Stomatin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stomatin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4E9_LEIBR

TriTrypDb:

LbrM.05.1040 , LBRM2903_050016400

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0005886	plasma membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H4E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.289
CLV_NRD_NRD_1	212	214	PF00675	0.260
CLV_NRD_NRD_1	222	224	PF00675	0.232
CLV_NRD_NRD_1	225	227	PF00675	0.226
CLV_NRD_NRD_1	4	6	PF00675	0.490
CLV_PCSK_FUR_1	223	227	PF00082	0.243
CLV_PCSK_KEX2_1	187	189	PF00082	0.271
CLV_PCSK_KEX2_1	198	200	PF00082	0.176
CLV_PCSK_KEX2_1	212	214	PF00082	0.243
CLV_PCSK_KEX2_1	225	227	PF00082	0.226
CLV_PCSK_KEX2_1	3	5	PF00082	0.484
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.243
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.243
CLV_PCSK_SKI1_1	227	231	PF00082	0.337
CLV_PCSK_SKI1_1	45	49	PF00082	0.618
CLV_PCSK_SKI1_1	5	9	PF00082	0.459
CLV_Separin_Metazoa	184	188	PF03568	0.258
CLV_Separin_Metazoa	209	213	PF03568	0.258
DEG_APCC_DBOX_1	164	172	PF00400	0.258
DEG_APCC_DBOX_1	2	10	PF00400	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.511
DOC_CYCLIN_RxL_1	223	233	PF00134	0.243
DOC_MAPK_gen_1	223	230	PF00069	0.243
DOC_MAPK_gen_1	3	9	PF00069	0.613
DOC_USP7_MATH_1	112	116	PF00917	0.249
DOC_USP7_MATH_1	20	24	PF00917	0.781
DOC_USP7_MATH_1	277	281	PF00917	0.478
DOC_USP7_MATH_1	284	288	PF00917	0.317
DOC_USP7_MATH_1	30	34	PF00917	0.685
DOC_USP7_MATH_1	316	320	PF00917	0.337
DOC_USP7_MATH_1	349	353	PF00917	0.700
DOC_WW_Pin1_4	14	19	PF00397	0.611
DOC_WW_Pin1_4	21	26	PF00397	0.537
DOC_WW_Pin1_4	350	355	PF00397	0.656
LIG_14-3-3_CanoR_1	165	169	PF00244	0.360
LIG_14-3-3_CanoR_1	175	179	PF00244	0.302
LIG_14-3-3_CanoR_1	212	216	PF00244	0.243
LIG_14-3-3_CanoR_1	59	63	PF00244	0.534
LIG_14-3-3_CanoR_1	79	85	PF00244	0.129
LIG_Actin_WH2_2	119	135	PF00022	0.243
LIG_APCC_ABBA_1	91	96	PF00400	0.337
LIG_deltaCOP1_diTrp_1	85	94	PF00928	0.277
LIG_EH1_1	199	207	PF00400	0.388
LIG_FHA_1	180	186	PF00498	0.324
LIG_FHA_1	235	241	PF00498	0.462
LIG_FHA_1	334	340	PF00498	0.337
LIG_FHA_2	22	28	PF00498	0.661
LIG_LIR_Gen_1	340	349	PF02991	0.277
LIG_LIR_Gen_1	61	67	PF02991	0.418
LIG_LIR_Gen_1	86	95	PF02991	0.388
LIG_LIR_Nem_3	310	315	PF02991	0.243
LIG_LIR_Nem_3	340	345	PF02991	0.258
LIG_LIR_Nem_3	61	66	PF02991	0.419
LIG_LIR_Nem_3	85	91	PF02991	0.243
LIG_PTB_Apo_2	143	150	PF02174	0.243
LIG_SH2_STAT3	12	15	PF00017	0.574
LIG_SH2_STAT5	252	255	PF00017	0.393
LIG_SH2_STAT5	259	262	PF00017	0.410
LIG_SH2_STAT5	308	311	PF00017	0.243
LIG_SH2_STAT5	72	75	PF00017	0.243
LIG_SH3_3	325	331	PF00018	0.247
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.308
LIG_SUMO_SIM_anti_2	280	288	PF11976	0.417
LIG_SUMO_SIM_par_1	122	127	PF11976	0.243
LIG_TRAF2_1	24	27	PF00917	0.628
LIG_UBA3_1	130	139	PF00899	0.243
LIG_WW_3	56	60	PF00397	0.529
MOD_CK1_1	115	121	PF00069	0.243
MOD_CK1_1	167	173	PF00069	0.388
MOD_CK1_1	236	242	PF00069	0.515
MOD_CK1_1	33	39	PF00069	0.605
MOD_CK2_1	178	184	PF00069	0.308
