Sre-2/carboxylate carrier-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sre-2/carboxylate carrier-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4B2_LEIBR

TriTrypDb:

LbrM.05.0670 , LBRM2903_050012300

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	7
GO:0016020	membrane	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A4H4B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4B2

Function

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Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	8
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0006865	amino acid transport	5	8
GO:0009987	cellular process	1	1
GO:0015711	organic anion transport	5	1
GO:0015804	neutral amino acid transport	6	1
GO:0015849	organic acid transport	5	8

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015175	neutral L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	8
GO:0022889	serine transmembrane transporter activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.314
CLV_C14_Caspase3-7	58	62	PF00656	0.485
CLV_C14_Caspase3-7	74	78	PF00656	0.533
CLV_NRD_NRD_1	62	64	PF00675	0.337
CLV_PCSK_SKI1_1	124	128	PF00082	0.533
CLV_PCSK_SKI1_1	214	218	PF00082	0.533
CLV_PCSK_SKI1_1	41	45	PF00082	0.306
CLV_PCSK_SKI1_1	49	53	PF00082	0.279
CLV_PCSK_SKI1_1	92	96	PF00082	0.333
DEG_APCC_DBOX_1	213	221	PF00400	0.333

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	74%	100%
A0A0N1I4E4	Leptomonas seymouri	28%	100%
A0A0S4IJR6	Bodo saltans	44%	100%
A0A1X0P3C3	Trypanosomatidae	29%	100%
A0A3R7KD90	Trypanosoma rangeli	31%	100%
A0A3S5H4W1	Leishmania donovani	28%	100%
A0A3S5H5J2	Leishmania donovani	88%	100%
A4H380	Leishmania braziliensis	28%	98%
A4HRI0	Leishmania infantum	28%	100%
A4HSJ0	Leishmania infantum	88%	100%

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