Putative double-strand-break repair protein rad21 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

double-strand-break repair protein rad21 homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4H4F4_LEIBR

TriTrypDb:

LbrM.05.1090 , LBRM2903_050016900

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0008278	cohesin complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0044815	DNA packaging complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4H4F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4F4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0007062	sister chromatid cohesion	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022402	cell cycle process	2	12
GO:0051276	chromosome organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1990414	replication-born double-strand break repair via sister chromatid exchange	8	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.652
CLV_NRD_NRD_1	161	163	PF00675	0.450
CLV_NRD_NRD_1	308	310	PF00675	0.568
CLV_NRD_NRD_1	345	347	PF00675	0.536
CLV_NRD_NRD_1	457	459	PF00675	0.607
CLV_NRD_NRD_1	499	501	PF00675	0.600
CLV_NRD_NRD_1	527	529	PF00675	0.266
CLV_PCSK_KEX2_1	161	163	PF00082	0.556
CLV_PCSK_KEX2_1	25	27	PF00082	0.264
CLV_PCSK_KEX2_1	345	347	PF00082	0.536
CLV_PCSK_KEX2_1	459	461	PF00082	0.591
CLV_PCSK_KEX2_1	526	528	PF00082	0.265
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.315
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.597
CLV_PCSK_SKI1_1	25	29	PF00082	0.231
CLV_PCSK_SKI1_1	326	330	PF00082	0.580
CLV_PCSK_SKI1_1	72	76	PF00082	0.242
DEG_Nend_Nbox_1	1	3	PF02207	0.431
DOC_ANK_TNKS_1	461	468	PF00023	0.577
DOC_CYCLIN_RxL_1	69	79	PF00134	0.442
DOC_MAPK_gen_1	205	213	PF00069	0.501
DOC_MAPK_gen_1	25	34	PF00069	0.442
DOC_MAPK_gen_1	309	316	PF00069	0.557
DOC_MAPK_gen_1	487	494	PF00069	0.479
DOC_MAPK_HePTP_8	51	63	PF00069	0.431
DOC_MAPK_MEF2A_6	46	53	PF00069	0.456
DOC_MAPK_MEF2A_6	54	63	PF00069	0.408
DOC_PP4_FxxP_1	287	290	PF00568	0.639
DOC_USP7_MATH_1	217	221	PF00917	0.700
DOC_USP7_MATH_1	334	338	PF00917	0.536
DOC_USP7_MATH_1	417	421	PF00917	0.694
DOC_USP7_MATH_1	475	479	PF00917	0.614
DOC_USP7_MATH_1	539	543	PF00917	0.452
DOC_USP7_UBL2_3	72	76	PF12436	0.456
LIG_14-3-3_CanoR_1	104	112	PF00244	0.754
LIG_14-3-3_CanoR_1	149	157	PF00244	0.374
LIG_14-3-3_CanoR_1	357	361	PF00244	0.615
LIG_14-3-3_CanoR_1	413	422	PF00244	0.685
LIG_14-3-3_CanoR_1	487	494	PF00244	0.532
LIG_14-3-3_CanoR_1	86	91	PF00244	0.498
LIG_Actin_WH2_2	377	392	PF00022	0.604
LIG_Actin_WH2_2	38	56	PF00022	0.498
