Putative paraflagellar rod protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4D5_LEIBR

TriTrypDb:

LbrM.05.0900 , LBRM2903_050015000

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0031514	motile cilium	5	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4H4D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005516	calmodulin binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.544
CLV_C14_Caspase3-7	91	95	PF00656	0.587
CLV_NRD_NRD_1	228	230	PF00675	0.638
CLV_NRD_NRD_1	29	31	PF00675	0.599
CLV_NRD_NRD_1	396	398	PF00675	0.522
CLV_NRD_NRD_1	497	499	PF00675	0.312
CLV_NRD_NRD_1	632	634	PF00675	0.312
CLV_NRD_NRD_1	741	743	PF00675	0.394
CLV_NRD_NRD_1	937	939	PF00675	0.569
CLV_PCSK_FUR_1	394	398	PF00082	0.357
CLV_PCSK_KEX2_1	187	189	PF00082	0.827
CLV_PCSK_KEX2_1	228	230	PF00082	0.627
CLV_PCSK_KEX2_1	29	31	PF00082	0.692
CLV_PCSK_KEX2_1	396	398	PF00082	0.522
CLV_PCSK_KEX2_1	496	498	PF00082	0.312
CLV_PCSK_KEX2_1	741	743	PF00082	0.388
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.712
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.312
CLV_PCSK_PC7_1	392	398	PF00082	0.514
CLV_PCSK_PC7_1	492	498	PF00082	0.312
CLV_PCSK_SKI1_1	218	222	PF00082	0.558
CLV_PCSK_SKI1_1	396	400	PF00082	0.524
CLV_PCSK_SKI1_1	465	469	PF00082	0.403
CLV_PCSK_SKI1_1	802	806	PF00082	0.699
CLV_PCSK_SKI1_1	884	888	PF00082	0.517
DEG_APCC_DBOX_1	391	399	PF00400	0.435
DEG_SPOP_SBC_1	836	840	PF00917	0.630
DEG_SPOP_SBC_1	933	937	PF00917	0.563
DOC_CKS1_1	250	255	PF01111	0.511
DOC_CKS1_1	64	69	PF01111	0.707
DOC_CYCLIN_RxL_1	636	649	PF00134	0.302
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.600
DOC_MAPK_gen_1	392	400	PF00069	0.441
DOC_MAPK_MEF2A_6	322	330	PF00069	0.501
DOC_MAPK_MEF2A_6	482	490	PF00069	0.291
DOC_PP2B_LxvP_1	141	144	PF13499	0.479
DOC_PP2B_LxvP_1	151	154	PF13499	0.636
DOC_PP4_FxxP_1	245	248	PF00568	0.556
DOC_PP4_FxxP_1	732	735	PF00568	0.312
DOC_PP4_FxxP_1	775	778	PF00568	0.512
DOC_USP7_MATH_1	112	116	PF00917	0.516
DOC_USP7_MATH_1	121	125	PF00917	0.652
DOC_USP7_MATH_1	15	19	PF00917	0.540
DOC_USP7_MATH_1	248	252	PF00917	0.529
DOC_USP7_MATH_1	854	858	PF00917	0.571
DOC_USP7_MATH_2	735	741	PF00917	0.231
DOC_WW_Pin1_4	10	15	PF00397	0.603
DOC_WW_Pin1_4	110	115	PF00397	0.584
DOC_WW_Pin1_4	134	139	PF00397	0.608
DOC_WW_Pin1_4	144	149	PF00397	0.635
DOC_WW_Pin1_4	213	218	PF00397	0.632
DOC_WW_Pin1_4	246	251	PF00397	0.499
DOC_WW_Pin1_4	50	55	PF00397	0.553
DOC_WW_Pin1_4	63	68	PF00397	0.784
DOC_WW_Pin1_4	731	736	PF00397	0.352
DOC_WW_Pin1_4	773	778	PF00397	0.694
DOC_WW_Pin1_4	817	822	PF00397	0.627
DOC_WW_Pin1_4	837	842	PF00397	0.605
DOC_WW_Pin1_4	876	881	PF00397	0.685
DOC_WW_Pin1_4	895	900	PF00397	0.559
DOC_WW_Pin1_4	929	934	PF00397	0.549
LIG_14-3-3_CanoR_1	120	128	PF00244	0.490
LIG_14-3-3_CanoR_1	196	204	PF00244	0.639
LIG_14-3-3_CanoR_1	20	28	PF00244	0.496
LIG_14-3-3_CanoR_1	362	368	PF00244	0.322
LIG_14-3-3_CanoR_1	497	501	PF00244	0.253
LIG_14-3-3_CanoR_1	506	512	PF00244	0.380
LIG_14-3-3_CanoR_1	797	805	PF00244	0.605
LIG_14-3-3_CanoR_1	826	836	PF00244	0.671
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_FHA_1	301	307	PF00498	0.614
LIG_FHA_1	311	317	PF00498	0.504
LIG_FHA_1	366	372	PF00498	0.403
LIG_FHA_1	457	463	PF00498	0.413
LIG_FHA_1	467	473	PF00498	0.281
LIG_FHA_1	478	484	PF00498	0.312
LIG_FHA_1	719	725	PF00498	0.460
LIG_FHA_2	135	141	PF00498	0.372
LIG_FHA_2	230	236	PF00498	0.595
LIG_FHA_2	381	387	PF00498	0.439
LIG_FHA_2	522	528	PF00498	0.388
LIG_FHA_2	644	650	PF00498	0.312
LIG_Integrin_RGD_1	868	870	PF01839	0.545
LIG_LIR_Apic_2	366	370	PF02991	0.448
LIG_LIR_Apic_2	731	735	PF02991	0.327
LIG_LIR_Apic_2	774	778	PF02991	0.513
LIG_LIR_Gen_1	125	136	PF02991	0.431
LIG_LIR_Gen_1	239	248	PF02991	0.582
LIG_LIR_Gen_1	320	330	PF02991	0.628
LIG_LIR_Nem_3	125	131	PF02991	0.447
LIG_LIR_Nem_3	239	244	PF02991	0.500
LIG_LIR_Nem_3	320	326	PF02991	0.651
LIG_LIR_Nem_3	58	64	PF02991	0.551
LIG_LIR_Nem_3	638	643	PF02991	0.388
LIG_LIR_Nem_3	666	670	PF02991	0.302
LIG_LIR_Nem_3	752	756	PF02991	0.312
LIG_LIR_Nem_3	859	865	PF02991	0.540
LIG_LYPXL_yS_3	862	865	PF13949	0.537
LIG_NRBOX	374	380	PF00104	0.406
LIG_NRP_CendR_1	942	943	PF00754	0.702
LIG_PCNA_yPIPBox_3	589	600	PF02747	0.388
LIG_RPA_C_Fungi	115	127	PF08784	0.599
LIG_SH2_CRK	241	245	PF00017	0.578
LIG_SH2_CRK	533	537	PF00017	0.231
LIG_SH2_CRK	753	757	PF00017	0.312
LIG_SH2_NCK_1	38	42	PF00017	0.514
LIG_SH2_NCK_1	426	430	PF00017	0.398
LIG_SH2_SRC	38	41	PF00017	0.592
LIG_SH2_STAP1	241	245	PF00017	0.502
LIG_SH2_STAT3	425	428	PF00017	0.404
LIG_SH2_STAT3	668	671	PF00017	0.350
LIG_SH2_STAT5	644	647	PF00017	0.312
LIG_SH2_STAT5	668	671	PF00017	0.312
LIG_SH3_3	151	157	PF00018	0.669
LIG_SH3_3	247	253	PF00018	0.572
LIG_SH3_3	451	457	PF00018	0.409
LIG_SH3_3	61	67	PF00018	0.713
LIG_SH3_3	675	681	PF00018	0.229
LIG_SH3_3	809	815	PF00018	0.676
LIG_SH3_3	822	828	PF00018	0.570
LIG_SH3_CIN85_PxpxPR_1	821	826	PF14604	0.551
LIG_TRAF2_1	383	386	PF00917	0.436
LIG_TRAF2_1	734	737	PF00917	0.388
LIG_TRAF2_1	907	910	PF00917	0.604
LIG_TYR_ITIM	665	670	PF00017	0.302
LIG_TYR_ITIM	751	756	PF00017	0.312
LIG_WRC_WIRS_1	220	225	PF05994	0.536
LIG_WW_3	811	815	PF00397	0.685
MOD_CDK_SPK_2	213	218	PF00069	0.687
MOD_CK1_1	197	203	PF00069	0.824
MOD_CK1_1	249	255	PF00069	0.516
MOD_CK1_1	300	306	PF00069	0.668
MOD_CK1_1	380	386	PF00069	0.437
MOD_CK1_1	481	487	PF00069	0.388
MOD_CK1_1	510	516	PF00069	0.231
MOD_CK1_1	7	13	PF00069	0.658
MOD_CK1_1	740	746	PF00069	0.315
MOD_CK1_1	771	777	PF00069	0.711
MOD_CK1_1	789	795	PF00069	0.671
MOD_CK1_1	837	843	PF00069	0.645
MOD_CK1_1	84	90	PF00069	0.646
MOD_CK1_1	904	910	PF00069	0.640
MOD_CK1_1	92	98	PF00069	0.665
MOD_CK1_1	932	938	PF00069	0.728
MOD_CK2_1	134	140	PF00069	0.367
MOD_CK2_1	229	235	PF00069	0.606
MOD_CK2_1	301	307	PF00069	0.569
MOD_CK2_1	380	386	PF00069	0.434
MOD_CK2_1	387	393	PF00069	0.437
MOD_CK2_1	427	433	PF00069	0.429
MOD_CK2_1	731	737	PF00069	0.316
MOD_CK2_1	904	910	PF00069	0.526
MOD_GlcNHglycan	196	199	PF01048	0.801
MOD_GlcNHglycan	21	24	PF01048	0.608
MOD_GlcNHglycan	211	214	PF01048	0.627
MOD_GlcNHglycan	581	584	PF01048	0.255
MOD_GlcNHglycan	602	605	PF01048	0.334
MOD_GlcNHglycan	770	773	PF01048	0.583
MOD_GlcNHglycan	788	791	PF01048	0.590
MOD_GlcNHglycan	91	94	PF01048	0.713
MOD_GlcNHglycan	95	98	PF01048	0.790
MOD_GSK3_1	1	8	PF00069	0.633
MOD_GSK3_1	15	22	PF00069	0.528
MOD_GSK3_1	188	195	PF00069	0.670
MOD_GSK3_1	209	216	PF00069	0.656
MOD_GSK3_1	229	236	PF00069	0.503
MOD_GSK3_1	297	304	PF00069	0.699
MOD_GSK3_1	466	473	PF00069	0.412
MOD_GSK3_1	477	484	PF00069	0.355
MOD_GSK3_1	510	517	PF00069	0.465
MOD_GSK3_1	740	747	PF00069	0.415
MOD_GSK3_1	76	83	PF00069	0.590
MOD_GSK3_1	763	770	PF00069	0.772
MOD_GSK3_1	791	798	PF00069	0.594
MOD_GSK3_1	84	91	PF00069	0.622
MOD_GSK3_1	854	861	PF00069	0.538
MOD_GSK3_1	900	907	PF00069	0.700
MOD_GSK3_1	929	936	PF00069	0.766
MOD_LATS_1	824	830	PF00433	0.548
MOD_N-GLC_1	171	176	PF02516	0.688
MOD_N-GLC_1	192	197	PF02516	0.643
MOD_N-GLC_1	478	483	PF02516	0.231
MOD_N-GLC_1	929	934	PF02516	0.565
MOD_N-GLC_2	848	850	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.809
MOD_NEK2_1	263	268	PF00069	0.409
MOD_NEK2_1	333	338	PF00069	0.528
MOD_NEK2_1	442	447	PF00069	0.350
MOD_NEK2_1	467	472	PF00069	0.482
MOD_NEK2_1	585	590	PF00069	0.312
MOD_NEK2_1	625	630	PF00069	0.471
MOD_NEK2_1	643	648	PF00069	0.341
MOD_NEK2_1	779	784	PF00069	0.586
MOD_NEK2_1	858	863	PF00069	0.672
MOD_NEK2_1	875	880	PF00069	0.634
MOD_NEK2_1	887	892	PF00069	0.489
MOD_NEK2_1	901	906	PF00069	0.518
MOD_NEK2_1	934	939	PF00069	0.563
