Dipeptidyl peptidase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan M-, Family M49

Species:

Leishmania braziliensis

UniProt:

A4H4D9_LEIBR

TriTrypDb:

LbrM.05.0940 , LBRM2903_050015500

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	8
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0008239	dipeptidyl-peptidase activity	5	7
GO:0016787	hydrolase activity	2	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.481
CLV_C14_Caspase3-7	512	516	PF00656	0.283
CLV_NRD_NRD_1	242	244	PF00675	0.404
CLV_NRD_NRD_1	635	637	PF00675	0.350
CLV_NRD_NRD_1	638	640	PF00675	0.349
CLV_PCSK_KEX2_1	185	187	PF00082	0.254
CLV_PCSK_KEX2_1	609	611	PF00082	0.483
CLV_PCSK_KEX2_1	635	637	PF00082	0.409
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.254
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.481
CLV_PCSK_SKI1_1	126	130	PF00082	0.482
CLV_PCSK_SKI1_1	160	164	PF00082	0.404
CLV_PCSK_SKI1_1	193	197	PF00082	0.344
CLV_PCSK_SKI1_1	25	29	PF00082	0.445
CLV_PCSK_SKI1_1	345	349	PF00082	0.344
CLV_PCSK_SKI1_1	385	389	PF00082	0.254
CLV_PCSK_SKI1_1	437	441	PF00082	0.283
CLV_PCSK_SKI1_1	508	512	PF00082	0.289
CLV_PCSK_SKI1_1	62	66	PF00082	0.479
DEG_APCC_DBOX_1	525	533	PF00400	0.344
DOC_CDC14_PxL_1	495	503	PF14671	0.481
DOC_CKS1_1	534	539	PF01111	0.404
DOC_CKS1_1	7	12	PF01111	0.465
DOC_CYCLIN_RxL_1	433	444	PF00134	0.254
DOC_MAPK_MEF2A_6	212	219	PF00069	0.283
DOC_MAPK_MEF2A_6	487	495	PF00069	0.344
DOC_MAPK_MEF2A_6	526	534	PF00069	0.404
DOC_MAPK_MEF2A_6	572	579	PF00069	0.437
DOC_PP1_RVXF_1	60	66	PF00149	0.449
DOC_PP4_FxxP_1	534	537	PF00568	0.344
DOC_SPAK_OSR1_1	550	554	PF12202	0.344
DOC_USP7_MATH_1	419	423	PF00917	0.307
DOC_USP7_UBL2_3	274	278	PF12436	0.344
DOC_USP7_UBL2_3	317	321	PF12436	0.344
DOC_USP7_UBL2_3	341	345	PF12436	0.404
DOC_WW_Pin1_4	131	136	PF00397	0.580
DOC_WW_Pin1_4	164	169	PF00397	0.404
DOC_WW_Pin1_4	25	30	PF00397	0.435
DOC_WW_Pin1_4	43	48	PF00397	0.256
DOC_WW_Pin1_4	51	56	PF00397	0.469
DOC_WW_Pin1_4	533	538	PF00397	0.344
DOC_WW_Pin1_4	6	11	PF00397	0.399
LIG_14-3-3_CanoR_1	379	383	PF00244	0.481
LIG_14-3-3_CanoR_1	583	592	PF00244	0.344
LIG_Actin_WH2_2	495	510	PF00022	0.289
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BRCT_BRCA1_1	472	476	PF00533	0.404
LIG_Clathr_ClatBox_1	529	533	PF01394	0.404
LIG_Clathr_ClatBox_1	576	580	PF01394	0.404
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.344
LIG_FHA_1	111	117	PF00498	0.563
LIG_FHA_1	137	143	PF00498	0.311
LIG_FHA_1	15	21	PF00498	0.433
LIG_FHA_1	199	205	PF00498	0.374
LIG_FHA_1	413	419	PF00498	0.264
LIG_FHA_1	433	439	PF00498	0.376
LIG_FHA_1	44	50	PF00498	0.289
LIG_FHA_1	603	609	PF00498	0.283
LIG_FHA_1	651	657	PF00498	0.481
LIG_FHA_2	127	133	PF00498	0.346
LIG_FHA_2	169	175	PF00498	0.404
LIG_FHA_2	352	358	PF00498	0.369
LIG_FHA_2	395	401	PF00498	0.367
LIG_FHA_2	404	410	PF00498	0.315
LIG_FHA_2	507	513	PF00498	0.404
LIG_Integrin_isoDGR_2	220	222	PF01839	0.404
LIG_LIR_Apic_2	163	168	PF02991	0.404
LIG_LIR_Apic_2	296	301	PF02991	0.344
LIG_LIR_Apic_2	464	468	PF02991	0.408
LIG_LIR_Apic_2	533	537	PF02991	0.344
LIG_LIR_Gen_1	122	131	PF02991	0.404
LIG_LIR_Gen_1	180	187	PF02991	0.254
LIG_LIR_Gen_1	309	315	PF02991	0.344
LIG_LIR_Gen_1	352	361	PF02991	0.342
LIG_LIR_Gen_1	470	479	PF02991	0.404
LIG_LIR_Gen_1	492	502	PF02991	0.412
LIG_LIR_Gen_1	95	104	PF02991	0.363
LIG_LIR_Nem_3	122	127	PF02991	0.404
LIG_LIR_Nem_3	180	184	PF02991	0.254
LIG_LIR_Nem_3	307	311	PF02991	0.344
LIG_LIR_Nem_3	320	326	PF02991	0.344
LIG_LIR_Nem_3	352	356	PF02991	0.342
LIG_LIR_Nem_3	381	387	PF02991	0.481
LIG_LIR_Nem_3	407	413	PF02991	0.344
LIG_LIR_Nem_3	470	475	PF02991	0.353
LIG_LIR_Nem_3	492	497	PF02991	0.412
LIG_LIR_Nem_3	623	628	PF02991	0.375
LIG_LIR_Nem_3	91	96	PF02991	0.363
LIG_PCNA_PIPBox_1	254	263	PF02747	0.494
LIG_PCNA_yPIPBox_3	424	437	PF02747	0.344
LIG_PDZ_Class_2	674	679	PF00595	0.485
LIG_Pex14_1	339	343	PF04695	0.344
LIG_Pex14_2	384	388	PF04695	0.254
LIG_Pex14_2	93	97	PF04695	0.410
LIG_PTB_Apo_2	109	116	PF02174	0.302
LIG_PTB_Apo_2	347	354	PF02174	0.254
LIG_PTB_Apo_2	619	626	PF02174	0.254
LIG_PTB_Phospho_1	619	625	PF10480	0.254
LIG_SH2_CRK	15	19	PF00017	0.436
LIG_SH2_CRK	323	327	PF00017	0.404
LIG_SH2_CRK	472	476	PF00017	0.404
LIG_SH2_GRB2like	101	104	PF00017	0.361
LIG_SH2_NCK_1	472	476	PF00017	0.404
LIG_SH2_PTP2	642	645	PF00017	0.413
LIG_SH2_PTP2	7	10	PF00017	0.410
LIG_SH2_SRC	261	264	PF00017	0.394
LIG_SH2_SRC	34	37	PF00017	0.435
LIG_SH2_SRC	375	378	PF00017	0.344
LIG_SH2_STAP1	34	38	PF00017	0.374
LIG_SH2_STAP1	472	476	PF00017	0.404
LIG_SH2_STAT5	107	110	PF00017	0.351
LIG_SH2_STAT5	15	18	PF00017	0.364
LIG_SH2_STAT5	261	264	PF00017	0.404
LIG_SH2_STAT5	404	407	PF00017	0.401
LIG_SH2_STAT5	494	497	PF00017	0.404
LIG_SH2_STAT5	518	521	PF00017	0.413
LIG_SH2_STAT5	535	538	PF00017	0.413
LIG_SH2_STAT5	625	628	PF00017	0.360
LIG_SH2_STAT5	642	645	PF00017	0.447
LIG_SH2_STAT5	7	10	PF00017	0.416
LIG_SH2_STAT5	96	99	PF00017	0.387
LIG_SH3_3	555	561	PF00018	0.289
LIG_SH3_4	637	644	PF00018	0.344
LIG_SUMO_SIM_anti_2	354	360	PF11976	0.404
LIG_SUMO_SIM_par_1	575	580	PF11976	0.344
LIG_SUMO_SIM_par_1	652	658	PF11976	0.481
LIG_TRAF2_1	482	485	PF00917	0.344
LIG_TYR_ITIM	13	18	PF00017	0.384
LIG_TYR_ITIM	626	631	PF00017	0.404
LIG_UBA3_1	497	506	PF00899	0.327
LIG_UBA3_1	595	603	PF00899	0.344
LIG_WRC_WIRS_1	107	112	PF05994	0.395
LIG_WRC_WIRS_1	667	672	PF05994	0.404
LIG_WRC_WIRS_1	73	78	PF05994	0.529
LIG_WW_3	157	161	PF00397	0.289
MOD_CDK_SPK_2	25	30	PF00069	0.495
MOD_CDK_SPK_2	6	11	PF00069	0.458
MOD_CDK_SPxK_1	533	539	PF00069	0.481
MOD_CDK_SPxxK_3	25	32	PF00069	0.485
MOD_CK1_1	443	449	PF00069	0.447
MOD_CK1_1	54	60	PF00069	0.387
MOD_CK1_1	650	656	PF00069	0.513
MOD_CK1_1	669	675	PF00069	0.406
MOD_CK1_1	78	84	PF00069	0.399
MOD_CK2_1	126	132	PF00069	0.321
MOD_CK2_1	273	279	PF00069	0.404
MOD_CK2_1	394	400	PF00069	0.283
MOD_CK2_1	478	484	PF00069	0.403
MOD_CK2_1	506	512	PF00069	0.404
MOD_GlcNHglycan	129	132	PF01048	0.482
MOD_GlcNHglycan	300	304	PF01048	0.344
MOD_GlcNHglycan	363	366	PF01048	0.352
MOD_GlcNHglycan	457	460	PF01048	0.404
MOD_GlcNHglycan	611	614	PF01048	0.450
MOD_GlcNHglycan	649	652	PF01048	0.499
MOD_GlcNHglycan	68	71	PF01048	0.382
MOD_GSK3_1	106	113	PF00069	0.389
MOD_GSK3_1	127	134	PF00069	0.563
MOD_GSK3_1	160	167	PF00069	0.353
MOD_N-GLC_1	105	110	PF02516	0.289
MOD_N-GLC_1	168	173	PF02516	0.405
MOD_N-GLC_1	250	255	PF02516	0.507
MOD_N-GLC_1	78	83	PF02516	0.367
MOD_NEK2_1	110	115	PF00069	0.391
MOD_NEK2_1	294	299	PF00069	0.344
MOD_NEK2_1	361	366	PF00069	0.344
MOD_NEK2_1	412	417	PF00069	0.340
MOD_NEK2_1	418	423	PF00069	0.349
MOD_NEK2_1	99	104	PF00069	0.361
MOD_NEK2_2	72	77	PF00069	0.525
MOD_PIKK_1	136	142	PF00454	0.349
MOD_PIKK_1	250	256	PF00454	0.254
MOD_PIKK_1	273	279	PF00454	0.344
MOD_PIKK_1	88	94	PF00454	0.300
MOD_PKA_1	609	615	PF00069	0.446
MOD_PKA_2	378	384	PF00069	0.509
MOD_PKA_2	582	588	PF00069	0.254
MOD_PKA_2	609	615	PF00069	0.464
