Protein phosphatase type 1 regulator-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase type 1 regulator-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4G5_LEIBR

TriTrypDb:

LbrM.05.1200 , LBRM2903_050018100

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H4G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.518
CLV_C14_Caspase3-7	256	260	PF00656	0.570
CLV_C14_Caspase3-7	394	398	PF00656	0.448
CLV_C14_Caspase3-7	55	59	PF00656	0.795
CLV_NRD_NRD_1	115	117	PF00675	0.413
CLV_NRD_NRD_1	144	146	PF00675	0.430
CLV_NRD_NRD_1	187	189	PF00675	0.511
CLV_NRD_NRD_1	415	417	PF00675	0.607
CLV_PCSK_KEX2_1	187	189	PF00082	0.474
CLV_PCSK_KEX2_1	380	382	PF00082	0.457
CLV_PCSK_KEX2_1	415	417	PF00082	0.619
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.457
CLV_PCSK_PC7_1	411	417	PF00082	0.695
CLV_PCSK_SKI1_1	148	152	PF00082	0.459
CLV_PCSK_SKI1_1	187	191	PF00082	0.551
CLV_PCSK_SKI1_1	21	25	PF00082	0.700
CLV_PCSK_SKI1_1	95	99	PF00082	0.548
DEG_COP1_1	149	159	PF00400	0.580
DOC_CYCLIN_RxL_1	197	206	PF00134	0.411
DOC_CYCLIN_yClb1_LxF_4	19	24	PF00134	0.526
DOC_CYCLIN_yClb5_NLxxxL_5	116	123	PF00134	0.416
DOC_MAPK_DCC_7	14	24	PF00069	0.525
DOC_MAPK_gen_1	380	390	PF00069	0.424
DOC_MAPK_MEF2A_6	383	392	PF00069	0.415
DOC_MAPK_NFAT4_5	385	393	PF00069	0.410
DOC_MAPK_RevD_3	102	117	PF00069	0.432
DOC_PP1_RVXF_1	19	25	PF00149	0.527
DOC_USP7_MATH_1	310	314	PF00917	0.489
DOC_USP7_MATH_1	52	56	PF00917	0.795
LIG_14-3-3_CanoR_1	133	140	PF00244	0.300
LIG_14-3-3_CanoR_1	242	248	PF00244	0.546
LIG_14-3-3_CanoR_1	95	100	PF00244	0.446
LIG_14-3-3_CterR_2	415	418	PF00244	0.728
LIG_Actin_WH2_2	172	189	PF00022	0.539
LIG_Clathr_ClatBox_1	96	100	PF01394	0.443
LIG_deltaCOP1_diTrp_1	352	359	PF00928	0.492
LIG_FHA_1	366	372	PF00498	0.399
LIG_FHA_2	133	139	PF00498	0.300
LIG_FHA_2	175	181	PF00498	0.398
LIG_FHA_2	196	202	PF00498	0.363
LIG_FHA_2	324	330	PF00498	0.585
LIG_FHA_2	392	398	PF00498	0.492
LIG_FHA_2	85	91	PF00498	0.558
LIG_FHA_2	96	102	PF00498	0.522
LIG_LIR_Gen_1	180	189	PF02991	0.392
LIG_LIR_Gen_1	216	226	PF02991	0.537
LIG_LIR_Gen_1	384	393	PF02991	0.410
LIG_LIR_Nem_3	180	186	PF02991	0.397
LIG_LIR_Nem_3	216	221	PF02991	0.548
LIG_LIR_Nem_3	318	324	PF02991	0.352
LIG_LIR_Nem_3	352	356	PF02991	0.403
LIG_LIR_Nem_3	384	390	PF02991	0.411
LIG_LIR_Nem_3	397	402	PF02991	0.447
LIG_LRP6_Inhibitor_1	139	145	PF00058	0.430
LIG_LRP6_Inhibitor_1	204	210	PF00058	0.405
LIG_LRP6_Inhibitor_1	226	232	PF00058	0.425
LIG_MAD2	38	46	PF02301	0.768
LIG_MYND_3	337	341	PF01753	0.486
LIG_OCRL_FandH_1	5	17	PF00620	0.509
LIG_PCNA_PIPBox_1	337	346	PF02747	0.433
LIG_Pex14_2	2	6	PF04695	0.484
LIG_PTB_Apo_2	386	393	PF02174	0.553
LIG_SH2_CRK	183	187	PF00017	0.406
LIG_SH2_CRK	387	391	PF00017	0.434
LIG_SH2_GRB2like	387	390	PF00017	0.560
LIG_SH2_STAT5	203	206	PF00017	0.407
LIG_SH2_STAT5	297	300	PF00017	0.333
LIG_SH2_STAT5	370	373	PF00017	0.417
LIG_SH3_1	14	20	PF00018	0.525
LIG_SH3_3	14	20	PF00018	0.525
LIG_SH3_3	153	159	PF00018	0.536
LIG_SH3_3	328	334	PF00018	0.501
LIG_SH3_3	44	50	PF00018	0.680
LIG_SUMO_SIM_par_1	315	320	PF11976	0.326
LIG_TYR_ITIM	181	186	PF00017	0.381
LIG_UBA3_1	112	117	PF00899	0.301
LIG_UBA3_1	23	32	PF00899	0.723
LIG_WRC_WIRS_1	215	220	PF05994	0.548
