Putative ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ATPase

Gene product:

ATPase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4F1_LEIBR

TriTrypDb:

LbrM.05.1060 , LBRM2903_050016600

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4F1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0016887	ATP hydrolysis activity	7	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.349
CLV_NRD_NRD_1	136	138	PF00675	0.342
CLV_NRD_NRD_1	167	169	PF00675	0.318
CLV_NRD_NRD_1	181	183	PF00675	0.288
CLV_NRD_NRD_1	3	5	PF00675	0.510
CLV_NRD_NRD_1	315	317	PF00675	0.347
CLV_NRD_NRD_1	61	63	PF00675	0.381
CLV_NRD_NRD_1	80	82	PF00675	0.510
CLV_PCSK_FUR_1	134	138	PF00082	0.389
CLV_PCSK_KEX2_1	135	137	PF00082	0.345
CLV_PCSK_KEX2_1	167	169	PF00082	0.196
CLV_PCSK_KEX2_1	181	183	PF00082	0.285
CLV_PCSK_KEX2_1	222	224	PF00082	0.290
CLV_PCSK_KEX2_1	3	5	PF00082	0.521
CLV_PCSK_KEX2_1	60	62	PF00082	0.458
CLV_PCSK_KEX2_1	80	82	PF00082	0.353
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.345
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.380
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.609
CLV_PCSK_PC7_1	177	183	PF00082	0.167
CLV_PCSK_SKI1_1	118	122	PF00082	0.259
CLV_PCSK_SKI1_1	18	22	PF00082	0.449
CLV_PCSK_SKI1_1	222	226	PF00082	0.253
CLV_PCSK_SKI1_1	3	7	PF00082	0.541
CLV_PCSK_SKI1_1	302	306	PF00082	0.377
CLV_PCSK_SKI1_1	380	384	PF00082	0.286
CLV_PCSK_SKI1_1	48	52	PF00082	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SCF_FBW7_2	180	187	PF00400	0.273
DOC_CKS1_1	288	293	PF01111	0.330
DOC_CYCLIN_RxL_1	217	227	PF00134	0.351
DOC_CYCLIN_RxL_1	377	387	PF00134	0.268
DOC_MAPK_DCC_7	253	262	PF00069	0.253
DOC_MAPK_gen_1	134	140	PF00069	0.244
DOC_MAPK_gen_1	3	11	PF00069	0.532
DOC_MAPK_gen_1	378	385	PF00069	0.268
DOC_MAPK_gen_1	459	466	PF00069	0.553
DOC_MAPK_MEF2A_6	230	237	PF00069	0.268
DOC_MAPK_MEF2A_6	253	262	PF00069	0.253
DOC_MAPK_MEF2A_6	299	307	PF00069	0.269
DOC_PP1_RVXF_1	134	141	PF00149	0.246
DOC_PP2B_LxvP_1	406	409	PF13499	0.497
DOC_PP2B_LxvP_1	464	467	PF13499	0.549
DOC_PP2B_LxvP_1	65	68	PF13499	0.510
DOC_USP7_MATH_1	441	445	PF00917	0.568
DOC_USP7_MATH_1	50	54	PF00917	0.415
DOC_WW_Pin1_4	180	185	PF00397	0.288
DOC_WW_Pin1_4	287	292	PF00397	0.347
LIG_14-3-3_CanoR_1	197	205	PF00244	0.347
LIG_14-3-3_CanoR_1	223	229	PF00244	0.380
LIG_APCC_ABBA_1	188	193	PF00400	0.281
LIG_APCC_ABBA_1	256	261	PF00400	0.268
LIG_BRCT_BRCA1_1	452	456	PF00533	0.362
LIG_CaM_IQ_9	144	159	PF13499	0.167
LIG_Clathr_ClatBox_1	204	208	PF01394	0.253
LIG_Clathr_ClatBox_1	382	386	PF01394	0.288
LIG_FHA_1	148	154	PF00498	0.192
LIG_FHA_1	359	365	PF00498	0.253
LIG_FHA_2	385	391	PF00498	0.326
LIG_Integrin_RGD_1	23	25	PF01839	0.477
LIG_LIR_Apic_2	286	291	PF02991	0.273
LIG_LIR_Gen_1	298	307	PF02991	0.255
LIG_LIR_Gen_1	349	359	PF02991	0.251
LIG_LIR_Gen_1	460	467	PF02991	0.566
LIG_LIR_Nem_3	14	20	PF02991	0.326
LIG_LIR_Nem_3	227	231	PF02991	0.383
LIG_LIR_Nem_3	298	303	PF02991	0.249
LIG_LIR_Nem_3	349	355	PF02991	0.248
LIG_LIR_Nem_3	460	466	PF02991	0.561
LIG_NRBOX	120	126	PF00104	0.259
LIG_OCRL_FandH_1	38	50	PF00620	0.338
LIG_PCNA_yPIPBox_3	240	253	PF02747	0.330
LIG_Pex14_2	2	6	PF04695	0.409
LIG_Pex14_2	300	304	PF04695	0.229
LIG_Pex14_2	359	363	PF04695	0.253
LIG_Rb_pABgroove_1	120	128	PF01858	0.389
LIG_REV1ctd_RIR_1	75	85	PF16727	0.418
LIG_SH2_CRK	17	21	PF00017	0.374
LIG_SH2_CRK	99	103	PF00017	0.360
LIG_SH2_GRB2like	126	129	PF00017	0.303
LIG_SH2_GRB2like	372	375	PF00017	0.330
LIG_SH2_NCK_1	126	130	PF00017	0.303
LIG_SH2_NCK_1	352	356	PF00017	0.268
