RBR-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania braziliensis

UniProt:

A4H4C7_LEIBR

TriTrypDb:

LbrM.05.0820 , LBRM2903_050014200

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.687
CLV_NRD_NRD_1	431	433	PF00675	0.664
CLV_NRD_NRD_1	521	523	PF00675	0.286
CLV_NRD_NRD_1	601	603	PF00675	0.458
CLV_NRD_NRD_1	637	639	PF00675	0.343
CLV_PCSK_KEX2_1	21	23	PF00082	0.505
CLV_PCSK_KEX2_1	213	215	PF00082	0.498
CLV_PCSK_KEX2_1	431	433	PF00082	0.665
CLV_PCSK_KEX2_1	601	603	PF00082	0.458
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.505
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.498
CLV_PCSK_SKI1_1	125	129	PF00082	0.522
CLV_PCSK_SKI1_1	218	222	PF00082	0.440
CLV_PCSK_SKI1_1	419	423	PF00082	0.812
CLV_PCSK_SKI1_1	529	533	PF00082	0.548
CLV_PCSK_SKI1_1	550	554	PF00082	0.497
CLV_PCSK_SKI1_1	651	655	PF00082	0.493
DEG_SPOP_SBC_1	239	243	PF00917	0.666
DEG_SPOP_SBC_1	367	371	PF00917	0.748
DOC_CKS1_1	135	140	PF01111	0.509
DOC_CKS1_1	291	296	PF01111	0.565
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.795
DOC_MAPK_gen_1	213	221	PF00069	0.417
DOC_MAPK_gen_1	507	515	PF00069	0.503
DOC_MAPK_MEF2A_6	113	122	PF00069	0.537
DOC_MAPK_MEF2A_6	507	515	PF00069	0.480
DOC_PP4_MxPP_1	475	478	PF00568	0.741
DOC_PP4_MxPP_1	616	619	PF00568	0.710
DOC_PP4_MxPP_1	85	88	PF00568	0.552
DOC_USP7_MATH_1	191	195	PF00917	0.666
DOC_USP7_MATH_1	239	243	PF00917	0.660
DOC_USP7_MATH_1	246	250	PF00917	0.653
DOC_USP7_MATH_1	255	259	PF00917	0.509
DOC_USP7_MATH_1	296	300	PF00917	0.739
DOC_USP7_MATH_1	339	343	PF00917	0.731
DOC_USP7_MATH_1	357	361	PF00917	0.534
DOC_USP7_MATH_1	366	370	PF00917	0.644
DOC_USP7_UBL2_3	523	527	PF12436	0.423
DOC_WW_Pin1_4	134	139	PF00397	0.515
DOC_WW_Pin1_4	154	159	PF00397	0.751
DOC_WW_Pin1_4	240	245	PF00397	0.811
DOC_WW_Pin1_4	290	295	PF00397	0.575
DOC_WW_Pin1_4	333	338	PF00397	0.577
DOC_WW_Pin1_4	411	416	PF00397	0.580
DOC_WW_Pin1_4	42	47	PF00397	0.607
DOC_WW_Pin1_4	6	11	PF00397	0.573
DOC_WW_Pin1_4	60	65	PF00397	0.671
LIG_14-3-3_CanoR_1	175	179	PF00244	0.583
LIG_14-3-3_CanoR_1	237	247	PF00244	0.766
LIG_14-3-3_CanoR_1	264	272	PF00244	0.582
LIG_14-3-3_CanoR_1	437	441	PF00244	0.688
LIG_14-3-3_CanoR_1	510	514	PF00244	0.338
LIG_14-3-3_CanoR_1	8	18	PF00244	0.537
LIG_Actin_WH2_2	193	208	PF00022	0.552
LIG_APCC_ABBA_1	317	322	PF00400	0.597
LIG_BRCT_BRCA1_1	505	509	PF00533	0.253
LIG_FHA_1	10	16	PF00498	0.539
LIG_FHA_1	353	359	PF00498	0.806
LIG_IBAR_NPY_1	58	60	PF08397	0.553
LIG_LIR_Apic_2	405	411	PF02991	0.565
LIG_NRP_CendR_1	666	667	PF00754	0.642
LIG_Pex14_1	467	471	PF04695	0.607
LIG_PTB_Apo_2	271	278	PF02174	0.572
LIG_PTB_Phospho_1	271	277	PF10480	0.573
LIG_SH2_CRK	408	412	PF00017	0.718
LIG_SH2_NCK_1	66	70	PF00017	0.787
LIG_SH2_SRC	16	19	PF00017	0.411
LIG_SH2_STAP1	16	20	PF00017	0.410
LIG_SH2_STAP1	268	272	PF00017	0.571
LIG_SH2_STAP1	627	631	PF00017	0.511
LIG_SH2_STAT5	121	124	PF00017	0.562
LIG_SH2_STAT5	211	214	PF00017	0.635
LIG_SH2_STAT5	66	69	PF00017	0.788
LIG_SH3_1	331	337	PF00018	0.576
LIG_SH3_3	152	158	PF00018	0.605
LIG_SH3_3	331	337	PF00018	0.586
LIG_SH3_3	404	410	PF00018	0.698
LIG_SH3_3	427	433	PF00018	0.665
LIG_SH3_3	53	59	PF00018	0.562
LIG_SH3_3	615	621	PF00018	0.608
