Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4E6_LEIBR

TriTrypDb:

LbrM.05.1010 , LBRM2903_050016100

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E6

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	6	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.472
CLV_C14_Caspase3-7	405	409	PF00656	0.471
CLV_C14_Caspase3-7	521	525	PF00656	0.566
CLV_MEL_PAP_1	473	479	PF00089	0.436
CLV_NRD_NRD_1	238	240	PF00675	0.411
CLV_NRD_NRD_1	317	319	PF00675	0.310
CLV_NRD_NRD_1	395	397	PF00675	0.217
CLV_NRD_NRD_1	483	485	PF00675	0.333
CLV_NRD_NRD_1	488	490	PF00675	0.355
CLV_NRD_NRD_1	536	538	PF00675	0.553
CLV_NRD_NRD_1	574	576	PF00675	0.629
CLV_PCSK_FUR_1	532	536	PF00082	0.599
CLV_PCSK_KEX2_1	111	113	PF00082	0.305
CLV_PCSK_KEX2_1	165	167	PF00082	0.418
CLV_PCSK_KEX2_1	240	242	PF00082	0.218
CLV_PCSK_KEX2_1	317	319	PF00082	0.310
CLV_PCSK_KEX2_1	483	485	PF00082	0.333
CLV_PCSK_KEX2_1	534	536	PF00082	0.503
CLV_PCSK_KEX2_1	538	540	PF00082	0.484
CLV_PCSK_KEX2_1	574	576	PF00082	0.664
CLV_PCSK_KEX2_1	578	580	PF00082	0.646
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.305
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.483
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.231
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.503
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.484
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.603
CLV_PCSK_PC7_1	574	580	PF00082	0.493
CLV_PCSK_SKI1_1	229	233	PF00082	0.448
CLV_PCSK_SKI1_1	318	322	PF00082	0.310
CLV_PCSK_SKI1_1	599	603	PF00082	0.620
CLV_PCSK_SKI1_1	85	89	PF00082	0.269
DEG_APCC_DBOX_1	475	483	PF00400	0.369
DEG_APCC_DBOX_1	75	83	PF00400	0.393
DEG_SCF_FBW7_1	493	500	PF00400	0.356
DEG_SPOP_SBC_1	549	553	PF00917	0.434
DOC_CKS1_1	494	499	PF01111	0.357
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.448
DOC_MAPK_gen_1	480	488	PF00069	0.449
DOC_MAPK_gen_1	507	515	PF00069	0.430
DOC_MAPK_MEF2A_6	508	517	PF00069	0.502
DOC_MAPK_RevD_3	477	490	PF00069	0.416
DOC_PP1_RVXF_1	52	58	PF00149	0.267
DOC_PP2B_LxvP_1	351	354	PF13499	0.429
DOC_PP2B_LxvP_1	44	47	PF13499	0.449
DOC_PP4_FxxP_1	32	35	PF00568	0.369
DOC_PP4_FxxP_1	448	451	PF00568	0.346
DOC_PP4_FxxP_1	70	73	PF00568	0.428
DOC_USP7_MATH_1	251	255	PF00917	0.510
DOC_USP7_MATH_1	548	552	PF00917	0.569
DOC_USP7_MATH_1	559	563	PF00917	0.566
DOC_USP7_MATH_1	74	78	PF00917	0.405
DOC_USP7_UBL2_3	534	538	PF12436	0.493
DOC_WW_Pin1_4	124	129	PF00397	0.643
DOC_WW_Pin1_4	307	312	PF00397	0.510
DOC_WW_Pin1_4	493	498	PF00397	0.418
DOC_WW_Pin1_4	506	511	PF00397	0.633
DOC_WW_Pin1_4	553	558	PF00397	0.618
DOC_WW_Pin1_4	69	74	PF00397	0.369
DOC_WW_Pin1_4	96	101	PF00397	0.474
LIG_14-3-3_CanoR_1	358	368	PF00244	0.510
LIG_14-3-3_CanoR_1	476	480	PF00244	0.385
LIG_14-3-3_CanoR_1	90	96	PF00244	0.362
LIG_Actin_WH2_2	466	482	PF00022	0.346
LIG_Actin_WH2_2	75	92	PF00022	0.343
LIG_AP2alpha_2	271	273	PF02296	0.416
LIG_BIR_II_1	1	5	PF00653	0.398
LIG_BIR_III_4	294	298	PF00653	0.447
LIG_CSL_BTD_1	448	451	PF09270	0.434
LIG_deltaCOP1_diTrp_1	334	346	PF00928	0.358
LIG_deltaCOP1_diTrp_1	63	70	PF00928	0.457
LIG_FHA_1	233	239	PF00498	0.374
LIG_FHA_1	274	280	PF00498	0.429
LIG_FHA_1	368	374	PF00498	0.454
LIG_FHA_1	41	47	PF00498	0.351
LIG_FHA_1	436	442	PF00498	0.421
LIG_FHA_1	97	103	PF00498	0.226
LIG_FHA_2	300	306	PF00498	0.463
LIG_FHA_2	331	337	PF00498	0.445
LIG_FHA_2	403	409	PF00498	0.472
LIG_FHA_2	455	461	PF00498	0.399
LIG_FHA_2	558	564	PF00498	0.633
LIG_FHA_2	92	98	PF00498	0.441
LIG_FHA_2	99	105	PF00498	0.413
LIG_LIR_Apic_2	181	187	PF02991	0.517
LIG_LIR_Apic_2	30	35	PF02991	0.399
LIG_LIR_Apic_2	447	451	PF02991	0.378
LIG_LIR_Apic_2	68	73	PF02991	0.369
LIG_LIR_Gen_1	103	110	PF02991	0.470
LIG_LIR_Gen_1	36	44	PF02991	0.422
LIG_LIR_Gen_1	64	74	PF02991	0.332
LIG_LIR_Nem_3	103	109	PF02991	0.465
LIG_LIR_Nem_3	188	194	PF02991	0.271
LIG_LIR_Nem_3	344	349	PF02991	0.421
LIG_LIR_Nem_3	36	40	PF02991	0.414
LIG_LIR_Nem_3	419	423	PF02991	0.522
LIG_LIR_Nem_3	526	531	PF02991	0.542
LIG_LIR_Nem_3	63	69	PF02991	0.374
LIG_PCNA_yPIPBox_3	207	219	PF02747	0.468
LIG_PDZ_Class_1	616	621	PF00595	0.479
LIG_Pex14_1	66	70	PF04695	0.426
LIG_SH2_CRK	349	353	PF00017	0.510
LIG_SH2_PTP2	19	22	PF00017	0.346
LIG_SH2_PTP2	192	195	PF00017	0.361
LIG_SH2_STAP1	149	153	PF00017	0.392
LIG_SH2_STAP1	160	164	PF00017	0.313
LIG_SH2_STAT3	149	152	PF00017	0.451
LIG_SH2_STAT5	19	22	PF00017	0.402
LIG_SH2_STAT5	192	195	PF00017	0.420
LIG_SH2_STAT5	243	246	PF00017	0.416
LIG_SH2_STAT5	268	271	PF00017	0.447
LIG_SH2_STAT5	456	459	PF00017	0.325
LIG_SH2_STAT5	93	96	PF00017	0.365
LIG_SH3_3	266	272	PF00018	0.445
LIG_SH3_3	459	465	PF00018	0.357
LIG_SH3_3	491	497	PF00018	0.481
LIG_TRAF2_1	250	253	PF00917	0.510
LIG_TRAF2_1	323	326	PF00917	0.358
LIG_TRAF2_1	333	336	PF00917	0.472
LIG_TRFH_1	349	353	PF08558	0.447
LIG_UBA3_1	485	490	PF00899	0.362
LIG_WRC_WIRS_1	417	422	PF05994	0.346
MOD_CDK_SPxxK_3	69	76	PF00069	0.380
MOD_CK1_1	123	129	PF00069	0.576
MOD_CK1_1	147	153	PF00069	0.505
MOD_CK1_1	227	233	PF00069	0.398
MOD_CK1_1	25	31	PF00069	0.456
MOD_CK1_1	341	347	PF00069	0.392
MOD_CK1_1	383	389	PF00069	0.514
MOD_CK1_1	463	469	PF00069	0.403
MOD_CK1_1	500	506	PF00069	0.489
MOD_CK1_1	551	557	PF00069	0.637
MOD_CK1_1	56	62	PF00069	0.369
MOD_CK1_1	72	78	PF00069	0.439
MOD_CK2_1	299	305	PF00069	0.358
MOD_CK2_1	330	336	PF00069	0.451
MOD_CK2_1	454	460	PF00069	0.409
MOD_CK2_1	557	563	PF00069	0.590
MOD_CK2_1	65	71	PF00069	0.440
MOD_CK2_1	72	78	PF00069	0.451
MOD_CK2_1	91	97	PF00069	0.217
MOD_Cter_Amidation	156	159	PF01082	0.441
MOD_Cter_Amidation	575	578	PF01082	0.708
MOD_GlcNHglycan	114	117	PF01048	0.544
MOD_GlcNHglycan	160	163	PF01048	0.454
MOD_GlcNHglycan	229	232	PF01048	0.399
MOD_GlcNHglycan	25	28	PF01048	0.380
MOD_GlcNHglycan	260	263	PF01048	0.270
MOD_GlcNHglycan	361	364	PF01048	0.278
MOD_GlcNHglycan	376	379	PF01048	0.365
MOD_GlcNHglycan	420	423	PF01048	0.489
