Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4B6_LEIBR

TriTrypDb:

LbrM.05.0710 , LBRM2903_050012900

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.702
CLV_NRD_NRD_1	170	172	PF00675	0.606
CLV_NRD_NRD_1	387	389	PF00675	0.593
CLV_NRD_NRD_1	479	481	PF00675	0.630
CLV_NRD_NRD_1	569	571	PF00675	0.738
CLV_NRD_NRD_1	581	583	PF00675	0.620
CLV_NRD_NRD_1	629	631	PF00675	0.553
CLV_NRD_NRD_1	633	635	PF00675	0.553
CLV_PCSK_FUR_1	727	731	PF00082	0.576
CLV_PCSK_KEX2_1	123	125	PF00082	0.702
CLV_PCSK_KEX2_1	170	172	PF00082	0.606
CLV_PCSK_KEX2_1	387	389	PF00082	0.593
CLV_PCSK_KEX2_1	479	481	PF00082	0.633
CLV_PCSK_KEX2_1	568	570	PF00082	0.742
CLV_PCSK_KEX2_1	628	630	PF00082	0.648
CLV_PCSK_KEX2_1	729	731	PF00082	0.592
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.588
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.569
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.618
CLV_PCSK_SKI1_1	302	306	PF00082	0.598
CLV_PCSK_SKI1_1	34	38	PF00082	0.556
CLV_PCSK_SKI1_1	730	734	PF00082	0.647
DEG_APCC_DBOX_1	33	41	PF00400	0.550
DEG_APCC_DBOX_1	694	702	PF00400	0.443
DEG_SCF_FBW7_1	253	258	PF00400	0.579
DEG_SCF_FBW7_1	334	341	PF00400	0.571
DEG_SCF_FBW7_1	518	525	PF00400	0.744
DEG_SPOP_SBC_1	182	186	PF00917	0.724
DEG_SPOP_SBC_1	473	477	PF00917	0.565
DOC_ANK_TNKS_1	455	462	PF00023	0.543
DOC_CKS1_1	241	246	PF01111	0.594
DOC_CKS1_1	335	340	PF01111	0.572
DOC_CKS1_1	373	378	PF01111	0.557
DOC_CKS1_1	519	524	PF01111	0.744
DOC_CYCLIN_yCln2_LP_2	557	563	PF00134	0.563
DOC_MAPK_MEF2A_6	554	561	PF00069	0.568
DOC_MAPK_MEF2A_6	700	709	PF00069	0.547
DOC_MAPK_NFAT4_5	554	562	PF00069	0.566
DOC_MAPK_NFAT4_5	700	708	PF00069	0.380
DOC_PP1_RVXF_1	735	741	PF00149	0.514
DOC_PP2B_LxvP_1	128	131	PF13499	0.568
DOC_PP2B_LxvP_1	557	560	PF13499	0.565
DOC_PP4_MxPP_1	220	223	PF00568	0.608
DOC_USP7_MATH_1	149	153	PF00917	0.622
DOC_USP7_MATH_1	235	239	PF00917	0.630
DOC_USP7_MATH_1	29	33	PF00917	0.525
DOC_USP7_MATH_1	393	397	PF00917	0.544
DOC_USP7_MATH_1	417	421	PF00917	0.772
DOC_USP7_MATH_1	466	470	PF00917	0.764
DOC_USP7_MATH_1	473	477	PF00917	0.725
DOC_USP7_MATH_1	599	603	PF00917	0.660
DOC_USP7_MATH_1	87	91	PF00917	0.558
DOC_USP7_UBL2_3	729	733	PF12436	0.517
DOC_USP7_UBL2_3	755	759	PF12436	0.539
DOC_WW_Pin1_4	172	177	PF00397	0.645
DOC_WW_Pin1_4	205	210	PF00397	0.688
DOC_WW_Pin1_4	240	245	PF00397	0.680
DOC_WW_Pin1_4	251	256	PF00397	0.796
DOC_WW_Pin1_4	278	283	PF00397	0.798
DOC_WW_Pin1_4	334	339	PF00397	0.764
DOC_WW_Pin1_4	341	346	PF00397	0.624
DOC_WW_Pin1_4	372	377	PF00397	0.624
DOC_WW_Pin1_4	432	437	PF00397	0.569
DOC_WW_Pin1_4	474	479	PF00397	0.581
DOC_WW_Pin1_4	518	523	PF00397	0.762
DOC_WW_Pin1_4	56	61	PF00397	0.535
DOC_WW_Pin1_4	577	582	PF00397	0.579
