Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4D3_LEIBR

TriTrypDb:

LbrM.05.0880 , LBRM2903_050014900

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.516
CLV_C14_Caspase3-7	40	44	PF00656	0.607
CLV_NRD_NRD_1	151	153	PF00675	0.601
CLV_NRD_NRD_1	182	184	PF00675	0.544
CLV_NRD_NRD_1	351	353	PF00675	0.549
CLV_NRD_NRD_1	355	357	PF00675	0.532
CLV_NRD_NRD_1	38	40	PF00675	0.522
CLV_NRD_NRD_1	508	510	PF00675	0.608
CLV_PCSK_FUR_1	149	153	PF00082	0.602
CLV_PCSK_KEX2_1	149	151	PF00082	0.594
CLV_PCSK_KEX2_1	250	252	PF00082	0.615
CLV_PCSK_KEX2_1	32	34	PF00082	0.506
CLV_PCSK_KEX2_1	351	353	PF00082	0.549
CLV_PCSK_KEX2_1	355	357	PF00082	0.532
CLV_PCSK_KEX2_1	38	40	PF00082	0.510
CLV_PCSK_KEX2_1	508	510	PF00082	0.608
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.634
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.506
CLV_PCSK_PC7_1	351	357	PF00082	0.432
CLV_PCSK_SKI1_1	168	172	PF00082	0.541
CLV_PCSK_SKI1_1	281	285	PF00082	0.413
CLV_PCSK_SKI1_1	351	355	PF00082	0.487
CLV_PCSK_SKI1_1	410	414	PF00082	0.546
CLV_PCSK_SKI1_1	495	499	PF00082	0.505
DEG_APCC_DBOX_1	350	358	PF00400	0.558
DEG_APCC_DBOX_1	507	515	PF00400	0.633
DEG_APCC_DBOX_1	66	74	PF00400	0.480
DEG_SCF_FBW7_1	218	225	PF00400	0.571
DOC_ANK_TNKS_1	708	715	PF00023	0.515
DOC_CKS1_1	329	334	PF01111	0.642
DOC_CKS1_1	655	660	PF01111	0.575
DOC_CYCLIN_RxL_1	47	57	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	268	274	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	655	661	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	732	735	PF00134	0.604
DOC_MAPK_gen_1	281	291	PF00069	0.442
DOC_MAPK_gen_1	71	81	PF00069	0.518
DOC_MAPK_MEF2A_6	284	291	PF00069	0.459
DOC_MAPK_MEF2A_6	371	379	PF00069	0.508
DOC_MAPK_MEF2A_6	615	624	PF00069	0.606
DOC_PP1_RVXF_1	48	55	PF00149	0.531
DOC_PP2B_LxvP_1	639	642	PF13499	0.580
DOC_PP2B_LxvP_1	732	735	PF13499	0.604
DOC_PP4_FxxP_1	323	326	PF00568	0.596
DOC_PP4_FxxP_1	329	332	PF00568	0.583
DOC_PP4_FxxP_1	595	598	PF00568	0.614
DOC_USP7_MATH_1	110	114	PF00917	0.505
DOC_USP7_MATH_1	120	124	PF00917	0.505
DOC_USP7_MATH_1	216	220	PF00917	0.579
DOC_USP7_MATH_1	233	237	PF00917	0.551
DOC_USP7_MATH_1	238	242	PF00917	0.550
DOC_USP7_MATH_1	246	250	PF00917	0.556
DOC_USP7_MATH_1	310	314	PF00917	0.627
DOC_USP7_MATH_1	316	320	PF00917	0.648
DOC_USP7_MATH_1	574	578	PF00917	0.498
DOC_WW_Pin1_4	211	216	PF00397	0.625
DOC_WW_Pin1_4	218	223	PF00397	0.655
DOC_WW_Pin1_4	311	316	PF00397	0.664
DOC_WW_Pin1_4	328	333	PF00397	0.510
DOC_WW_Pin1_4	371	376	PF00397	0.513
DOC_WW_Pin1_4	473	478	PF00397	0.631
DOC_WW_Pin1_4	556	561	PF00397	0.605
DOC_WW_Pin1_4	589	594	PF00397	0.588
DOC_WW_Pin1_4	654	659	PF00397	0.576
LIG_14-3-3_CanoR_1	14	19	PF00244	0.539
LIG_14-3-3_CanoR_1	168	177	PF00244	0.585
LIG_14-3-3_CanoR_1	508	512	PF00244	0.565
LIG_14-3-3_CanoR_1	562	568	PF00244	0.632
LIG_14-3-3_CanoR_1	58	62	PF00244	0.474
LIG_14-3-3_CanoR_1	605	610	PF00244	0.498
LIG_14-3-3_CanoR_1	88	97	PF00244	0.470
LIG_Actin_WH2_1	58	76	PF00022	0.510
LIG_Actin_WH2_2	350	368	PF00022	0.502
LIG_Actin_WH2_2	61	76	PF00022	0.511
LIG_Actin_WH2_2	83	100	PF00022	0.480
LIG_BRCT_BRCA1_1	379	383	PF00533	0.484
LIG_BRCT_BRCA1_1	59	63	PF00533	0.489
LIG_BRCT_BRCA1_1	591	595	PF00533	0.548
LIG_Clathr_ClatBox_1	274	278	PF01394	0.547
LIG_Clathr_ClatBox_1	619	623	PF01394	0.605
LIG_deltaCOP1_diTrp_1	556	563	PF00928	0.604
LIG_DLG_GKlike_1	14	21	PF00625	0.540
LIG_EVH1_2	325	329	PF00568	0.586
LIG_FHA_1	160	166	PF00498	0.556
LIG_FHA_1	267	273	PF00498	0.536
LIG_FHA_1	284	290	PF00498	0.455
LIG_FHA_1	380	386	PF00498	0.567
LIG_FHA_1	577	583	PF00498	0.613
LIG_FHA_1	650	656	PF00498	0.765
LIG_FHA_1	713	719	PF00498	0.528
LIG_FHA_2	223	229	PF00498	0.691
LIG_FHA_2	582	588	PF00498	0.473
LIG_FHA_2	606	612	PF00498	0.566
LIG_FHA_2	683	689	PF00498	0.448
LIG_FHA_2	705	711	PF00498	0.617
LIG_LIR_Apic_2	327	332	PF02991	0.598
LIG_LIR_Apic_2	592	598	PF02991	0.604
LIG_LIR_Gen_1	17	24	PF02991	0.546
LIG_LIR_Gen_1	378	389	PF02991	0.608
LIG_LIR_Gen_1	541	551	PF02991	0.481
LIG_LIR_Gen_1	637	644	PF02991	0.581
LIG_LIR_Gen_1	82	90	PF02991	0.479
LIG_LIR_Nem_3	17	21	PF02991	0.541
LIG_LIR_Nem_3	378	384	PF02991	0.609
LIG_LIR_Nem_3	480	486	PF02991	0.632
LIG_LIR_Nem_3	541	547	PF02991	0.517
LIG_LIR_Nem_3	556	561	PF02991	0.730
LIG_LIR_Nem_3	608	612	PF02991	0.497
LIG_LIR_Nem_3	637	641	PF02991	0.732
LIG_LIR_Nem_3	82	87	PF02991	0.478
LIG_NRBOX	615	621	PF00104	0.618
LIG_PAM2_1	314	326	PF00658	0.545
LIG_PCNA_yPIPBox_3	387	397	PF02747	0.606
LIG_PCNA_yPIPBox_3	627	636	PF02747	0.578
LIG_Pex14_2	634	638	PF04695	0.577
LIG_SH2_CRK	18	22	PF00017	0.437
LIG_SH2_CRK	381	385	PF00017	0.605
LIG_SH2_NCK_1	401	405	PF00017	0.647
LIG_SH2_NCK_1	448	452	PF00017	0.528
LIG_SH2_NCK_1	583	587	PF00017	0.454
LIG_SH2_SRC	448	451	PF00017	0.524
LIG_SH2_SRC	643	646	PF00017	0.470
LIG_SH2_STAP1	161	165	PF00017	0.552
LIG_SH2_STAP1	381	385	PF00017	0.478
LIG_SH2_STAP1	686	690	PF00017	0.447
LIG_SH2_STAT3	28	31	PF00017	0.488
LIG_SH2_STAT3	367	370	PF00017	0.664
LIG_SH2_STAT5	161	164	PF00017	0.560
LIG_SH2_STAT5	28	31	PF00017	0.488
LIG_SH2_STAT5	381	384	PF00017	0.601
LIG_SH2_STAT5	396	399	PF00017	0.508
LIG_SH2_STAT5	543	546	PF00017	0.573
LIG_SH2_STAT5	583	586	PF00017	0.473
LIG_SH2_STAT5	64	67	PF00017	0.511
LIG_SH2_STAT5	643	646	PF00017	0.470