MOD_CK2_1	21	27	PF00069	0.485
MOD_CK2_1	229	235	PF00069	0.246
MOD_CK2_1	304	310	PF00069	0.402
MOD_CK2_1	49	55	PF00069	0.480
MOD_GlcNHglycan	114	117	PF01048	0.270
MOD_GlcNHglycan	32	35	PF01048	0.612
MOD_GlcNHglycan	347	350	PF01048	0.578
MOD_GlcNHglycan	85	88	PF01048	0.337
MOD_GSK3_1	112	119	PF00069	0.277
MOD_GSK3_1	134	141	PF00069	0.337
MOD_GSK3_1	154	161	PF00069	0.122
MOD_GSK3_1	174	181	PF00069	0.122
MOD_GSK3_1	229	236	PF00069	0.337
MOD_GSK3_1	318	325	PF00069	0.337
MOD_GSK3_1	333	340	PF00069	0.122
MOD_GSK3_1	341	348	PF00069	0.232
MOD_GSK3_1	349	356	PF00069	0.517
MOD_N-GLC_1	112	117	PF02516	0.243
MOD_N-GLC_1	178	183	PF02516	0.308
MOD_N-GLC_1	21	26	PF02516	0.611
MOD_NEK2_1	154	159	PF00069	0.243
MOD_NEK2_1	178	183	PF00069	0.327
MOD_NEK2_1	333	338	PF00069	0.220
MOD_NEK2_1	40	45	PF00069	0.613
MOD_NEK2_2	155	160	PF00069	0.243
MOD_NEK2_2	58	63	PF00069	0.442
MOD_PIKK_1	333	339	PF00454	0.299
MOD_PIKK_1	40	46	PF00454	0.662
MOD_PKA_2	164	170	PF00069	0.360
MOD_PKA_2	174	180	PF00069	0.302
MOD_PKA_2	211	217	PF00069	0.243
MOD_PKA_2	262	268	PF00069	0.534
MOD_PKA_2	58	64	PF00069	0.421
MOD_Plk_1	112	118	PF00069	0.243
MOD_Plk_1	178	184	PF00069	0.360
MOD_Plk_2-3	257	263	PF00069	0.300
MOD_Plk_2-3	49	55	PF00069	0.566
MOD_Plk_4	167	173	PF00069	0.243
MOD_Plk_4	304	310	PF00069	0.346
MOD_Plk_4	318	324	PF00069	0.170
MOD_Plk_4	337	343	PF00069	0.258
MOD_Plk_4	49	55	PF00069	0.492
MOD_Plk_4	58	64	PF00069	0.415
MOD_ProDKin_1	14	20	PF00069	0.611
MOD_ProDKin_1	21	27	PF00069	0.537
MOD_ProDKin_1	350	356	PF00069	0.660
TRG_ER_diArg_1	186	188	PF00400	0.277
TRG_ER_diArg_1	2	5	PF00400	0.483
TRG_ER_diArg_1	211	213	PF00400	0.252
TRG_NES_CRM1_1	125	136	PF08389	0.243
TRG_NLS_Bipartite_1	212	229	PF00514	0.258
TRG_NLS_MonoCore_2	223	228	PF00514	0.337
TRG_NLS_MonoExtN_4	223	229	PF00514	0.243
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTU5	Leptomonas seymouri	84%	99%
A0A0S4INS2	Bodo saltans	61%	100%
A0A1X0NKE1	Trypanosomatidae	68%	84%
A0A3R7M6V7	Trypanosoma rangeli	62%	93%
A0A3S5H5L4	Leishmania donovani	93%	100%
A4HSM6	Leishmania infantum	93%	100%
C9ZND8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	67%
E9AKL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AS80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O60121	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P0AA53	Escherichia coli (strain K12)	36%	100%
P0AA54	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AA55	Escherichia coli O157:H7	36%	100%
P0AA56	Shigella flexneri	36%	100%
P0DKS0	Wigglesworthia glossinidia brevipalpis	33%	100%
P63694	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	94%
P72655	Synechocystis sp. (strain PCC 6803 / Kazusa)	36%	100%
P9WPR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	94%
P9WPR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	94%
Q32LL2	Bos taurus	47%	100%
Q4FZT0	Rattus norvegicus	46%	100%
Q4QJ98	Leishmania major	93%	100%
Q99JB2	Mus musculus	46%	100%
Q9FHM7	Arabidopsis thaliana	23%	100%
Q9UJZ1	Homo sapiens	45%	100%
V5BBU5	Trypanosoma cruzi	68%	88%