Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4D0_LEIBR

TriTrypDb:

LbrM.05.0850 , LBRM2903_050014500

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H4D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4D0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.391
CLV_NRD_NRD_1	114	116	PF00675	0.399
CLV_NRD_NRD_1	154	156	PF00675	0.662
CLV_NRD_NRD_1	30	32	PF00675	0.451
CLV_NRD_NRD_1	48	50	PF00675	0.460
CLV_PCSK_KEX2_1	114	116	PF00082	0.399
CLV_PCSK_KEX2_1	156	158	PF00082	0.672
CLV_PCSK_KEX2_1	195	197	PF00082	0.635
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.672
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.635
CLV_PCSK_SKI1_1	157	161	PF00082	0.694
CLV_PCSK_SKI1_1	196	200	PF00082	0.659
CLV_PCSK_SKI1_1	32	36	PF00082	0.461
DEG_Nend_UBRbox_3	1	3	PF02207	0.756
DEG_SPOP_SBC_1	13	17	PF00917	0.668
DOC_CKS1_1	146	151	PF01111	0.481
DOC_CKS1_1	23	28	PF01111	0.716
DOC_CYCLIN_RxL_1	28	36	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.359
DOC_MAPK_gen_1	114	122	PF00069	0.478
DOC_MAPK_MEF2A_6	115	124	PF00069	0.478
DOC_PP2B_LxvP_1	178	181	PF13499	0.571
DOC_PP4_FxxP_1	35	38	PF00568	0.655
DOC_USP7_MATH_1	11	15	PF00917	0.707
DOC_USP7_UBL2_3	156	160	PF12436	0.526
DOC_USP7_UBL2_3	62	66	PF12436	0.643
DOC_WW_Pin1_4	145	150	PF00397	0.480
DOC_WW_Pin1_4	15	20	PF00397	0.712
DOC_WW_Pin1_4	22	27	PF00397	0.709
LIG_14-3-3_CanoR_1	196	201	PF00244	0.521
LIG_Actin_WH2_2	27	44	PF00022	0.728
LIG_Actin_WH2_2	75	93	PF00022	0.649
LIG_APCC_ABBAyCdc20_2	106	112	PF00400	0.622
LIG_BRCT_BRCA1_1	26	30	PF00533	0.737
LIG_BRCT_BRCA1_2	26	32	PF00533	0.735
LIG_FHA_1	133	139	PF00498	0.506
LIG_FHA_1	141	147	PF00498	0.428
LIG_FHA_1	19	25	PF00498	0.591
LIG_FHA_2	180	186	PF00498	0.535
LIG_FHA_2	91	97	PF00498	0.658
LIG_LIR_Apic_2	142	147	PF02991	0.419
LIG_LIR_Apic_2	33	38	PF02991	0.657
LIG_LIR_Nem_3	113	119	PF02991	0.471
LIG_SH2_GRB2like	116	119	PF00017	0.310
LIG_SH2_PTP2	119	122	PF00017	0.330
LIG_SH2_STAP1	116	120	PF00017	0.339
LIG_SH2_STAP1	134	138	PF00017	0.480
LIG_SH2_STAT5	119	122	PF00017	0.310
LIG_SH2_STAT5	134	137	PF00017	0.529
MOD_CDK_SPxK_1	22	28	PF00069	0.717
MOD_CK1_1	12	18	PF00069	0.718
MOD_CK2_1	179	185	PF00069	0.537
MOD_CK2_1	90	96	PF00069	0.659
MOD_GlcNHglycan	168	172	PF01048	0.718
MOD_GSK3_1	179	186	PF00069	0.440
MOD_GSK3_1	18	25	PF00069	0.741
MOD_GSK3_1	9	16	PF00069	0.747
MOD_GSK3_1	95	102	PF00069	0.642
MOD_NEK2_1	132	137	PF00069	0.454
MOD_NEK2_1	198	203	PF00069	0.366
MOD_NEK2_1	67	72	PF00069	0.639
MOD_NEK2_1	90	95	PF00069	0.658
MOD_NEK2_1	99	104	PF00069	0.632
MOD_PIKK_1	150	156	PF00454	0.450
MOD_PIKK_1	90	96	PF00454	0.660
MOD_PKA_2	2	8	PF00069	0.649
MOD_PKA_2	90	96	PF00069	0.659
MOD_ProDKin_1	145	151	PF00069	0.482
MOD_ProDKin_1	15	21	PF00069	0.712
MOD_ProDKin_1	22	28	PF00069	0.706
MOD_SUMO_rev_2	36	43	PF00179	0.657
TRG_ENDOCYTIC_2	119	122	PF00928	0.319
TRG_ER_diArg_1	114	116	PF00400	0.603
TRG_ER_diArg_1	155	158	PF00400	0.530
TRG_ER_diArg_1	88	91	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV2	Leptomonas seymouri	85%	97%
A0A0S4J1S7	Bodo saltans	67%	100%
A0A1X0NK70	Trypanosomatidae	73%	70%
A0A3R7RHS1	Trypanosoma rangeli	67%	87%
A0A3S5H5K7	Leishmania donovani	91%	100%
A4HSL0	Leishmania infantum	91%	100%
C9ZU79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	68%
E9AKJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJB4	Leishmania major	90%	100%