LIG_SH2_STAT5	89	92	PF00017	0.446
LIG_SH3_3	114	120	PF00018	0.600
LIG_SH3_3	212	218	PF00018	0.682
LIG_SH3_3	312	318	PF00018	0.638
LIG_SH3_3	319	325	PF00018	0.600
LIG_SH3_3	335	341	PF00018	0.521
LIG_SH3_3	728	734	PF00018	0.598
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.444
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.424
LIG_SUMO_SIM_par_1	269	276	PF11976	0.571
LIG_SUMO_SIM_par_1	618	623	PF11976	0.606
LIG_SxIP_EBH_1	87	98	PF03271	0.471
LIG_TRAF2_1	468	471	PF00917	0.551
LIG_TYR_ITIM	379	384	PF00017	0.605
LIG_WRC_WIRS_1	606	611	PF05994	0.496
LIG_WRC_WIRS_1	81	86	PF05994	0.492
MOD_CDC14_SPxK_1	559	562	PF00782	0.613
MOD_CDK_SPK_2	473	478	PF00069	0.650
MOD_CDK_SPK_2	589	594	PF00069	0.461
MOD_CDK_SPxK_1	556	562	PF00069	0.608
MOD_CDK_SPxK_1	654	660	PF00069	0.512
MOD_CK1_1	138	144	PF00069	0.434
MOD_CK1_1	199	205	PF00069	0.535
MOD_CK1_1	214	220	PF00069	0.628
MOD_CK1_1	245	251	PF00069	0.600
MOD_CK1_1	292	298	PF00069	0.537
MOD_CK1_1	314	320	PF00069	0.674
MOD_CK1_1	465	471	PF00069	0.668
MOD_CK1_1	473	479	PF00069	0.682
MOD_CK1_1	501	507	PF00069	0.628
MOD_CK1_1	646	652	PF00069	0.763
MOD_CK1_1	653	659	PF00069	0.671
MOD_CK1_1	673	679	PF00069	0.514
MOD_CK2_1	465	471	PF00069	0.662
MOD_CK2_1	510	516	PF00069	0.493
MOD_CK2_1	581	587	PF00069	0.584
MOD_CK2_1	605	611	PF00069	0.568
MOD_CK2_1	682	688	PF00069	0.449
MOD_DYRK1A_RPxSP_1	371	375	PF00069	0.516
MOD_GlcNHglycan	171	174	PF01048	0.506
MOD_GlcNHglycan	231	234	PF01048	0.618
MOD_GlcNHglycan	244	247	PF01048	0.566
MOD_GlcNHglycan	291	294	PF01048	0.644
MOD_GlcNHglycan	318	321	PF01048	0.682
MOD_GlcNHglycan	371	374	PF01048	0.516
MOD_GlcNHglycan	404	407	PF01048	0.651
MOD_GlcNHglycan	415	418	PF01048	0.601
MOD_GlcNHglycan	470	475	PF01048	0.564
MOD_GlcNHglycan	563	566	PF01048	0.503
MOD_GlcNHglycan	576	579	PF01048	0.549
MOD_GlcNHglycan	623	627	PF01048	0.632
MOD_GlcNHglycan	672	675	PF01048	0.547
MOD_GlcNHglycan	680	683	PF01048	0.531
MOD_GlcNHglycan	91	94	PF01048	0.328
MOD_GSK3_1	159	166	PF00069	0.602
MOD_GSK3_1	195	202	PF00069	0.604
MOD_GSK3_1	214	221	PF00069	0.580
MOD_GSK3_1	22	29	PF00069	0.509
MOD_GSK3_1	222	229	PF00069	0.648
MOD_GSK3_1	238	245	PF00069	0.642
MOD_GSK3_1	283	290	PF00069	0.442
MOD_GSK3_1	297	304	PF00069	0.552
MOD_GSK3_1	310	317	PF00069	0.635
MOD_GSK3_1	324	331	PF00069	0.547
MOD_GSK3_1	371	378	PF00069	0.638
MOD_GSK3_1	422	429	PF00069	0.659
MOD_GSK3_1	435	442	PF00069	0.535
MOD_GSK3_1	538	545	PF00069	0.556
MOD_GSK3_1	618	625	PF00069	0.533
MOD_GSK3_1	643	650	PF00069	0.659
MOD_GSK3_1	666	673	PF00069	0.495
MOD_GSK3_1	678	685	PF00069	0.477
MOD_GSK3_1	713	720	PF00069	0.650
