LeishMANIAdb
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Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Reverse transcriptase domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H4E1_LEIBR
TriTrypDb:
LbrM.05.0960 , LBRM2903_220020300
Length:
139

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4E1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4E1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 24 26 PF00082 0.518
CLV_PCSK_KEX2_1 60 62 PF00082 0.581
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.518
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.641
CLV_PCSK_SKI1_1 115 119 PF00082 0.655
CLV_PCSK_SKI1_1 75 79 PF00082 0.442
DOC_MAPK_gen_1 35 44 PF00069 0.439
DOC_MAPK_MEF2A_6 35 44 PF00069 0.438
DOC_USP7_MATH_1 49 53 PF00917 0.474
LIG_14-3-3_CanoR_1 5 12 PF00244 0.677
LIG_BRCT_BRCA1_1 46 50 PF00533 0.454
LIG_FHA_1 5 11 PF00498 0.581
LIG_LIR_Gen_1 47 58 PF02991 0.464
LIG_LIR_Nem_3 47 53 PF02991 0.456
LIG_Pex14_1 122 126 PF04695 0.511
LIG_Pex14_1 73 77 PF04695 0.462
LIG_Pex14_2 46 50 PF04695 0.377
LIG_SH2_STAP1 100 104 PF00017 0.508
LIG_SH3_3 56 62 PF00018 0.562
LIG_SUMO_SIM_par_1 40 45 PF11976 0.496
LIG_UBA3_1 39 48 PF00899 0.522
MOD_CK1_1 131 137 PF00069 0.515
MOD_CK1_1 4 10 PF00069 0.681
MOD_Cter_Amidation 22 25 PF01082 0.513
MOD_GlcNHglycan 130 133 PF01048 0.512
MOD_GSK3_1 127 134 PF00069 0.513
MOD_NEK2_1 1 6 PF00069 0.629
MOD_NEK2_1 127 132 PF00069 0.686
MOD_NEK2_1 98 103 PF00069 0.501
MOD_PIKK_1 131 137 PF00454 0.515
MOD_PKA_2 4 10 PF00069 0.651
MOD_PKA_2 89 95 PF00069 0.456
TRG_DiLeu_BaLyEn_6 113 118 PF01217 0.553
TRG_ENDOCYTIC_2 18 21 PF00928 0.553
TRG_ENDOCYTIC_2 95 98 PF00928 0.502

Homologs

Protein Taxonomy Sequence identity Coverage
A4HCI7 Leishmania braziliensis 82% 91%
V5A483 Trypanosoma cruzi 38% 93%
V5AIQ5 Trypanosoma cruzi 40% 94%
V5AIZ9 Trypanosoma cruzi 37% 72%
V5AKX1 Trypanosoma cruzi 37% 76%
V5AP98 Trypanosoma cruzi 39% 72%
V5D0T5 Trypanosoma cruzi 34% 67%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS