Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4G0_LEIBR

TriTrypDb:

LbrM.05.1150 , LBRM2903_050017500

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4H4G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.505
CLV_C14_Caspase3-7	164	168	PF00656	0.580
CLV_C14_Caspase3-7	224	228	PF00656	0.824
CLV_NRD_NRD_1	138	140	PF00675	0.608
CLV_NRD_NRD_1	358	360	PF00675	0.532
CLV_NRD_NRD_1	383	385	PF00675	0.433
CLV_NRD_NRD_1	429	431	PF00675	0.693
CLV_NRD_NRD_1	7	9	PF00675	0.658
CLV_NRD_NRD_1	784	786	PF00675	0.661
CLV_NRD_NRD_1	836	838	PF00675	0.475
CLV_PCSK_FUR_1	381	385	PF00082	0.436
CLV_PCSK_KEX2_1	138	140	PF00082	0.586
CLV_PCSK_KEX2_1	358	360	PF00082	0.532
CLV_PCSK_KEX2_1	383	385	PF00082	0.433
CLV_PCSK_KEX2_1	429	431	PF00082	0.693
CLV_PCSK_KEX2_1	585	587	PF00082	0.815
CLV_PCSK_KEX2_1	7	9	PF00082	0.658
CLV_PCSK_KEX2_1	783	785	PF00082	0.678
CLV_PCSK_KEX2_1	836	838	PF00082	0.475
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.815
CLV_PCSK_SKI1_1	358	362	PF00082	0.546
CLV_PCSK_SKI1_1	460	464	PF00082	0.695
CLV_PCSK_SKI1_1	680	684	PF00082	0.704
CLV_PCSK_SKI1_1	746	750	PF00082	0.563
CLV_PCSK_SKI1_1	808	812	PF00082	0.537
CLV_PCSK_SKI1_1	90	94	PF00082	0.527
DEG_APCC_DBOX_1	49	57	PF00400	0.540
DEG_SPOP_SBC_1	518	522	PF00917	0.785
DEG_SPOP_SBC_1	588	592	PF00917	0.582
DEG_SPOP_SBC_1	709	713	PF00917	0.710
DEG_SPOP_SBC_1	855	859	PF00917	0.567
DOC_CKS1_1	360	365	PF01111	0.666
DOC_CKS1_1	577	582	PF01111	0.547
DOC_CKS1_1	631	636	PF01111	0.709
DOC_CYCLIN_RxL_1	355	362	PF00134	0.418
DOC_MAPK_DCC_7	460	468	PF00069	0.519
DOC_MAPK_gen_1	138	145	PF00069	0.562
DOC_MAPK_gen_1	567	577	PF00069	0.772
DOC_MAPK_gen_1	637	646	PF00069	0.817
DOC_MAPK_MEF2A_6	138	145	PF00069	0.369
DOC_MAPK_MEF2A_6	289	296	PF00069	0.522
DOC_MAPK_MEF2A_6	460	468	PF00069	0.519
DOC_MAPK_RevD_3	770	784	PF00069	0.546
DOC_PP2B_LxvP_1	160	163	PF13499	0.716
DOC_PP2B_LxvP_1	481	484	PF13499	0.549
DOC_PP2B_LxvP_1	575	578	PF13499	0.692
DOC_PP2B_LxvP_1	632	635	PF13499	0.712
DOC_PP2B_LxvP_1	862	865	PF13499	0.741
DOC_PP4_FxxP_1	631	634	PF00568	0.713
DOC_PP4_FxxP_1	673	676	PF00568	0.567
DOC_USP7_MATH_1	127	131	PF00917	0.512
DOC_USP7_MATH_1	161	165	PF00917	0.735
DOC_USP7_MATH_1	168	172	PF00917	0.822
DOC_USP7_MATH_1	447	451	PF00917	0.586
DOC_USP7_MATH_1	484	488	PF00917	0.714
DOC_USP7_MATH_1	49	53	PF00917	0.702
DOC_USP7_MATH_1	492	496	PF00917	0.730
DOC_USP7_MATH_1	517	521	PF00917	0.718
DOC_USP7_MATH_1	587	591	PF00917	0.676
DOC_USP7_MATH_1	624	628	PF00917	0.750
DOC_USP7_MATH_1	64	68	PF00917	0.622
DOC_USP7_MATH_1	732	736	PF00917	0.729
DOC_USP7_MATH_1	755	759	PF00917	0.664
DOC_USP7_MATH_1	856	860	PF00917	0.679
DOC_USP7_MATH_1	91	95	PF00917	0.617
DOC_WW_Pin1_4	166	171	PF00397	0.802
DOC_WW_Pin1_4	278	283	PF00397	0.600
DOC_WW_Pin1_4	323	328	PF00397	0.558
DOC_WW_Pin1_4	359	364	PF00397	0.628