LIG_Actin_WH2_2	62	78	PF00022	0.456
LIG_AP2alpha_2	285	287	PF02296	0.593
LIG_BIR_III_2	377	381	PF00653	0.575
LIG_FHA_1	103	109	PF00498	0.589
LIG_FHA_1	3	9	PF00498	0.431
LIG_FHA_1	370	376	PF00498	0.587
LIG_FHA_1	506	512	PF00498	0.427
LIG_FHA_1	80	86	PF00498	0.442
LIG_FHA_2	104	110	PF00498	0.675
LIG_FHA_2	166	172	PF00498	0.565
LIG_FHA_2	194	200	PF00498	0.446
LIG_FHA_2	26	32	PF00498	0.440
LIG_FHA_2	292	298	PF00498	0.602
LIG_FHA_2	53	59	PF00498	0.433
LIG_FHA_2	531	537	PF00498	0.569
LIG_FHA_2	558	564	PF00498	0.432
LIG_LIR_Apic_2	284	290	PF02991	0.624
LIG_LIR_Gen_1	147	157	PF02991	0.472
LIG_LIR_Gen_1	199	208	PF02991	0.452
LIG_LIR_Gen_1	533	541	PF02991	0.454
LIG_LIR_Gen_1	82	91	PF02991	0.544
LIG_LIR_Nem_3	147	153	PF02991	0.455
LIG_LIR_Nem_3	177	182	PF02991	0.532
LIG_LIR_Nem_3	199	203	PF02991	0.456
LIG_LIR_Nem_3	246	252	PF02991	0.487
LIG_LIR_Nem_3	533	537	PF02991	0.454
LIG_LIR_Nem_3	82	87	PF02991	0.535
LIG_MYND_1	286	290	PF01753	0.654
LIG_SH2_NCK_1	200	204	PF00017	0.470
LIG_SH2_SRC	200	203	PF00017	0.473
LIG_SH2_STAP1	200	204	PF00017	0.470
LIG_SH2_STAP1	393	397	PF00017	0.496
LIG_SH2_STAP1	67	71	PF00017	0.466
LIG_SH2_STAT5	180	183	PF00017	0.613
LIG_SH2_STAT5	358	361	PF00017	0.669
LIG_SH2_STAT5	545	548	PF00017	0.535
LIG_SH2_STAT5	6	9	PF00017	0.433
LIG_SH3_3	257	263	PF00018	0.628
LIG_SH3_3	280	286	PF00018	0.692
LIG_SH3_3	381	387	PF00018	0.611
LIG_SH3_3	44	50	PF00018	0.431
LIG_SUMO_SIM_anti_2	533	539	PF11976	0.456
LIG_SUMO_SIM_par_1	33	38	PF11976	0.498
LIG_SUMO_SIM_par_1	49	56	PF11976	0.372
LIG_SUMO_SIM_par_1	536	542	PF11976	0.431
LIG_TRAF2_1	351	354	PF00917	0.612
LIG_TRAF2_1	400	403	PF00917	0.490
MOD_CK1_1	220	226	PF00069	0.593
MOD_CK1_1	228	234	PF00069	0.547
MOD_CK1_1	507	513	PF00069	0.608
MOD_CK2_1	115	121	PF00069	0.575
MOD_CK2_1	165	171	PF00069	0.566
MOD_CK2_1	228	234	PF00069	0.714
MOD_CK2_1	25	31	PF00069	0.464
MOD_CK2_1	291	297	PF00069	0.633
MOD_CK2_1	397	403	PF00069	0.581
MOD_CK2_1	500	506	PF00069	0.500
MOD_CK2_1	52	58	PF00069	0.431
MOD_CK2_1	557	563	PF00069	0.430
MOD_Cter_Amidation	159	162	PF01082	0.538
MOD_Cter_Amidation	307	310	PF01082	0.619
MOD_Cter_Amidation	498	501	PF01082	0.580
MOD_GlcNHglycan	150	153	PF01048	0.459
MOD_GlcNHglycan	158	161	PF01048	0.535
MOD_GlcNHglycan	176	179	PF01048	0.519
MOD_GlcNHglycan	217	220	PF01048	0.607
MOD_GlcNHglycan	278	281	PF01048	0.627
MOD_GlcNHglycan	341	344	PF01048	0.589
MOD_GlcNHglycan	381	384	PF01048	0.542
MOD_GlcNHglycan	443	447	PF01048	0.766
MOD_GlcNHglycan	479	482	PF01048	0.442
MOD_GlcNHglycan	546	549	PF01048	0.309
MOD_GlcNHglycan	55	58	PF01048	0.266
MOD_GSK3_1	174	181	PF00069	0.568
MOD_GSK3_1	2	9	PF00069	0.431
MOD_GSK3_1	215	222	PF00069	0.548
MOD_GSK3_1	225	232	PF00069	0.624
MOD_GSK3_1	318	325	PF00069	0.644
MOD_GSK3_1	356	363	PF00069	0.671
MOD_GSK3_1	413	420	PF00069	0.502
MOD_GSK3_1	477	484	PF00069	0.421
MOD_GSK3_1	500	507	PF00069	0.550
MOD_GSK3_1	85	92	PF00069	0.498
MOD_LATS_1	498	504	PF00433	0.495
MOD_N-GLC_2	315	317	PF02516	0.579
MOD_NEK2_1	1	6	PF00069	0.431
MOD_NEK2_1	156	161	PF00069	0.575
MOD_NEK2_1	174	179	PF00069	0.506
MOD_NEK2_1	193	198	PF00069	0.510
MOD_NEK2_1	319	324	PF00069	0.543
MOD_NEK2_1	366	371	PF00069	0.431
MOD_NEK2_1	37	42	PF00069	0.451
MOD_NEK2_1	412	417	PF00069	0.710
MOD_NEK2_1	442	447	PF00069	0.747
MOD_NEK2_1	85	90	PF00069	0.480
MOD_NEK2_2	178	183	PF00069	0.426
MOD_PIKK_1	183	189	PF00454	0.522
MOD_PIKK_1	193	199	PF00454	0.489
MOD_PIKK_1	35	41	PF00454	0.535
MOD_PIKK_1	451	457	PF00454	0.502
MOD_PK_1	104	110	PF00069	0.677
MOD_PKA_1	25	31	PF00069	0.431
MOD_PKA_1	500	506	PF00069	0.490
MOD_PKA_2	103	109	PF00069	0.750
MOD_PKA_2	148	154	PF00069	0.374
MOD_PKA_2	215	221	PF00069	0.564
MOD_PKA_2	236	242	PF00069	0.559
MOD_PKA_2	25	31	PF00069	0.442
MOD_PKA_2	356	362	PF00069	0.606
MOD_PKA_2	412	418	PF00069	0.572
MOD_PKA_2	53	59	PF00069	0.462
MOD_PKA_2	85	91	PF00069	0.474
MOD_Plk_1	245	251	PF00069	0.595
MOD_Plk_1	490	496	PF00069	0.483
MOD_Plk_1	79	85	PF00069	0.448
MOD_Plk_2-3	121	127	PF00069	0.549
MOD_Plk_2-3	291	297	PF00069	0.481
MOD_Plk_4	2	8	PF00069	0.431
MOD_Plk_4	37	43	PF00069	0.442
MOD_Plk_4	507	513	PF00069	0.592
MOD_Plk_4	79	85	PF00069	0.442
TRG_DiLeu_BaEn_2	79	85	PF01217	0.535
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.399
TRG_ENDOCYTIC_2	200	203	PF00928	0.503
TRG_ER_diArg_1	161	163	PF00400	0.450
TRG_ER_diArg_1	344	346	PF00400	0.564
TRG_ER_diArg_1	457	460	PF00400	0.660
TRG_ER_diArg_1	525	528	PF00400	0.456
TRG_NLS_MonoExtC_3	308	313	PF00514	0.664
TRG_NLS_MonoExtC_3	457	462	PF00514	0.627
TRG_NLS_MonoExtC_3	499	504	PF00514	0.468
TRG_NLS_MonoExtN_4	307	313	PF00514	0.618
TRG_NLS_MonoExtN_4	457	463	PF00514	0.742
TRG_NLS_MonoExtN_4	500	505	PF00514	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV6	Leptomonas seymouri	66%	100%
A0A0S4ISR7	Bodo saltans	39%	100%
A0A1X0NLU9	Trypanosomatidae	45%	92%
A0A3S5H5L9	Leishmania donovani	86%	100%
A0A422NBQ8	Trypanosoma rangeli	48%	99%
A4HSN1	Leishmania infantum	86%	100%
C9ZU64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AKL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QJ93	Leishmania major	86%	100%
V5D7E1	Trypanosoma cruzi	45%	97%