Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4G1_LEIBR

TriTrypDb:

LbrM.05.1160 , LBRM2903_050017700

Length:

249

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H4G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006631	fatty acid metabolic process	4	12
GO:0006633	fatty acid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016053	organic acid biosynthetic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046394	carboxylic acid biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0072330	monocarboxylic acid biosynthetic process	6	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0001676	long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019367	fatty acid elongation, saturated fatty acid	7	1
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	1
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	1
GO:0042759	long-chain fatty acid biosynthetic process	6	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004312	fatty acid synthase activity	5	12
GO:0009922	fatty acid elongase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.218
CLV_NRD_NRD_1	240	242	PF00675	0.233
CLV_PCSK_SKI1_1	186	190	PF00082	0.225
CLV_PCSK_SKI1_1	241	245	PF00082	0.252
DEG_Nend_UBRbox_1	1	4	PF02207	0.393
DOC_CDC14_PxL_1	24	32	PF14671	0.355
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.474
DOC_MAPK_gen_1	121	129	PF00069	0.407
DOC_MAPK_gen_1	215	222	PF00069	0.237
DOC_PP1_RVXF_1	11	18	PF00149	0.217
DOC_PP2B_LxvP_1	211	214	PF13499	0.254
DOC_USP7_MATH_1	4	8	PF00917	0.374
DOC_USP7_UBL2_3	181	185	PF12436	0.427
DOC_USP7_UBL2_3	238	242	PF12436	0.426
DOC_USP7_UBL2_3	244	248	PF12436	0.522
LIG_AP2alpha_1	109	113	PF02296	0.386
LIG_BRCT_BRCA1_1	13	17	PF00533	0.270
LIG_deltaCOP1_diTrp_1	98	102	PF00928	0.217
LIG_EH1_1	36	44	PF00400	0.301
LIG_FHA_1	105	111	PF00498	0.242
LIG_FHA_1	50	56	PF00498	0.536
LIG_FHA_1	64	70	PF00498	0.191
LIG_FHA_1	71	77	PF00498	0.345
LIG_FHA_1	92	98	PF00498	0.262
LIG_GBD_Chelix_1	40	48	PF00786	0.175
LIG_LIR_Apic_2	177	183	PF02991	0.417
LIG_LIR_Gen_1	107	117	PF02991	0.241
LIG_LIR_Gen_1	128	136	PF02991	0.241
LIG_LIR_Gen_1	227	236	PF02991	0.299
LIG_LIR_Gen_1	98	106	PF02991	0.207
LIG_LIR_Nem_3	111	116	PF02991	0.235
LIG_LIR_Nem_3	128	132	PF02991	0.149
LIG_LIR_Nem_3	23	27	PF02991	0.169
LIG_LIR_Nem_3	96	102	PF02991	0.208
LIG_LYPXL_yS_3	27	30	PF13949	0.355
LIG_LYPXL_yS_3	58	61	PF13949	0.453
LIG_PCNA_yPIPBox_3	185	197	PF02747	0.351
LIG_Pex14_2	109	113	PF04695	0.344
LIG_Pex14_2	156	160	PF04695	0.256
LIG_SH2_CRK	175	179	PF00017	0.490
LIG_SH2_CRK	180	184	PF00017	0.456
LIG_SH2_STAT3	187	190	PF00017	0.510
LIG_SH2_STAT5	105	108	PF00017	0.211
LIG_SH2_STAT5	116	119	PF00017	0.312
LIG_SH2_STAT5	170	173	PF00017	0.250
LIG_SH2_STAT5	175	178	PF00017	0.400
LIG_SH2_STAT5	187	190	PF00017	0.380
LIG_SH2_STAT5	230	233	PF00017	0.335
LIG_SH2_STAT5	37	40	PF00017	0.261
LIG_SH2_STAT5	54	57	PF00017	0.407
LIG_SH3_3	22	28	PF00018	0.304
LIG_SUMO_SIM_par_1	204	210	PF11976	0.270
LIG_SUMO_SIM_par_1	68	73	PF11976	0.164
LIG_TYR_ITIM	25	30	PF00017	0.335
LIG_TYR_ITIM	35	40	PF00017	0.256
LIG_TYR_ITIM	56	61	PF00017	0.383
LIG_WRC_WIRS_1	21	26	PF05994	0.273
MOD_CK2_1	92	98	PF00069	0.227
MOD_Cter_Amidation	10	13	PF01082	0.466
MOD_GlcNHglycan	162	165	PF01048	0.324
MOD_N-GLC_1	151	156	PF02516	0.431
MOD_N-GLC_1	63	68	PF02516	0.251
MOD_NEK2_1	112	117	PF00069	0.256
MOD_NEK2_1	174	179	PF00069	0.271
MOD_NEK2_1	30	35	PF00069	0.266
MOD_NEK2_1	70	75	PF00069	0.340
MOD_PIKK_1	186	192	PF00454	0.510
MOD_PIKK_1	4	10	PF00454	0.257
MOD_PIKK_1	63	69	PF00454	0.278
MOD_Plk_1	63	69	PF00069	0.258