DOC_WW_Pin1_4	405	410	PF00397	0.575
DOC_WW_Pin1_4	413	418	PF00397	0.533
DOC_WW_Pin1_4	421	426	PF00397	0.458
DOC_WW_Pin1_4	482	487	PF00397	0.771
DOC_WW_Pin1_4	531	536	PF00397	0.729
DOC_WW_Pin1_4	576	581	PF00397	0.630
DOC_WW_Pin1_4	589	594	PF00397	0.718
DOC_WW_Pin1_4	598	603	PF00397	0.652
DOC_WW_Pin1_4	630	635	PF00397	0.713
DOC_WW_Pin1_4	65	70	PF00397	0.734
DOC_WW_Pin1_4	675	680	PF00397	0.696
DOC_WW_Pin1_4	75	80	PF00397	0.587
LIG_14-3-3_CanoR_1	181	186	PF00244	0.586
LIG_14-3-3_CanoR_1	269	277	PF00244	0.829
LIG_14-3-3_CanoR_1	335	344	PF00244	0.520
LIG_14-3-3_CanoR_1	50	54	PF00244	0.538
LIG_14-3-3_CanoR_1	640	645	PF00244	0.603
LIG_14-3-3_CanoR_1	846	856	PF00244	0.551
LIG_14-3-3_CanoR_1	90	96	PF00244	0.610
LIG_Actin_WH2_2	831	848	PF00022	0.427
LIG_Actin_WH2_2	9	26	PF00022	0.678
LIG_APCC_ABBAyCdc20_2	138	144	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.373
LIG_BIR_III_2	167	171	PF00653	0.592
LIG_BRCT_BRCA1_1	237	241	PF00533	0.625
LIG_Clathr_ClatBox_1	140	144	PF01394	0.358
LIG_EVH1_2	464	468	PF00568	0.501
LIG_FHA_1	115	121	PF00498	0.481
LIG_FHA_1	194	200	PF00498	0.579
LIG_FHA_1	29	35	PF00498	0.581
LIG_FHA_1	401	407	PF00498	0.537
LIG_FHA_1	536	542	PF00498	0.610
LIG_FHA_1	577	583	PF00498	0.549
LIG_FHA_1	646	652	PF00498	0.646
LIG_FHA_1	709	715	PF00498	0.710
LIG_FHA_1	758	764	PF00498	0.661
LIG_FHA_1	795	801	PF00498	0.594
LIG_FHA_2	127	133	PF00498	0.499
LIG_FHA_2	241	247	PF00498	0.607
LIG_FHA_2	340	346	PF00498	0.406
LIG_FHA_2	804	810	PF00498	0.621
LIG_GSK3_LRP6_1	675	680	PF00069	0.568
LIG_IRF3_LxIS_1	382	388	PF10401	0.441
LIG_LIR_Apic_2	670	676	PF02991	0.581
LIG_LIR_Gen_1	144	153	PF02991	0.480
LIG_LIR_Gen_1	308	319	PF02991	0.473
LIG_LIR_Gen_1	416	426	PF02991	0.574
LIG_LIR_Gen_1	527	535	PF02991	0.690
LIG_LIR_Nem_3	144	150	PF02991	0.472
LIG_LIR_Nem_3	308	314	PF02991	0.421
LIG_LIR_Nem_3	416	421	PF02991	0.583
LIG_LIR_Nem_3	457	462	PF02991	0.556
LIG_LIR_Nem_3	527	533	PF02991	0.694
LIG_LIR_Nem_3	713	719	PF02991	0.713
LIG_MAD2	181	189	PF02301	0.583
LIG_NRBOX	94	100	PF00104	0.579
LIG_PCNA_yPIPBox_3	500	513	PF02747	0.718
LIG_PDZ_Class_3	865	870	PF00595	0.547
LIG_RPA_C_Fungi	284	296	PF08784	0.460
LIG_SH2_CRK	459	463	PF00017	0.546
LIG_SH2_NCK_1	147	151	PF00017	0.571
LIG_SH2_PTP2	142	145	PF00017	0.464
LIG_SH2_STAT5	142	145	PF00017	0.464
LIG_SH2_STAT5	350	353	PF00017	0.348
LIG_SH2_STAT5	356	359	PF00017	0.471
LIG_SH3_3	403	409	PF00018	0.566
LIG_SH3_3	419	425	PF00018	0.465
LIG_SH3_3	459	465	PF00018	0.535
LIG_SH3_3	488	494	PF00018	0.604
LIG_SH3_3	574	580	PF00018	0.633
LIG_SH3_3	63	69	PF00018	0.561
LIG_SH3_3	673	679	PF00018	0.748
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.541
LIG_SUMO_SIM_anti_2	290	297	PF11976	0.407
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.625
LIG_SUMO_SIM_par_1	116	124	PF11976	0.567
LIG_SUMO_SIM_par_1	181	187	PF11976	0.616
