Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4E8_LEIBR

TriTrypDb:

LbrM.05.1030 , LBRM2903_050016300

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.648
CLV_PCSK_KEX2_1	11	13	PF00082	0.648
CLV_PCSK_KEX2_1	36	38	PF00082	0.515
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.436
DOC_CKS1_1	84	89	PF01111	0.299
DOC_CKS1_1	94	99	PF01111	0.283
DOC_MAPK_HePTP_8	8	22	PF00069	0.322
DOC_USP7_UBL2_3	63	67	PF12436	0.492
DOC_WW_Pin1_4	103	108	PF00397	0.150
DOC_WW_Pin1_4	83	88	PF00397	0.455
DOC_WW_Pin1_4	93	98	PF00397	0.352
LIG_14-3-3_CanoR_1	30	38	PF00244	0.370
LIG_14-3-3_CanoR_1	57	61	PF00244	0.478
LIG_APCC_ABBA_1	20	25	PF00400	0.310
LIG_FHA_1	117	123	PF00498	0.260
LIG_FHA_1	133	139	PF00498	0.572
LIG_FHA_2	94	100	PF00498	0.465
LIG_LIR_Gen_1	106	117	PF02991	0.289
LIG_LIR_Gen_1	4	10	PF02991	0.390
LIG_LIR_Nem_3	106	112	PF02991	0.282
LIG_LIR_Nem_3	119	123	PF02991	0.247
LIG_LIR_Nem_3	4	8	PF02991	0.506
LIG_LIR_Nem_3	76	82	PF02991	0.412
LIG_NRBOX	89	95	PF00104	0.356
LIG_Pex14_1	120	124	PF04695	0.271
LIG_SH2_CRK	109	113	PF00017	0.289
LIG_SH2_STAP1	133	137	PF00017	0.565
LIG_SH2_STAT5	109	112	PF00017	0.271
LIG_SH2_STAT5	128	131	PF00017	0.548
LIG_SH3_3	81	87	PF00018	0.417
LIG_SUMO_SIM_par_1	101	106	PF11976	0.236
MOD_CDK_SPK_2	83	88	PF00069	0.305
MOD_CK2_1	55	61	PF00069	0.499
MOD_GlcNHglycan	64	67	PF01048	0.614
MOD_GlcNHglycan	8	11	PF01048	0.537
MOD_GlcNHglycan	90	93	PF01048	0.597
MOD_NEK2_1	1	6	PF00069	0.467
MOD_NEK2_1	113	118	PF00069	0.193
MOD_PIKK_1	23	29	PF00454	0.468
MOD_PKA_2	29	35	PF00069	0.404
MOD_PKA_2	56	62	PF00069	0.385
MOD_Plk_4	1	7	PF00069	0.543
MOD_Plk_4	132	138	PF00069	0.560
MOD_Plk_4	16	22	PF00069	0.422
MOD_ProDKin_1	103	109	PF00069	0.150
MOD_ProDKin_1	83	89	PF00069	0.452
MOD_ProDKin_1	93	99	PF00069	0.355
MOD_SUMO_rev_2	58	65	PF00179	0.435
TRG_ENDOCYTIC_2	109	112	PF00928	0.284
TRG_ENDOCYTIC_2	124	127	PF00928	0.484
TRG_ENDOCYTIC_2	133	136	PF00928	0.596
TRG_ENDOCYTIC_2	82	85	PF00928	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY8	Leptomonas seymouri	70%	100%
A0A1X0NKT0	Trypanosomatidae	52%	99%
A0A3R7K2B2	Trypanosoma rangeli	54%	100%
A0A3S5H5L3	Leishmania donovani	85%	100%
A4HSM5	Leishmania infantum	85%	100%
C9ZND7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AKK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QJ99	Leishmania major	84%	100%
V5BBW2	Trypanosoma cruzi	50%	100%