LeishMANIAdb
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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H4C1_LEIBR
TriTrypDb:
LbrM.05.0760 , LBRM2903_050013500
Length:
147

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4H4C1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4C1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 97 101 PF00082 0.317
DEG_Nend_Nbox_1 1 3 PF02207 0.622
DOC_CKS1_1 73 78 PF01111 0.556
DOC_CYCLIN_yCln2_LP_2 73 79 PF00134 0.621
DOC_MAPK_MEF2A_6 106 113 PF00069 0.209
DOC_MAPK_MEF2A_6 29 36 PF00069 0.544
DOC_MAPK_NFAT4_5 106 114 PF00069 0.189
DOC_PP1_RVXF_1 108 114 PF00149 0.308
DOC_PP4_FxxP_1 99 102 PF00568 0.544
DOC_WW_Pin1_4 28 33 PF00397 0.571
DOC_WW_Pin1_4 72 77 PF00397 0.599
LIG_14-3-3_CanoR_1 110 114 PF00244 0.401
LIG_14-3-3_CanoR_1 35 40 PF00244 0.628
LIG_AP2alpha_2 66 68 PF02296 0.629
LIG_APCC_ABBA_1 41 46 PF00400 0.694
LIG_FHA_1 36 42 PF00498 0.654
LIG_FHA_1 72 78 PF00498 0.698
LIG_LIR_Apic_2 61 67 PF02991 0.653
LIG_LIR_Gen_1 31 41 PF02991 0.605
LIG_LIR_Nem_3 31 36 PF02991 0.602
LIG_LIR_Nem_3 66 71 PF02991 0.588
LIG_SH2_CRK 121 125 PF00017 0.203
LIG_SH2_STAP1 126 130 PF00017 0.488
LIG_SH2_STAT5 33 36 PF00017 0.628
LIG_SH3_1 64 70 PF00018 0.660
LIG_SH3_3 64 70 PF00018 0.577
MOD_CDK_SPxK_1 72 78 PF00069 0.595
MOD_CDK_SPxxK_3 28 35 PF00069 0.543
MOD_CK1_1 122 128 PF00069 0.323
MOD_CK1_1 16 22 PF00069 0.756
MOD_CMANNOS 105 108 PF00535 0.606
MOD_CMANNOS 56 59 PF00535 0.390
MOD_GlcNHglycan 3 6 PF01048 0.458
MOD_GlcNHglycan 8 11 PF01048 0.448
MOD_GSK3_1 109 116 PF00069 0.457
MOD_GSK3_1 13 20 PF00069 0.741
MOD_NEK2_1 1 6 PF00069 0.647
MOD_NEK2_1 109 114 PF00069 0.388
MOD_NEK2_1 34 39 PF00069 0.663
MOD_PK_1 23 29 PF00069 0.558
MOD_PKA_2 109 115 PF00069 0.401
MOD_PKA_2 34 40 PF00069 0.700
MOD_PKA_2 6 12 PF00069 0.656
MOD_Plk_4 109 115 PF00069 0.426
MOD_Plk_4 119 125 PF00069 0.439
MOD_ProDKin_1 28 34 PF00069 0.572
MOD_ProDKin_1 72 78 PF00069 0.595
TRG_ENDOCYTIC_2 121 124 PF00928 0.203
TRG_ENDOCYTIC_2 33 36 PF00928 0.611
TRG_ER_diArg_1 49 52 PF00400 0.621

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P790 Leptomonas seymouri 78% 100%
A0A1X0NK03 Trypanosomatidae 63% 100%
A0A3S7WP53 Leishmania donovani 83% 100%
A0A422NJC6 Trypanosoma rangeli 64% 99%
A4HSK0 Leishmania infantum 83% 100%
C9ZU94 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 95%
E9AKI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QJC4 Leishmania major 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS