BBE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4E7_LEIBR

TriTrypDb:

LbrM.05.1020 , LBRM2903_050016200

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005856	cytoskeleton	5	1

Expansion

Sequence features

A4H4E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.649
CLV_C14_Caspase3-7	215	219	PF00656	0.509
CLV_C14_Caspase3-7	301	305	PF00656	0.442
CLV_NRD_NRD_1	195	197	PF00675	0.417
CLV_NRD_NRD_1	281	283	PF00675	0.605
CLV_NRD_NRD_1	308	310	PF00675	0.609
CLV_NRD_NRD_1	386	388	PF00675	0.403
CLV_NRD_NRD_1	422	424	PF00675	0.487
CLV_NRD_NRD_1	478	480	PF00675	0.416
CLV_NRD_NRD_1	638	640	PF00675	0.368
CLV_NRD_NRD_1	695	697	PF00675	0.458
CLV_NRD_NRD_1	703	705	PF00675	0.431
CLV_NRD_NRD_1	707	709	PF00675	0.430
CLV_NRD_NRD_1	779	781	PF00675	0.502
CLV_NRD_NRD_1	831	833	PF00675	0.279
CLV_PCSK_FUR_1	306	310	PF00082	0.549
CLV_PCSK_KEX2_1	195	197	PF00082	0.504
CLV_PCSK_KEX2_1	281	283	PF00082	0.549
CLV_PCSK_KEX2_1	308	310	PF00082	0.577
CLV_PCSK_KEX2_1	386	388	PF00082	0.398
CLV_PCSK_KEX2_1	422	424	PF00082	0.276
CLV_PCSK_KEX2_1	703	705	PF00082	0.490
CLV_PCSK_KEX2_1	774	776	PF00082	0.420
CLV_PCSK_KEX2_1	831	833	PF00082	0.369
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.485
CLV_PCSK_SKI1_1	200	204	PF00082	0.393
CLV_PCSK_SKI1_1	281	285	PF00082	0.623
CLV_PCSK_SKI1_1	386	390	PF00082	0.499
CLV_PCSK_SKI1_1	423	427	PF00082	0.280
CLV_PCSK_SKI1_1	452	456	PF00082	0.332
CLV_PCSK_SKI1_1	479	483	PF00082	0.337
CLV_PCSK_SKI1_1	802	806	PF00082	0.385
DEG_COP1_1	358	366	PF00400	0.259
DEG_Nend_Nbox_1	1	3	PF02207	0.240
DOC_CDC14_PxL_1	524	532	PF14671	0.539
DOC_CYCLIN_yCln2_LP_2	719	725	PF00134	0.454
DOC_MAPK_DCC_7	525	535	PF00069	0.348
DOC_MAPK_gen_1	506	515	PF00069	0.438
DOC_MAPK_gen_1	654	663	PF00069	0.457
DOC_MAPK_MEF2A_6	613	621	PF00069	0.466
DOC_MAPK_MEF2A_6	672	679	PF00069	0.310
DOC_PP1_RVXF_1	421	428	PF00149	0.470
DOC_PP1_SILK_1	586	591	PF00149	0.485
DOC_PP2B_LxvP_1	189	192	PF13499	0.321
DOC_PP2B_LxvP_1	719	722	PF13499	0.394
DOC_PP2B_PxIxI_1	674	680	PF00149	0.322
DOC_PP4_FxxP_1	203	206	PF00568	0.321
DOC_PP4_FxxP_1	5	8	PF00568	0.243
DOC_PP4_FxxP_1	556	559	PF00568	0.444
DOC_PP4_FxxP_1	595	598	PF00568	0.459
DOC_USP7_MATH_1	183	187	PF00917	0.432
DOC_USP7_MATH_1	242	246	PF00917	0.416
DOC_USP7_MATH_1	263	267	PF00917	0.604
DOC_USP7_MATH_1	302	306	PF00917	0.470
DOC_USP7_MATH_1	407	411	PF00917	0.659
DOC_USP7_MATH_1	596	600	PF00917	0.529
DOC_USP7_MATH_1	834	838	PF00917	0.284
DOC_USP7_MATH_2	114	120	PF00917	0.540
DOC_USP7_UBL2_3	426	430	PF12436	0.407
DOC_USP7_UBL2_3	482	486	PF12436	0.445