MOD_PIKK_1	1	7	PF00454	0.540
MOD_PIKK_1	263	269	PF00454	0.456
MOD_PIKK_1	352	358	PF00454	0.594
MOD_PIKK_1	365	371	PF00454	0.370
MOD_PIKK_1	39	45	PF00454	0.524
MOD_PIKK_1	467	473	PF00454	0.363
MOD_PIKK_1	585	591	PF00454	0.342
MOD_PIKK_1	625	631	PF00454	0.315
MOD_PIKK_1	684	690	PF00454	0.225
MOD_PIKK_1	740	746	PF00454	0.329
MOD_PIKK_1	76	82	PF00454	0.542
MOD_PKA_1	496	502	PF00069	0.225
MOD_PKA_2	19	25	PF00069	0.490
MOD_PKA_2	342	348	PF00069	0.462
MOD_PKA_2	496	502	PF00069	0.225
MOD_PKA_2	507	513	PF00069	0.225
MOD_PKA_2	718	724	PF00069	0.312
MOD_PKA_2	740	746	PF00069	0.410
MOD_PKA_2	763	769	PF00069	0.601
MOD_PKA_2	798	804	PF00069	0.598
MOD_PKB_1	924	932	PF00069	0.705
MOD_Plk_1	442	448	PF00069	0.425
MOD_Plk_1	807	813	PF00069	0.537
MOD_Plk_2-3	171	177	PF00069	0.543
MOD_Plk_2-3	427	433	PF00069	0.476
MOD_Plk_4	233	239	PF00069	0.425
MOD_Plk_4	442	448	PF00069	0.322
MOD_ProDKin_1	10	16	PF00069	0.597
MOD_ProDKin_1	110	116	PF00069	0.580
MOD_ProDKin_1	134	140	PF00069	0.614
MOD_ProDKin_1	144	150	PF00069	0.640
MOD_ProDKin_1	213	219	PF00069	0.633
MOD_ProDKin_1	246	252	PF00069	0.505
MOD_ProDKin_1	50	56	PF00069	0.557
MOD_ProDKin_1	63	69	PF00069	0.781
MOD_ProDKin_1	731	737	PF00069	0.352
MOD_ProDKin_1	773	779	PF00069	0.692
MOD_ProDKin_1	817	823	PF00069	0.622
MOD_ProDKin_1	837	843	PF00069	0.603
MOD_ProDKin_1	876	882	PF00069	0.685
MOD_ProDKin_1	895	901	PF00069	0.562
MOD_ProDKin_1	929	935	PF00069	0.549
MOD_SUMO_for_1	696	699	PF00179	0.312
MOD_SUMO_rev_2	870	875	PF00179	0.542
TRG_AP2beta_CARGO_1	125	135	PF09066	0.434
TRG_DiLeu_BaEn_1	463	468	PF01217	0.461
TRG_DiLeu_BaEn_1	752	757	PF01217	0.312
TRG_DiLeu_BaEn_2	547	553	PF01217	0.231
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.398
TRG_ENDOCYTIC_2	241	244	PF00928	0.574
TRG_ENDOCYTIC_2	439	442	PF00928	0.446
TRG_ENDOCYTIC_2	533	536	PF00928	0.312
TRG_ENDOCYTIC_2	644	647	PF00928	0.312
TRG_ENDOCYTIC_2	667	670	PF00928	0.302
TRG_ENDOCYTIC_2	753	756	PF00928	0.334
TRG_ENDOCYTIC_2	862	865	PF00928	0.537
TRG_ER_diArg_1	228	231	PF00400	0.520
TRG_ER_diArg_1	275	278	PF00400	0.398
TRG_ER_diArg_1	28	30	PF00400	0.600
TRG_ER_diArg_1	394	397	PF00400	0.513
TRG_ER_diArg_1	710	713	PF00400	0.312
TRG_ER_diArg_1	796	799	PF00400	0.530
TRG_NES_CRM1_1	635	649	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P7	Leptomonas seymouri	44%	93%
A0A3S5H5K8	Leishmania donovani	64%	87%
A4HSL4	Leishmania infantum	64%	87%
E9AKJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	88%
Q4QJB0	Leishmania major	62%	100%