Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4C4_LEIBR

TriTrypDb:

LbrM.05.0790 , LBRM2903_050013900

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.750
CLV_C14_Caspase3-7	149	153	PF00656	0.488
CLV_C14_Caspase3-7	392	396	PF00656	0.324
CLV_MEL_PAP_1	413	419	PF00089	0.588
CLV_NRD_NRD_1	190	192	PF00675	0.354
CLV_NRD_NRD_1	232	234	PF00675	0.506
CLV_NRD_NRD_1	323	325	PF00675	0.275
CLV_NRD_NRD_1	716	718	PF00675	0.338
CLV_NRD_NRD_1	8	10	PF00675	0.563
CLV_NRD_NRD_1	818	820	PF00675	0.334
CLV_NRD_NRD_1	878	880	PF00675	0.506
CLV_PCSK_FUR_1	230	234	PF00082	0.503
CLV_PCSK_KEX2_1	15	17	PF00082	0.511
CLV_PCSK_KEX2_1	190	192	PF00082	0.355
CLV_PCSK_KEX2_1	230	232	PF00082	0.563
CLV_PCSK_KEX2_1	322	324	PF00082	0.282
CLV_PCSK_KEX2_1	7	9	PF00082	0.541
CLV_PCSK_KEX2_1	818	820	PF00082	0.332
CLV_PCSK_KEX2_1	877	879	PF00082	0.494
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.446
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.296
CLV_PCSK_PC1ET2_1	877	879	PF00082	0.494
CLV_PCSK_PC7_1	319	325	PF00082	0.289
CLV_PCSK_SKI1_1	129	133	PF00082	0.372
CLV_PCSK_SKI1_1	191	195	PF00082	0.341
CLV_PCSK_SKI1_1	284	288	PF00082	0.349
CLV_PCSK_SKI1_1	572	576	PF00082	0.489
CLV_PCSK_SKI1_1	779	783	PF00082	0.293
CLV_PCSK_SKI1_1	797	801	PF00082	0.338
CLV_PCSK_SKI1_1	824	828	PF00082	0.181
DEG_APCC_DBOX_1	778	786	PF00400	0.490
DEG_ODPH_VHL_1	458	471	PF01847	0.415
DEG_SPOP_SBC_1	225	229	PF00917	0.601
DEG_SPOP_SBC_1	285	289	PF00917	0.563
DOC_CYCLIN_RxL_1	464	474	PF00134	0.514
DOC_CYCLIN_RxL_1	794	804	PF00134	0.550
DOC_MAPK_DCC_7	484	494	PF00069	0.424
DOC_MAPK_gen_1	517	525	PF00069	0.418
DOC_MAPK_gen_1	818	827	PF00069	0.592
DOC_MAPK_MEF2A_6	406	413	PF00069	0.408
DOC_PIKK_1	30	37	PF02985	0.610
DOC_PP1_RVXF_1	570	577	PF00149	0.473
DOC_PP1_RVXF_1	740	746	PF00149	0.485
DOC_PP2B_LxvP_1	645	648	PF13499	0.349
DOC_PP4_FxxP_1	99	102	PF00568	0.617
DOC_USP7_MATH_1	114	118	PF00917	0.667
DOC_USP7_MATH_1	141	145	PF00917	0.493
DOC_USP7_MATH_1	157	161	PF00917	0.604
DOC_USP7_MATH_1	225	229	PF00917	0.739
DOC_USP7_MATH_1	254	258	PF00917	0.577
DOC_USP7_MATH_1	309	313	PF00917	0.608
DOC_USP7_MATH_1	367	371	PF00917	0.553
DOC_USP7_MATH_1	375	379	PF00917	0.528
DOC_USP7_MATH_1	614	618	PF00917	0.363
DOC_USP7_MATH_1	648	652	PF00917	0.404
DOC_USP7_MATH_1	676	680	PF00917	0.572
DOC_USP7_UBL2_3	11	15	PF12436	0.815
DOC_USP7_UBL2_3	916	920	PF12436	0.428
DOC_WW_Pin1_4	112	117	PF00397	0.674
DOC_WW_Pin1_4	191	196	PF00397	0.527
DOC_WW_Pin1_4	219	224	PF00397	0.611
DOC_WW_Pin1_4	341	346	PF00397	0.479
DOC_WW_Pin1_4	369	374	PF00397	0.549
DOC_WW_Pin1_4	575	580	PF00397	0.429
DOC_WW_Pin1_4	893	898	PF00397	0.441
DOC_WW_Pin1_4	98	103	PF00397	0.590
LIG_14-3-3_CanoR_1	239	243	PF00244	0.565
LIG_14-3-3_CanoR_1	284	294	PF00244	0.577
LIG_14-3-3_CanoR_1	416	423	PF00244	0.383
LIG_14-3-3_CanoR_1	446	450	PF00244	0.407
LIG_14-3-3_CanoR_1	515	523	PF00244	0.569
LIG_14-3-3_CanoR_1	742	746	PF00244	0.566
LIG_14-3-3_CanoR_1	864	872	PF00244	0.373
LIG_14-3-3_CanoR_1	891	897	PF00244	0.429
LIG_14-3-3_CanoR_1	9	18	PF00244	0.810
LIG_Actin_WH2_2	270	286	PF00022	0.414
LIG_APCC_ABBA_1	199	204	PF00400	0.515
LIG_APCC_ABBA_1	670	675	PF00400	0.454
LIG_APCC_ABBA_1	843	848	PF00400	0.310
LIG_APCC_ABBAyCdc20_2	669	675	PF00400	0.600
LIG_BIR_III_2	113	117	PF00653	0.685
LIG_BIR_III_4	582	586	PF00653	0.441
LIG_Clathr_ClatBox_1	277	281	PF01394	0.512
LIG_eIF4E_1	565	571	PF01652	0.289
LIG_FHA_1	271	277	PF00498	0.578
LIG_FHA_1	334	340	PF00498	0.422
LIG_FHA_1	385	391	PF00498	0.332
LIG_FHA_1	446	452	PF00498	0.404
LIG_FHA_1	511	517	PF00498	0.568
LIG_FHA_1	597	603	PF00498	0.455
LIG_FHA_1	640	646	PF00498	0.267
LIG_FHA_1	758	764	PF00498	0.541
LIG_FHA_1	802	808	PF00498	0.609
LIG_FHA_2	108	114	PF00498	0.677
LIG_FHA_2	192	198	PF00498	0.556
LIG_FHA_2	208	214	PF00498	0.707
LIG_FHA_2	287	293	PF00498	0.531
LIG_FHA_2	390	396	PF00498	0.390
LIG_FHA_2	675	681	PF00498	0.582
LIG_FHA_2	731	737	PF00498	0.534
LIG_FHA_2	839	845	PF00498	0.402
LIG_GBD_Chelix_1	639	647	PF00786	0.531
LIG_LIR_Apic_2	101	106	PF02991	0.679
LIG_LIR_Apic_2	573	579	PF02991	0.352
LIG_LIR_Gen_1	182	189	PF02991	0.513
LIG_LIR_Gen_1	196	202	PF02991	0.620
LIG_LIR_Gen_1	23	34	PF02991	0.613
LIG_LIR_Gen_1	241	249	PF02991	0.532
LIG_LIR_Gen_1	288	299	PF02991	0.636
LIG_LIR_Gen_1	59	68	PF02991	0.584
LIG_LIR_Gen_1	699	708	PF02991	0.430
LIG_LIR_Nem_3	182	186	PF02991	0.463
LIG_LIR_Nem_3	196	201	PF02991	0.647
LIG_LIR_Nem_3	23	29	PF02991	0.617
LIG_LIR_Nem_3	241	246	PF02991	0.536
LIG_LIR_Nem_3	288	294	PF02991	0.577
LIG_LIR_Nem_3	562	567	PF02991	0.319
LIG_LIR_Nem_3	59	65	PF02991	0.605
LIG_LIR_Nem_3	658	662	PF02991	0.509
LIG_LIR_Nem_3	699	705	PF02991	0.428
LIG_LIR_Nem_3	907	913	PF02991	0.285
LIG_NRBOX	275	281	PF00104	0.495
LIG_NRBOX	440	446	PF00104	0.348
LIG_PCNA_yPIPBox_3	347	358	PF02747	0.274
LIG_Pex14_1	198	202	PF04695	0.581
LIG_SH2_CRK	133	137	PF00017	0.425
LIG_SH2_CRK	442	446	PF00017	0.260
LIG_SH2_NCK_1	103	107	PF00017	0.626
LIG_SH2_NCK_1	26	30	PF00017	0.615
LIG_SH2_SRC	103	106	PF00017	0.580
LIG_SH2_SRC	26	29	PF00017	0.616
LIG_SH2_STAP1	302	306	PF00017	0.598
LIG_SH2_STAT3	74	77	PF00017	0.445
LIG_SH2_STAT3	915	918	PF00017	0.289