DOC_USP7_UBL2_3	549	553	PF12436	0.469
DOC_WW_Pin1_4	149	154	PF00397	0.433
DOC_WW_Pin1_4	170	175	PF00397	0.610
DOC_WW_Pin1_4	244	249	PF00397	0.488
DOC_WW_Pin1_4	388	393	PF00397	0.508
DOC_WW_Pin1_4	395	400	PF00397	0.652
DOC_WW_Pin1_4	55	60	PF00397	0.332
DOC_WW_Pin1_4	568	573	PF00397	0.599
LIG_14-3-3_CanoR_1	144	149	PF00244	0.543
LIG_14-3-3_CanoR_1	220	225	PF00244	0.392
LIG_14-3-3_CanoR_1	386	394	PF00244	0.425
LIG_14-3-3_CanoR_1	432	441	PF00244	0.500
LIG_14-3-3_CanoR_1	459	466	PF00244	0.428
LIG_14-3-3_CanoR_1	495	500	PF00244	0.310
LIG_14-3-3_CanoR_1	501	506	PF00244	0.384
LIG_14-3-3_CanoR_1	544	551	PF00244	0.535
LIG_14-3-3_CanoR_1	620	625	PF00244	0.475
LIG_14-3-3_CanoR_1	733	737	PF00244	0.384
LIG_14-3-3_CanoR_1	838	845	PF00244	0.506
LIG_Actin_WH2_2	130	146	PF00022	0.630
LIG_APCC_ABBA_1	633	638	PF00400	0.511
LIG_BRCT_BRCA1_1	21	25	PF00533	0.197
LIG_BRCT_BRCA1_1	535	539	PF00533	0.458
LIG_Clathr_ClatBox_1	16	20	PF01394	0.443
LIG_deltaCOP1_diTrp_1	490	497	PF00928	0.327
LIG_deltaCOP1_diTrp_1	576	581	PF00928	0.300
LIG_deltaCOP1_diTrp_1	64	71	PF00928	0.358
LIG_eIF4E_1	466	472	PF01652	0.434
LIG_FHA_1	140	146	PF00498	0.624
LIG_FHA_1	171	177	PF00498	0.691
LIG_FHA_1	206	212	PF00498	0.328
LIG_FHA_1	283	289	PF00498	0.526
LIG_FHA_1	356	362	PF00498	0.351
LIG_FHA_1	467	473	PF00498	0.459
LIG_FHA_1	487	493	PF00498	0.476
LIG_FHA_1	552	558	PF00498	0.395
LIG_FHA_1	569	575	PF00498	0.402
LIG_FHA_1	94	100	PF00498	0.477
LIG_FHA_2	105	111	PF00498	0.468
LIG_FHA_2	145	151	PF00498	0.623
LIG_FHA_2	220	226	PF00498	0.366
LIG_FHA_2	434	440	PF00498	0.493
LIG_FHA_2	502	508	PF00498	0.470
LIG_FHA_2	521	527	PF00498	0.492
LIG_FHA_2	59	65	PF00498	0.444
LIG_FHA_2	688	694	PF00498	0.468
LIG_IBAR_NPY_1	131	133	PF08397	0.623
LIG_LIR_Apic_2	261	265	PF02991	0.526
LIG_LIR_Apic_2	4	8	PF02991	0.288
LIG_LIR_Apic_2	496	502	PF02991	0.405
LIG_LIR_Apic_2	554	559	PF02991	0.414
LIG_LIR_Apic_2	710	714	PF02991	0.347
LIG_LIR_Gen_1	186	192	PF02991	0.315
LIG_LIR_Gen_1	218	228	PF02991	0.477
LIG_LIR_Gen_1	232	242	PF02991	0.553
LIG_LIR_Gen_1	365	376	PF02991	0.421
LIG_LIR_Gen_1	576	585	PF02991	0.336
LIG_LIR_Gen_1	678	687	PF02991	0.417
LIG_LIR_Gen_1	726	737	PF02991	0.399
LIG_LIR_Gen_1	823	834	PF02991	0.351
LIG_LIR_Nem_3	165	170	PF02991	0.455
LIG_LIR_Nem_3	186	190	PF02991	0.306
LIG_LIR_Nem_3	218	224	PF02991	0.360
LIG_LIR_Nem_3	28	32	PF02991	0.354
LIG_LIR_Nem_3	347	351	PF02991	0.335
LIG_LIR_Nem_3	354	359	PF02991	0.395
LIG_LIR_Nem_3	365	371	PF02991	0.325
LIG_LIR_Nem_3	526	530	PF02991	0.413
LIG_LIR_Nem_3	576	581	PF02991	0.343
LIG_LIR_Nem_3	678	683	PF02991	0.410
