NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4H4E3_LEIBR

TriTrypDb:

LbrM.05.0980 , LBRM2903_050015800

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0030964	NADH dehydrogenase complex	3	11
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0032991	protein-containing complex	1	11
GO:0045271	respiratory chain complex I	4	11
GO:0098796	membrane protein complex	2	11
GO:0098803	respiratory chain complex	3	11
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	11
GO:1902495	transmembrane transporter complex	3	11
GO:1990204	oxidoreductase complex	3	11
GO:1990351	transporter complex	2	11
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4H4E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E3

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003954	NADH dehydrogenase activity	4	11
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	5	11
GO:0005215	transporter activity	1	11
GO:0005488	binding	1	11
GO:0008137	NADH dehydrogenase (ubiquinone) activity	4	11
GO:0009055	electron transfer activity	3	11
GO:0010181	FMN binding	4	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	11
GO:0016491	oxidoreductase activity	2	11
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	11
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	11
GO:0022804	active transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11
GO:0032553	ribonucleotide binding	3	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0050136	NADH dehydrogenase (quinone) activity	5	11
GO:0051287	NAD binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	242	244	PF00675	0.307
CLV_NRD_NRD_1	252	254	PF00675	0.325
CLV_NRD_NRD_1	43	45	PF00675	0.353
CLV_NRD_NRD_1	454	456	PF00675	0.449
CLV_PCSK_KEX2_1	242	244	PF00082	0.307
CLV_PCSK_KEX2_1	383	385	PF00082	0.282
CLV_PCSK_KEX2_1	43	45	PF00082	0.335
CLV_PCSK_KEX2_1	454	456	PF00082	0.449
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.390
CLV_PCSK_SKI1_1	25	29	PF00082	0.335
CLV_PCSK_SKI1_1	380	384	PF00082	0.325
CLV_PCSK_SKI1_1	51	55	PF00082	0.317
CLV_Separin_Metazoa	115	119	PF03568	0.257
DEG_MDM2_SWIB_1	148	155	PF02201	0.257
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DOC_AGCK_PIF_1	179	184	PF00069	0.238
DOC_CKS1_1	367	372	PF01111	0.257
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.238
DOC_MAPK_gen_1	136	144	PF00069	0.257
DOC_PP1_RVXF_1	467	473	PF00149	0.426
DOC_PP2B_LxvP_1	211	214	PF13499	0.238
DOC_PP4_FxxP_1	5	8	PF00568	0.427
DOC_USP7_MATH_1	172	176	PF00917	0.238
DOC_USP7_MATH_1	305	309	PF00917	0.238
DOC_USP7_UBL2_3	208	212	PF12436	0.238
DOC_WW_Pin1_4	234	239	PF00397	0.299
DOC_WW_Pin1_4	366	371	PF00397	0.238
DOC_WW_Pin1_4	372	377	PF00397	0.238
DOC_WW_Pin1_4	448	453	PF00397	0.435
LIG_14-3-3_CanoR_1	270	275	PF00244	0.257
LIG_14-3-3_CanoR_1	355	361	PF00244	0.316
LIG_14-3-3_CanoR_1	454	464	PF00244	0.450
LIG_Actin_WH2_2	314	331	PF00022	0.293
LIG_ActinCP_TwfCPI_2	5	15	PF01115	0.408
LIG_deltaCOP1_diTrp_1	437	446	PF00928	0.357
LIG_FHA_1	194	200	PF00498	0.238
LIG_FHA_1	231	237	PF00498	0.238
LIG_FHA_1	335	341	PF00498	0.282
LIG_FHA_1	345	351	PF00498	0.301
LIG_FHA_1	48	54	PF00498	0.303
LIG_FHA_2	108	114	PF00498	0.260
LIG_FHA_2	227	233	PF00498	0.238
LIG_FHA_2	271	277	PF00498	0.238
LIG_FHA_2	395	401	PF00498	0.238
LIG_Integrin_RGD_1	44	46	PF01839	0.301
LIG_Integrin_RGDW_4	44	47	PF00362	0.296
LIG_LIR_Gen_1	24	34	PF02991	0.315
LIG_LIR_Gen_1	324	331	PF02991	0.297
LIG_LIR_Gen_1	97	105	PF02991	0.283
LIG_LIR_Nem_3	151	155	PF02991	0.295
LIG_LIR_Nem_3	178	182	PF02991	0.206
LIG_LIR_Nem_3	24	30	PF02991	0.290
LIG_LIR_Nem_3	324	328	PF02991	0.277
LIG_LIR_Nem_3	458	464	PF02991	0.373
LIG_LIR_Nem_3	97	101	PF02991	0.283
LIG_MYND_1	209	213	PF01753	0.238
LIG_Pex14_1	247	251	PF04695	0.308
LIG_Pex14_2	148	152	PF04695	0.257
LIG_SH2_CRK	139	143	PF00017	0.238
LIG_SH2_CRK	222	226	PF00017	0.272
LIG_SH2_CRK	325	329	PF00017	0.338
LIG_SH2_PTP2	141	144	PF00017	0.281
LIG_SH2_PTP2	98	101	PF00017	0.281
LIG_SH2_SRC	141	144	PF00017	0.281
LIG_SH2_STAT3	462	465	PF00017	0.442
LIG_SH2_STAT5	141	144	PF00017	0.263
LIG_SH2_STAT5	167	170	PF00017	0.238
LIG_SH2_STAT5	182	185	PF00017	0.238
LIG_SH2_STAT5	190	193	PF00017	0.238
LIG_SH2_STAT5	396	399	PF00017	0.383
LIG_SH2_STAT5	462	465	PF00017	0.485
LIG_SH2_STAT5	98	101	PF00017	0.238
LIG_SH3_1	210	216	PF00018	0.238
LIG_SH3_3	210	216	PF00018	0.258
LIG_SH3_3	265	271	PF00018	0.238
LIG_SH3_3	308	314	PF00018	0.252
LIG_SH3_4	208	215	PF00018	0.238
LIG_SUMO_SIM_par_1	232	237	PF11976	0.281
LIG_TRAF2_1	273	276	PF00917	0.257
LIG_TRAF2_1	281	284	PF00917	0.257
MOD_CDC14_SPxK_1	451	454	PF00782	0.426
MOD_CDK_SPxK_1	366	372	PF00069	0.238
MOD_CDK_SPxK_1	448	454	PF00069	0.437
MOD_CDK_SPxxK_3	448	455	PF00069	0.440
MOD_CK2_1	226	232	PF00069	0.276
MOD_CK2_1	270	276	PF00069	0.257
MOD_CMANNOS	453	456	PF00535	0.446
MOD_Cter_Amidation	251	254	PF01082	0.315
MOD_GlcNHglycan	174	177	PF01048	0.236
MOD_GlcNHglycan	264	267	PF01048	0.316
MOD_GlcNHglycan	448	451	PF01048	0.395
MOD_GlcNHglycan	67	70	PF01048	0.238
MOD_GlcNHglycan	79	82	PF01048	0.238
MOD_GlcNHglycan	8	11	PF01048	0.543
MOD_GSK3_1	103	110	PF00069	0.257
MOD_GSK3_1	226	233	PF00069	0.247
MOD_GSK3_1	330	337	PF00069	0.316
MOD_N-GLC_2	171	173	PF02516	0.229
MOD_NEK2_1	262	267	PF00069	0.362
MOD_NEK2_1	361	366	PF00069	0.371
MOD_NEK2_1	82	87	PF00069	0.299
MOD_PIKK_1	354	360	PF00454	0.281
MOD_PKA_2	354	360	PF00069	0.243
MOD_PKA_2	6	12	PF00069	0.576
MOD_PKA_2	94	100	PF00069	0.238
MOD_Plk_1	193	199	PF00069	0.251
MOD_Plk_1	276	282	PF00069	0.238
MOD_Plk_2-3	151	157	PF00069	0.368
MOD_Plk_2-3	394	400	PF00069	0.238
MOD_Plk_4	236	242	PF00069	0.316
MOD_Plk_4	394	400	PF00069	0.293
MOD_Plk_4	94	100	PF00069	0.238
MOD_ProDKin_1	234	240	PF00069	0.298
MOD_ProDKin_1	366	372	PF00069	0.238
MOD_ProDKin_1	448	454	PF00069	0.437
MOD_SUMO_for_1	390	393	PF00179	0.257
MOD_SUMO_rev_2	468	477	PF00179	0.419
MOD_SUMO_rev_2	59	68	PF00179	0.299
TRG_DiLeu_BaEn_1	120	125	PF01217	0.164
TRG_DiLeu_BaEn_4	393	399	PF01217	0.316
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.257
TRG_ENDOCYTIC_2	139	142	PF00928	0.238
TRG_ENDOCYTIC_2	31	34	PF00928	0.393
TRG_ENDOCYTIC_2	325	328	PF00928	0.324
TRG_ENDOCYTIC_2	461	464	PF00928	0.455
TRG_ENDOCYTIC_2	98	101	PF00928	0.238
TRG_ER_diArg_1	135	138	PF00400	0.257
TRG_ER_diArg_1	241	243	PF00400	0.299
TRG_ER_diArg_1	453	455	PF00400	0.447
TRG_ER_diArg_1	70	73	PF00400	0.238
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V1	Leptomonas seymouri	92%	100%
A0A0S4IZI2	Bodo saltans	82%	100%
A0A1X0NK40	Trypanosomatidae	84%	100%
A0A3S5H5L2	Leishmania donovani	96%	100%
A4HSM0	Leishmania infantum	96%	100%
A8EXI1	Rickettsia canadensis (strain McKiel)	63%	100%
A8F0M0	Rickettsia massiliae (strain Mtu5)	63%	100%
A8GM77	Rickettsia akari (strain Hartford)	62%	100%
A8GQT6	Rickettsia rickettsii (strain Sheila Smith)	62%	100%
A8GYE0	Rickettsia bellii (strain OSU 85-389)	63%	100%
C9ZNC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	97%
E9AKK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O07948	Rhodobacter capsulatus	63%	100%
O66841	Aquifex aeolicus (strain VF5)	40%	100%
O94500	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P22317	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	33%	80%
P24917	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	68%	98%
P25708	Bos taurus	72%	100%
P29913	Paracoccus denitrificans	63%	100%
P31979	Escherichia coli (strain K12)	41%	100%
P33901	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	41%	100%
P49821	Homo sapiens	72%	100%
P56912	Rhizobium meliloti (strain 1021)	65%	100%
P56913	Rhizobium meliloti (strain 1021)	48%	100%
P57256	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	38%	100%
P65568	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	48%	100%
P9WIV6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	48%	100%
P9WIV7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	48%	100%
Q0MQI4	Pongo pygmaeus	72%	100%
Q0MQI5	Gorilla gorilla gorilla	72%	100%
Q0MQI6	Pan troglodytes	72%	100%
Q1RHA0	Rickettsia bellii (strain RML369-C)	63%	100%
Q46507	Solidesulfovibrio fructosivorans	37%	98%
Q4QJA4	Leishmania major	96%	100%
Q4UKA6	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	63%	100%
Q54I90	Dictyostelium discoideum	70%	100%
Q56222	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	47%	100%
Q68XY3	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	63%	100%
Q89AU2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	42%	100%
Q8HXQ9	Macaca fascicularis	72%	100%
Q8K9Y3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	41%	100%
Q91YT0	Mus musculus	69%	100%
Q92406	Aspergillus niger	69%	97%
Q92JB2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	62%	100%
Q9FNN5	Arabidopsis thaliana	74%	99%
Q9I0J7	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	40%	100%
Q9XAQ9	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	44%	100%
Q9ZE33	Rickettsia prowazekii (strain Madrid E)	62%	100%
V5D7U6	Trypanosoma cruzi	85%	99%