Complex I-B17

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex I-B17

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4C8_LEIBR

TriTrypDb:

LbrM.05.0830 , LBRM2903_050014300

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C8

PDB structure(s): 7aih_Af , 7am2_Af , 7ane_Af

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	61	67	PF00089	0.565
CLV_NRD_NRD_1	26	28	PF00675	0.406
CLV_NRD_NRD_1	3	5	PF00675	0.596
CLV_NRD_NRD_1	9	11	PF00675	0.510
CLV_NRD_NRD_1	91	93	PF00675	0.510
CLV_PCSK_KEX2_1	3	5	PF00082	0.616
CLV_PCSK_KEX2_1	33	35	PF00082	0.389
CLV_PCSK_KEX2_1	9	11	PF00082	0.553
CLV_PCSK_KEX2_1	91	93	PF00082	0.450
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.397
CLV_PCSK_SKI1_1	16	20	PF00082	0.399
DEG_APCC_DBOX_1	15	23	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_SIAH_1	56	64	PF03145	0.517
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.429
DOC_MAPK_DCC_7	16	24	PF00069	0.392
DOC_PP4_FxxP_1	60	63	PF00568	0.498
DOC_USP7_MATH_1	150	154	PF00917	0.553
DOC_USP7_MATH_1	55	59	PF00917	0.497
DOC_USP7_MATH_1	63	67	PF00917	0.578
DOC_WW_Pin1_4	2	7	PF00397	0.572
DOC_WW_Pin1_4	59	64	PF00397	0.517
DOC_WW_Pin1_4	92	97	PF00397	0.470
LIG_14-3-3_CanoR_1	9	19	PF00244	0.448
LIG_FHA_2	123	129	PF00498	0.386
LIG_LIR_Apic_2	53	57	PF02991	0.417
LIG_LIR_Apic_2	58	63	PF02991	0.467
LIG_LIR_Gen_1	140	150	PF02991	0.465
LIG_LIR_Nem_3	13	18	PF02991	0.405
LIG_LIR_Nem_3	140	145	PF02991	0.453
LIG_LIR_Nem_3	46	51	PF02991	0.493
LIG_PDZ_Class_1	150	155	PF00595	0.566
LIG_SH2_CRK	54	58	PF00017	0.320
LIG_SH2_NCK_1	54	58	PF00017	0.311
LIG_SH3_1	133	139	PF00018	0.461
LIG_SH3_2	147	152	PF14604	0.481
LIG_SH3_3	111	117	PF00018	0.565
LIG_SH3_3	133	139	PF00018	0.488
LIG_SH3_3	144	150	PF00018	0.462
MOD_CDC14_SPxK_1	95	98	PF00782	0.497
MOD_CDK_SPK_2	59	64	PF00069	0.517
MOD_CDK_SPxK_1	92	98	PF00069	0.504
MOD_CDK_SPxxK_3	2	9	PF00069	0.564
MOD_CK1_1	141	147	PF00069	0.487
MOD_CK2_1	148	154	PF00069	0.547
MOD_DYRK1A_RPxSP_1	92	96	PF00069	0.505
MOD_GlcNHglycan	57	60	PF01048	0.545
MOD_GSK3_1	55	62	PF00069	0.536
MOD_GSK3_1	63	70	PF00069	0.573
MOD_GSK3_1	72	79	PF00069	0.515
MOD_PIKK_1	72	78	PF00454	0.569
MOD_PKA_1	33	39	PF00069	0.529
MOD_PKA_2	33	39	PF00069	0.531
MOD_PKA_2	63	69	PF00069	0.644
MOD_ProDKin_1	2	8	PF00069	0.567
MOD_ProDKin_1	59	65	PF00069	0.525
MOD_ProDKin_1	92	98	PF00069	0.469
TRG_ENDOCYTIC_2	48	51	PF00928	0.424
TRG_ER_diArg_1	133	136	PF00400	0.438
TRG_ER_diArg_1	2	4	PF00400	0.594
TRG_ER_diArg_1	8	10	PF00400	0.484
TRG_ER_diArg_1	90	92	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF6	Leptomonas seymouri	71%	100%
A0A0S4J4H9	Bodo saltans	37%	100%
A0A1X0NJY4	Trypanosomatidae	53%	100%
A0A3R7M1F1	Trypanosoma rangeli	57%	97%
A0A3S5H5K6	Leishmania donovani	92%	100%
A4HSK8	Leishmania infantum	92%	100%
C9ZU82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	79%
E9AKJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QJB6	Leishmania major	90%	100%