LIG_SH3_3	628	634	PF00018	0.341
LIG_SH3_3	77	83	PF00018	0.630
LIG_SH3_3	84	90	PF00018	0.761
LIG_SUMO_SIM_par_1	168	174	PF11976	0.726
LIG_SUMO_SIM_par_1	293	299	PF11976	0.572
LIG_TRAF2_1	494	497	PF00917	0.645
MOD_CDK_SPK_2	60	65	PF00069	0.661
MOD_CK1_1	100	106	PF00069	0.772
MOD_CK1_1	166	172	PF00069	0.641
MOD_CK1_1	174	180	PF00069	0.751
MOD_CK1_1	201	207	PF00069	0.514
MOD_CK1_1	263	269	PF00069	0.574
MOD_CK1_1	335	341	PF00069	0.678
MOD_CK1_1	45	51	PF00069	0.629
MOD_CK2_1	263	269	PF00069	0.576
MOD_CK2_1	281	287	PF00069	0.564
MOD_Cter_Amidation	636	639	PF01082	0.343
MOD_DYRK1A_RPxSP_1	154	158	PF00069	0.744
MOD_GlcNHglycan	106	109	PF01048	0.705
MOD_GlcNHglycan	158	161	PF01048	0.606
MOD_GlcNHglycan	180	183	PF01048	0.665
MOD_GlcNHglycan	189	192	PF01048	0.696
MOD_GlcNHglycan	298	301	PF01048	0.762
MOD_GlcNHglycan	337	340	PF01048	0.681
MOD_GlcNHglycan	341	344	PF01048	0.675
MOD_GlcNHglycan	370	373	PF01048	0.738
MOD_GlcNHglycan	419	422	PF01048	0.756
MOD_GlcNHglycan	444	447	PF01048	0.741
MOD_GlcNHglycan	50	53	PF01048	0.675
MOD_GlcNHglycan	612	615	PF01048	0.677
MOD_GlcNHglycan	70	73	PF01048	0.785
MOD_GlcNHglycan	99	102	PF01048	0.813
MOD_GSK3_1	174	181	PF00069	0.636
MOD_GSK3_1	187	194	PF00069	0.519
MOD_GSK3_1	201	208	PF00069	0.522
MOD_GSK3_1	227	234	PF00069	0.600
MOD_GSK3_1	335	342	PF00069	0.721
MOD_GSK3_1	411	418	PF00069	0.614
MOD_GSK3_1	505	512	PF00069	0.258
MOD_GSK3_1	60	67	PF00069	0.674
MOD_GSK3_1	96	103	PF00069	0.675
MOD_N-GLC_1	178	183	PF02516	0.639
MOD_N-GLC_1	247	252	PF02516	0.590
MOD_N-GLC_1	397	402	PF02516	0.577
MOD_N-GLC_1	483	488	PF02516	0.472
MOD_NEK2_1	171	176	PF00069	0.602
MOD_NEK2_1	196	201	PF00069	0.572
MOD_NEK2_1	205	210	PF00069	0.500
MOD_NEK2_1	247	252	PF00069	0.772
MOD_NEK2_1	509	514	PF00069	0.353
MOD_NEK2_2	505	510	PF00069	0.241
MOD_PIKK_1	128	134	PF00454	0.512
MOD_PIKK_1	231	237	PF00454	0.586
MOD_PIKK_1	253	259	PF00454	0.662
MOD_PIKK_1	263	269	PF00454	0.574
MOD_PIKK_1	382	388	PF00454	0.732
MOD_PIKK_1	45	51	PF00454	0.550
MOD_PKA_2	174	180	PF00069	0.580
MOD_PKA_2	205	211	PF00069	0.500
MOD_PKA_2	263	269	PF00069	0.574
MOD_PKA_2	380	386	PF00069	0.766
MOD_PKA_2	436	442	PF00069	0.781
MOD_PKA_2	509	515	PF00069	0.343
MOD_PKB_1	94	102	PF00069	0.586
MOD_Plk_1	483	489	PF00069	0.470
MOD_Plk_4	166	172	PF00069	0.581
MOD_ProDKin_1	134	140	PF00069	0.514
MOD_ProDKin_1	154	160	PF00069	0.749
MOD_ProDKin_1	240	246	PF00069	0.812
MOD_ProDKin_1	290	296	PF00069	0.576
MOD_ProDKin_1	333	339	PF00069	0.577
MOD_ProDKin_1	411	417	PF00069	0.582
MOD_ProDKin_1	42	48	PF00069	0.611
MOD_ProDKin_1	6	12	PF00069	0.566
MOD_ProDKin_1	60	66	PF00069	0.673
MOD_SUMO_for_1	212	215	PF00179	0.489
MOD_SUMO_rev_2	124	130	PF00179	0.507
TRG_DiLeu_BaEn_1	215	220	PF01217	0.411
TRG_DiLeu_LyEn_5	215	220	PF01217	0.411
TRG_ER_diArg_1	430	432	PF00400	0.670
TRG_ER_diArg_1	600	602	PF00400	0.450
TRG_ER_diArg_1	665	667	PF00400	0.633
TRG_ER_diArg_1	93	96	PF00400	0.782
TRG_NLS_MonoCore_2	347	352	PF00514	0.662
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II98	Leptomonas seymouri	53%	100%
A0A3S7WP70	Leishmania donovani	73%	100%
A4HSK7	Leishmania infantum	73%	100%
E9AKJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QJB7	Leishmania major	73%	98%