Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4G2_LEIBR

TriTrypDb:

LbrM.05.1170 , LBRM2903_050017800

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.508
CLV_NRD_NRD_1	131	133	PF00675	0.388
CLV_NRD_NRD_1	2	4	PF00675	0.518
CLV_NRD_NRD_1	20	22	PF00675	0.596
CLV_NRD_NRD_1	239	241	PF00675	0.434
CLV_NRD_NRD_1	242	244	PF00675	0.500
CLV_NRD_NRD_1	342	344	PF00675	0.702
CLV_NRD_NRD_1	398	400	PF00675	0.511
CLV_NRD_NRD_1	402	404	PF00675	0.508
CLV_NRD_NRD_1	470	472	PF00675	0.529
CLV_NRD_NRD_1	56	58	PF00675	0.559
CLV_PCSK_FUR_1	352	356	PF00082	0.567
CLV_PCSK_KEX2_1	100	102	PF00082	0.498
CLV_PCSK_KEX2_1	122	124	PF00082	0.506
CLV_PCSK_KEX2_1	131	133	PF00082	0.473
CLV_PCSK_KEX2_1	2	4	PF00082	0.518
CLV_PCSK_KEX2_1	20	22	PF00082	0.487
CLV_PCSK_KEX2_1	239	241	PF00082	0.434
CLV_PCSK_KEX2_1	354	356	PF00082	0.566
CLV_PCSK_KEX2_1	398	400	PF00082	0.570
CLV_PCSK_KEX2_1	402	404	PF00082	0.603
CLV_PCSK_KEX2_1	490	492	PF00082	0.805
CLV_PCSK_KEX2_1	56	58	PF00082	0.543
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.506
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.473
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.566
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.699
CLV_PCSK_PC7_1	235	241	PF00082	0.457
CLV_PCSK_PC7_1	398	404	PF00082	0.471
CLV_PCSK_PC7_1	486	492	PF00082	0.798
CLV_PCSK_SKI1_1	114	118	PF00082	0.464
CLV_PCSK_SKI1_1	207	211	PF00082	0.442
CLV_PCSK_SKI1_1	288	292	PF00082	0.593
CLV_PCSK_SKI1_1	3	7	PF00082	0.515
CLV_PCSK_SKI1_1	333	337	PF00082	0.634
DEG_MDM2_SWIB_1	225	232	PF02201	0.530
DEG_Nend_UBRbox_1	1	4	PF02207	0.513
DEG_SCF_FBW7_2	448	454	PF00400	0.540
DEG_SPOP_SBC_1	45	49	PF00917	0.736
DOC_CDC14_PxL_1	27	35	PF14671	0.481
DOC_CKS1_1	420	425	PF01111	0.672
DOC_CKS1_1	448	453	PF01111	0.540
DOC_CYCLIN_RxL_1	120	130	PF00134	0.361
DOC_CYCLIN_RxL_1	467	478	PF00134	0.545
DOC_MAPK_gen_1	100	109	PF00069	0.602
DOC_MAPK_gen_1	120	127	PF00069	0.557
DOC_PP1_RVXF_1	191	198	PF00149	0.407
DOC_PP2B_LxvP_1	437	440	PF13499	0.573
DOC_PP4_FxxP_1	496	499	PF00568	0.643
DOC_USP7_MATH_1	29	33	PF00917	0.514
DOC_USP7_MATH_1	55	59	PF00917	0.559
DOC_USP7_UBL2_3	244	248	PF12436	0.550
DOC_WW_Pin1_4	419	424	PF00397	0.693
DOC_WW_Pin1_4	447	452	PF00397	0.547
DOC_WW_Pin1_4	51	56	PF00397	0.643
LIG_14-3-3_CanoR_1	167	173	PF00244	0.631
LIG_14-3-3_CanoR_1	181	187	PF00244	0.635
LIG_14-3-3_CanoR_1	207	216	PF00244	0.433
LIG_14-3-3_CanoR_1	314	320	PF00244	0.542
LIG_14-3-3_CanoR_1	355	361	PF00244	0.553
LIG_14-3-3_CanoR_1	56	60	PF00244	0.559
LIG_BIR_III_2	443	447	PF00653	0.574
LIG_BIR_III_4	173	177	PF00653	0.528
LIG_BRCT_BRCA1_1	315	319	PF00533	0.649
LIG_CtBP_PxDLS_1	346	352	PF00389	0.644
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.417
LIG_FHA_1	177	183	PF00498	0.661
LIG_FHA_1	209	215	PF00498	0.510
LIG_FHA_1	32	38	PF00498	0.500
LIG_FHA_1	357	363	PF00498	0.551
LIG_FHA_1	41	47	PF00498	0.467
LIG_FHA_1	448	454	PF00498	0.572
LIG_FHA_1	91	97	PF00498	0.536
LIG_FHA_2	316	322	PF00498	0.563
LIG_FHA_2	447	453	PF00498	0.544
LIG_Integrin_RGD_1	271	273	PF01839	0.449
LIG_Integrin_RGD_1	366	368	PF01839	0.553
LIG_LIR_Gen_1	226	236	PF02991	0.568
LIG_LIR_Gen_1	316	327	PF02991	0.561
LIG_LIR_Gen_1	391	397	PF02991	0.599
LIG_LIR_Nem_3	185	189	PF02991	0.494