LIG_SH2_STAT5	242	245	PF00017	0.566
LIG_SH2_STAT5	74	77	PF00017	0.514
LIG_SH2_STAT5	875	878	PF00017	0.388
LIG_SH3_1	15	21	PF00018	0.616
LIG_SH3_3	121	127	PF00018	0.638
LIG_SH3_3	15	21	PF00018	0.617
LIG_SH3_3	342	348	PF00018	0.486
LIG_SH3_3	476	482	PF00018	0.430
LIG_SH3_3	590	596	PF00018	0.434
LIG_SH3_3	809	815	PF00018	0.595
LIG_SH3_3	852	858	PF00018	0.338
LIG_SH3_3	99	105	PF00018	0.619
LIG_Sin3_3	749	756	PF02671	0.429
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.593
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.470
LIG_SUMO_SIM_anti_2	641	647	PF11976	0.269
LIG_SUMO_SIM_anti_2	736	741	PF11976	0.494
LIG_SUMO_SIM_par_1	250	257	PF11976	0.550
LIG_SUMO_SIM_par_1	275	281	PF11976	0.480
LIG_SUMO_SIM_par_1	338	344	PF11976	0.475
LIG_SUMO_SIM_par_1	626	633	PF11976	0.292
LIG_SUMO_SIM_par_1	798	804	PF11976	0.470
LIG_SxIP_EBH_1	42	54	PF03271	0.550
LIG_TYR_ITIM	131	136	PF00017	0.495
LIG_TYR_ITIM	440	445	PF00017	0.261
LIG_WRC_WIRS_1	422	427	PF05994	0.402
MOD_CDC14_SPxK_1	578	581	PF00782	0.314
MOD_CDK_SPxK_1	575	581	PF00069	0.287
MOD_CK1_1	272	278	PF00069	0.639
MOD_CK1_1	361	367	PF00069	0.509
MOD_CK1_1	418	424	PF00069	0.373
MOD_CK1_1	518	524	PF00069	0.481
MOD_CK1_1	744	750	PF00069	0.581
MOD_CK1_1	767	773	PF00069	0.464
MOD_CK1_1	893	899	PF00069	0.438
MOD_CK2_1	167	173	PF00069	0.514
MOD_CK2_1	286	292	PF00069	0.598
MOD_CK2_1	665	671	PF00069	0.573
MOD_CK2_1	674	680	PF00069	0.603
MOD_CK2_1	98	104	PF00069	0.557
MOD_GlcNHglycan	116	119	PF01048	0.552
MOD_GlcNHglycan	159	162	PF01048	0.509
MOD_GlcNHglycan	297	300	PF01048	0.446
MOD_GlcNHglycan	360	363	PF01048	0.739
MOD_GlcNHglycan	365	368	PF01048	0.720
MOD_GlcNHglycan	520	523	PF01048	0.264
MOD_GlcNHglycan	559	562	PF01048	0.335
MOD_GlcNHglycan	684	687	PF01048	0.431
MOD_GlcNHglycan	693	696	PF01048	0.333
MOD_GlcNHglycan	720	723	PF01048	0.517
MOD_GlcNHglycan	733	736	PF01048	0.272
MOD_GlcNHglycan	746	750	PF01048	0.381
MOD_GlcNHglycan	769	772	PF01048	0.340
MOD_GlcNHglycan	865	868	PF01048	0.428
MOD_GSK3_1	234	241	PF00069	0.641
MOD_GSK3_1	266	273	PF00069	0.643
MOD_GSK3_1	286	293	PF00069	0.620
MOD_GSK3_1	328	335	PF00069	0.423
MOD_GSK3_1	354	361	PF00069	0.383
MOD_GSK3_1	363	370	PF00069	0.521
MOD_GSK3_1	380	387	PF00069	0.309
MOD_GSK3_1	506	513	PF00069	0.559
MOD_GSK3_1	718	725	PF00069	0.672
MOD_GSK3_1	741	748	PF00069	0.578
MOD_GSK3_1	863	870	PF00069	0.349
MOD_N-GLC_1	35	40	PF02516	0.466
MOD_N-GLC_1	536	541	PF02516	0.404
MOD_NEK2_1	1	6	PF00069	0.740
MOD_NEK2_1	270	275	PF00069	0.574
MOD_NEK2_1	328	333	PF00069	0.404
MOD_NEK2_1	354	359	PF00069	0.435
MOD_NEK2_1	37	42	PF00069	0.611
MOD_NEK2_1	389	394	PF00069	0.336
MOD_NEK2_1	445	450	PF00069	0.292
MOD_NEK2_1	493	498	PF00069	0.509
MOD_NEK2_1	516	521	PF00069	0.609
MOD_NEK2_1	557	562	PF00069	0.239
MOD_NEK2_1	674	679	PF00069	0.489
MOD_NEK2_1	691	696	PF00069	0.588
MOD_NEK2_1	711	716	PF00069	0.427
MOD_NEK2_1	764	769	PF00069	0.494
MOD_NEK2_2	830	835	PF00069	0.404
MOD_PIKK_1	604	610	PF00454	0.300
MOD_PIKK_1	801	807	PF00454	0.600
MOD_PIKK_1	867	873	PF00454	0.323
MOD_PKA_1	717	723	PF00069	0.597
MOD_PKA_2	238	244	PF00069	0.516
MOD_PKA_2	415	421	PF00069	0.447
MOD_PKA_2	445	451	PF00069	0.331
MOD_PKA_2	516	522	PF00069	0.570
MOD_PKA_2	741	747	PF00069	0.571
MOD_PKA_2	863	869	PF00069	0.375
MOD_PKA_2	890	896	PF00069	0.324
MOD_Plk_1	384	390	PF00069	0.419
MOD_Plk_1	418	424	PF00069	0.380
MOD_Plk_4	238	244	PF00069	0.575
MOD_Plk_4	272	278	PF00069	0.484
MOD_Plk_4	290	296	PF00069	0.600
MOD_Plk_4	311	317	PF00069	0.603
MOD_Plk_4	421	427	PF00069	0.373
MOD_Plk_4	428	434	PF00069	0.331
MOD_Plk_4	559	565	PF00069	0.231
MOD_Plk_4	639	645	PF00069	0.236
MOD_Plk_4	838	844	PF00069	0.492
MOD_ProDKin_1	112	118	PF00069	0.674
MOD_ProDKin_1	191	197	PF00069	0.526
MOD_ProDKin_1	219	225	PF00069	0.611
MOD_ProDKin_1	341	347	PF00069	0.476
MOD_ProDKin_1	369	375	PF00069	0.549
MOD_ProDKin_1	575	581	PF00069	0.437
MOD_ProDKin_1	893	899	PF00069	0.438
MOD_ProDKin_1	98	104	PF00069	0.600
TRG_DiLeu_BaEn_2	384	390	PF01217	0.405
TRG_DiLeu_BaEn_4	250	256	PF01217	0.499
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.575
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.490
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.563
TRG_ENDOCYTIC_2	133	136	PF00928	0.492
TRG_ENDOCYTIC_2	242	245	PF00928	0.566
TRG_ENDOCYTIC_2	26	29	PF00928	0.616
TRG_ENDOCYTIC_2	442	445	PF00928	0.259
TRG_ENDOCYTIC_2	62	65	PF00928	0.621
TRG_ENDOCYTIC_2	856	859	PF00928	0.340
TRG_ENDOCYTIC_2	910	913	PF00928	0.237
TRG_ER_diArg_1	230	233	PF00400	0.752
TRG_ER_diArg_1	6	9	PF00400	0.748
TRG_ER_diArg_1	821	824	PF00400	0.532
TRG_NES_CRM1_1	268	281	PF08389	0.608
TRG_NES_CRM1_1	626	638	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	610	615	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF34	Leptomonas seymouri	59%	100%
A0A1X0NLT0	Trypanosomatidae	35%	100%
A0A3S5H5K4	Leishmania donovani	77%	98%
A0A422NJC1	Trypanosoma rangeli	37%	100%
A4HSK4	Leishmania infantum	77%	98%
C9ZU88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
E9AKI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QJC0	Leishmania major	76%	100%
V5BBH0	Trypanosoma cruzi	35%	94%