Nitroreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitroreductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4B0_LEIBR

TriTrypDb:

LbrM.05.0650 , LBRM2903_050011900

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4B0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	86	88	PF00675	0.251
CLV_PCSK_KEX2_1	276	278	PF00082	0.581
CLV_PCSK_KEX2_1	86	88	PF00082	0.384
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.581
CLV_PCSK_SKI1_1	120	124	PF00082	0.267
CLV_PCSK_SKI1_1	248	252	PF00082	0.385
CLV_PCSK_SKI1_1	283	287	PF00082	0.547
CLV_PCSK_SKI1_1	86	90	PF00082	0.306
DEG_Nend_Nbox_1	1	3	PF02207	0.447
DEG_SPOP_SBC_1	108	112	PF00917	0.173
DEG_SPOP_SBC_1	36	40	PF00917	0.594
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.385
DOC_MAPK_MEF2A_6	197	206	PF00069	0.295
DOC_MAPK_MEF2A_6	257	266	PF00069	0.272
DOC_PP2B_LxvP_1	129	132	PF13499	0.385
DOC_PP2B_LxvP_1	251	254	PF13499	0.413
DOC_USP7_MATH_1	180	184	PF00917	0.278
DOC_USP7_MATH_1	186	190	PF00917	0.242
DOC_USP7_MATH_1	202	206	PF00917	0.381
DOC_USP7_MATH_1	37	41	PF00917	0.578
DOC_WW_Pin1_4	198	203	PF00397	0.298
DOC_WW_Pin1_4	278	283	PF00397	0.418
DOC_WW_Pin1_4	38	43	PF00397	0.462
LIG_14-3-3_CanoR_1	12	20	PF00244	0.407
LIG_14-3-3_CanoR_1	24	30	PF00244	0.330
LIG_14-3-3_CanoR_1	257	261	PF00244	0.302
LIG_14-3-3_CanoR_1	283	292	PF00244	0.399
LIG_14-3-3_CanoR_1	31	37	PF00244	0.421
LIG_14-3-3_CanoR_1	66	74	PF00244	0.270
LIG_14-3-3_CanoR_1	86	96	PF00244	0.357
LIG_BRCT_BRCA1_1	15	19	PF00533	0.397
LIG_BRCT_BRCA1_1	280	284	PF00533	0.404
LIG_FHA_1	199	205	PF00498	0.298
LIG_FHA_1	221	227	PF00498	0.304
LIG_FHA_1	257	263	PF00498	0.254
LIG_FHA_1	77	83	PF00498	0.269
LIG_FHA_2	268	274	PF00498	0.407
LIG_LIR_Apic_2	156	162	PF02991	0.353
LIG_LIR_Apic_2	256	261	PF02991	0.337
LIG_LIR_Gen_1	223	232	PF02991	0.272
LIG_LIR_Gen_1	289	295	PF02991	0.512
LIG_LIR_Nem_3	157	163	PF02991	0.310
LIG_LIR_Nem_3	223	228	PF02991	0.275
LIG_LIR_Nem_3	289	295	PF02991	0.512
LIG_PTB_Apo_2	168	175	PF02174	0.333
LIG_PTB_Phospho_1	168	174	PF10480	0.333
LIG_SH2_CRK	160	164	PF00017	0.277
LIG_SH2_CRK	258	262	PF00017	0.333
LIG_SH2_NCK_1	195	199	PF00017	0.298
LIG_SH2_NCK_1	268	272	PF00017	0.408
LIG_SH2_STAP1	195	199	PF00017	0.393
LIG_SH2_STAP1	268	272	PF00017	0.348
LIG_SH2_STAT5	168	171	PF00017	0.283
LIG_SH2_STAT5	174	177	PF00017	0.288
LIG_SH2_STAT5	258	261	PF00017	0.362
LIG_SH3_3	201	207	PF00018	0.368
LIG_SH3_3	276	282	PF00018	0.335
LIG_SUMO_SIM_par_1	259	265	PF11976	0.272
LIG_SUMO_SIM_par_1	78	84	PF11976	0.337
LIG_SxIP_EBH_1	216	226	PF03271	0.333
MOD_CDK_SPK_2	278	283	PF00069	0.339
MOD_CK1_1	189	195	PF00069	0.288
MOD_CK1_1	25	31	PF00069	0.442
MOD_CK1_1	38	44	PF00069	0.609
MOD_CK1_1	5	11	PF00069	0.528
MOD_CK2_1	267	273	PF00069	0.396
MOD_GlcNHglycan	16	19	PF01048	0.607
MOD_GlcNHglycan	165	168	PF01048	0.286
MOD_GlcNHglycan	188	191	PF01048	0.311
MOD_GlcNHglycan	32	35	PF01048	0.423
MOD_GlcNHglycan	52	55	PF01048	0.498
MOD_GSK3_1	189	196	PF00069	0.285
MOD_GSK3_1	198	205	PF00069	0.214
MOD_GSK3_1	32	39	PF00069	0.594
MOD_GSK3_1	41	48	PF00069	0.626
MOD_GSK3_1	90	97	PF00069	0.298
MOD_N-GLC_1	12	17	PF02516	0.634
MOD_NEK2_1	163	168	PF00069	0.298
MOD_NEK2_1	19	24	PF00069	0.517
MOD_NEK2_1	2	7	PF00069	0.565
MOD_NEK2_1	284	289	PF00069	0.492
MOD_NEK2_1	89	94	PF00069	0.272
MOD_PKA_2	2	8	PF00069	0.694
MOD_PKA_2	256	262	PF00069	0.282
MOD_PKA_2	30	36	PF00069	0.528
MOD_PKA_2	67	73	PF00069	0.274
MOD_Plk_4	131	137	PF00069	0.254
MOD_Plk_4	215	221	PF00069	0.297
MOD_ProDKin_1	198	204	PF00069	0.298
MOD_ProDKin_1	278	284	PF00069	0.414
MOD_ProDKin_1	38	44	PF00069	0.461
TRG_ENDOCYTIC_2	160	163	PF00928	0.303
TRG_ENDOCYTIC_2	173	176	PF00928	0.275
TRG_ER_diArg_1	65	68	PF00400	0.344
TRG_ER_diArg_1	85	87	PF00400	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M3	Leptomonas seymouri	64%	93%
A0A1X0NKR5	Trypanosomatidae	54%	94%
A0A3R7M8G7	Trypanosoma rangeli	59%	96%
A0A3S5H5J0	Leishmania donovani	82%	91%
A4HSI8	Leishmania infantum	82%	91%
C9ZUB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	92%
E9AKH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	94%
P81102	Bacillus subtilis (strain 168)	25%	100%
Q4QJD6	Leishmania major	80%	100%
Q60049	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	30%	100%
V5BAS5	Trypanosoma cruzi	57%	93%