SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4F8_LEIBR

TriTrypDb:

LbrM.05.1130 , LBRM2903_050017300

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.789
CLV_C14_Caspase3-7	229	233	PF00656	0.763
CLV_NRD_NRD_1	108	110	PF00675	0.600
CLV_NRD_NRD_1	266	268	PF00675	0.557
CLV_NRD_NRD_1	527	529	PF00675	0.531
CLV_NRD_NRD_1	60	62	PF00675	0.762
CLV_PCSK_KEX2_1	108	110	PF00082	0.600
CLV_PCSK_KEX2_1	266	268	PF00082	0.557
CLV_PCSK_KEX2_1	401	403	PF00082	0.541
CLV_PCSK_KEX2_1	527	529	PF00082	0.531
CLV_PCSK_KEX2_1	60	62	PF00082	0.665
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.565
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.533
CLV_PCSK_SKI1_1	147	151	PF00082	0.525
CLV_PCSK_SKI1_1	258	262	PF00082	0.422
CLV_PCSK_SKI1_1	328	332	PF00082	0.524
CLV_PCSK_SKI1_1	356	360	PF00082	0.453
CLV_PCSK_SKI1_1	47	51	PF00082	0.595
CLV_PCSK_SKI1_1	472	476	PF00082	0.619
CLV_PCSK_SKI1_1	503	507	PF00082	0.483
DEG_APCC_DBOX_1	8	16	PF00400	0.561
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DEG_SCF_FBW7_1	17	24	PF00400	0.534
DOC_CKS1_1	18	23	PF01111	0.533
DOC_CKS1_1	224	229	PF01111	0.802
DOC_CKS1_1	414	419	PF01111	0.666
DOC_CYCLIN_RxL_1	323	333	PF00134	0.560
DOC_CYCLIN_RxL_1	377	387	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.457
DOC_MAPK_DCC_7	5	15	PF00069	0.601
DOC_MAPK_gen_1	470	479	PF00069	0.639
DOC_MAPK_gen_1	501	509	PF00069	0.463
DOC_MAPK_MEF2A_6	258	265	PF00069	0.460
DOC_MAPK_MEF2A_6	380	388	PF00069	0.529
DOC_MAPK_MEF2A_6	501	509	PF00069	0.593
DOC_PP2B_LxvP_1	382	385	PF13499	0.475
DOC_PP2B_LxvP_1	386	389	PF13499	0.434
DOC_PP2B_LxvP_1	407	410	PF13499	0.456
DOC_SPAK_OSR1_1	211	215	PF12202	0.698
DOC_SPAK_OSR1_1	392	396	PF12202	0.427
DOC_USP7_MATH_1	177	181	PF00917	0.556
DOC_USP7_MATH_1	21	25	PF00917	0.724
DOC_USP7_MATH_1	271	275	PF00917	0.416
DOC_USP7_MATH_1	378	382	PF00917	0.528
DOC_USP7_MATH_1	45	49	PF00917	0.629
DOC_USP7_MATH_1	481	485	PF00917	0.558
DOC_USP7_MATH_1	78	82	PF00917	0.642
DOC_USP7_UBL2_3	52	56	PF12436	0.719
DOC_USP7_UBL2_3	58	62	PF12436	0.732
DOC_WW_Pin1_4	166	171	PF00397	0.508
DOC_WW_Pin1_4	17	22	PF00397	0.541
DOC_WW_Pin1_4	220	225	PF00397	0.675
DOC_WW_Pin1_4	413	418	PF00397	0.639
DOC_WW_Pin1_4	431	436	PF00397	0.486
LIG_14-3-3_CanoR_1	114	118	PF00244	0.483
LIG_14-3-3_CanoR_1	129	136	PF00244	0.511
LIG_Actin_WH2_2	184	202	PF00022	0.594
LIG_BIR_III_4	440	444	PF00653	0.429
LIG_BRCT_BRCA1_1	114	118	PF00533	0.502
LIG_deltaCOP1_diTrp_1	397	403	PF00928	0.439
LIG_FHA_1	167	173	PF00498	0.472
LIG_FHA_1	229	235	PF00498	0.754
LIG_FHA_1	348	354	PF00498	0.442
LIG_FHA_1	357	363	PF00498	0.437
LIG_FHA_1	36	42	PF00498	0.555
LIG_FHA_1	462	468	PF00498	0.628
LIG_FHA_2	114	120	PF00498	0.479
LIG_FHA_2	227	233	PF00498	0.761
LIG_FHA_2	337	343	PF00498	0.594
LIG_FHA_2	414	420	PF00498	0.599
LIG_FHA_2	451	457	PF00498	0.602
LIG_FHA_2	489	495	PF00498	0.497
LIG_GSK3_LRP6_1	17	22	PF00069	0.536
LIG_GSK3_LRP6_1	413	418	PF00069	0.592
LIG_Integrin_RGD_1	340	342	PF01839	0.632
LIG_IRF3_LxIS_1	488	493	PF10401	0.354
LIG_LIR_Gen_1	453	462	PF02991	0.618
LIG_LIR_Gen_1	48	57	PF02991	0.621
LIG_LIR_LC3C_4	504	508	PF02991	0.594
LIG_LIR_Nem_3	387	393	PF02991	0.454
LIG_LIR_Nem_3	397	403	PF02991	0.385
LIG_LIR_Nem_3	453	457	PF02991	0.621
LIG_LIR_Nem_3	48	53	PF02991	0.613
LIG_LIR_Nem_3	484	489	PF02991	0.499
LIG_Pex14_1	400	404	PF04695	0.469
LIG_Pex14_2	140	144	PF04695	0.534
LIG_Pex14_2	399	403	PF04695	0.408