MOD_PKB_1	581	589	PF00069	0.404
MOD_Plk_1	105	111	PF00069	0.232
MOD_Plk_1	210	216	PF00069	0.404
MOD_Plk_1	250	256	PF00069	0.254
MOD_Plk_1	351	357	PF00069	0.344
MOD_Plk_1	88	94	PF00069	0.352
MOD_Plk_2-3	352	358	PF00069	0.404
MOD_Plk_2-3	403	409	PF00069	0.254
MOD_Plk_2-3	450	456	PF00069	0.404
MOD_Plk_4	198	204	PF00069	0.404
MOD_Plk_4	413	419	PF00069	0.404
MOD_Plk_4	461	467	PF00069	0.375
MOD_Plk_4	471	477	PF00069	0.344
MOD_Plk_4	489	495	PF00069	0.404
MOD_Plk_4	560	566	PF00069	0.254
MOD_Plk_4	616	622	PF00069	0.392
MOD_Plk_4	644	650	PF00069	0.496
MOD_Plk_4	666	672	PF00069	0.404
MOD_ProDKin_1	131	137	PF00069	0.577
MOD_ProDKin_1	164	170	PF00069	0.404
MOD_ProDKin_1	25	31	PF00069	0.428
MOD_ProDKin_1	43	49	PF00069	0.257
MOD_ProDKin_1	51	57	PF00069	0.465
MOD_ProDKin_1	533	539	PF00069	0.344
MOD_ProDKin_1	6	12	PF00069	0.407
MOD_SUMO_for_1	195	198	PF00179	0.481
MOD_SUMO_rev_2	147	154	PF00179	0.398
TRG_DiLeu_BaEn_1	198	203	PF01217	0.481
TRG_DiLeu_BaEn_2	306	312	PF01217	0.344
TRG_DiLeu_BaEn_2	88	94	PF01217	0.528
TRG_DiLeu_LyEn_5	56	61	PF01217	0.430
TRG_ENDOCYTIC_2	101	104	PF00928	0.347
TRG_ENDOCYTIC_2	107	110	PF00928	0.369
TRG_ENDOCYTIC_2	15	18	PF00928	0.379
TRG_ENDOCYTIC_2	267	270	PF00928	0.446
TRG_ENDOCYTIC_2	323	326	PF00928	0.404
TRG_ENDOCYTIC_2	375	378	PF00928	0.344
TRG_ENDOCYTIC_2	472	475	PF00928	0.404
TRG_ENDOCYTIC_2	494	497	PF00928	0.404
TRG_ENDOCYTIC_2	615	618	PF00928	0.337
TRG_ENDOCYTIC_2	628	631	PF00928	0.465
TRG_ENDOCYTIC_2	96	99	PF00928	0.371
TRG_ER_diArg_1	547	550	PF00400	0.348
TRG_NES_CRM1_1	56	71	PF08389	0.516
TRG_NLS_MonoCore_2	635	640	PF00514	0.344
TRG_NLS_MonoExtC_3	242	247	PF00514	0.254
TRG_NLS_MonoExtC_3	635	640	PF00514	0.344
TRG_NLS_MonoExtN_4	635	640	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I084	Leptomonas seymouri	81%	100%
A0A0S4JJ29	Bodo saltans	55%	73%
A0A3S7WP65	Leishmania donovani	89%	100%
A4HSL8	Leishmania infantum	89%	100%
A7RZW4	Nematostella vectensis	43%	93%
E9AKK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O55096	Rattus norvegicus	43%	92%
Q08225	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
Q4QJA6	Leishmania major	88%	100%
Q557H1	Dictyostelium discoideum	43%	98%
Q99KK7	Mus musculus	43%	92%
Q9NY33	Homo sapiens	43%	92%
Q9VHR8	Drosophila melanogaster	42%	86%