Putative prefoldin subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H4G4_LEIBR

TriTrypDb:

LbrM.05.1190 , LBRM2903_050018000

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051082	unfolded protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.433
CLV_NRD_NRD_1	104	106	PF00675	0.266
CLV_NRD_NRD_1	119	121	PF00675	0.402
CLV_NRD_NRD_1	36	38	PF00675	0.267
CLV_PCSK_KEX2_1	119	121	PF00082	0.335
CLV_PCSK_KEX2_1	36	38	PF00082	0.266
CLV_PCSK_KEX2_1	94	96	PF00082	0.246
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.246
CLV_PCSK_SKI1_1	16	20	PF00082	0.491
CLV_Separin_Metazoa	47	51	PF03568	0.452
DEG_APCC_DBOX_1	15	23	PF00400	0.414
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.452
LIG_LIR_Nem_3	61	66	PF02991	0.455
LIG_MYND_1	68	72	PF01753	0.502
LIG_NRBOX	10	16	PF00104	0.528
LIG_SH2_CRK	63	67	PF00017	0.452
LIG_SH2_GRB2like	88	91	PF00017	0.466
LIG_SH2_SRC	88	91	PF00017	0.466
LIG_SH2_STAT5	88	91	PF00017	0.441
LIG_TYR_ITSM	59	66	PF00017	0.527
LIG_UBA3_1	14	20	PF00899	0.540
MOD_CK1_1	96	102	PF00069	0.545
MOD_CK2_1	96	102	PF00069	0.482
MOD_GSK3_1	73	80	PF00069	0.489
MOD_NEK2_2	58	63	PF00069	0.527
MOD_Plk_1	58	64	PF00069	0.512
MOD_Plk_1	96	102	PF00069	0.447
MOD_Plk_4	58	64	PF00069	0.527
MOD_Plk_4	77	83	PF00069	0.527
MOD_SUMO_rev_2	74	81	PF00179	0.463
MOD_SUMO_rev_2	87	96	PF00179	0.438
MOD_SUMO_rev_2	98	108	PF00179	0.424
TRG_ENDOCYTIC_2	118	121	PF00928	0.537
TRG_ENDOCYTIC_2	63	66	PF00928	0.452
TRG_ER_diArg_1	118	120	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y5	Leptomonas seymouri	86%	99%
A0A0S4INB7	Bodo saltans	50%	100%
A0A1X0NLX1	Trypanosomatidae	67%	97%
A0A3R7LL27	Trypanosoma rangeli	66%	100%
A0A3S5H5M5	Leishmania donovani	94%	100%
A4HSP1	Leishmania infantum	94%	100%
C9ZNE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AKM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P52553	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
Q2HIK4	Arabidopsis thaliana	40%	100%
Q4QJ82	Leishmania major	94%	100%
Q54M71	Dictyostelium discoideum	35%	98%
V5B7F5	Trypanosoma cruzi	68%	99%