Phosphatidylinositol 4-phosphate 5-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatidylinositol 4-phosphate 5-kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4F3_LEIBR

TriTrypDb:

LbrM.05.1080 , LBRM2903_050016800

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4F3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.666
CLV_C14_Caspase3-7	578	582	PF00656	0.544
CLV_NRD_NRD_1	678	680	PF00675	0.499
CLV_NRD_NRD_1	717	719	PF00675	0.619
CLV_PCSK_FUR_1	113	117	PF00082	0.351
CLV_PCSK_KEX2_1	112	114	PF00082	0.337
CLV_PCSK_KEX2_1	115	117	PF00082	0.346
CLV_PCSK_KEX2_1	159	161	PF00082	0.534
CLV_PCSK_KEX2_1	213	215	PF00082	0.561
CLV_PCSK_KEX2_1	300	302	PF00082	0.357
CLV_PCSK_KEX2_1	513	515	PF00082	0.414
CLV_PCSK_KEX2_1	678	680	PF00082	0.535
CLV_PCSK_KEX2_1	717	719	PF00082	0.512
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.337
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.346
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.540
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.561
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.409
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.414
CLV_PCSK_SKI1_1	112	116	PF00082	0.356
DEG_APCC_DBOX_1	704	712	PF00400	0.520
DEG_APCC_KENBOX_2	249	253	PF00400	0.409
DEG_COP1_1	394	404	PF00400	0.544
DEG_SCF_TRCP1_1	27	33	PF00400	0.500
DEG_SIAH_1	684	692	PF03145	0.627
DEG_SPOP_SBC_1	646	650	PF00917	0.405
DOC_MAPK_gen_1	213	220	PF00069	0.539
DOC_MAPK_HePTP_8	407	419	PF00069	0.383
DOC_MAPK_MEF2A_6	132	140	PF00069	0.368
DOC_MAPK_MEF2A_6	213	222	PF00069	0.488
DOC_MAPK_MEF2A_6	410	419	PF00069	0.478
DOC_PP1_RVXF_1	255	262	PF00149	0.411
DOC_PP1_RVXF_1	289	296	PF00149	0.219
DOC_PP2B_LxvP_1	138	141	PF13499	0.402
DOC_PP2B_LxvP_1	417	420	PF13499	0.556
DOC_PP2B_LxvP_1	535	538	PF13499	0.545
DOC_PP2B_LxvP_1	599	602	PF13499	0.537
DOC_USP7_MATH_1	134	138	PF00917	0.574
DOC_USP7_MATH_1	287	291	PF00917	0.285
DOC_USP7_MATH_1	310	314	PF00917	0.284
DOC_USP7_MATH_1	421	425	PF00917	0.562
DOC_USP7_MATH_1	518	522	PF00917	0.432
DOC_USP7_MATH_1	613	617	PF00917	0.524
DOC_USP7_UBL2_3	300	304	PF12436	0.325
DOC_WW_Pin1_4	551	556	PF00397	0.628
DOC_WW_Pin1_4	693	698	PF00397	0.580
LIG_14-3-3_CanoR_1	456	462	PF00244	0.416
LIG_14-3-3_CanoR_1	568	575	PF00244	0.647
LIG_14-3-3_CanoR_1	588	597	PF00244	0.368
LIG_Actin_WH2_2	368	385	PF00022	0.187
LIG_Actin_WH2_2	441	458	PF00022	0.506
LIG_Actin_WH2_2	466	483	PF00022	0.452
LIG_APCC_ABBA_1	411	416	PF00400	0.561
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BIR_III_2	492	496	PF00653	0.379
LIG_BIR_III_4	581	585	PF00653	0.480
LIG_BRCT_BRCA1_1	592	596	PF00533	0.349
LIG_CaM_NSCaTE_8	457	464	PF13499	0.441
LIG_CSL_BTD_1	399	402	PF09270	0.453
LIG_CtBP_PxDLS_1	189	193	PF00389	0.548
LIG_FHA_1	327	333	PF00498	0.325
LIG_FHA_1	407	413	PF00498	0.502
LIG_FHA_1	584	590	PF00498	0.437
LIG_FHA_2	140	146	PF00498	0.551
LIG_FHA_2	194	200	PF00498	0.561
LIG_FHA_2	31	37	PF00498	0.603
LIG_FHA_2	439	445	PF00498	0.429
LIG_FHA_2	714	720	PF00498	0.397
LIG_GBD_Chelix_1	106	114	PF00786	0.396
LIG_HP1_1	542	546	PF01393	0.377
LIG_LIR_Gen_1	131	141	PF02991	0.459
LIG_LIR_Gen_1	191	200	PF02991	0.514
LIG_LIR_Gen_1	329	338	PF02991	0.411
LIG_LIR_Gen_1	53	62	PF02991	0.637
LIG_LIR_Gen_1	593	604	PF02991	0.359
LIG_LIR_Gen_1	648	659	PF02991	0.441
LIG_LIR_LC3C_4	416	419	PF02991	0.479
LIG_LIR_Nem_3	191	197	PF02991	0.512
LIG_LIR_Nem_3	329	333	PF02991	0.411
LIG_LIR_Nem_3	53	57	PF02991	0.667
LIG_LIR_Nem_3	593	599	PF02991	0.357
LIG_LIR_Nem_3	648	654	PF02991	0.457
LIG_MYND_1	700	704	PF01753	0.596
LIG_MYND_1	706	710	PF01753	0.492
LIG_NRBOX	530	536	PF00104	0.493
LIG_Pex14_2	338	342	PF04695	0.323
LIG_Rb_pABgroove_1	706	714	PF01858	0.518
LIG_SH2_CRK	451	455	PF00017	0.552
LIG_SH2_CRK	651	655	PF00017	0.315
LIG_SH2_NCK_1	23	27	PF00017	0.452
LIG_SH2_NCK_1	490	494	PF00017	0.557
LIG_SH2_PTP2	221	224	PF00017	0.447
LIG_SH2_PTP2	54	57	PF00017	0.661
LIG_SH2_SRC	307	310	PF00017	0.300
LIG_SH2_SRC	490	493	PF00017	0.360
LIG_SH2_STAP1	130	134	PF00017	0.498
LIG_SH2_STAP1	620	624	PF00017	0.614
LIG_SH2_STAT3	634	637	PF00017	0.524
LIG_SH2_STAT5	109	112	PF00017	0.348
LIG_SH2_STAT5	221	224	PF00017	0.444
LIG_SH2_STAT5	245	248	PF00017	0.268
LIG_SH2_STAT5	269	272	PF00017	0.322
LIG_SH2_STAT5	292	295	PF00017	0.292
LIG_SH2_STAT5	307	310	PF00017	0.304
LIG_SH2_STAT5	361	364	PF00017	0.297
LIG_SH2_STAT5	376	379	PF00017	0.435
LIG_SH2_STAT5	54	57	PF00017	0.637
LIG_SH3_1	221	227	PF00018	0.550
LIG_SH3_3	221	227	PF00018	0.550
LIG_SH3_3	415	421	PF00018	0.446
LIG_SH3_3	512	518	PF00018	0.578
LIG_SH3_3	692	698	PF00018	0.575
LIG_SH3_3	7	13	PF00018	0.559
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.553
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.478
LIG_SUMO_SIM_anti_2	529	536	PF11976	0.394
LIG_SUMO_SIM_par_1	504	509	PF11976	0.461
LIG_SUMO_SIM_par_1	531	536	PF11976	0.416
LIG_SUMO_SIM_par_1	541	547	PF11976	0.373
LIG_TRAF2_1	179	182	PF00917	0.708
LIG_TYR_ITIM	192	197	PF00017	0.505
LIG_TYR_ITSM	647	654	PF00017	0.574
MOD_CDK_SPxxK_3	551	558	PF00069	0.448
MOD_CK1_1	42	48	PF00069	0.505
MOD_CK1_1	424	430	PF00069	0.656
MOD_CK1_1	460	466	PF00069	0.453
MOD_CK1_1	549	555	PF00069	0.698
MOD_CK1_1	570	576	PF00069	0.506
MOD_CK1_1	640	646	PF00069	0.584
MOD_CK1_1	657	663	PF00069	0.538
MOD_CK2_1	139	145	PF00069	0.578
MOD_CK2_1	176	182	PF00069	0.761
MOD_CK2_1	30	36	PF00069	0.746
MOD_CK2_1	551	557	PF00069	0.674
MOD_Cter_Amidation	298	301	PF01082	0.409
MOD_Cter_Amidation	511	514	PF01082	0.437
MOD_DYRK1A_RPxSP_1	693	697	PF00069	0.584
MOD_GlcNHglycan	240	243	PF01048	0.531
MOD_GlcNHglycan	27	30	PF01048	0.686
MOD_GlcNHglycan	301	304	PF01048	0.378
MOD_GlcNHglycan	348	351	PF01048	0.339
MOD_GlcNHglycan	355	358	PF01048	0.401
MOD_GlcNHglycan	423	426	PF01048	0.509
MOD_GlcNHglycan	462	465	PF01048	0.599
MOD_GlcNHglycan	575	578	PF01048	0.446
MOD_GlcNHglycan	59	62	PF01048	0.593
MOD_GlcNHglycan	639	642	PF01048	0.528
MOD_GlcNHglycan	685	688	PF01048	0.484
MOD_GSK3_1	234	241	PF00069	0.519
MOD_GSK3_1	516	523	PF00069	0.525
MOD_GSK3_1	546	553	PF00069	0.502
MOD_GSK3_1	567	574	PF00069	0.558
MOD_GSK3_1	657	664	PF00069	0.515
MOD_N-GLC_1	42	47	PF02516	0.689
MOD_NEK2_1	234	239	PF00069	0.419
MOD_NEK2_1	333	338	PF00069	0.283
MOD_NEK2_1	405	410	PF00069	0.496
MOD_NEK2_1	546	551	PF00069	0.433
MOD_NEK2_1	57	62	PF00069	0.614
MOD_NEK2_1	589	594	PF00069	0.495
MOD_NEK2_1	647	652	PF00069	0.370
MOD_NEK2_2	355	360	PF00069	0.546
MOD_PIKK_1	87	93	PF00454	0.305
MOD_PKA_2	567	573	PF00069	0.516
MOD_PKA_2	625	631	PF00069	0.470
MOD_Plk_1	134	140	PF00069	0.532
MOD_Plk_1	499	505	PF00069	0.438
MOD_Plk_1	546	552	PF00069	0.526
MOD_Plk_1	570	576	PF00069	0.590
MOD_Plk_1	613	619	PF00069	0.570
MOD_Plk_1	657	663	PF00069	0.387
MOD_Plk_2-3	121	127	PF00069	0.548
MOD_Plk_2-3	176	182	PF00069	0.623
MOD_Plk_2-3	30	36	PF00069	0.791
MOD_Plk_2-3	311	317	PF00069	0.279
MOD_Plk_4	234	240	PF00069	0.402
MOD_Plk_4	334	340	PF00069	0.376
MOD_Plk_4	400	406	PF00069	0.616
MOD_Plk_4	499	505	PF00069	0.409
MOD_Plk_4	613	619	PF00069	0.570
MOD_Plk_4	647	653	PF00069	0.519
MOD_Plk_4	90	96	PF00069	0.355
MOD_ProDKin_1	551	557	PF00069	0.633
MOD_ProDKin_1	693	699	PF00069	0.580
MOD_SUMO_for_1	320	323	PF00179	0.409
MOD_SUMO_rev_2	390	399	PF00179	0.435
MOD_SUMO_rev_2	707	716	PF00179	0.628
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.509
TRG_ENDOCYTIC_2	194	197	PF00928	0.512
TRG_ENDOCYTIC_2	281	284	PF00928	0.391
TRG_ENDOCYTIC_2	330	333	PF00928	0.469
TRG_ENDOCYTIC_2	451	454	PF00928	0.406
TRG_ENDOCYTIC_2	54	57	PF00928	0.661
TRG_ENDOCYTIC_2	651	654	PF00928	0.451
TRG_NES_CRM1_1	496	509	PF08389	0.413
TRG_NLS_MonoExtC_3	111	116	PF00514	0.336
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V4	Leptomonas seymouri	71%	100%
A0A0S4IJQ0	Bodo saltans	36%	100%
A0A1X0NLQ2	Trypanosomatidae	42%	86%
A0A3S5H5L8	Leishmania donovani	87%	100%
A0A422NBM9	Trypanosoma rangeli	49%	93%
A4HSN0	Leishmania infantum	87%	100%
C9ZU66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	88%
E9AKL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QJ94	Leishmania major	86%	100%
V5BBF6	Trypanosoma cruzi	50%	100%