Putative glutaminyl cyclase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaminyl cyclase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4D8_LEIBR

TriTrypDb:

LbrM.05.0930 , LBRM2903_050015300 , LBRM2903_050015400

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H4D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018199	peptidyl-glutamine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016603	glutaminyl-peptide cyclotransferase activity	4	5
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016755	aminoacyltransferase activity	3	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.524
CLV_C14_Caspase3-7	180	184	PF00656	0.468
CLV_C14_Caspase3-7	220	224	PF00656	0.494
CLV_NRD_NRD_1	10	12	PF00675	0.504
CLV_NRD_NRD_1	122	124	PF00675	0.708
CLV_NRD_NRD_1	139	141	PF00675	0.582
CLV_NRD_NRD_1	17	19	PF00675	0.454
CLV_NRD_NRD_1	200	202	PF00675	0.589
CLV_NRD_NRD_1	237	239	PF00675	0.684
CLV_NRD_NRD_1	328	330	PF00675	0.604
CLV_NRD_NRD_1	353	355	PF00675	0.703
CLV_NRD_NRD_1	359	361	PF00675	0.701
CLV_NRD_NRD_1	46	48	PF00675	0.294
CLV_NRD_NRD_1	679	681	PF00675	0.572
CLV_NRD_NRD_1	735	737	PF00675	0.707
CLV_NRD_NRD_1	825	827	PF00675	0.652
CLV_NRD_NRD_1	892	894	PF00675	0.675
CLV_PCSK_KEX2_1	139	141	PF00082	0.712
CLV_PCSK_KEX2_1	17	19	PF00082	0.449
CLV_PCSK_KEX2_1	200	202	PF00082	0.589
CLV_PCSK_KEX2_1	221	223	PF00082	0.635
CLV_PCSK_KEX2_1	236	238	PF00082	0.631
CLV_PCSK_KEX2_1	29	31	PF00082	0.434
CLV_PCSK_KEX2_1	328	330	PF00082	0.604
CLV_PCSK_KEX2_1	352	354	PF00082	0.707
CLV_PCSK_KEX2_1	46	48	PF00082	0.311
CLV_PCSK_KEX2_1	678	680	PF00082	0.534
CLV_PCSK_KEX2_1	734	736	PF00082	0.703
CLV_PCSK_KEX2_1	825	827	PF00082	0.661
CLV_PCSK_KEX2_1	9	11	PF00082	0.513
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.635
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.450
CLV_PCSK_SKI1_1	147	151	PF00082	0.688
CLV_PCSK_SKI1_1	222	226	PF00082	0.742
CLV_PCSK_SKI1_1	263	267	PF00082	0.649
CLV_PCSK_SKI1_1	361	365	PF00082	0.792
CLV_PCSK_SKI1_1	397	401	PF00082	0.768
CLV_PCSK_SKI1_1	408	412	PF00082	0.760
CLV_PCSK_SKI1_1	46	50	PF00082	0.284
CLV_PCSK_SKI1_1	473	477	PF00082	0.478
CLV_PCSK_SKI1_1	735	739	PF00082	0.728
DEG_APCC_DBOX_1	138	146	PF00400	0.504
DEG_APCC_DBOX_1	45	53	PF00400	0.481
DEG_APCC_DBOX_1	524	532	PF00400	0.408
DEG_APCC_DBOX_1	574	582	PF00400	0.338
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DOC_CYCLIN_RxL_1	732	742	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.399
DOC_MAPK_DCC_7	29	37	PF00069	0.618
DOC_MAPK_DCC_7	845	854	PF00069	0.400
DOC_MAPK_FxFP_2	192	195	PF00069	0.442
DOC_MAPK_FxFP_2	319	322	PF00069	0.344
DOC_MAPK_gen_1	29	37	PF00069	0.618
DOC_MAPK_gen_1	43	52	PF00069	0.490
DOC_MAPK_gen_1	708	717	PF00069	0.456
DOC_MAPK_MEF2A_6	29	37	PF00069	0.618
DOC_MAPK_MEF2A_6	46	54	PF00069	0.492
DOC_MAPK_MEF2A_6	569	576	PF00069	0.343
DOC_MAPK_MEF2A_6	845	854	PF00069	0.400
DOC_MAPK_RevD_3	224	238	PF00069	0.457
DOC_PP2B_LxvP_1	193	196	PF13499	0.438
DOC_PP2B_PxIxI_1	584	590	PF00149	0.358
DOC_PP4_FxxP_1	192	195	PF00568	0.442
DOC_PP4_FxxP_1	319	322	PF00568	0.348
DOC_PP4_FxxP_1	545	548	PF00568	0.403
DOC_PP4_FxxP_1	815	818	PF00568	0.406
DOC_USP7_MATH_1	149	153	PF00917	0.515
DOC_USP7_MATH_1	176	180	PF00917	0.396
DOC_USP7_MATH_1	264	268	PF00917	0.432
DOC_USP7_MATH_1	322	326	PF00917	0.344
DOC_USP7_MATH_1	335	339	PF00917	0.506
DOC_USP7_MATH_1	461	465	PF00917	0.298
DOC_USP7_MATH_1	660	664	PF00917	0.432
DOC_USP7_MATH_1	796	800	PF00917	0.560
DOC_USP7_MATH_1	85	89	PF00917	0.566
DOC_USP7_UBL2_3	565	569	PF12436	0.417
DOC_WW_Pin1_4	157	162	PF00397	0.409
DOC_WW_Pin1_4	18	23	PF00397	0.578
DOC_WW_Pin1_4	251	256	PF00397	0.536
DOC_WW_Pin1_4	409	414	PF00397	0.496
DOC_WW_Pin1_4	530	535	PF00397	0.408
DOC_WW_Pin1_4	617	622	PF00397	0.421
DOC_WW_Pin1_4	718	723	PF00397	0.487
DOC_WW_Pin1_4	76	81	PF00397	0.516
DOC_WW_Pin1_4	814	819	PF00397	0.410
DOC_WW_Pin1_4	99	104	PF00397	0.460
LIG_14-3-3_CanoR_1	10	16	PF00244	0.623
LIG_14-3-3_CanoR_1	139	143	PF00244	0.513
LIG_14-3-3_CanoR_1	290	296	PF00244	0.357
LIG_14-3-3_CanoR_1	41	50	PF00244	0.644
LIG_14-3-3_CanoR_1	516	522	PF00244	0.419
LIG_14-3-3_CanoR_1	527	532	PF00244	0.395
LIG_14-3-3_CanoR_1	547	552	PF00244	0.341
LIG_14-3-3_CanoR_1	615	621	PF00244	0.471
LIG_14-3-3_CanoR_1	625	635	PF00244	0.450
LIG_14-3-3_CanoR_1	683	692	PF00244	0.343
LIG_Actin_RPEL_3	737	756	PF02755	0.500
LIG_Actin_WH2_2	25	40	PF00022	0.551
LIG_BIR_III_4	414	418	PF00653	0.535
LIG_BRCT_BRCA1_1	188	192	PF00533	0.493
LIG_BRCT_BRCA1_1	449	453	PF00533	0.337
LIG_BRCT_BRCA1_1	662	666	PF00533	0.431
LIG_deltaCOP1_diTrp_1	286	295	PF00928	0.428
LIG_eIF4E_1	636	642	PF01652	0.376
LIG_FHA_1	297	303	PF00498	0.429
LIG_FHA_1	405	411	PF00498	0.548
LIG_FHA_1	43	49	PF00498	0.605
LIG_FHA_1	618	624	PF00498	0.510
LIG_FHA_1	828	834	PF00498	0.391
LIG_FHA_1	841	847	PF00498	0.420
LIG_FHA_1	871	877	PF00498	0.351
LIG_FHA_2	131	137	PF00498	0.447
LIG_FHA_2	158	164	PF00498	0.500
LIG_FHA_2	218	224	PF00498	0.445
LIG_FHA_2	353	359	PF00498	0.609
LIG_FHA_2	518	524	PF00498	0.537
LIG_FHA_2	77	83	PF00498	0.531
LIG_FHA_2	770	776	PF00498	0.506
LIG_FHA_2	858	864	PF00498	0.451
LIG_FHA_2	870	876	PF00498	0.341
LIG_FHA_2	881	887	PF00498	0.332
LIG_FXI_DFP_1	453	457	PF00024	0.412
LIG_LIR_Apic_2	189	195	PF02991	0.505
LIG_LIR_Gen_1	185	195	PF02991	0.495
LIG_LIR_Gen_1	21	32	PF02991	0.680
LIG_LIR_Gen_1	292	303	PF02991	0.358
LIG_LIR_Gen_1	450	461	PF02991	0.337
LIG_LIR_Gen_1	634	644	PF02991	0.314
LIG_LIR_Gen_1	712	722	PF02991	0.480
LIG_LIR_Gen_1	780	788	PF02991	0.553
LIG_LIR_Gen_1	804	814	PF02991	0.347
LIG_LIR_Nem_3	133	137	PF02991	0.442
LIG_LIR_Nem_3	185	190	PF02991	0.446
LIG_LIR_Nem_3	21	27	PF02991	0.685
LIG_LIR_Nem_3	292	298	PF02991	0.349
LIG_LIR_Nem_3	450	456	PF02991	0.288
LIG_LIR_Nem_3	634	639	PF02991	0.320
LIG_LIR_Nem_3	640	645	PF02991	0.306
LIG_LIR_Nem_3	712	717	PF02991	0.479
LIG_LIR_Nem_3	753	757	PF02991	0.425
LIG_LIR_Nem_3	780	785	PF02991	0.549
LIG_LIR_Nem_3	804	809	PF02991	0.394
LIG_MAD2	845	853	PF02301	0.337
LIG_MLH1_MIPbox_1	449	453	PF16413	0.337
LIG_MYND_1	251	255	PF01753	0.481
LIG_NRBOX	527	533	PF00104	0.396
LIG_NRBOX	62	68	PF00104	0.317
LIG_NRBOX	875	881	PF00104	0.409
LIG_PCNA_yPIPBox_3	429	443	PF02747	0.346
LIG_Pex14_1	448	452	PF04695	0.337
LIG_Pex14_2	854	858	PF04695	0.377
LIG_PTB_Apo_2	313	320	PF02174	0.409
LIG_Rb_pABgroove_1	639	647	PF01858	0.308
LIG_REV1ctd_RIR_1	542	547	PF16727	0.450
LIG_SH2_CRK	667	671	PF00017	0.375
LIG_SH2_CRK	757	761	PF00017	0.425
LIG_SH2_CRK	788	792	PF00017	0.357
LIG_SH2_GRB2like	806	809	PF00017	0.453
LIG_SH2_NCK_1	636	640	PF00017	0.381
LIG_SH2_SRC	806	809	PF00017	0.347
LIG_SH2_STAP1	684	688	PF00017	0.450
LIG_SH2_STAT3	492	495	PF00017	0.340
LIG_SH2_STAT3	659	662	PF00017	0.383
LIG_SH2_STAT5	452	455	PF00017	0.398
LIG_SH2_STAT5	543	546	PF00017	0.386
LIG_SH2_STAT5	69	72	PF00017	0.390
LIG_SH2_STAT5	806	809	PF00017	0.472
LIG_SH3_3	245	251	PF00018	0.501
LIG_SH3_3	266	272	PF00018	0.463
LIG_SH3_3	390	396	PF00018	0.560
LIG_SH3_3	407	413	PF00018	0.511
LIG_SH3_3	418	424	PF00018	0.475
LIG_SH3_3	745	751	PF00018	0.447
LIG_SH3_3	77	83	PF00018	0.532
LIG_SH3_3	849	855	PF00018	0.346
LIG_SH3_3	97	103	PF00018	0.484
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.304
LIG_SUMO_SIM_par_1	160	167	PF11976	0.390
LIG_SUMO_SIM_par_1	762	768	PF11976	0.446
LIG_SUMO_SIM_par_1	882	889	PF11976	0.394
LIG_TRAF2_1	819	822	PF00917	0.461
LIG_TYR_ITIM	665	670	PF00017	0.373
LIG_UBA3_1	471	476	PF00899	0.278
MOD_CDK_SPK_2	251	256	PF00069	0.484
MOD_CDK_SPxxK_3	409	416	PF00069	0.535
MOD_CK1_1	102	108	PF00069	0.473
MOD_CK1_1	530	536	PF00069	0.465
MOD_CK1_1	619	625	PF00069	0.444
MOD_CK1_1	686	692	PF00069	0.429
MOD_CK1_1	74	80	PF00069	0.499
MOD_CK1_1	743	749	PF00069	0.444
MOD_CK1_1	827	833	PF00069	0.432
MOD_CK1_1	857	863	PF00069	0.459
MOD_CK2_1	130	136	PF00069	0.499
MOD_CK2_1	149	155	PF00069	0.381
MOD_CK2_1	307	313	PF00069	0.461
MOD_CK2_1	517	523	PF00069	0.420
MOD_CK2_1	76	82	PF00069	0.520
MOD_CK2_1	816	822	PF00069	0.510
MOD_CK2_1	880	886	PF00069	0.335
MOD_CK2_1	889	895	PF00069	0.489
MOD_CMANNOS	577	580	PF00535	0.528
MOD_Cter_Amidation	15	18	PF01082	0.451
MOD_Cter_Amidation	234	237	PF01082	0.690
MOD_GlcNHglycan	426	429	PF01048	0.786
MOD_GlcNHglycan	463	466	PF01048	0.490
MOD_GlcNHglycan	497	500	PF01048	0.744
MOD_GlcNHglycan	662	665	PF01048	0.580
MOD_GlcNHglycan	685	688	PF01048	0.688
MOD_GlcNHglycan	698	702	PF01048	0.645
MOD_GSK3_1	37	44	PF00069	0.629
MOD_GSK3_1	511	518	PF00069	0.345
MOD_GSK3_1	52	59	PF00069	0.234
MOD_GSK3_1	619	626	PF00069	0.386
MOD_GSK3_1	631	638	PF00069	0.355
MOD_GSK3_1	651	658	PF00069	0.302
MOD_GSK3_1	682	689	PF00069	0.409
MOD_GSK3_1	72	79	PF00069	0.373
MOD_GSK3_1	746	753	PF00069	0.465
MOD_GSK3_1	765	772	PF00069	0.388
MOD_N-GLC_1	296	301	PF02516	0.553
MOD_N-GLC_1	516	521	PF02516	0.678
MOD_N-GLC_1	740	745	PF02516	0.711
MOD_NEK2_1	186	191	PF00069	0.551
MOD_NEK2_1	23	28	PF00069	0.603
MOD_NEK2_1	37	42	PF00069	0.605
MOD_NEK2_1	488	493	PF00069	0.429
MOD_NEK2_1	511	516	PF00069	0.404
MOD_NEK2_1	56	61	PF00069	0.376
MOD_NEK2_1	655	660	PF00069	0.310
MOD_NEK2_1	682	687	PF00069	0.432
MOD_NEK2_1	879	884	PF00069	0.338
MOD_NEK2_2	651	656	PF00069	0.339
MOD_PIKK_1	322	328	PF00454	0.337
MOD_PIKK_1	377	383	PF00454	0.546
MOD_PIKK_1	432	438	PF00454	0.491
MOD_PIKK_1	658	664	PF00454	0.375
MOD_PIKK_1	840	846	PF00454	0.351
MOD_PK_1	547	553	PF00069	0.499
MOD_PKA_1	352	358	PF00069	0.543
MOD_PKA_2	130	136	PF00069	0.499
MOD_PKA_2	138	144	PF00069	0.445
MOD_PKA_2	289	295	PF00069	0.365
MOD_PKA_2	352	358	PF00069	0.502
MOD_PKA_2	37	43	PF00069	0.573
MOD_PKA_2	495	501	PF00069	0.375
MOD_PKA_2	515	521	PF00069	0.344
MOD_PKA_2	626	632	PF00069	0.407
MOD_PKA_2	672	678	PF00069	0.337
MOD_PKA_2	682	688	PF00069	0.329
