Vta1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vta1 like, putative

Species:

Leishmania braziliensis

UniProt:

A4H4B7_LEIBR

TriTrypDb:

LbrM.05.0720 , LBRM2903_050013000

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	8
GO:0012506	vesicle membrane	4	8
GO:0016020	membrane	2	8
GO:0030659	cytoplasmic vesicle membrane	5	8
GO:0031090	organelle membrane	3	8
GO:0098588	bounding membrane of organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4H4B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4B7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0045324	late endosome to vacuole transport	5	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071985	multivesicular body sorting pathway	5	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.506
CLV_C14_Caspase3-7	220	224	PF00656	0.510
CLV_C14_Caspase3-7	64	68	PF00656	0.443
CLV_NRD_NRD_1	159	161	PF00675	0.332
CLV_NRD_NRD_1	50	52	PF00675	0.196
CLV_PCSK_SKI1_1	145	149	PF00082	0.306
CLV_PCSK_SKI1_1	155	159	PF00082	0.265
CLV_PCSK_SKI1_1	19	23	PF00082	0.258
CLV_PCSK_SKI1_1	86	90	PF00082	0.270
CLV_PCSK_SKI1_1	91	95	PF00082	0.263
DEG_SPOP_SBC_1	208	212	PF00917	0.490
DEG_SPOP_SBC_1	296	300	PF00917	0.554
DOC_CKS1_1	239	244	PF01111	0.557
DOC_PP4_FxxP_1	201	204	PF00568	0.593
DOC_USP7_MATH_1	135	139	PF00917	0.467
DOC_USP7_MATH_1	172	176	PF00917	0.605
DOC_USP7_MATH_1	216	220	PF00917	0.577
DOC_USP7_MATH_1	296	300	PF00917	0.619
DOC_USP7_UBL2_3	52	56	PF12436	0.403
DOC_WW_Pin1_4	163	168	PF00397	0.472
DOC_WW_Pin1_4	212	217	PF00397	0.566
DOC_WW_Pin1_4	238	243	PF00397	0.562
DOC_WW_Pin1_4	268	273	PF00397	0.617
DOC_WW_Pin1_4	292	297	PF00397	0.541
DOC_WW_Pin1_4	308	313	PF00397	0.559
LIG_14-3-3_CanoR_1	115	124	PF00244	0.475
LIG_14-3-3_CanoR_1	203	208	PF00244	0.541
LIG_14-3-3_CanoR_1	287	297	PF00244	0.595
LIG_BIR_II_1	1	5	PF00653	0.390
LIG_BIR_III_4	176	180	PF00653	0.586
LIG_BRCT_BRCA1_1	24	28	PF00533	0.475
LIG_eIF4E_1	118	124	PF01652	0.432
LIG_FHA_1	117	123	PF00498	0.498
LIG_FHA_1	57	63	PF00498	0.432
LIG_FHA_2	218	224	PF00498	0.767
LIG_FHA_2	62	68	PF00498	0.479
LIG_LIR_Apic_2	162	167	PF02991	0.463
LIG_LIR_Apic_2	199	204	PF02991	0.593
LIG_LIR_Gen_1	192	201	PF02991	0.480
LIG_LIR_Gen_1	245	250	PF02991	0.488
LIG_LIR_Gen_1	90	100	PF02991	0.496
LIG_LIR_Nem_3	192	196	PF02991	0.494
LIG_LIR_Nem_3	245	249	PF02991	0.490
LIG_LIR_Nem_3	90	95	PF02991	0.433
LIG_NRBOX	61	67	PF00104	0.475
LIG_SH2_CRK	230	234	PF00017	0.610
LIG_SH2_CRK	246	250	PF00017	0.480
LIG_SH2_NCK_1	230	234	PF00017	0.610
LIG_SH2_PTP2	164	167	PF00017	0.454
LIG_SH2_SRC	230	233	PF00017	0.521
LIG_SH2_STAP1	118	122	PF00017	0.432
LIG_SH2_STAP1	146	150	PF00017	0.432
LIG_SH2_STAP1	246	250	PF00017	0.575
LIG_SH2_STAT5	118	121	PF00017	0.475
