.380
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HSP2 Leptomonas seymouri 35% 89%
A0A0N1HZC7 Leptomonas seymouri 28% 97%
A0A0S4IJ55 Bodo saltans 34% 86%
A0A0S4IUG8 Bodo saltans 53% 100%
A0A0S4IUY5 Bodo saltans 29% 100%
A0A0S4IY23 Bodo saltans 35% 100%
A0A0S4J724 Bodo saltans 39% 100%
A0A0S4J7U2 Bodo saltans 35% 94%
A0A0S4JAS9 Bodo saltans 26% 80%
A0A0S4JBG7 Bodo saltans 23% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS