Mitochondrial glyco protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4C2_LEIBR

TriTrypDb:

LbrM.05.0770 , LBRM2903_050013600

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	10
GO:0031974	membrane-enclosed lumen	2	10
GO:0043233	organelle lumen	3	10
GO:0070013	intracellular organelle lumen	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.684
CLV_C14_Caspase3-7	164	168	PF00656	0.576
CLV_C14_Caspase3-7	193	197	PF00656	0.477
CLV_C14_Caspase3-7	241	245	PF00656	0.530
CLV_C14_Caspase3-7	293	297	PF00656	0.490
CLV_NRD_NRD_1	103	105	PF00675	0.464
CLV_PCSK_KEX2_1	103	105	PF00082	0.464
CLV_PCSK_SKI1_1	156	160	PF00082	0.435
CLV_PCSK_SKI1_1	46	50	PF00082	0.629
CLV_PCSK_SKI1_1	67	71	PF00082	0.538
DEG_Kelch_Keap1_1	205	210	PF01344	0.632
DEG_SPOP_SBC_1	109	113	PF00917	0.671
DOC_CDC14_PxL_1	39	47	PF14671	0.500
DOC_MAPK_DCC_7	78	87	PF00069	0.582
DOC_MAPK_MEF2A_6	156	163	PF00069	0.425
DOC_MAPK_MEF2A_6	78	87	PF00069	0.582
DOC_PP2B_LxvP_1	105	108	PF13499	0.615
DOC_USP7_MATH_1	110	114	PF00917	0.648
DOC_USP7_MATH_1	213	217	PF00917	0.804
DOC_USP7_MATH_1	259	263	PF00917	0.533
DOC_USP7_MATH_1	265	269	PF00917	0.577
DOC_USP7_MATH_1	57	61	PF00917	0.507
DOC_USP7_UBL2_3	63	67	PF12436	0.450
DOC_WW_Pin1_4	112	117	PF00397	0.651
DOC_WW_Pin1_4	261	266	PF00397	0.432
DOC_WW_Pin1_4	6	11	PF00397	0.775
LIG_14-3-3_CanoR_1	160	170	PF00244	0.482
LIG_14-3-3_CanoR_1	3	12	PF00244	0.685
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BIR_III_3	1	5	PF00653	0.516
LIG_EH_1	276	280	PF12763	0.561
LIG_FHA_1	7	13	PF00498	0.513
LIG_FHA_1	95	101	PF00498	0.549
LIG_FHA_2	162	168	PF00498	0.468
LIG_LIR_Gen_1	155	165	PF02991	0.531
LIG_LIR_Nem_3	155	161	PF02991	0.516
LIG_LIR_Nem_3	276	282	PF02991	0.517
LIG_PDZ_Class_2	335	340	PF00595	0.490
LIG_Pex14_2	181	185	PF04695	0.464
LIG_PTB_Apo_2	248	255	PF02174	0.432
LIG_PTB_Phospho_1	248	254	PF10480	0.472
LIG_REV1ctd_RIR_1	183	193	PF16727	0.511
LIG_SH2_CRK	254	258	PF00017	0.590
LIG_SH2_CRK	275	279	PF00017	0.508
LIG_SH2_GRB2like	232	235	PF00017	0.596
LIG_SH2_GRB2like	275	278	PF00017	0.561
LIG_SH2_NCK_1	275	279	PF00017	0.508
LIG_SH2_STAP1	318	322	PF00017	0.490
LIG_SH2_STAP1	327	331	PF00017	0.490
LIG_SH2_STAT5	275	278	PF00017	0.561
LIG_SH2_STAT5	337	340	PF00017	0.631
LIG_SH3_3	267	273	PF00018	0.504
LIG_SH3_3	51	57	PF00018	0.552
LIG_SH3_3	80	86	PF00018	0.508
LIG_TRAF2_1	134	137	PF00917	0.785
LIG_TRAF2_1	290	293	PF00917	0.465
MOD_CDK_SPK_2	112	117	PF00069	0.497
MOD_CDK_SPxxK_3	112	119	PF00069	0.501
MOD_CK1_1	111	117	PF00069	0.669
MOD_CK1_1	120	126	PF00069	0.698
MOD_CK1_1	131	137	PF00069	0.725
MOD_CK1_1	217	223	PF00069	0.641
MOD_CK1_1	264	270	PF00069	0.450
MOD_CK2_1	131	137	PF00069	0.784
MOD_CK2_1	204	210	PF00069	0.799
MOD_CK2_1	49	55	PF00069	0.700
MOD_Cter_Amidation	101	104	PF01082	0.438
MOD_GlcNHglycan	129	133	PF01048	0.785
MOD_GlcNHglycan	198	201	PF01048	0.680
MOD_GlcNHglycan	207	210	PF01048	0.684
MOD_GlcNHglycan	267	270	PF01048	0.390
MOD_GlcNHglycan	46	49	PF01048	0.650
MOD_GlcNHglycan	51	54	PF01048	0.617
MOD_GSK3_1	108	115	PF00069	0.665
MOD_GSK3_1	128	135	PF00069	0.757
MOD_GSK3_1	201	208	PF00069	0.705
MOD_GSK3_1	213	220	PF00069	0.729
MOD_GSK3_1	223	230	PF00069	0.441
MOD_GSK3_1	259	266	PF00069	0.548
MOD_GSK3_1	87	94	PF00069	0.558
MOD_NEK2_1	12	17	PF00069	0.568
MOD_NEK2_1	87	92	PF00069	0.508
MOD_PIKK_1	132	138	PF00454	0.786
MOD_PKA_2	120	126	PF00069	0.562
MOD_PKA_2	273	279	PF00069	0.590
MOD_Plk_1	166	172	PF00069	0.589
MOD_Plk_1	217	223	PF00069	0.679
MOD_Plk_1	227	233	PF00069	0.503
MOD_Plk_1	57	63	PF00069	0.497
MOD_Plk_4	227	233	PF00069	0.593
MOD_Plk_4	297	303	PF00069	0.556
MOD_Plk_4	316	322	PF00069	0.369
MOD_Plk_4	57	63	PF00069	0.529
MOD_Plk_4	95	101	PF00069	0.449
MOD_ProDKin_1	112	118	PF00069	0.654
MOD_ProDKin_1	261	267	PF00069	0.432
MOD_ProDKin_1	6	12	PF00069	0.778
MOD_SUMO_rev_2	66	74	PF00179	0.597
TRG_DiLeu_BaEn_2	94	100	PF01217	0.552
TRG_ER_diArg_1	103	105	PF00400	0.464
TRG_ER_diArg_1	116	119	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY6	Leptomonas seymouri	60%	88%
A0A3S5H5K1	Leishmania donovani	81%	88%
A0A422NJ89	Trypanosoma rangeli	49%	100%
A4HSK1	Leishmania infantum	80%	87%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	92%
E9AKI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	87%
Q4QJC3	Leishmania major	81%	100%
V5B710	Trypanosoma cruzi	49%	87%