LIG_PTB_Apo_2	274	281	PF02174	0.535
LIG_REV1ctd_RIR_1	47	56	PF16727	0.609
LIG_SH2_CRK	308	312	PF00017	0.462
LIG_SH2_CRK	404	408	PF00017	0.526
LIG_SH2_CRK	486	490	PF00017	0.579
LIG_SH2_SRC	486	489	PF00017	0.466
LIG_SH2_STAT5	255	258	PF00017	0.406
LIG_SH2_STAT5	348	351	PF00017	0.556
LIG_SH2_STAT5	437	440	PF00017	0.514
LIG_SH3_1	60	66	PF00018	0.685
LIG_SH3_3	13	19	PF00018	0.579
LIG_SH3_3	20	26	PF00018	0.486
LIG_SH3_3	221	227	PF00018	0.768
LIG_SH3_3	407	413	PF00018	0.472
LIG_SH3_3	60	66	PF00018	0.667
LIG_SH3_3	74	80	PF00018	0.413
LIG_SH3_4	316	323	PF00018	0.604
LIG_Sin3_3	296	303	PF02671	0.551
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.549
LIG_SUMO_SIM_par_1	174	182	PF11976	0.364
LIG_SUMO_SIM_par_1	326	333	PF11976	0.340
LIG_SUMO_SIM_par_1	488	494	PF11976	0.390
LIG_SUMO_SIM_par_1	504	511	PF11976	0.553
LIG_TRAF2_1	179	182	PF00917	0.545
LIG_TRAF2_1	416	419	PF00917	0.594
LIG_TYR_ITIM	306	311	PF00017	0.461
LIG_WRC_WIRS_1	32	37	PF05994	0.674
LIG_WRC_WIRS_1	451	456	PF05994	0.592
LIG_WRC_WIRS_1	46	51	PF05994	0.584
LIG_WRC_WIRS_1	509	514	PF05994	0.624
MOD_CDK_SPK_2	223	228	PF00069	0.796
MOD_CDK_SPxxK_3	166	173	PF00069	0.499
MOD_CK1_1	48	54	PF00069	0.633
MOD_CK2_1	413	419	PF00069	0.577
MOD_CK2_1	488	494	PF00069	0.493
MOD_CK2_1	99	105	PF00069	0.603
MOD_GSK3_1	17	24	PF00069	0.801
MOD_GSK3_1	226	233	PF00069	0.779
MOD_GSK3_1	27	34	PF00069	0.701
MOD_GSK3_1	307	314	PF00069	0.568
MOD_GSK3_1	343	350	PF00069	0.546
MOD_GSK3_1	352	359	PF00069	0.449
MOD_GSK3_1	360	367	PF00069	0.480
MOD_GSK3_1	48	55	PF00069	0.700
MOD_GSK3_1	80	87	PF00069	0.537
MOD_NEK2_1	1	6	PF00069	0.577
MOD_NEK2_1	31	36	PF00069	0.678
MOD_NEK2_1	311	316	PF00069	0.643
MOD_NEK2_1	330	335	PF00069	0.331
MOD_NEK2_1	336	341	PF00069	0.583
MOD_NEK2_2	230	235	PF00069	0.794
MOD_NEK2_2	45	50	PF00069	0.461
MOD_PKA_2	113	119	PF00069	0.484
MOD_PKA_2	128	134	PF00069	0.508
MOD_Plk_1	249	255	PF00069	0.525
MOD_Plk_1	285	291	PF00069	0.587
MOD_Plk_4	113	119	PF00069	0.462
MOD_Plk_4	250	256	PF00069	0.504
MOD_Plk_4	27	33	PF00069	0.536
MOD_Plk_4	271	277	PF00069	0.447
MOD_Plk_4	36	42	PF00069	0.743
MOD_Plk_4	45	51	PF00069	0.660
MOD_ProDKin_1	166	172	PF00069	0.499
MOD_ProDKin_1	17	23	PF00069	0.540
MOD_ProDKin_1	220	226	PF00069	0.678
MOD_ProDKin_1	413	419	PF00069	0.642
MOD_ProDKin_1	431	437	PF00069	0.474
MOD_SUMO_rev_2	180	184	PF00179	0.370
MOD_SUMO_rev_2	418	422	PF00179	0.741
TRG_DiLeu_BaEn_1	171	176	PF01217	0.598
TRG_DiLeu_BaEn_1	327	332	PF01217	0.595
TRG_DiLeu_BaEn_4	249	255	PF01217	0.515
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.480
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.564
TRG_ENDOCYTIC_2	308	311	PF00928	0.452
TRG_ENDOCYTIC_2	390	393	PF00928	0.437
TRG_ENDOCYTIC_2	404	407	PF00928	0.419
TRG_ENDOCYTIC_2	486	489	PF00928	0.482
TRG_ER_diArg_1	265	267	PF00400	0.565
TRG_ER_diArg_1	287	290	PF00400	0.491
TRG_ER_diArg_1	527	529	PF00400	0.531
TRG_NLS_MonoExtN_4	58	64	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F7	Leptomonas seymouri	77%	100%
A0A0S4IPB6	Bodo saltans	43%	100%
A0A1X0NKA7	Trypanosomatidae	49%	93%
A0A3R7NCC1	Trypanosoma rangeli	55%	100%
A0A3S7WPA3	Leishmania donovani	91%	100%
A4HSN5	Leishmania infantum	92%	100%
C9ZND9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	82%
E9AKM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
Q4QJ89	Leishmania major	89%	100%
V5D7S2	Trypanosoma cruzi	55%	100%