MOD_GlcNHglycan	58	61	PF01048	0.397
MOD_GlcNHglycan	7	10	PF01048	0.412
MOD_GSK3_1	112	119	PF00069	0.540
MOD_GSK3_1	120	127	PF00069	0.618
MOD_GSK3_1	139	146	PF00069	0.388
MOD_GSK3_1	23	30	PF00069	0.280
MOD_GSK3_1	398	405	PF00069	0.686
MOD_GSK3_1	406	413	PF00069	0.437
MOD_GSK3_1	450	457	PF00069	0.379
MOD_GSK3_1	493	500	PF00069	0.608
MOD_GSK3_1	548	555	PF00069	0.572
MOD_GSK3_1	61	68	PF00069	0.433
MOD_GSK3_1	612	619	PF00069	0.677
MOD_GSK3_1	91	98	PF00069	0.475
MOD_N-GLC_1	258	263	PF02516	0.310
MOD_N-GLC_1	359	364	PF02516	0.272
MOD_NEK2_1	144	149	PF00069	0.532
MOD_NEK2_1	23	28	PF00069	0.398
MOD_NEK2_1	273	278	PF00069	0.428
MOD_NEK2_1	359	364	PF00069	0.472
MOD_NEK2_1	435	440	PF00069	0.357
MOD_NEK2_1	65	70	PF00069	0.439
MOD_NEK2_1	95	100	PF00069	0.422
MOD_NEK2_2	91	96	PF00069	0.357
MOD_PKA_1	158	164	PF00069	0.439
MOD_PKA_2	475	481	PF00069	0.373
MOD_PKA_2	5	11	PF00069	0.397
MOD_PKA_2	500	506	PF00069	0.515
MOD_Plk_1	139	145	PF00069	0.502
MOD_Plk_1	251	257	PF00069	0.472
MOD_Plk_1	359	365	PF00069	0.472
MOD_Plk_2-3	454	460	PF00069	0.497
MOD_Plk_4	251	257	PF00069	0.472
MOD_Plk_4	275	281	PF00069	0.430
MOD_Plk_4	338	344	PF00069	0.392
MOD_Plk_4	380	386	PF00069	0.510
MOD_Plk_4	444	450	PF00069	0.334
MOD_Plk_4	61	67	PF00069	0.501
MOD_Plk_4	91	97	PF00069	0.481
MOD_ProDKin_1	124	130	PF00069	0.644
MOD_ProDKin_1	307	313	PF00069	0.510
MOD_ProDKin_1	493	499	PF00069	0.414
MOD_ProDKin_1	506	512	PF00069	0.635
MOD_ProDKin_1	553	559	PF00069	0.622
MOD_ProDKin_1	69	75	PF00069	0.373
MOD_ProDKin_1	96	102	PF00069	0.474
MOD_SUMO_for_1	533	536	PF00179	0.596
MOD_SUMO_rev_2	161	167	PF00179	0.489
MOD_SUMO_rev_2	597	604	PF00179	0.398
TRG_DiLeu_BaEn_1	84	89	PF01217	0.412
TRG_DiLeu_BaEn_3	252	258	PF01217	0.453
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.463
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.393
TRG_ENDOCYTIC_2	106	109	PF00928	0.419
TRG_ENDOCYTIC_2	19	22	PF00928	0.346
TRG_ENDOCYTIC_2	191	194	PF00928	0.377
TRG_ENDOCYTIC_2	270	273	PF00928	0.461
TRG_ENDOCYTIC_2	93	96	PF00928	0.365
TRG_ER_diArg_1	238	241	PF00400	0.410
TRG_ER_diArg_1	317	319	PF00400	0.510
TRG_ER_diArg_1	356	359	PF00400	0.429
TRG_ER_diArg_1	482	484	PF00400	0.331
TRG_ER_diArg_1	574	577	PF00400	0.661
TRG_NLS_MonoExtN_4	574	581	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW4	Leptomonas seymouri	67%	100%
A0A0S4JG90	Bodo saltans	36%	100%
A0A1X0NLX9	Trypanosomatidae	43%	100%
A0A3S7WP82	Leishmania donovani	85%	100%
A0A422N510	Trypanosoma rangeli	42%	100%
A4HSM3	Leishmania infantum	85%	100%
E9AKK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q05B63	Bos taurus	27%	100%
Q12463	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q4QJA1	Leishmania major	84%	100%
Q54QA6	Dictyostelium discoideum	26%	100%
Q5R962	Pongo abelii	27%	100%
Q6NS23	Xenopus laevis	26%	100%
Q7TNK6	Rattus norvegicus	28%	100%
Q7Z4G4	Homo sapiens	28%	100%
Q9CWH5	Mus musculus	27%	100%
V5B7D5	Trypanosoma cruzi	44%	100%