LIG_WW_3	18	22	PF00397	0.529
MOD_CK1_1	194	200	PF00069	0.539
MOD_CK1_1	243	249	PF00069	0.462
MOD_CK1_1	260	266	PF00069	0.329
MOD_CK2_1	195	201	PF00069	0.399
MOD_CK2_1	260	266	PF00069	0.489
MOD_CK2_1	276	282	PF00069	0.354
MOD_CK2_1	301	307	PF00069	0.472
MOD_CK2_1	323	329	PF00069	0.551
MOD_CK2_1	56	62	PF00069	0.692
MOD_CK2_1	84	90	PF00069	0.465
MOD_CK2_1	95	101	PF00069	0.432
MOD_GlcNHglycan	122	126	PF01048	0.564
MOD_GlcNHglycan	152	155	PF01048	0.531
MOD_GlcNHglycan	160	163	PF01048	0.594
MOD_GlcNHglycan	235	238	PF01048	0.477
MOD_GSK3_1	187	194	PF00069	0.503
MOD_GSK3_1	253	260	PF00069	0.346
MOD_GSK3_1	323	330	PF00069	0.576
MOD_GSK3_1	391	398	PF00069	0.496
MOD_GSK3_1	52	59	PF00069	0.684
MOD_GSK3_1	74	81	PF00069	0.693
MOD_N-GLC_1	327	332	PF02516	0.339
MOD_N-GLC_1	69	74	PF02516	0.644
MOD_NEK2_1	150	155	PF00069	0.441
MOD_NEK2_1	165	170	PF00069	0.458
MOD_NEK2_1	179	184	PF00069	0.372
MOD_NEK2_1	195	200	PF00069	0.393
MOD_NEK2_1	317	322	PF00069	0.437
MOD_NEK2_1	362	367	PF00069	0.406
MOD_NEK2_2	310	315	PF00069	0.498
MOD_PIKK_1	391	397	PF00454	0.524
MOD_PK_1	253	259	PF00069	0.472
MOD_PK_1	276	282	PF00069	0.367
MOD_PKA_1	187	193	PF00069	0.535
MOD_PKA_2	132	138	PF00069	0.301
MOD_PKA_2	187	193	PF00069	0.313
MOD_PKA_2	275	281	PF00069	0.341
MOD_Plk_1	121	127	PF00069	0.496
MOD_Plk_1	179	185	PF00069	0.381
MOD_Plk_1	317	323	PF00069	0.362
MOD_Plk_1	327	333	PF00069	0.436
MOD_Plk_1	69	75	PF00069	0.761
MOD_Plk_4	160	166	PF00069	0.550
MOD_Plk_4	214	220	PF00069	0.437
MOD_Plk_4	243	249	PF00069	0.538
MOD_Plk_4	327	333	PF00069	0.584
MOD_SUMO_rev_2	103	113	PF00179	0.567
MOD_SUMO_rev_2	136	144	PF00179	0.397
MOD_SUMO_rev_2	201	209	PF00179	0.401
MOD_SUMO_rev_2	28	33	PF00179	0.618
MOD_SUMO_rev_2	352	359	PF00179	0.489
TRG_DiLeu_BaEn_1	160	165	PF01217	0.395
TRG_DiLeu_BaEn_1	408	413	PF01217	0.670
TRG_DiLeu_LyEn_5	408	413	PF01217	0.670
TRG_ENDOCYTIC_2	183	186	PF00928	0.398
TRG_ENDOCYTIC_2	387	390	PF00928	0.413
TRG_ER_diArg_1	186	188	PF00400	0.478
TRG_NES_CRM1_1	128	141	PF08389	0.439
TRG_NES_CRM1_1	213	225	PF08389	0.293
TRG_NES_CRM1_1	90	103	PF08389	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J8	Leptomonas seymouri	76%	100%
A0A0S4IT07	Bodo saltans	57%	100%
A0A1X0NLS5	Trypanosomatidae	59%	100%
A0A3R7JZE2	Trypanosoma rangeli	59%	100%
A0A3S7WPA7	Leishmania donovani	92%	100%
A4HSP2	Leishmania infantum	92%	100%
C9ZNE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AKM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35125	Mus musculus	26%	100%
P21793	Bos taurus	28%	100%
P22194	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P36047	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P45969	Caenorhabditis elegans	33%	100%
Q15435	Homo sapiens	38%	100%
Q32PL1	Danio rerio	37%	100%
Q3T0W4	Bos taurus	35%	100%
Q3UM45	Mus musculus	37%	100%
Q4QJ81	Leishmania major	91%	100%
Q54Q39	Dictyostelium discoideum	35%	100%
Q5HZV9	Rattus norvegicus	37%	100%
Q5RFS7	Pongo abelii	37%	100%
Q6DIQ3	Xenopus tropicalis	38%	100%
Q7SXW3	Danio rerio	28%	70%
Q84WJ9	Arabidopsis thaliana	36%	100%
Q8AVI4	Xenopus laevis	27%	72%
Q8S7M7	Oryza sativa subsp. japonica	27%	77%
Q8VYG9	Arabidopsis thaliana	27%	84%
Q9TTE2	Ovis aries	28%	100%
V5ARU0	Trypanosoma cruzi	59%	100%