LIG_LIR_Nem_3	199	205	PF02991	0.364
LIG_LIR_Nem_3	226	232	PF02991	0.539
LIG_LIR_Nem_3	316	322	PF02991	0.552
LIG_LIR_Nem_3	391	395	PF02991	0.600
LIG_Pex14_1	198	202	PF04695	0.375
LIG_Pex14_1	360	364	PF04695	0.525
LIG_Pex14_2	221	225	PF04695	0.377
LIG_SH2_CRK	253	257	PF00017	0.499
LIG_SH2_GRB2like	202	205	PF00017	0.364
LIG_SH2_STAT3	286	289	PF00017	0.487
LIG_SH2_STAT3	397	400	PF00017	0.565
LIG_SH2_STAT5	168	171	PF00017	0.498
LIG_SH2_STAT5	208	211	PF00017	0.408
LIG_SH2_STAT5	98	101	PF00017	0.634
LIG_SH3_3	417	423	PF00018	0.605
LIG_SH3_3	492	498	PF00018	0.632
LIG_SH3_3	56	62	PF00018	0.623
LIG_TRAF2_1	126	129	PF00917	0.531
LIG_TRAF2_1	278	281	PF00917	0.454
LIG_TRAF2_1	318	321	PF00917	0.550
LIG_TRAF2_1	345	348	PF00917	0.640
LIG_UBA3_1	78	83	PF00899	0.566
MOD_CDC14_SPxK_1	54	57	PF00782	0.474
MOD_CDK_SPK_2	51	56	PF00069	0.475
MOD_CDK_SPxK_1	51	57	PF00069	0.477
MOD_CK1_1	32	38	PF00069	0.681
MOD_CK1_1	44	50	PF00069	0.587
MOD_CK1_1	513	519	PF00069	0.651
MOD_CK1_1	77	83	PF00069	0.582
MOD_CK2_1	273	279	PF00069	0.451
MOD_CK2_1	315	321	PF00069	0.542
MOD_CK2_1	446	452	PF00069	0.551
MOD_CMANNOS	263	266	PF00535	0.404
MOD_GlcNHglycan	14	17	PF01048	0.605
MOD_GlcNHglycan	3	6	PF01048	0.514
MOD_GlcNHglycan	517	520	PF01048	0.693
MOD_GlcNHglycan	67	70	PF01048	0.629
MOD_GSK3_1	29	36	PF00069	0.602
MOD_GSK3_1	40	47	PF00069	0.573
MOD_GSK3_1	415	422	PF00069	0.691
MOD_GSK3_1	51	58	PF00069	0.491
MOD_GSK3_1	61	68	PF00069	0.531
MOD_GSK3_1	77	84	PF00069	0.543
MOD_N-GLC_1	12	17	PF02516	0.516
MOD_N-GLC_1	74	79	PF02516	0.538
MOD_NEK2_1	1	6	PF00069	0.678
MOD_NEK2_1	182	187	PF00069	0.552
MOD_NEK2_1	225	230	PF00069	0.383
MOD_NEK2_1	33	38	PF00069	0.760
MOD_NEK2_1	65	70	PF00069	0.630
MOD_NEK2_2	176	181	PF00069	0.529
MOD_PIKK_1	208	214	PF00454	0.431
MOD_PIKK_1	313	319	PF00454	0.515
MOD_PIKK_1	373	379	PF00454	0.658
MOD_PIKK_1	499	505	PF00454	0.685
MOD_PKA_1	243	249	PF00069	0.571
MOD_PKA_2	1	7	PF00069	0.622
MOD_PKA_2	313	319	PF00069	0.651
MOD_PKA_2	338	344	PF00069	0.599
MOD_PKA_2	55	61	PF00069	0.553
MOD_PKA_2	71	77	PF00069	0.523
MOD_PKB_1	455	463	PF00069	0.612
MOD_Plk_1	163	169	PF00069	0.617
MOD_Plk_1	176	182	PF00069	0.527
MOD_Plk_1	373	379	PF00069	0.671
MOD_Plk_1	510	516	PF00069	0.656
MOD_Plk_1	74	80	PF00069	0.538
MOD_Plk_2-3	273	279	PF00069	0.451
MOD_Plk_4	41	47	PF00069	0.604
MOD_Plk_4	74	80	PF00069	0.575
MOD_ProDKin_1	419	425	PF00069	0.683
MOD_ProDKin_1	447	453	PF00069	0.544
MOD_ProDKin_1	51	57	PF00069	0.645
MOD_SUMO_rev_2	340	345	PF00179	0.686
TRG_ENDOCYTIC_2	253	256	PF00928	0.500
TRG_ER_diArg_1	1	3	PF00400	0.513
TRG_ER_diArg_1	19	21	PF00400	0.492
TRG_ER_diArg_1	239	241	PF00400	0.435
TRG_ER_diArg_1	397	399	PF00400	0.560
TRG_ER_diArg_1	401	403	PF00400	0.575
TRG_ER_diArg_1	455	458	PF00400	0.580
TRG_ER_diArg_1	55	57	PF00400	0.598
TRG_ER_diArg_1	70	73	PF00400	0.617
TRG_ER_diArg_1	99	102	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF1	Leptomonas seymouri	84%	100%
A0A0S4IU67	Bodo saltans	63%	100%
A0A1X0NK32	Trypanosomatidae	75%	100%
A0A3S7WP90	Leishmania donovani	96%	100%
A4HSN9	Leishmania infantum	96%	100%
C9ZNE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AKM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QJ84	Leishmania major	96%	100%
V5BGD5	Trypanosoma cruzi	76%	100%