LIG_LIR_Nem_3	726	732	PF02991	0.430
LIG_LIR_Nem_3	794	800	PF02991	0.364
LIG_LIR_Nem_3	823	829	PF02991	0.350
LIG_LYPXL_yS_3	167	170	PF13949	0.455
LIG_LYPXL_yS_3	527	530	PF13949	0.514
LIG_MYND_1	528	532	PF01753	0.498
LIG_MYND_1	8	12	PF01753	0.253
LIG_NRBOX	76	82	PF00104	0.210
LIG_Pex14_1	256	260	PF04695	0.486
LIG_Pex14_1	493	497	PF04695	0.433
LIG_Rb_LxCxE_1	794	813	PF01857	0.473
LIG_RPA_C_Fungi	215	227	PF08784	0.351
LIG_RPA_C_Fungi	691	703	PF08784	0.567
LIG_SH2_CRK	13	17	PF00017	0.235
LIG_SH2_CRK	133	137	PF00017	0.482
LIG_SH2_CRK	262	266	PF00017	0.475
LIG_SH2_CRK	499	503	PF00017	0.489
LIG_SH2_CRK	680	684	PF00017	0.482
LIG_SH2_CRK	826	830	PF00017	0.363
LIG_SH2_GRB2like	234	237	PF00017	0.350
LIG_SH2_GRB2like	262	265	PF00017	0.474
LIG_SH2_GRB2like	340	343	PF00017	0.335
LIG_SH2_NCK_1	221	225	PF00017	0.456
LIG_SH2_NCK_1	262	266	PF00017	0.409
LIG_SH2_PTP2	89	92	PF00017	0.264
LIG_SH2_SRC	262	265	PF00017	0.409
LIG_SH2_SRC	340	343	PF00017	0.342
LIG_SH2_SRC	36	39	PF00017	0.512
LIG_SH2_SRC	446	449	PF00017	0.470
LIG_SH2_STAP1	13	17	PF00017	0.377
LIG_SH2_STAP1	327	331	PF00017	0.353
LIG_SH2_STAP1	378	382	PF00017	0.408
LIG_SH2_STAP1	41	45	PF00017	0.460
LIG_SH2_STAT3	671	674	PF00017	0.320
LIG_SH2_STAT5	221	224	PF00017	0.334
LIG_SH2_STAT5	234	237	PF00017	0.355
LIG_SH2_STAT5	29	32	PF00017	0.321
LIG_SH2_STAT5	311	314	PF00017	0.525
LIG_SH2_STAT5	340	343	PF00017	0.484
LIG_SH2_STAT5	466	469	PF00017	0.460
LIG_SH2_STAT5	605	608	PF00017	0.551
LIG_SH2_STAT5	711	714	PF00017	0.349
LIG_SH2_STAT5	715	718	PF00017	0.352
LIG_SH2_STAT5	729	732	PF00017	0.372
LIG_SH2_STAT5	800	803	PF00017	0.354
LIG_SH2_STAT5	89	92	PF00017	0.264
LIG_SH3_2	396	401	PF14604	0.570
LIG_SH3_2	418	423	PF14604	0.447
LIG_SH3_3	236	242	PF00018	0.393
LIG_SH3_3	358	364	PF00018	0.406
LIG_SH3_3	393	399	PF00018	0.526
LIG_SH3_3	415	421	PF00018	0.513
LIG_SH3_3	611	617	PF00018	0.528
LIG_SH3_3	619	625	PF00018	0.396
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.315
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.334
LIG_SUMO_SIM_anti_2	72	77	PF11976	0.220
LIG_SUMO_SIM_par_1	675	682	PF11976	0.444
LIG_SUMO_SIM_par_1	74	79	PF11976	0.200
LIG_TRAF2_1	601	604	PF00917	0.588
LIG_TRAF2_1	746	749	PF00917	0.411
LIG_TYR_ITIM	11	16	PF00017	0.530
LIG_TYR_ITIM	30	35	PF00017	0.210
LIG_UBA3_1	663	672	PF00899	0.532
LIG_WRC_WIRS_1	2	7	PF05994	0.294
LIG_WRC_WIRS_1	494	499	PF05994	0.432
MOD_CDC14_SPxK_1	398	401	PF00782	0.477
MOD_CDK_SPxK_1	395	401	PF00069	0.461
MOD_CDK_SPxxK_3	149	156	PF00069	0.441
MOD_CDK_SPxxK_3	170	177	PF00069	0.606
MOD_CK1_1	244	250	PF00069	0.407
