Surface antigen like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen like protein

Species:

Leishmania braziliensis

UniProt:

A4H4G6_LEIBR

TriTrypDb:

LbrM.05.1210 , LBRM2903_050018200

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 1
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0016020	membrane	2	8
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15

Expansion

Sequence features

A4H4G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.408
DOC_CDC14_PxL_1	148	156	PF14671	0.209
DOC_MAPK_gen_1	126	135	PF00069	0.276
DOC_USP7_MATH_1	192	196	PF00917	0.385
DOC_USP7_MATH_1	202	206	PF00917	0.254
DOC_USP7_MATH_1	21	25	PF00917	0.503
DOC_USP7_MATH_1	69	73	PF00917	0.287
DOC_USP7_MATH_1	79	83	PF00917	0.311
DOC_USP7_MATH_1	92	96	PF00917	0.332
LIG_14-3-3_CanoR_1	129	134	PF00244	0.219
LIG_14-3-3_CanoR_1	244	253	PF00244	0.323
LIG_BIR_III_2	44	48	PF00653	0.284
LIG_BRCT_BRCA1_1	131	135	PF00533	0.211
LIG_BRCT_BRCA1_1	155	159	PF00533	0.232
LIG_BRCT_BRCA1_1	239	243	PF00533	0.334
LIG_BRCT_BRCA1_1	280	284	PF00533	0.222
LIG_BRCT_BRCA1_1	81	85	PF00533	0.335
LIG_FHA_1	115	121	PF00498	0.263
LIG_FHA_1	13	19	PF00498	0.470
LIG_FHA_1	269	275	PF00498	0.278
LIG_FHA_1	68	74	PF00498	0.316
LIG_FHA_2	129	135	PF00498	0.325
LIG_FHA_2	88	94	PF00498	0.303
LIG_LIR_Gen_1	123	130	PF02991	0.291
LIG_LIR_Gen_1	195	204	PF02991	0.302
LIG_LIR_Gen_1	35	46	PF02991	0.257
LIG_LIR_Gen_1	82	92	PF02991	0.381
LIG_LIR_LC3C_4	15	20	PF02991	0.372
LIG_LIR_Nem_3	123	127	PF02991	0.295
LIG_LIR_Nem_3	195	200	PF02991	0.335
LIG_LIR_Nem_3	82	88	PF02991	0.405
LIG_PDZ_Class_2	279	284	PF00595	0.262
LIG_Pex14_2	193	197	PF04695	0.252
LIG_PTB_Apo_2	158	165	PF02174	0.230
LIG_SH2_CRK	166	170	PF00017	0.239
LIG_SH2_STAT5	163	166	PF00017	0.241
LIG_SH2_STAT5	253	256	PF00017	0.280
LIG_SH3_3	17	23	PF00018	0.480
LIG_SH3_3	252	258	PF00018	0.300
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.386
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.394
LIG_SUMO_SIM_par_1	275	281	PF11976	0.250
MOD_CK1_1	111	117	PF00069	0.263
MOD_CK1_1	195	201	PF00069	0.273
MOD_CK1_1	220	226	PF00069	0.381
MOD_CK1_1	245	251	PF00069	0.332
MOD_CK1_1	4	10	PF00069	0.439
MOD_CK2_1	59	65	PF00069	0.236
MOD_CK2_1	87	93	PF00069	0.333
MOD_GlcNHglycan	110	113	PF01048	0.473
MOD_GlcNHglycan	140	143	PF01048	0.648
MOD_GlcNHglycan	173	176	PF01048	0.547
MOD_GlcNHglycan	239	242	PF01048	0.521
MOD_GlcNHglycan	247	250	PF01048	0.633
MOD_GlcNHglycan	61	64	PF01048	0.512
MOD_GlcNHglycan	67	70	PF01048	0.535
MOD_GlcNHglycan	81	84	PF01048	0.581
MOD_GSK3_1	104	111	PF00069	0.289
MOD_GSK3_1	116	123	PF00069	0.310
MOD_GSK3_1	125	132	PF00069	0.335
MOD_GSK3_1	192	199	PF00069	0.306
MOD_GSK3_1	202	209	PF00069	0.287
MOD_GSK3_1	21	28	PF00069	0.551
MOD_GSK3_1	245	252	PF00069	0.327
MOD_GSK3_1	264	271	PF00069	0.213
MOD_GSK3_1	65	72	PF00069	0.320
MOD_GSK3_1	94	101	PF00069	0.315
MOD_N-GLC_1	171	176	PF02516	0.482
MOD_N-GLC_2	57	59	PF02516	0.447
MOD_NEK2_1	1	6	PF00069	0.459
MOD_NEK2_1	103	108	PF00069	0.327
MOD_NEK2_1	116	121	PF00069	0.335
MOD_NEK2_1	133	138	PF00069	0.284
MOD_NEK2_1	193	198	PF00069	0.256
MOD_NEK2_1	206	211	PF00069	0.308
MOD_NEK2_1	268	273	PF00069	0.216
MOD_NEK2_1	87	92	PF00069	0.306
MOD_PIKK_1	177	183	PF00454	0.295
MOD_PIKK_1	98	104	PF00454	0.215
MOD_PKA_2	114	120	PF00069	0.280
MOD_PKA_2	125	131	PF00069	0.248
MOD_PKA_2	138	144	PF00069	0.260
MOD_Plk_4	12	18	PF00069	0.432
MOD_Plk_4	25	31	PF00069	0.311
MOD_Plk_4	268	274	PF00069	0.237
MOD_Plk_4	4	10	PF00069	0.436
MOD_SUMO_rev_2	220	225	PF00179	0.307
TRG_ER_diArg_1	137	140	PF00400	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L4	Leptomonas seymouri	28%	96%
A0A0N0P4M2	Leptomonas seymouri	31%	100%
A0A0S4IVH1	Bodo saltans	27%	100%
A0A0S4KFY6	Bodo saltans	27%	85%
A0A1X0NKN8	Trypanosomatidae	36%	99%
A0A3Q8I9A6	Leishmania donovani	23%	74%
A0A3Q8IIJ9	Leishmania donovani	25%	94%
A0A3S5H6D6	Leishmania donovani	28%	100%
A0A3S7WP69	Leishmania donovani	28%	99%
A0A3S7WPB2	Leishmania donovani	80%	100%
A0A3S7X4J4	Leishmania donovani	25%	94%
A4H4D2	Leishmania braziliensis	28%	100%
A4H5P0	Leishmania braziliensis	27%	99%
A4HJC8	Leishmania braziliensis	23%	94%
A4HSL2	Leishmania infantum	28%	99%
A4HTX9	Leishmania infantum	27%	100%
A4HVB0	Leishmania infantum	23%	70%
A4I6S4	Leishmania infantum	25%	94%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
E9ACQ0	Leishmania major	79%	100%
E9AG65	Leishmania infantum	80%	100%
E9AGG5	Leishmania infantum	24%	68%
E9AGH0	Leishmania infantum	24%	75%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	77%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
P35334	Phaseolus vulgaris	28%	83%
P58822	Phaseolus vulgaris	28%	83%
P58823	Phaseolus vulgaris	28%	83%
Q25331	Leishmania major	29%	74%
Q4Q6B6	Leishmania major	29%	94%
Q4Q6B7	Leishmania major	29%	94%
Q4QGJ4	Leishmania major	29%	74%
Q4QGJ7	Leishmania major	29%	76%
Q4QGK6	Leishmania major	29%	74%
Q4QGL4	Leishmania major	26%	72%
Q4QHW6	Leishmania major	29%	100%
Q4QJB2	Leishmania major	23%	100%