LIG_SH2_SRC	126	129	PF00017	0.361
LIG_SH2_SRC	372	375	PF00017	0.330
LIG_SH2_SRC	463	466	PF00017	0.430
LIG_SH2_STAP1	352	356	PF00017	0.255
LIG_SH2_STAT5	109	112	PF00017	0.244
LIG_SH2_STAT5	288	291	PF00017	0.253
LIG_SH2_STAT5	336	339	PF00017	0.396
LIG_SH2_STAT5	463	466	PF00017	0.378
LIG_SH3_3	322	328	PF00018	0.288
LIG_SH3_3	365	371	PF00018	0.347
LIG_SH3_3	95	101	PF00018	0.530
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.270
LIG_SUMO_SIM_par_1	232	239	PF11976	0.268
LIG_SUMO_SIM_par_1	381	387	PF11976	0.313
LIG_TRAF2_1	158	161	PF00917	0.396
LIG_UBA3_1	144	152	PF00899	0.309
LIG_UBA3_1	268	273	PF00899	0.265
LIG_UBA3_1	303	309	PF00899	0.313
LIG_UBA3_1	384	392	PF00899	0.216
LIG_UBA3_1	455	461	PF00899	0.371
LIG_WRC_WIRS_1	225	230	PF05994	0.396
LIG_WRC_WIRS_1	74	79	PF05994	0.431
MOD_CK1_1	53	59	PF00069	0.436
MOD_CK2_1	155	161	PF00069	0.351
MOD_CK2_1	24	30	PF00069	0.496
MOD_CK2_1	295	301	PF00069	0.353
MOD_CK2_1	384	390	PF00069	0.218
MOD_CK2_1	423	429	PF00069	0.525
MOD_GlcNHglycan	33	36	PF01048	0.398
MOD_GlcNHglycan	433	436	PF01048	0.548
MOD_GlcNHglycan	442	446	PF01048	0.444
MOD_GSK3_1	166	173	PF00069	0.254
MOD_GSK3_1	7	14	PF00069	0.442
MOD_N-GLC_1	295	300	PF02516	0.396
MOD_NEK2_1	147	152	PF00069	0.309
MOD_NEK2_1	224	229	PF00069	0.396
MOD_NEK2_1	384	389	PF00069	0.347
MOD_NEK2_1	7	12	PF00069	0.524
MOD_NEK2_2	358	363	PF00069	0.167
MOD_PKA_2	11	17	PF00069	0.334
MOD_PKA_2	166	172	PF00069	0.399
MOD_PKA_2	431	437	PF00069	0.516
MOD_Plk_1	441	447	PF00069	0.488
MOD_Plk_2-3	425	431	PF00069	0.577
MOD_Plk_4	116	122	PF00069	0.279
MOD_Plk_4	224	230	PF00069	0.418
MOD_Plk_4	284	290	PF00069	0.295
MOD_Plk_4	358	364	PF00069	0.284
MOD_Plk_4	384	390	PF00069	0.370
MOD_Plk_4	73	79	PF00069	0.514
MOD_ProDKin_1	180	186	PF00069	0.288
MOD_ProDKin_1	287	293	PF00069	0.347
MOD_SUMO_rev_2	82	87	PF00179	0.507
MOD_SUMO_rev_2	88	98	PF00179	0.526
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.390
TRG_ENDOCYTIC_2	17	20	PF00928	0.335
TRG_ENDOCYTIC_2	336	339	PF00928	0.347
TRG_ENDOCYTIC_2	352	355	PF00928	0.165
TRG_ENDOCYTIC_2	463	466	PF00928	0.504
TRG_ENDOCYTIC_2	99	102	PF00928	0.366
TRG_ER_diArg_1	133	136	PF00400	0.342
TRG_ER_diArg_1	180	182	PF00400	0.347
TRG_ER_diArg_1	2	4	PF00400	0.527
TRG_ER_diArg_1	61	63	PF00400	0.408
TRG_ER_diArg_1	79	81	PF00400	0.508
TRG_NES_CRM1_1	203	214	PF08389	0.253
TRG_NES_CRM1_1	447	462	PF08389	0.483
TRG_NLS_MonoCore_2	133	138	PF00514	0.303
TRG_NLS_MonoExtN_4	131	138	PF00514	0.286
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	78%	100%
A0A0N1I0J7	Leptomonas seymouri	27%	93%
A0A0S4J9H9	Bodo saltans	48%	100%
A0A0S4JPV5	Bodo saltans	29%	94%
A0A1X0NK74	Trypanosomatidae	61%	100%
A0A1X0NN10	Trypanosomatidae	29%	100%
A0A3R7K771	Trypanosoma rangeli	57%	100%
A0A3R7L848	Trypanosoma rangeli	27%	100%
A0A3S5H5L6	Leishmania donovani	89%	100%
A0A3S7XCB8	Leishmania donovani	29%	90%
A4HSM8	Leishmania infantum	90%	100%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
E9AIY4	Leishmania braziliensis	29%	91%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AKL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AUB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	94%
P46441	Haematobia irritans	36%	100%
P64612	Escherichia coli (strain K12)	32%	100%
P64613	Escherichia coli O157:H7	32%	100%
Q32PX9	Rattus norvegicus	36%	100%
Q3V384	Mus musculus	34%	100%
Q4Q076	Leishmania major	29%	100%
Q4QJ96	Leishmania major	88%	100%
Q5TYS0	Danio rerio	33%	95%
Q8WV93	Homo sapiens	31%	99%
V5D7E6	Trypanosoma cruzi	58%	90%