MOD_CK1_1	258	264	PF00069	0.538
MOD_CK1_1	400	406	PF00069	0.687
MOD_CK1_1	408	414	PF00069	0.587
MOD_CK1_1	520	526	PF00069	0.543
MOD_CK1_1	565	571	PF00069	0.745
MOD_CK1_1	58	64	PF00069	0.307
MOD_CK1_1	837	843	PF00069	0.286
MOD_CK2_1	116	122	PF00069	0.446
MOD_CK2_1	219	225	PF00069	0.397
MOD_CK2_1	263	269	PF00069	0.563
MOD_CK2_1	433	439	PF00069	0.500
MOD_CK2_1	44	50	PF00069	0.313
MOD_CK2_1	501	507	PF00069	0.469
MOD_CK2_1	520	526	PF00069	0.411
MOD_CK2_1	570	576	PF00069	0.489
MOD_CK2_1	597	603	PF00069	0.566
MOD_CK2_1	640	646	PF00069	0.441
MOD_CK2_1	687	693	PF00069	0.498
MOD_CK2_1	783	789	PF00069	0.595
MOD_Cter_Amidation	193	196	PF01082	0.388
MOD_GlcNHglycan	214	217	PF01048	0.456
MOD_GlcNHglycan	265	268	PF01048	0.546
MOD_GlcNHglycan	277	280	PF01048	0.580
MOD_GlcNHglycan	519	522	PF01048	0.531
MOD_GlcNHglycan	545	548	PF01048	0.571
MOD_GlcNHglycan	564	567	PF01048	0.699
MOD_GlcNHglycan	608	611	PF01048	0.594
MOD_GlcNHglycan	642	645	PF01048	0.253
MOD_GlcNHglycan	784	788	PF01048	0.549
MOD_GlcNHglycan	839	842	PF01048	0.355
MOD_GSK3_1	139	146	PF00069	0.570
MOD_GSK3_1	152	159	PF00069	0.487
MOD_GSK3_1	273	280	PF00069	0.541
MOD_GSK3_1	293	300	PF00069	0.653
MOD_GSK3_1	351	358	PF00069	0.270
MOD_GSK3_1	386	393	PF00069	0.415
MOD_GSK3_1	397	404	PF00069	0.593
MOD_GSK3_1	408	415	PF00069	0.429
MOD_GSK3_1	515	522	PF00069	0.543
MOD_GSK3_1	558	565	PF00069	0.547
MOD_GSK3_1	675	682	PF00069	0.413
MOD_GSK3_1	728	735	PF00069	0.484
MOD_GSK3_1	99	106	PF00069	0.500
MOD_N-GLC_1	297	302	PF02516	0.456
MOD_N-GLC_1	434	439	PF02516	0.556
MOD_N-GLC_1	568	573	PF02516	0.532
MOD_NEK2_1	1	6	PF00069	0.339
MOD_NEK2_1	19	24	PF00069	0.308
MOD_NEK2_1	273	278	PF00069	0.526
MOD_NEK2_1	288	293	PF00069	0.558
MOD_NEK2_1	320	325	PF00069	0.310
MOD_NEK2_1	371	376	PF00069	0.392
MOD_NEK2_1	412	417	PF00069	0.501
MOD_NEK2_1	433	438	PF00069	0.467
MOD_NEK2_1	71	76	PF00069	0.266
MOD_NEK2_2	675	680	PF00069	0.392
MOD_PIKK_1	349	355	PF00454	0.478
MOD_PIKK_1	533	539	PF00454	0.437
MOD_PK_1	156	162	PF00069	0.614
MOD_PK_1	220	226	PF00069	0.388
MOD_PK_1	401	407	PF00069	0.558
MOD_PKA_1	386	392	PF00069	0.365
MOD_PKA_2	143	149	PF00069	0.549
MOD_PKA_2	219	225	PF00069	0.403
MOD_PKA_2	386	392	PF00069	0.365
MOD_PKA_2	500	506	PF00069	0.414
MOD_PKA_2	533	539	PF00069	0.356
MOD_PKA_2	543	549	PF00069	0.399
MOD_PKA_2	6	12	PF00069	0.388
MOD_PKA_2	732	738	PF00069	0.322
MOD_PKA_2	791	797	PF00069	0.322
MOD_PKA_2	837	843	PF00069	0.490
MOD_Plk_1	401	407	PF00069	0.613
MOD_Plk_1	434	440	PF00069	0.493
MOD_Plk_1	45	51	PF00069	0.452
MOD_Plk_1	645	651	PF00069	0.348
MOD_Plk_1	71	77	PF00069	0.258
MOD_Plk_1	783	789	PF00069	0.582
MOD_Plk_1	802	808	PF00069	0.219
MOD_Plk_1	834	840	PF00069	0.281
MOD_Plk_2-3	116	122	PF00069	0.478
MOD_Plk_2-3	355	361	PF00069	0.249
MOD_Plk_4	1	7	PF00069	0.299
MOD_Plk_4	104	110	PF00069	0.502
MOD_Plk_4	156	162	PF00069	0.614
MOD_Plk_4	183	189	PF00069	0.314
MOD_Plk_4	255	261	PF00069	0.596
MOD_Plk_4	36	42	PF00069	0.422
MOD_Plk_4	401	407	PF00069	0.682
MOD_Plk_4	509	515	PF00069	0.399
MOD_Plk_4	552	558	PF00069	0.402
MOD_Plk_4	584	590	PF00069	0.400
MOD_Plk_4	732	738	PF00069	0.334
MOD_ProDKin_1	149	155	PF00069	0.437
MOD_ProDKin_1	170	176	PF00069	0.606
MOD_ProDKin_1	244	250	PF00069	0.481
MOD_ProDKin_1	388	394	PF00069	0.519
MOD_ProDKin_1	395	401	PF00069	0.656
MOD_ProDKin_1	55	61	PF00069	0.332
MOD_ProDKin_1	568	574	PF00069	0.585
MOD_SUMO_for_1	717	720	PF00179	0.404
MOD_SUMO_rev_2	102	107	PF00179	0.419
MOD_SUMO_rev_2	561	565	PF00179	0.586
MOD_SUMO_rev_2	632	642	PF00179	0.387
MOD_SUMO_rev_2	668	673	PF00179	0.559
TRG_DiLeu_BaEn_1	646	651	PF01217	0.469
TRG_DiLeu_BaLyEn_6	750	755	PF01217	0.356
TRG_DiLeu_BaLyEn_6	811	816	PF01217	0.395
TRG_ENDOCYTIC_2	13	16	PF00928	0.511
TRG_ENDOCYTIC_2	133	136	PF00928	0.504
TRG_ENDOCYTIC_2	167	170	PF00928	0.455
TRG_ENDOCYTIC_2	221	224	PF00928	0.315
TRG_ENDOCYTIC_2	234	237	PF00928	0.337
TRG_ENDOCYTIC_2	32	35	PF00928	0.200
TRG_ENDOCYTIC_2	335	338	PF00928	0.414
TRG_ENDOCYTIC_2	356	359	PF00928	0.401
TRG_ENDOCYTIC_2	368	371	PF00928	0.333
TRG_ENDOCYTIC_2	494	497	PF00928	0.425
TRG_ENDOCYTIC_2	527	530	PF00928	0.514
TRG_ENDOCYTIC_2	592	595	PF00928	0.418
TRG_ENDOCYTIC_2	680	683	PF00928	0.485
TRG_ENDOCYTIC_2	729	732	PF00928	0.372
TRG_ENDOCYTIC_2	826	829	PF00928	0.346
TRG_ENDOCYTIC_2	89	92	PF00928	0.264
TRG_ER_diArg_1	306	309	PF00400	0.558
TRG_ER_diArg_1	385	387	PF00400	0.391
TRG_ER_diArg_1	421	423	PF00400	0.330
TRG_ER_diArg_1	458	461	PF00400	0.386
TRG_ER_diArg_1	683	686	PF00400	0.412
TRG_ER_diArg_1	831	833	PF00400	0.279
TRG_NES_CRM1_1	710	724	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W5	Leptomonas seymouri	67%	93%
A0A0S4JUW0	Bodo saltans	43%	98%
A0A1X0NLT5	Trypanosomatidae	43%	87%
A0A3R7LNV4	Trypanosoma rangeli	44%	87%
A0A3S7WP94	Leishmania donovani	85%	92%
A4HSM4	Leishmania infantum	85%	92%
E9AKK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	92%
G2HE57	Pan troglodytes	27%	97%
Q0V9S9	Xenopus tropicalis	27%	99%
Q2T9M4	Bos taurus	27%	97%
Q4QJA0	Leishmania major	83%	100%
Q6V3W6	Mus musculus	26%	97%
Q8IY82	Homo sapiens	27%	97%
Q95JL1	Macaca fascicularis	27%	97%
V5BGF3	Trypanosoma cruzi	44%	86%