MOD_PKA_2	743	749	PF00069	0.444
MOD_PKA_2	789	795	PF00069	0.359
MOD_PKA_2	824	830	PF00069	0.381
MOD_PKB_1	525	533	PF00069	0.457
MOD_PKB_1	9	17	PF00069	0.622
MOD_Plk_1	516	522	PF00069	0.353
MOD_Plk_1	604	610	PF00069	0.348
MOD_Plk_1	697	703	PF00069	0.492
MOD_Plk_2-3	775	781	PF00069	0.371
MOD_Plk_4	130	136	PF00069	0.441
MOD_Plk_4	149	155	PF00069	0.436
MOD_Plk_4	23	29	PF00069	0.581
MOD_Plk_4	374	380	PF00069	0.508
MOD_Plk_4	503	509	PF00069	0.386
MOD_Plk_4	527	533	PF00069	0.483
MOD_Plk_4	56	62	PF00069	0.376
MOD_Plk_4	619	625	PF00069	0.449
MOD_Plk_4	631	637	PF00069	0.309
MOD_Plk_4	710	716	PF00069	0.359
MOD_Plk_4	743	749	PF00069	0.378
MOD_Plk_4	827	833	PF00069	0.367
MOD_Plk_4	880	886	PF00069	0.335
MOD_ProDKin_1	157	163	PF00069	0.408
MOD_ProDKin_1	18	24	PF00069	0.574
MOD_ProDKin_1	251	257	PF00069	0.531
MOD_ProDKin_1	409	415	PF00069	0.494
MOD_ProDKin_1	530	536	PF00069	0.406
MOD_ProDKin_1	617	623	PF00069	0.427
MOD_ProDKin_1	718	724	PF00069	0.483
MOD_ProDKin_1	76	82	PF00069	0.521
MOD_ProDKin_1	814	820	PF00069	0.412
MOD_ProDKin_1	99	105	PF00069	0.460
MOD_SUMO_for_1	415	418	PF00179	0.410
MOD_SUMO_rev_2	301	310	PF00179	0.354
MOD_SUMO_rev_2	358	363	PF00179	0.538
TRG_DiLeu_BaEn_1	313	318	PF01217	0.410
TRG_DiLeu_BaEn_3	804	810	PF01217	0.351
TRG_DiLeu_BaLyEn_6	713	718	PF01217	0.479
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.502
TRG_ENDOCYTIC_2	134	137	PF00928	0.440
TRG_ENDOCYTIC_2	541	544	PF00928	0.495
TRG_ENDOCYTIC_2	636	639	PF00928	0.356
TRG_ENDOCYTIC_2	645	648	PF00928	0.278
TRG_ENDOCYTIC_2	667	670	PF00928	0.372
TRG_ENDOCYTIC_2	788	791	PF00928	0.432
TRG_ENDOCYTIC_2	806	809	PF00928	0.347
TRG_ER_diArg_1	200	202	PF00400	0.389
TRG_ER_diArg_1	236	238	PF00400	0.489
TRG_ER_diArg_1	327	329	PF00400	0.385
TRG_ER_diArg_1	352	354	PF00400	0.552
TRG_ER_diArg_1	46	48	PF00400	0.507
TRG_ER_diArg_1	624	627	PF00400	0.543
TRG_ER_diArg_1	677	680	PF00400	0.452
TRG_ER_diArg_1	733	736	PF00400	0.446
TRG_ER_diArg_1	824	826	PF00400	0.444
TRG_ER_diArg_1	9	11	PF00400	0.709
TRG_NES_CRM1_1	633	646	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	611	616	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	771	775	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR2	Leptomonas seymouri	51%	98%
A0A3S7WP80	Leishmania donovani	81%	99%
A4HSL7	Leishmania infantum	81%	99%
E9AKK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QJA7	Leishmania major	80%	100%