DOC_WW_Pin1_4	597	602	PF00397	0.771
DOC_WW_Pin1_4	753	758	PF00397	0.763
DOC_WW_Pin1_4	90	95	PF00397	0.721
LIG_14-3-3_CanoR_1	187	197	PF00244	0.731
LIG_14-3-3_CanoR_1	246	255	PF00244	0.584
LIG_14-3-3_CanoR_1	533	537	PF00244	0.594
LIG_14-3-3_CanoR_1	570	579	PF00244	0.744
LIG_14-3-3_CanoR_1	720	728	PF00244	0.572
LIG_Actin_WH2_2	728	745	PF00022	0.526
LIG_APCC_ABBAyCdc20_2	634	640	PF00400	0.533
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BIR_III_2	651	655	PF00653	0.565
LIG_BRCT_BRCA1_1	399	403	PF00533	0.522
LIG_EVH1_1	128	132	PF00568	0.553
LIG_EVH1_1	559	563	PF00568	0.560
LIG_FHA_1	23	29	PF00498	0.565
LIG_FHA_1	335	341	PF00498	0.574
LIG_FHA_1	422	428	PF00498	0.555
LIG_FHA_1	669	675	PF00498	0.538
LIG_FHA_2	153	159	PF00498	0.590
LIG_FHA_2	256	262	PF00498	0.590
LIG_FHA_2	303	309	PF00498	0.591
LIG_FHA_2	679	685	PF00498	0.657
LIG_FHA_2	694	700	PF00498	0.428
LIG_LIR_Gen_1	314	319	PF02991	0.558
LIG_LIR_Gen_1	400	409	PF02991	0.521
LIG_LIR_Gen_1	704	710	PF02991	0.450
LIG_LIR_Gen_1	718	728	PF02991	0.547
LIG_LIR_Nem_3	314	318	PF02991	0.559
LIG_LIR_Nem_3	38	44	PF02991	0.592
LIG_LIR_Nem_3	400	406	PF02991	0.582
LIG_LIR_Nem_3	704	709	PF02991	0.443
LIG_LIR_Nem_3	718	724	PF02991	0.562
LIG_PCNA_TLS_4	700	707	PF02747	0.380
LIG_PCNA_yPIPBox_3	720	732	PF02747	0.561
LIG_SH2_CRK	41	45	PF00017	0.476
LIG_SH2_CRK	721	725	PF00017	0.576
LIG_SH2_PTP2	706	709	PF00017	0.406
LIG_SH2_STAT3	431	434	PF00017	0.577
LIG_SH2_STAT5	368	371	PF00017	0.575
LIG_SH2_STAT5	706	709	PF00017	0.406
LIG_SH2_STAT5	721	724	PF00017	0.578
LIG_SH3_1	126	132	PF00018	0.639
LIG_SH3_2	241	246	PF14604	0.590
LIG_SH3_2	563	568	PF14604	0.573
LIG_SH3_3	126	132	PF00018	0.713
LIG_SH3_3	216	222	PF00018	0.608
LIG_SH3_3	238	244	PF00018	0.682
LIG_SH3_3	332	338	PF00018	0.569
LIG_SH3_3	370	376	PF00018	0.663
LIG_SH3_3	475	481	PF00018	0.736
LIG_SH3_3	516	522	PF00018	0.744
LIG_SH3_3	533	539	PF00018	0.716
LIG_SH3_3	557	563	PF00018	0.572
LIG_TRAF2_1	132	135	PF00917	0.570
LIG_TRAF2_1	297	300	PF00917	0.578
LIG_TRAF2_1	682	685	PF00917	0.573
LIG_WW_3	243	247	PF00397	0.590
MOD_CDC14_SPxK_1	756	759	PF00782	0.624
MOD_CDK_SPK_2	251	256	PF00069	0.588
MOD_CDK_SPK_2	474	479	PF00069	0.572
MOD_CDK_SPK_2	577	582	PF00069	0.579
MOD_CDK_SPxK_1	240	246	PF00069	0.571
MOD_CDK_SPxK_1	474	480	PF00069	0.575
MOD_CDK_SPxK_1	522	528	PF00069	0.744
MOD_CDK_SPxK_1	577	583	PF00069	0.578
MOD_CDK_SPxK_1	753	759	PF00069	0.606
MOD_CK1_1	115	121	PF00069	0.669
MOD_CK1_1	144	150	PF00069	0.740
MOD_CK1_1	152	158	PF00069	0.650
MOD_CK1_1	163	169	PF00069	0.719
MOD_CK1_1	186	192	PF00069	0.719
MOD_CK1_1	200	206	PF00069	0.584
MOD_CK1_1	267	273	PF00069	0.755
MOD_CK1_1	277	283	PF00069	0.742
MOD_CK1_1	323	329	PF00069	0.827
MOD_CK1_1	336	342	PF00069	0.733
