L-type lectin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Legume-like lectin family, putative

Species:

Leishmania braziliensis

UniProt:

A4H4F2_LEIBR

TriTrypDb:

LbrM.05.1070 , LBRM2903_050016700

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000139	Golgi membrane	5	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4H4F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4F2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005537	mannose binding	4	1
GO:0030246	carbohydrate binding	2	2
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.630
CLV_NRD_NRD_1	206	208	PF00675	0.533
CLV_NRD_NRD_1	309	311	PF00675	0.447
CLV_NRD_NRD_1	367	369	PF00675	0.363
CLV_PCSK_KEX2_1	206	208	PF00082	0.520
CLV_PCSK_KEX2_1	213	215	PF00082	0.471
CLV_PCSK_KEX2_1	219	221	PF00082	0.552
CLV_PCSK_KEX2_1	223	225	PF00082	0.481
CLV_PCSK_KEX2_1	367	369	PF00082	0.366
CLV_PCSK_KEX2_1	373	375	PF00082	0.435
CLV_PCSK_KEX2_1	486	488	PF00082	0.482
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.495
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.544
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.501
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.494
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.467
CLV_PCSK_SKI1_1	207	211	PF00082	0.518
CLV_PCSK_SKI1_1	219	223	PF00082	0.446
CLV_PCSK_SKI1_1	360	364	PF00082	0.282
CLV_PCSK_SKI1_1	424	428	PF00082	0.647
CLV_PCSK_SKI1_1	435	439	PF00082	0.604
CLV_Separin_Metazoa	391	395	PF03568	0.490
DEG_APCC_DBOX_1	455	463	PF00400	0.343
DEG_Nend_UBRbox_2	1	3	PF02207	0.438
DOC_CYCLIN_RxL_1	213	226	PF00134	0.608
DOC_MAPK_DCC_7	5	13	PF00069	0.418
DOC_MAPK_gen_1	233	242	PF00069	0.485
DOC_MAPK_gen_1	360	366	PF00069	0.336
DOC_MAPK_gen_1	486	492	PF00069	0.613
DOC_MAPK_MEF2A_6	233	242	PF00069	0.485
DOC_MAPK_MEF2A_6	5	13	PF00069	0.579
DOC_PP1_RVXF_1	102	108	PF00149	0.231
DOC_PP1_RVXF_1	487	493	PF00149	0.545
DOC_PP2B_LxvP_1	285	288	PF13499	0.424
DOC_PP4_FxxP_1	48	51	PF00568	0.244
DOC_SPAK_OSR1_1	106	110	PF12202	0.244
DOC_USP7_MATH_1	116	120	PF00917	0.253
DOC_USP7_MATH_1	19	23	PF00917	0.673
DOC_USP7_UBL2_3	219	223	PF12436	0.712
DOC_WW_Pin1_4	152	157	PF00397	0.647
DOC_WW_Pin1_4	496	501	PF00397	0.473
LIG_14-3-3_CanoR_1	224	229	PF00244	0.544
LIG_14-3-3_CanoR_1	310	314	PF00244	0.505
LIG_14-3-3_CanoR_1	317	321	PF00244	0.536
LIG_14-3-3_CanoR_1	429	435	PF00244	0.575
LIG_14-3-3_CanoR_1	78	84	PF00244	0.257
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.598
LIG_deltaCOP1_diTrp_1	99	107	PF00928	0.338
LIG_FHA_1	276	282	PF00498	0.480
LIG_FHA_1	361	367	PF00498	0.409
LIG_FHA_1	385	391	PF00498	0.546
LIG_FHA_1	472	478	PF00498	0.645
LIG_FHA_1	79	85	PF00498	0.275
LIG_FHA_1	91	97	PF00498	0.275
LIG_FHA_2	191	197	PF00498	0.665
LIG_FHA_2	224	230	PF00498	0.522
LIG_FHA_2	343	349	PF00498	0.417
LIG_FHA_2	393	399	PF00498	0.464
LIG_FHA_2	445	451	PF00498	0.466
LIG_FHA_2	78	84	PF00498	0.345
LIG_LIR_Apic_2	45	51	PF02991	0.244
LIG_LIR_Gen_1	279	288	PF02991	0.499
LIG_LIR_Gen_1	444	454	PF02991	0.531
LIG_LIR_Gen_1	74	84	PF02991	0.269
LIG_LIR_Nem_3	215	221	PF02991	0.460
LIG_LIR_Nem_3	243	248	PF02991	0.282
LIG_LIR_Nem_3	279	285	PF02991	0.488
LIG_LIR_Nem_3	444	449	PF02991	0.545
LIG_LIR_Nem_3	74	79	PF02991	0.269
