Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4D2_LEIBR

TriTrypDb:

LbrM.05.0870 , LBRM2903_050014700

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 25, no: 7
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	33
GO:0042995	cell projection	2	33
GO:0043226	organelle	2	33
GO:0043227	membrane-bounded organelle	3	33
GO:0110165	cellular anatomical entity	1	33
GO:0120025	plasma membrane bounded cell projection	3	33
GO:0016020	membrane	2	6

Expansion

Sequence features

A4H4D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.266
CLV_MEL_PAP_1	82	88	PF00089	0.417
CLV_PCSK_SKI1_1	107	111	PF00082	0.417
CLV_PCSK_SKI1_1	177	181	PF00082	0.639
DOC_CKS1_1	251	256	PF01111	0.243
DOC_MAPK_gen_1	177	187	PF00069	0.276
DOC_MAPK_MEF2A_6	215	224	PF00069	0.274
DOC_USP7_MATH_1	173	177	PF00917	0.324
DOC_USP7_MATH_1	25	29	PF00917	0.488
DOC_USP7_MATH_2	221	227	PF00917	0.242
DOC_USP7_UBL2_3	62	66	PF12436	0.223
DOC_WW_Pin1_4	250	255	PF00397	0.270
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_2	121	125	PF00653	0.211
LIG_BRCT_BRCA1_1	119	123	PF00533	0.260
LIG_EH1_1	228	236	PF00400	0.245
LIG_eIF4E_1	229	235	PF01652	0.239
LIG_FHA_1	108	114	PF00498	0.274
LIG_FHA_1	278	284	PF00498	0.415
LIG_FHA_1	78	84	PF00498	0.333
LIG_FHA_1	87	93	PF00498	0.412
LIG_FHA_2	251	257	PF00498	0.273
LIG_FHA_2	34	40	PF00498	0.272
LIG_LIR_Gen_1	150	159	PF02991	0.252
LIG_LIR_Gen_1	181	192	PF02991	0.316
LIG_LIR_Gen_1	226	235	PF02991	0.333
LIG_LIR_Gen_1	42	53	PF02991	0.365
LIG_LIR_Nem_3	125	130	PF02991	0.302
LIG_LIR_Nem_3	150	154	PF02991	0.300
LIG_LIR_Nem_3	181	187	PF02991	0.345
LIG_LIR_Nem_3	203	207	PF02991	0.362
LIG_LIR_Nem_3	42	48	PF02991	0.307
LIG_PDZ_Class_2	286	291	PF00595	0.369
LIG_Pex14_1	49	53	PF04695	0.360
LIG_Pex14_2	45	49	PF04695	0.331
LIG_SH2_CRK	127	131	PF00017	0.321
LIG_SH2_STAT5	137	140	PF00017	0.261
LIG_SH2_STAT5	44	47	PF00017	0.279
LIG_SH2_STAT5	57	60	PF00017	0.323
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.378
LIG_SUMO_SIM_par_1	158	163	PF11976	0.316
LIG_SUMO_SIM_par_1	280	288	PF11976	0.255
LIG_WRC_WIRS_1	201	206	PF05994	0.332
MOD_CK1_1	200	206	PF00069	0.303
MOD_CK1_1	208	214	PF00069	0.293
MOD_CK1_1	271	277	PF00069	0.290
MOD_CK1_1	28	34	PF00069	0.654
MOD_CK1_1	38	44	PF00069	0.388
MOD_CK1_1	71	77	PF00069	0.325
MOD_GlcNHglycan	27	30	PF01048	0.566
MOD_GlcNHglycan	270	273	PF01048	0.660
MOD_GlcNHglycan	59	62	PF01048	0.608
MOD_GlcNHglycan	98	101	PF01048	0.524
MOD_GSK3_1	139	146	PF00069	0.306
MOD_GSK3_1	193	200	PF00069	0.306
MOD_GSK3_1	205	212	PF00069	0.336
MOD_GSK3_1	246	253	PF00069	0.330
MOD_GSK3_1	278	285	PF00069	0.229
MOD_GSK3_1	35	42	PF00069	0.340
MOD_GSK3_1	71	78	PF00069	0.359
MOD_N-GLC_1	139	144	PF02516	0.516
MOD_N-GLC_2	250	252	PF02516	0.571
MOD_NEK2_1	138	143	PF00069	0.318
MOD_NEK2_1	160	165	PF00069	0.326
MOD_NEK2_1	193	198	PF00069	0.292
MOD_NEK2_1	209	214	PF00069	0.266
MOD_NEK2_1	224	229	PF00069	0.265
MOD_NEK2_1	88	93	PF00069	0.316
MOD_OFUCOSY	65	72	PF10250	0.529
MOD_Plk_1	139	145	PF00069	0.270
MOD_Plk_4	225	231	PF00069	0.314
MOD_Plk_4	278	284	PF00069	0.313
MOD_Plk_4	285	291	PF00069	0.301
MOD_Plk_4	77	83	PF00069	0.372
MOD_ProDKin_1	250	256	PF00069	0.268
TRG_ENDOCYTIC_2	127	130	PF00928	0.317
TRG_ENDOCYTIC_2	184	187	PF00928	0.341
TRG_ENDOCYTIC_2	229	232	PF00928	0.246
TRG_ENDOCYTIC_2	67	70	PF00928	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P227	Leptomonas seymouri	24%	93%
A0A0N0P2E6	Leptomonas seymouri	22%	100%
A0A0N0P2L4	Leptomonas seymouri	26%	98%
A0A0N0P4M2	Leptomonas seymouri	32%	100%
A0A0S4IN83	Bodo saltans	24%	100%
A0A0S4IQP4	Bodo saltans	23%	74%
A0A0S4IR61	Bodo saltans	24%	72%
A0A0S4IVN7	Bodo saltans	25%	76%
A0A0S4IZC7	Bodo saltans	25%	71%
A0A0S4KFY6	Bodo saltans	28%	87%
A0A0S4KHE4	Bodo saltans	25%	79%
A0A1X0NKN8	Trypanosomatidae	31%	100%
A0A3Q8I9A6	Leishmania donovani	24%	75%
A0A3Q8IFC2	Leishmania donovani	26%	67%
A0A3Q8IIJ9	Leishmania donovani	24%	96%
A0A3S5H6D6	Leishmania donovani	30%	100%
A0A3S7WP69	Leishmania donovani	75%	100%
A0A3S7WPB2	Leishmania donovani	29%	100%
A4H4G6	Leishmania braziliensis	28%	100%
A4H5P0	Leishmania braziliensis	28%	100%
A4HJX1	Leishmania braziliensis	26%	66%
A4HSL2	Leishmania infantum	75%	100%
A4HTX9	Leishmania infantum	30%	100%
A4I6S2	Leishmania infantum	28%	66%
A4I6S4	Leishmania infantum	25%	96%
E9ACQ0	Leishmania major	27%	100%
E9AG65	Leishmania infantum	29%	100%
E9AGG5	Leishmania infantum	23%	70%
E9AGH0	Leishmania infantum	22%	77%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	86%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	74%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	79%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	69%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	69%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
Q05091	Pyrus communis	24%	88%
Q25331	Leishmania major	24%	76%
Q4PSE6	Arabidopsis thaliana	24%	67%
Q4Q6B6	Leishmania major	25%	96%
Q4Q6B7	Leishmania major	24%	96%
Q4QGJ4	Leishmania major	23%	76%
Q4QGJ7	Leishmania major	24%	78%
Q4QGK6	Leishmania major	23%	76%
Q4QHW6	Leishmania major	28%	100%
Q4QJB2	Leishmania major	78%	100%