MOD_CK1_1	350	356	PF00069	0.546
MOD_CK1_1	380	386	PF00069	0.741
MOD_CK1_1	42	48	PF00069	0.512
MOD_CK1_1	432	438	PF00069	0.708
MOD_CK1_1	449	455	PF00069	0.649
MOD_CK1_1	471	477	PF00069	0.825
MOD_CK1_1	531	537	PF00069	0.595
MOD_CK1_1	600	606	PF00069	0.724
MOD_CK1_1	689	695	PF00069	0.390
MOD_CK1_1	90	96	PF00069	0.567
MOD_CK2_1	139	145	PF00069	0.727
MOD_CK2_1	294	300	PF00069	0.582
MOD_CK2_1	380	386	PF00069	0.572
MOD_CK2_1	483	489	PF00069	0.584
MOD_CK2_1	498	504	PF00069	0.541
MOD_CK2_1	585	591	PF00069	0.713
MOD_CK2_1	678	684	PF00069	0.698
MOD_CK2_1	693	699	PF00069	0.394
MOD_CK2_1	733	739	PF00069	0.357
MOD_CK2_1	86	92	PF00069	0.701
MOD_Cter_Amidation	566	569	PF01082	0.580
MOD_DYRK1A_RPxSP_1	240	244	PF00069	0.573
MOD_DYRK1A_RPxSP_1	597	601	PF00069	0.619
MOD_GlcNHglycan	14	18	PF01048	0.421
MOD_GlcNHglycan	141	144	PF01048	0.577
MOD_GlcNHglycan	147	150	PF01048	0.697
MOD_GlcNHglycan	162	165	PF01048	0.651
MOD_GlcNHglycan	199	202	PF01048	0.662
MOD_GlcNHglycan	249	252	PF01048	0.635
MOD_GlcNHglycan	266	269	PF01048	0.757
MOD_GlcNHglycan	276	279	PF01048	0.663
MOD_GlcNHglycan	283	286	PF01048	0.568
MOD_GlcNHglycan	341	344	PF01048	0.733
MOD_GlcNHglycan	349	352	PF01048	0.758
MOD_GlcNHglycan	382	385	PF01048	0.729
MOD_GlcNHglycan	413	416	PF01048	0.702
MOD_GlcNHglycan	419	422	PF01048	0.769
MOD_GlcNHglycan	485	488	PF01048	0.647
MOD_GlcNHglycan	500	503	PF01048	0.600
MOD_GlcNHglycan	522	525	PF01048	0.652
MOD_GlcNHglycan	597	600	PF01048	0.724
MOD_GlcNHglycan	89	92	PF01048	0.604
MOD_GSK3_1	108	115	PF00069	0.615
MOD_GSK3_1	141	148	PF00069	0.623
MOD_GSK3_1	159	166	PF00069	0.746
MOD_GSK3_1	181	188	PF00069	0.728
MOD_GSK3_1	236	243	PF00069	0.612
MOD_GSK3_1	247	254	PF00069	0.574
MOD_GSK3_1	270	277	PF00069	0.648
MOD_GSK3_1	334	341	PF00069	0.740
MOD_GSK3_1	387	394	PF00069	0.793
MOD_GSK3_1	39	46	PF00069	0.526
MOD_GSK3_1	417	424	PF00069	0.657
MOD_GSK3_1	434	441	PF00069	0.674
MOD_GSK3_1	444	451	PF00069	0.663
MOD_GSK3_1	468	475	PF00069	0.754
MOD_GSK3_1	508	515	PF00069	0.764
MOD_GSK3_1	518	525	PF00069	0.722
MOD_GSK3_1	527	534	PF00069	0.602
MOD_GSK3_1	573	580	PF00069	0.684
MOD_GSK3_1	585	592	PF00069	0.693
MOD_GSK3_1	595	602	PF00069	0.686
MOD_GSK3_1	689	696	PF00069	0.555
MOD_GSK3_1	719	726	PF00069	0.677
MOD_GSK3_1	749	756	PF00069	0.648
MOD_GSK3_1	86	93	PF00069	0.572
MOD_LATS_1	293	299	PF00433	0.585
MOD_N-GLC_1	112	117	PF02516	0.574
MOD_N-GLC_1	197	202	PF02516	0.574
MOD_N-GLC_1	311	316	PF02516	0.564
MOD_N-GLC_1	584	589	PF02516	0.717
MOD_NEK2_1	159	164	PF00069	0.587
MOD_NEK2_1	165	170	PF00069	0.581
MOD_NEK2_1	183	188	PF00069	0.685
MOD_NEK2_1	212	217	PF00069	0.590
MOD_NEK2_1	283	288	PF00069	0.591
MOD_NEK2_1	318	323	PF00069	0.566
MOD_NEK2_1	4	9	PF00069	0.515