LIG_SH2_STAT5	149	152	PF00017	0.432
LIG_SH2_STAT5	164	167	PF00017	0.454
LIG_SH2_STAT5	246	249	PF00017	0.537
LIG_SH2_STAT5	38	41	PF00017	0.479
LIG_SH3_1	226	232	PF00018	0.478
LIG_SH3_3	226	232	PF00018	0.666
LIG_SH3_3	271	277	PF00018	0.621
LIG_SH3_3	7	13	PF00018	0.423
LIG_SH3_5	242	246	PF00018	0.463
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.338
LIG_UBA3_1	65	73	PF00899	0.453
LIG_WW_1	243	246	PF00397	0.578
MOD_CDC14_SPxK_1	166	169	PF00782	0.498
MOD_CDK_SPK_2	268	273	PF00069	0.515
MOD_CDK_SPxK_1	163	169	PF00069	0.487
MOD_CK1_1	199	205	PF00069	0.561
MOD_CK1_1	2	8	PF00069	0.446
MOD_CK1_1	206	212	PF00069	0.598
MOD_CK1_1	256	262	PF00069	0.540
MOD_CK1_1	298	304	PF00069	0.587
MOD_CK2_1	2	8	PF00069	0.450
MOD_GlcNHglycan	258	261	PF01048	0.697
MOD_GlcNHglycan	268	271	PF01048	0.481
MOD_GlcNHglycan	292	295	PF01048	0.754
MOD_GlcNHglycan	318	321	PF01048	0.578
MOD_GlcNHglycan	341	344	PF01048	0.275
MOD_GlcNHglycan	76	79	PF01048	0.177
MOD_GSK3_1	103	110	PF00069	0.475
MOD_GSK3_1	124	131	PF00069	0.475
MOD_GSK3_1	192	199	PF00069	0.586
MOD_GSK3_1	202	209	PF00069	0.577
MOD_GSK3_1	210	217	PF00069	0.745
MOD_GSK3_1	249	256	PF00069	0.676
MOD_GSK3_1	286	293	PF00069	0.736
MOD_GSK3_1	335	342	PF00069	0.475
MOD_GSK3_1	80	87	PF00069	0.397
MOD_N-GLC_1	107	112	PF02516	0.279
MOD_N-GLC_1	256	261	PF02516	0.553
MOD_N-GLC_1	266	271	PF02516	0.474
MOD_NEK2_1	116	121	PF00069	0.454
MOD_NEK2_1	124	129	PF00069	0.404
MOD_NEK2_1	288	293	PF00069	0.654
MOD_NEK2_1	61	66	PF00069	0.485
MOD_NEK2_1	69	74	PF00069	0.511
MOD_PIKK_1	249	255	PF00454	0.652
MOD_PIKK_1	298	304	PF00454	0.568
MOD_PIKK_1	335	341	PF00454	0.479
MOD_PIKK_1	71	77	PF00454	0.427
MOD_PKA_2	202	208	PF00069	0.559
MOD_PKA_2	286	292	PF00069	0.602
MOD_PKB_1	285	293	PF00069	0.514
MOD_Plk_1	107	113	PF00069	0.479
MOD_Plk_1	244	250	PF00069	0.483
MOD_Plk_4	118	124	PF00069	0.475
MOD_Plk_4	2	8	PF00069	0.557
MOD_Plk_4	244	250	PF00069	0.493
MOD_Plk_4	61	67	PF00069	0.506
MOD_ProDKin_1	163	169	PF00069	0.482
MOD_ProDKin_1	212	218	PF00069	0.563
MOD_ProDKin_1	238	244	PF00069	0.561
MOD_ProDKin_1	268	274	PF00069	0.719
MOD_ProDKin_1	292	298	PF00069	0.541
MOD_ProDKin_1	308	314	PF00069	0.561
MOD_SUMO_rev_2	25	33	PF00179	0.479
TRG_ENDOCYTIC_2	246	249	PF00928	0.490
TRG_ER_diArg_1	285	288	PF00400	0.521
TRG_ER_diArg_1	48	51	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8N6	Leptomonas seymouri	54%	98%
A0A0S4IWD6	Bodo saltans	39%	100%
A0A3S5H5J7	Leishmania donovani	73%	100%
A4HSJ6	Leishmania infantum	73%	100%
E9AKI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q32L63	Bos taurus	26%	100%
Q4QJC8	Leishmania major	73%	99%
Q5R5W5	Pongo abelii	26%	100%
Q9CR26	Mus musculus	25%	100%
Q9NP79	Homo sapiens	26%	100%