LIG_PDZ_Class_3	500	505	PF00595	0.610
LIG_Pex14_2	218	222	PF04695	0.606
LIG_PTB_Apo_2	70	77	PF02174	0.257
LIG_SH2_STAP1	150	154	PF00017	0.611
LIG_SH2_STAP1	396	400	PF00017	0.488
LIG_SH2_STAP1	471	475	PF00017	0.503
LIG_SH2_STAT3	135	138	PF00017	0.257
LIG_SH2_STAT5	135	138	PF00017	0.244
LIG_SH2_STAT5	282	285	PF00017	0.484
LIG_SH2_STAT5	396	399	PF00017	0.406
LIG_SH3_1	494	500	PF00018	0.532
LIG_SH3_3	108	114	PF00018	0.251
LIG_SH3_3	326	332	PF00018	0.604
LIG_SH3_3	494	500	PF00018	0.534
LIG_SUMO_SIM_anti_2	312	317	PF11976	0.301
LIG_SUMO_SIM_anti_2	348	355	PF11976	0.340
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.485
LIG_TRAF2_1	193	196	PF00917	0.571
LIG_TRAF2_1	346	349	PF00917	0.449
LIG_TRAF2_1	47	50	PF00917	0.400
LIG_UBA3_1	217	223	PF00899	0.608
MOD_CDK_SPxxK_3	152	159	PF00069	0.643
MOD_CK1_1	119	125	PF00069	0.195
MOD_CK1_1	293	299	PF00069	0.553
MOD_CK1_1	418	424	PF00069	0.401
MOD_CK1_1	430	436	PF00069	0.530
MOD_CK1_1	499	505	PF00069	0.491
MOD_CK2_1	190	196	PF00069	0.638
MOD_CK2_1	224	230	PF00069	0.511
MOD_CK2_1	342	348	PF00069	0.480
MOD_CK2_1	392	398	PF00069	0.471
MOD_CK2_1	44	50	PF00069	0.412
MOD_CK2_1	77	83	PF00069	0.224
MOD_GlcNHglycan	117	121	PF01048	0.195
MOD_GlcNHglycan	417	420	PF01048	0.363
MOD_GlcNHglycan	68	71	PF01048	0.300
MOD_GSK3_1	148	155	PF00069	0.644
MOD_GSK3_1	224	231	PF00069	0.500
MOD_GSK3_1	290	297	PF00069	0.567
MOD_GSK3_1	338	345	PF00069	0.585
MOD_GSK3_1	380	387	PF00069	0.478
MOD_GSK3_1	392	399	PF00069	0.406
MOD_N-GLC_1	288	293	PF02516	0.538
MOD_NEK2_1	118	123	PF00069	0.369
MOD_NEK2_1	415	420	PF00069	0.343
MOD_NEK2_1	469	474	PF00069	0.479
MOD_NEK2_1	490	495	PF00069	0.624
MOD_NEK2_1	77	82	PF00069	0.425
MOD_PK_1	224	230	PF00069	0.547
MOD_PKA_1	223	229	PF00069	0.459
MOD_PKA_1	360	366	PF00069	0.294
MOD_PKA_2	105	111	PF00069	0.279
MOD_PKA_2	205	211	PF00069	0.618
MOD_PKA_2	223	229	PF00069	0.419
MOD_PKA_2	309	315	PF00069	0.481
MOD_PKA_2	316	322	PF00069	0.468
MOD_PKA_2	77	83	PF00069	0.298
MOD_Plk_1	190	196	PF00069	0.432
MOD_Plk_1	288	294	PF00069	0.393
MOD_Plk_1	374	380	PF00069	0.525
MOD_Plk_1	44	50	PF00069	0.298
MOD_Plk_2-3	190	196	PF00069	0.648
MOD_Plk_2-3	375	381	PF00069	0.457
MOD_Plk_4	277	283	PF00069	0.454
MOD_Plk_4	294	300	PF00069	0.522
MOD_Plk_4	360	366	PF00069	0.351
MOD_Plk_4	375	381	PF00069	0.468
MOD_ProDKin_1	152	158	PF00069	0.644
MOD_ProDKin_1	496	502	PF00069	0.472
MOD_SUMO_for_1	372	375	PF00179	0.491
MOD_SUMO_rev_2	243	248	PF00179	0.280
TRG_DiLeu_BaEn_1	349	354	PF01217	0.418
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.432
TRG_ENDOCYTIC_2	282	285	PF00928	0.484
TRG_ER_diArg_1	104	107	PF00400	0.282
TRG_ER_diArg_1	366	368	PF00400	0.367
TRG_NLS_MonoCore_2	209	214	PF00514	0.593
TRG_NLS_MonoExtC_3	209	214	PF00514	0.593
TRG_NLS_MonoExtN_4	207	214	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA0	Leptomonas seymouri	78%	99%
A0A1X0NKB0	Trypanosomatidae	42%	78%
A0A3R7LT82	Trypanosoma rangeli	46%	93%
A0A3S5H5L7	Leishmania donovani	87%	84%
A4HSM9	Leishmania infantum	87%	98%
C9ZU67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	81%
E8NHN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	83%
E9AKL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4QJ95	Leishmania major	87%	100%
V5ARI9	Trypanosoma cruzi	46%	86%