MOD_GSK3_1	734	741	PF00069	0.612
MOD_N-GLC_1	297	302	PF02516	0.544
MOD_N-GLC_1	426	431	PF02516	0.529
MOD_N-GLC_1	465	470	PF02516	0.548
MOD_N-GLC_1	568	573	PF02516	0.468
MOD_N-GLC_1	666	671	PF02516	0.489
MOD_NEK2_1	135	140	PF00069	0.550
MOD_NEK2_1	169	174	PF00069	0.576
MOD_NEK2_1	287	292	PF00069	0.490
MOD_NEK2_1	400	405	PF00069	0.519
MOD_NEK2_1	491	496	PF00069	0.549
MOD_NEK2_1	498	503	PF00069	0.620
MOD_NEK2_1	54	59	PF00069	0.421
MOD_NEK2_1	622	627	PF00069	0.672
MOD_NEK2_2	643	648	PF00069	0.472
MOD_OFUCOSY	107	114	PF10250	0.502
MOD_OFUCOSY	153	158	PF10250	0.581
MOD_PIKK_1	27	33	PF00454	0.607
MOD_PIKK_1	529	535	PF00454	0.483
MOD_PIKK_1	576	582	PF00454	0.559
MOD_PKA_2	226	232	PF00069	0.575
MOD_PKA_2	233	239	PF00069	0.572
MOD_PKA_2	242	248	PF00069	0.575
MOD_PKA_2	421	427	PF00069	0.601
MOD_PKA_2	435	441	PF00069	0.505
MOD_PKA_2	484	490	PF00069	0.599
MOD_PKA_2	507	513	PF00069	0.528
MOD_PKA_2	529	535	PF00069	0.483
MOD_PKA_2	561	567	PF00069	0.468
MOD_PKA_2	57	63	PF00069	0.502
MOD_PKA_2	647	653	PF00069	0.575
MOD_Plk_1	465	471	PF00069	0.629
MOD_Plk_1	538	544	PF00069	0.461
MOD_Plk_1	54	60	PF00069	0.424
MOD_Plk_4	120	126	PF00069	0.537
MOD_Plk_4	135	141	PF00069	0.395
MOD_Plk_4	379	385	PF00069	0.607
MOD_Plk_4	57	63	PF00069	0.502
MOD_Plk_4	581	587	PF00069	0.566
MOD_Plk_4	650	656	PF00069	0.671
MOD_Plk_4	738	744	PF00069	0.619
MOD_ProDKin_1	211	217	PF00069	0.627
MOD_ProDKin_1	218	224	PF00069	0.655
MOD_ProDKin_1	311	317	PF00069	0.666
MOD_ProDKin_1	328	334	PF00069	0.508
MOD_ProDKin_1	371	377	PF00069	0.512
MOD_ProDKin_1	473	479	PF00069	0.628
MOD_ProDKin_1	556	562	PF00069	0.608
MOD_ProDKin_1	589	595	PF00069	0.592
MOD_ProDKin_1	654	660	PF00069	0.576
TRG_DiLeu_BaEn_1	270	275	PF01217	0.524
TRG_DiLeu_BaEn_2	81	87	PF01217	0.484
TRG_DiLeu_BaEn_4	470	476	PF01217	0.535
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.620
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.471
TRG_ENDOCYTIC_2	18	21	PF00928	0.415
TRG_ENDOCYTIC_2	381	384	PF00928	0.601
TRG_ENDOCYTIC_2	4	7	PF00928	0.516
TRG_ENDOCYTIC_2	583	586	PF00928	0.580
TRG_ER_diArg_1	13	16	PF00400	0.550
TRG_ER_diArg_1	149	152	PF00400	0.599
TRG_ER_diArg_1	351	353	PF00400	0.549
TRG_ER_diArg_1	354	356	PF00400	0.546
TRG_ER_diArg_1	37	39	PF00400	0.534
TRG_ER_diArg_1	488	491	PF00400	0.583
TRG_ER_diArg_1	507	509	PF00400	0.544
TRG_ER_diArg_1	659	662	PF00400	0.629
TRG_NES_CRM1_1	55	66	PF08389	0.505
TRG_NES_CRM1_1	611	623	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WP72	Leishmania donovani	68%	68%
A4HSL3	Leishmania infantum	68%	68%
E9AKJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	71%
Q4QJB1	Leishmania major	69%	100%