LIG_SUMO_SIM_par_1	235	240	PF11976	0.728
LIG_SUMO_SIM_par_1	290	297	PF11976	0.586
LIG_SUMO_SIM_par_1	573	579	PF11976	0.544
LIG_SUMO_SIM_par_1	729	735	PF11976	0.599
LIG_TRAF2_1	81	84	PF00917	0.606
LIG_TYR_ITIM	140	145	PF00017	0.471
LIG_WW_3	634	638	PF00397	0.805
MOD_CDK_SPK_2	675	680	PF00069	0.568
MOD_CDK_SPxK_1	359	365	PF00069	0.611
MOD_CDK_SPxK_1	589	595	PF00069	0.752
MOD_CDK_SPxxK_3	630	637	PF00069	0.711
MOD_CK1_1	146	152	PF00069	0.589
MOD_CK1_1	169	175	PF00069	0.814
MOD_CK1_1	184	190	PF00069	0.553
MOD_CK1_1	240	246	PF00069	0.686
MOD_CK1_1	287	293	PF00069	0.538
MOD_CK1_1	369	375	PF00069	0.684
MOD_CK1_1	405	411	PF00069	0.628
MOD_CK1_1	531	537	PF00069	0.775
MOD_CK1_1	598	604	PF00069	0.766
MOD_CK1_1	639	645	PF00069	0.696
MOD_CK1_1	649	655	PF00069	0.742
MOD_CK1_1	67	73	PF00069	0.714
MOD_CK1_1	699	705	PF00069	0.737
MOD_CK1_1	758	764	PF00069	0.616
MOD_CK1_1	78	84	PF00069	0.717
MOD_CK2_1	194	200	PF00069	0.675
MOD_CK2_1	226	232	PF00069	0.667
MOD_CK2_1	240	246	PF00069	0.485
MOD_CK2_1	394	400	PF00069	0.491
MOD_CK2_1	506	512	PF00069	0.573
MOD_CK2_1	704	710	PF00069	0.736
MOD_CK2_1	78	84	PF00069	0.632
MOD_CK2_1	803	809	PF00069	0.619
MOD_DYRK1A_RPxSP_1	482	486	PF00069	0.558
MOD_GlcNHglycan	196	199	PF01048	0.724
MOD_GlcNHglycan	257	260	PF01048	0.679
MOD_GlcNHglycan	289	292	PF01048	0.552
MOD_GlcNHglycan	328	331	PF01048	0.735
MOD_GlcNHglycan	368	371	PF01048	0.697
MOD_GlcNHglycan	386	390	PF01048	0.596
MOD_GlcNHglycan	486	489	PF01048	0.684
MOD_GlcNHglycan	521	524	PF01048	0.775
MOD_GlcNHglycan	597	600	PF01048	0.728
MOD_GlcNHglycan	604	607	PF01048	0.799
MOD_GlcNHglycan	651	654	PF01048	0.810
MOD_GlcNHglycan	734	737	PF01048	0.769
MOD_GlcNHglycan	738	741	PF01048	0.770
MOD_GlcNHglycan	75	78	PF01048	0.745
MOD_GlcNHglycan	751	754	PF01048	0.576
MOD_GlcNHglycan	765	768	PF01048	0.601
MOD_GlcNHglycan	83	89	PF01048	0.485
MOD_GlcNHglycan	847	850	PF01048	0.480
MOD_GSK3_1	189	196	PF00069	0.691
MOD_GSK3_1	23	30	PF00069	0.493
MOD_GSK3_1	237	244	PF00069	0.693
MOD_GSK3_1	246	253	PF00069	0.624
MOD_GSK3_1	365	372	PF00069	0.669
MOD_GSK3_1	482	489	PF00069	0.700
MOD_GSK3_1	519	526	PF00069	0.727
MOD_GSK3_1	531	538	PF00069	0.516
MOD_GSK3_1	598	605	PF00069	0.785
MOD_GSK3_1	636	643	PF00069	0.727
MOD_GSK3_1	64	71	PF00069	0.786
MOD_GSK3_1	645	652	PF00069	0.701
MOD_GSK3_1	663	670	PF00069	0.594
MOD_GSK3_1	696	703	PF00069	0.832
MOD_GSK3_1	704	711	PF00069	0.624
MOD_GSK3_1	732	739	PF00069	0.811
MOD_GSK3_1	757	764	PF00069	0.660
MOD_GSK3_1	790	797	PF00069	0.646
MOD_GSK3_1	845	852	PF00069	0.535
MOD_GSK3_1	854	861	PF00069	0.651
MOD_N-GLC_1	287	292	PF02516	0.475
MOD_N-GLC_1	394	399	PF02516	0.606
MOD_N-GLC_1	703	708	PF02516	0.591
MOD_NEK2_1	121	126	PF00069	0.469
MOD_NEK2_1	294	299	PF00069	0.572
MOD_NEK2_1	34	39	PF00069	0.586
MOD_NEK2_1	344	349	PF00069	0.406
MOD_NEK2_1	385	390	PF00069	0.563
MOD_NEK2_1	402	407	PF00069	0.532
MOD_NEK2_1	420	425	PF00069	0.647
MOD_NEK2_1	48	53	PF00069	0.520
MOD_NEK2_1	506	511	PF00069	0.668
MOD_NEK2_1	845	850	PF00069	0.499
MOD_NEK2_2	525	530	PF00069	0.791
MOD_OFUCOSY	759	765	PF10250	0.514
MOD_PIKK_1	161	167	PF00454	0.570
MOD_PIKK_1	542	548	PF00454	0.575
MOD_PIKK_1	847	853	PF00454	0.502
MOD_PK_1	181	187	PF00069	0.586
MOD_PK_1	640	646	PF00069	0.820
MOD_PKA_1	429	435	PF00069	0.701
MOD_PKA_2	193	199	PF00069	0.578
MOD_PKA_2	250	256	PF00069	0.636
MOD_PKA_2	268	274	PF00069	0.702
MOD_PKA_2	429	435	PF00069	0.701
MOD_PKA_2	49	55	PF00069	0.534
MOD_PKA_2	636	642	PF00069	0.811
MOD_PKA_2	663	669	PF00069	0.774
MOD_PKA_2	790	796	PF00069	0.551
MOD_PKA_2	845	851	PF00069	0.482
MOD_Plk_1	143	149	PF00069	0.559
MOD_Plk_1	219	225	PF00069	0.579
MOD_Plk_1	555	561	PF00069	0.623
MOD_Plk_1	646	652	PF00069	0.752
MOD_Plk_1	709	715	PF00069	0.688
MOD_Plk_1	746	752	PF00069	0.734
MOD_Plk_1	794	800	PF00069	0.643
MOD_Plk_1	803	809	PF00069	0.474
MOD_Plk_1	84	90	PF00069	0.559
MOD_Plk_2-3	219	225	PF00069	0.627
MOD_Plk_2-3	537	543	PF00069	0.570
MOD_Plk_4	116	122	PF00069	0.436
MOD_Plk_4	237	243	PF00069	0.585
MOD_Plk_4	458	464	PF00069	0.540
MOD_Plk_4	525	531	PF00069	0.788
MOD_Plk_4	555	561	PF00069	0.623
MOD_Plk_4	646	652	PF00069	0.734
MOD_Plk_4	758	764	PF00069	0.519
MOD_ProDKin_1	166	172	PF00069	0.805
MOD_ProDKin_1	278	284	PF00069	0.597
MOD_ProDKin_1	323	329	PF00069	0.553
MOD_ProDKin_1	359	365	PF00069	0.643
MOD_ProDKin_1	405	411	PF00069	0.574
MOD_ProDKin_1	413	419	PF00069	0.534
MOD_ProDKin_1	421	427	PF00069	0.459
MOD_ProDKin_1	482	488	PF00069	0.773
MOD_ProDKin_1	531	537	PF00069	0.730
MOD_ProDKin_1	576	582	PF00069	0.631
MOD_ProDKin_1	589	595	PF00069	0.724
MOD_ProDKin_1	598	604	PF00069	0.653
MOD_ProDKin_1	630	636	PF00069	0.710
MOD_ProDKin_1	65	71	PF00069	0.736
MOD_ProDKin_1	675	681	PF00069	0.701
MOD_ProDKin_1	75	81	PF00069	0.579
MOD_SUMO_rev_2	804	812	PF00179	0.626
MOD_SUMO_rev_2	820	826	PF00179	0.388
TRG_DiLeu_BaEn_4	84	90	PF01217	0.532
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.410
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.401
TRG_ENDOCYTIC_2	142	145	PF00928	0.464
TRG_ENDOCYTIC_2	147	150	PF00928	0.468
TRG_ENDOCYTIC_2	459	462	PF00928	0.553
TRG_ENDOCYTIC_2	786	789	PF00928	0.600
TRG_ER_diArg_1	138	140	PF00400	0.608
TRG_ER_diArg_1	301	304	PF00400	0.498
TRG_ER_diArg_1	357	359	PF00400	0.533
TRG_ER_diArg_1	381	384	PF00400	0.450
TRG_ER_diArg_1	429	431	PF00400	0.750
TRG_ER_diArg_1	782	785	PF00400	0.562
TRG_ER_diArg_1	835	837	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	787	792	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I133	Leptomonas seymouri	37%	98%
A0A3S7WPA4	Leishmania donovani	67%	95%
A4HSN7	Leishmania infantum	67%	95%
E9AKM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%