MOD_NEK2_1	429	434	PF00069	0.587
MOD_NEK2_1	448	453	PF00069	0.720
MOD_NEK2_1	572	577	PF00069	0.581
MOD_NEK2_1	584	589	PF00069	0.525
MOD_OFUCOSY	395	401	PF10250	0.524
MOD_PIKK_1	147	153	PF00454	0.581
MOD_PIKK_1	165	171	PF00454	0.535
MOD_PIKK_1	283	289	PF00454	0.589
MOD_PIKK_1	295	301	PF00454	0.554
MOD_PIKK_1	350	356	PF00454	0.593
MOD_PIKK_1	362	368	PF00454	0.602
MOD_PIKK_1	39	45	PF00454	0.434
MOD_PIKK_1	446	452	PF00454	0.671
MOD_PIKK_1	508	514	PF00454	0.736
MOD_PIKK_1	573	579	PF00454	0.744
MOD_PIKK_1	585	591	PF00454	0.585
MOD_PIKK_1	693	699	PF00454	0.537
MOD_PIKK_1	719	725	PF00454	0.589
MOD_PKA_1	387	393	PF00069	0.586
MOD_PKA_2	152	158	PF00069	0.699
MOD_PKA_2	186	192	PF00069	0.711
MOD_PKA_2	255	261	PF00069	0.607
MOD_PKA_2	274	280	PF00069	0.572
MOD_PKA_2	386	392	PF00069	0.627
MOD_PKA_2	497	503	PF00069	0.601
MOD_PKA_2	527	533	PF00069	0.764
MOD_PKA_2	553	559	PF00069	0.571
MOD_PKA_2	572	578	PF00069	0.535
MOD_PKA_2	719	725	PF00069	0.634
MOD_Plk_1	112	118	PF00069	0.574
MOD_Plk_1	13	19	PF00069	0.475
MOD_Plk_1	585	591	PF00069	0.713
MOD_Plk_1	689	695	PF00069	0.463
MOD_Plk_1	733	739	PF00069	0.357
MOD_Plk_2-3	489	495	PF00069	0.572
MOD_Plk_4	189	195	PF00069	0.727
MOD_Plk_4	4	10	PF00069	0.554
MOD_Plk_4	590	596	PF00069	0.716
MOD_Plk_4	689	695	PF00069	0.465
MOD_ProDKin_1	172	178	PF00069	0.646
MOD_ProDKin_1	205	211	PF00069	0.691
MOD_ProDKin_1	240	246	PF00069	0.684
MOD_ProDKin_1	251	257	PF00069	0.788
MOD_ProDKin_1	278	284	PF00069	0.798
MOD_ProDKin_1	334	340	PF00069	0.766
MOD_ProDKin_1	341	347	PF00069	0.626
MOD_ProDKin_1	372	378	PF00069	0.625
MOD_ProDKin_1	432	438	PF00069	0.570
MOD_ProDKin_1	474	480	PF00069	0.583
MOD_ProDKin_1	518	524	PF00069	0.762
MOD_ProDKin_1	56	62	PF00069	0.532
MOD_ProDKin_1	577	583	PF00069	0.578
MOD_ProDKin_1	597	603	PF00069	0.770
MOD_ProDKin_1	753	759	PF00069	0.769
MOD_ProDKin_1	90	96	PF00069	0.717
MOD_SUMO_rev_2	307	311	PF00179	0.697
MOD_SUMO_rev_2	486	492	PF00179	0.581
TRG_DiLeu_BaEn_1	622	627	PF01217	0.449
TRG_DiLeu_BaEn_2	613	619	PF01217	0.640
TRG_DiLeu_BaLyEn_6	651	656	PF01217	0.561
TRG_ENDOCYTIC_2	180	183	PF00928	0.730
TRG_ENDOCYTIC_2	315	318	PF00928	0.559
TRG_ENDOCYTIC_2	41	44	PF00928	0.544
TRG_ENDOCYTIC_2	706	709	PF00928	0.406
TRG_ENDOCYTIC_2	721	724	PF00928	0.578
TRG_ER_diArg_1	170	172	PF00400	0.582
TRG_ER_diArg_1	478	480	PF00400	0.631
TRG_ER_diArg_1	569	571	PF00400	0.745
TRG_ER_diArg_1	629	631	PF00400	0.532
TRG_ER_diArg_1	710	713	PF00400	0.525
TRG_NLS_MonoExtC_3	627	633	PF00514	0.469
TRG_NLS_MonoExtN_4	566	572	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WP68	Leishmania donovani	51%	92%
A4HSJ5	Leishmania infantum	48%	92%
E9AKH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4QJC9	Leishmania major	48%	91%