MOD_Plk_4	112	118	PF00069	0.269
MOD_Plk_4	125	131	PF00069	0.464
MOD_Plk_4	20	26	PF00069	0.250
MOD_Plk_4	224	230	PF00069	0.300
TRG_DiLeu_BaEn_2	19	25	PF01217	0.328
TRG_DiLeu_BaEn_2	97	103	PF01217	0.217
TRG_DiLeu_BaEn_3	124	130	PF01217	0.422
TRG_ENDOCYTIC_2	116	119	PF00928	0.218
TRG_ENDOCYTIC_2	133	136	PF00928	0.180
TRG_ENDOCYTIC_2	175	178	PF00928	0.494
TRG_ENDOCYTIC_2	230	233	PF00928	0.323
TRG_ENDOCYTIC_2	27	30	PF00928	0.279
TRG_ENDOCYTIC_2	37	40	PF00928	0.291
TRG_ENDOCYTIC_2	45	48	PF00928	0.445
TRG_ENDOCYTIC_2	58	61	PF00928	0.330
TRG_ENDOCYTIC_2	84	87	PF00928	0.247
TRG_ENDOCYTIC_2	99	102	PF00928	0.254
TRG_ER_diLys_1	244	249	PF00400	0.644
TRG_NLS_MonoExtN_4	238	245	PF00514	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	34%	85%
A0A0N0P5E5	Leptomonas seymouri	31%	83%
A0A0N0P7D1	Leptomonas seymouri	26%	75%
A0A0N0P7D6	Leptomonas seymouri	25%	86%
A0A0N0P994	Leptomonas seymouri	34%	69%
A0A0N1HZJ8	Leptomonas seymouri	28%	77%
A0A0N1IM10	Leptomonas seymouri	26%	87%
A0A0N1PBS4	Leptomonas seymouri	73%	100%
A0A0N1PDR8	Leptomonas seymouri	28%	92%
A0A0S4J4C4	Bodo saltans	58%	95%
A0A0S4JCZ3	Bodo saltans	31%	77%
A0A0S4JH58	Bodo saltans	35%	83%
A0A1X0NNK7	Trypanosomatidae	30%	87%
A0A1X0NNL0	Trypanosomatidae	26%	82%
A0A1X0NUJ4	Trypanosomatidae	33%	69%
A0A1X0P2P0	Trypanosomatidae	54%	100%
A0A3Q8IC05	Leishmania donovani	34%	82%
A0A3R7KG78	Trypanosoma rangeli	29%	88%
A0A3R7MJR2	Trypanosoma rangeli	24%	89%
A0A3R7NSQ3	Trypanosoma rangeli	29%	86%
A0A3S5H5M3	Leishmania donovani	84%	100%
A0A422NYI1	Trypanosoma rangeli	56%	98%
A0JNC4	Bos taurus	34%	89%
A1L3X0	Homo sapiens	35%	89%
A4H7M2	Leishmania braziliensis	28%	87%
A4H7N0	Leishmania braziliensis	34%	84%
A4HKA3	Leishmania braziliensis	34%	76%
A4HSN8	Leishmania infantum	84%	100%
A4HW12	Leishmania infantum	26%	74%
A4HW18	Leishmania infantum	32%	82%
B4QVX4	Drosophila simulans	32%	95%
C9ZPY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	99%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	92%
D4A612	Rattus norvegicus	36%	89%
D4ADY9	Rattus norvegicus	36%	89%
E9AKM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	74%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	83%
G5EEE5	Caenorhabditis elegans	29%	86%
O35949	Mus musculus	26%	92%
P49191	Caenorhabditis elegans	26%	78%
Q1HRV8	Aedes aegypti	31%	70%
Q20300	Caenorhabditis elegans	29%	91%
Q20303	Caenorhabditis elegans	28%	91%
Q2KJD9	Bos taurus	33%	83%
Q32NI8	Xenopus laevis	31%	84%
Q3S8M4	Macaca mulatta	32%	79%
Q4QFQ9	Leishmania major	33%	83%
Q4QFR7	Leishmania major	27%	100%
Q4QJ85	Leishmania major	83%	100%
Q4R516	Macaca fascicularis	33%	83%
Q5M8U1	Xenopus tropicalis	33%	84%
Q5RFL5	Pongo abelii	32%	83%
Q5ZJR8	Gallus gallus	26%	94%
Q6PC64	Danio rerio	29%	94%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	68%
Q86JM5	Dictyostelium discoideum	30%	84%
Q8BHI7	Mus musculus	33%	83%
Q920L5	Mus musculus	26%	93%
Q920L6	Rattus norvegicus	28%	93%
Q920L7	Rattus norvegicus	32%	83%
Q95K73	Macaca fascicularis	32%	79%
Q9BW60	Homo sapiens	35%	89%
Q9D2Y9	Mus musculus	34%	89%
Q9EQC4	Mus musculus	32%	80%
Q9GZR5	Homo sapiens	33%	79%
Q9H5J4	Homo sapiens	28%	94%
Q9HB03	Homo sapiens	27%	92%
Q9JLJ4	Mus musculus	35%	85%
Q9JLJ5	Mus musculus	36%	89%
Q9NXB9	Homo sapiens	37%	84%
Q9NYP7	Homo sapiens	33%	83%
Q9UTF7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	75%
Q9VHX7	Drosophila melanogaster	31%	76%
Q9VV87	Drosophila melanogaster	25%	79%
Q9XVQ9	Caenorhabditis elegans	29%	91%
V5AUX1	Trypanosoma cruzi	56%	98%
V5BE99	Trypanosoma cruzi	28%	87%
V5BIX9	Trypanosoma cruzi	24%	89%
V5DF68	Trypanosoma cruzi	27%	86%