MYND zinc finger (ZnF) domain-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND zinc finger (ZnF) domain-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4C3_LEIBR

TriTrypDb:

LbrM.05.0780 , LBRM2903_050013700

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.649
CLV_C14_Caspase3-7	277	281	PF00656	0.513
CLV_NRD_NRD_1	254	256	PF00675	0.531
CLV_NRD_NRD_1	408	410	PF00675	0.523
CLV_NRD_NRD_1	88	90	PF00675	0.495
CLV_PCSK_KEX2_1	254	256	PF00082	0.531
CLV_PCSK_KEX2_1	318	320	PF00082	0.401
CLV_PCSK_KEX2_1	388	390	PF00082	0.637
CLV_PCSK_KEX2_1	408	410	PF00082	0.523
CLV_PCSK_KEX2_1	88	90	PF00082	0.499
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.401
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.637
CLV_PCSK_SKI1_1	254	258	PF00082	0.466
CLV_PCSK_SKI1_1	329	333	PF00082	0.490
CLV_PCSK_SKI1_1	385	389	PF00082	0.703
CLV_PCSK_SKI1_1	53	57	PF00082	0.557
CLV_PCSK_SKI1_1	91	95	PF00082	0.561
DEG_APCC_KENBOX_2	148	152	PF00400	0.551
DEG_SPOP_SBC_1	205	209	PF00917	0.699
DOC_ANK_TNKS_1	226	233	PF00023	0.537
DOC_CYCLIN_RxL_1	326	336	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.540
DOC_MAPK_gen_1	383	395	PF00069	0.624
DOC_MAPK_gen_1	88	98	PF00069	0.594
DOC_MAPK_MEF2A_6	388	397	PF00069	0.717
DOC_PP1_RVXF_1	285	292	PF00149	0.625
DOC_PP1_RVXF_1	92	99	PF00149	0.485
DOC_PP2B_LxvP_1	395	398	PF13499	0.545
DOC_PP4_FxxP_1	57	60	PF00568	0.692
DOC_USP7_MATH_1	204	208	PF00917	0.734
DOC_USP7_MATH_1	294	298	PF00917	0.595
DOC_USP7_MATH_1	32	36	PF00917	0.602
DOC_USP7_MATH_1	321	325	PF00917	0.468
DOC_USP7_MATH_1	63	67	PF00917	0.598
DOC_USP7_UBL2_3	216	220	PF12436	0.532
DOC_USP7_UBL2_3	384	388	PF12436	0.710
DOC_WW_Pin1_4	355	360	PF00397	0.484
LIG_14-3-3_CanoR_1	212	216	PF00244	0.555
LIG_14-3-3_CanoR_1	333	342	PF00244	0.394
LIG_APCC_ABBA_1	54	59	PF00400	0.688
LIG_APCC_ABBAyCdc20_2	287	293	PF00400	0.640
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.693
LIG_BRCT_BRCA1_1	401	405	PF00533	0.655
LIG_BRCT_BRCA1_1	424	428	PF00533	0.603
LIG_BRCT_BRCA1_1	94	98	PF00533	0.492
LIG_BRCT_BRCA1_2	424	430	PF00533	0.627
LIG_Clathr_ClatBox_1	289	293	PF01394	0.540
LIG_Clathr_ClatBox_1	54	58	PF01394	0.551
LIG_FHA_1	113	119	PF00498	0.487
LIG_FHA_1	132	138	PF00498	0.564
LIG_FHA_1	294	300	PF00498	0.546
LIG_FHA_1	35	41	PF00498	0.364
LIG_FHA_2	212	218	PF00498	0.483
LIG_FHA_2	236	242	PF00498	0.653
LIG_FHA_2	25	31	PF00498	0.470
LIG_LIR_Gen_1	110	119	PF02991	0.523
LIG_LIR_Gen_1	20	31	PF02991	0.456
LIG_LIR_Gen_1	350	359	PF02991	0.444
LIG_LIR_Gen_1	416	427	PF02991	0.559
LIG_LIR_Nem_3	110	116	PF02991	0.536
LIG_LIR_Nem_3	20	26	PF02991	0.459
LIG_LIR_Nem_3	35	41	PF02991	0.456
LIG_LIR_Nem_3	350	355	PF02991	0.427
LIG_LIR_Nem_3	416	422	PF02991	0.545
LIG_LIR_Nem_3	423	427	PF02991	0.494
LIG_MLH1_MIPbox_1	401	405	PF16413	0.655
LIG_MLH1_MIPbox_1	424	428	PF16413	0.603
LIG_REV1ctd_RIR_1	402	413	PF16727	0.660
LIG_SH2_STAP1	424	428	PF00017	0.612
LIG_SH2_STAT3	154	157	PF00017	0.640
LIG_SH2_STAT5	154	157	PF00017	0.598
LIG_SH2_STAT5	342	345	PF00017	0.344
LIG_SH2_STAT5	39	42	PF00017	0.398
LIG_SH2_STAT5	410	413	PF00017	0.506
LIG_SH2_STAT5	427	430	PF00017	0.513
LIG_SH2_STAT5	431	434	PF00017	0.588
LIG_SH3_2	8	13	PF14604	0.674
LIG_SH3_3	26	32	PF00018	0.359
LIG_SH3_3	395	401	PF00018	0.540
LIG_SH3_3	4	10	PF00018	0.634
LIG_SH3_CIN85_PxpxPR_1	8	13	PF14604	0.674
LIG_SUMO_SIM_anti_2	114	121	PF11976	0.504
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.567
LIG_SUMO_SIM_par_1	15	20	PF11976	0.540
LIG_SUMO_SIM_par_1	241	252	PF11976	0.633
LIG_SUMO_SIM_par_1	39	45	PF11976	0.460
LIG_SUMO_SIM_par_1	390	396	PF11976	0.623
LIG_TYR_ITIM	340	345	PF00017	0.272
LIG_WW_3	10	14	PF00397	0.644
MOD_CDK_SPxK_1	355	361	PF00069	0.444
MOD_CK1_1	127	133	PF00069	0.724
MOD_CK1_1	207	213	PF00069	0.737
MOD_CK1_1	264	270	PF00069	0.578
MOD_CK1_1	377	383	PF00069	0.654
MOD_CK1_1	76	82	PF00069	0.503
MOD_CK2_1	108	114	PF00069	0.407
MOD_CK2_1	211	217	PF00069	0.651
MOD_CK2_1	235	241	PF00069	0.639
MOD_CK2_1	366	372	PF00069	0.513
MOD_Cter_Amidation	381	384	PF01082	0.681
MOD_GlcNHglycan	126	129	PF01048	0.673
MOD_GlcNHglycan	134	137	PF01048	0.684
MOD_GlcNHglycan	202	205	PF01048	0.712
MOD_GlcNHglycan	233	236	PF01048	0.686
MOD_GlcNHglycan	325	328	PF01048	0.412
MOD_GlcNHglycan	78	81	PF01048	0.511
MOD_GSK3_1	108	115	PF00069	0.413
MOD_GSK3_1	127	134	PF00069	0.653
MOD_GSK3_1	200	207	PF00069	0.703
MOD_GSK3_1	231	238	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.621
MOD_GSK3_1	319	326	PF00069	0.454
MOD_GSK3_1	347	354	PF00069	0.437
MOD_GSK3_1	429	436	PF00069	0.628
MOD_GSK3_1	69	76	PF00069	0.627
MOD_N-GLC_1	377	382	PF02516	0.486
MOD_NEK2_1	24	29	PF00069	0.475
MOD_NEK2_1	332	337	PF00069	0.439
MOD_NEK2_1	404	409	PF00069	0.518
MOD_NEK2_1	429	434	PF00069	0.603
MOD_NEK2_1	92	97	PF00069	0.533
MOD_PK_1	366	372	PF00069	0.393
MOD_PKA_2	211	217	PF00069	0.597
MOD_PKA_2	261	267	PF00069	0.710
MOD_PKA_2	332	338	PF00069	0.401
MOD_PKA_2	72	78	PF00069	0.717
MOD_Plk_1	415	421	PF00069	0.543
MOD_Plk_2-3	15	21	PF00069	0.537
MOD_Plk_4	114	120	PF00069	0.577
MOD_Plk_4	164	170	PF00069	0.628
MOD_Plk_4	294	300	PF00069	0.546
MOD_Plk_4	34	40	PF00069	0.370
MOD_Plk_4	366	372	PF00069	0.456
MOD_Plk_4	399	405	PF00069	0.532
MOD_ProDKin_1	355	361	PF00069	0.484
MOD_SUMO_rev_2	135	144	PF00179	0.636
MOD_SUMO_rev_2	30	37	PF00179	0.588
TRG_DiLeu_BaEn_1	114	119	PF01217	0.503
TRG_ENDOCYTIC_2	342	345	PF00928	0.272
TRG_ENDOCYTIC_2	38	41	PF00928	0.560
TRG_ER_diArg_1	253	255	PF00400	0.551
TRG_ER_diArg_1	408	410	PF00400	0.523
TRG_NES_CRM1_1	20	34	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V4	Leptomonas seymouri	61%	100%
A0A3S5H5K2	Leishmania donovani	81%	86%
A0A422NJC5	Trypanosoma rangeli	46%	99%
A4HSK2	Leishmania infantum	81%	88%
C9ZU91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
E9AKI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QJC2	Leishmania major	81%	100%
V5BG20	Trypanosoma cruzi	43%	99%