LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H4A9_LEIBR
TriTrypDb:
LbrM.05.0640 , LBRM2903_050011100 *
Length:
778

Annotations

LeishMANIAdb annotations

This Kinetoplastid-unique protein has a 4TM central helical bundle and long cytoplasmic termini with strikingly low complexity. Its function is unknown.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0000123 histone acetyltransferase complex 4 1
GO:0000124 SAGA complex 4 1
GO:0005815 microtubule organizing center 2 1
GO:0031248 protein acetyltransferase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0070461 SAGA-type complex 5 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902493 acetyltransferase complex 4 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4H4A9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A9

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 3
GO:0003713 transcription coactivator activity 3 3
GO:0140110 transcription regulator activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 119 121 PF00675 0.805
CLV_NRD_NRD_1 160 162 PF00675 0.324
CLV_NRD_NRD_1 255 257 PF00675 0.509
CLV_NRD_NRD_1 446 448 PF00675 0.344
CLV_NRD_NRD_1 639 641 PF00675 0.592
CLV_NRD_NRD_1 678 680 PF00675 0.607
CLV_PCSK_FUR_1 676 680 PF00082 0.604
CLV_PCSK_KEX2_1 119 121 PF00082 0.805
CLV_PCSK_KEX2_1 160 162 PF00082 0.324
CLV_PCSK_KEX2_1 446 448 PF00082 0.238
CLV_PCSK_KEX2_1 488 490 PF00082 0.493
CLV_PCSK_KEX2_1 520 522 PF00082 0.449
CLV_PCSK_KEX2_1 637 639 PF00082 0.596
CLV_PCSK_KEX2_1 678 680 PF00082 0.604
CLV_PCSK_PC1ET2_1 488 490 PF00082 0.493
CLV_PCSK_PC1ET2_1 520 522 PF00082 0.449
CLV_PCSK_PC1ET2_1 637 639 PF00082 0.663
CLV_PCSK_PC7_1 484 490 PF00082 0.474
CLV_PCSK_PC7_1 634 640 PF00082 0.663
CLV_PCSK_PC7_1 674 680 PF00082 0.661
CLV_PCSK_SKI1_1 256 260 PF00082 0.456
CLV_PCSK_SKI1_1 495 499 PF00082 0.492
CLV_PCSK_SKI1_1 537 541 PF00082 0.486
CLV_PCSK_SKI1_1 696 700 PF00082 0.588
DEG_APCC_DBOX_1 286 294 PF00400 0.546
DEG_APCC_KENBOX_2 668 672 PF00400 0.862
DEG_Nend_UBRbox_2 1 3 PF02207 0.661
DEG_SCF_FBW7_1 653 660 PF00400 0.668
DOC_CKS1_1 392 397 PF01111 0.458
DOC_CKS1_1 598 603 PF01111 0.659
DOC_CKS1_1 84 89 PF01111 0.568
DOC_CYCLIN_RxL_1 252 261 PF00134 0.652
DOC_CYCLIN_yCln2_LP_2 476 482 PF00134 0.513
DOC_CYCLIN_yCln2_LP_2 620 626 PF00134 0.680
DOC_MAPK_gen_1 446 454 PF00069 0.549
DOC_MAPK_gen_1 645 655 PF00069 0.679
DOC_MAPK_RevD_3 145 161 PF00069 0.261
DOC_PP1_RVXF_1 518 525 PF00149 0.665
DOC_PP1_RVXF_1 559 565 PF00149 0.657
DOC_PP2B_LxvP_1 476 479 PF13499 0.513
DOC_PP2B_PxIxI_1 185 191 PF00149 0.605
DOC_PP4_MxPP_1 571 574 PF00568 0.710
DOC_USP7_MATH_1 207 211 PF00917 0.622
DOC_USP7_MATH_1 322 326 PF00917 0.639
DOC_USP7_MATH_1 68 72 PF00917 0.508
DOC_USP7_MATH_1 711 715 PF00917 0.786
DOC_WW_Pin1_4 114 119 PF00397 0.590
DOC_WW_Pin1_4 19 24 PF00397 0.488
DOC_WW_Pin1_4 26 31 PF00397 0.587
DOC_WW_Pin1_4 312 317 PF00397 0.579
DOC_WW_Pin1_4 330 335 PF00397 0.505
DOC_WW_Pin1_4 341 346 PF00397 0.497
DOC_WW_Pin1_4 374 379 PF00397 0.578
DOC_WW_Pin1_4 391 396 PF00397 0.446
DOC_WW_Pin1_4 597 602 PF00397 0.687
DOC_WW_Pin1_4 6 11 PF00397 0.646
DOC_WW_Pin1_4 619 624 PF00397 0.858
DOC_WW_Pin1_4 653 658 PF00397 0.669
DOC_WW_Pin1_4 70 75 PF00397 0.540
DOC_WW_Pin1_4 83 88 PF00397 0.499
LIG_14-3-3_CanoR_1 312 316 PF00244 0.502
LIG_14-3-3_CanoR_1 447 453 PF00244 0.261
LIG_14-3-3_CanoR_1 484 491 PF00244 0.676
LIG_14-3-3_CanoR_1 561 571 PF00244 0.590
LIG_BIR_III_4 630 634 PF00653 0.687
LIG_BRCT_BRCA1_1 53 57 PF00533 0.437
LIG_deltaCOP1_diTrp_1 136 139 PF00928 0.411
LIG_EH_1 111 115 PF12763 0.431
LIG_EVH1_1 703 707 PF00568 0.668
LIG_FHA_1 136 142 PF00498 0.411
LIG_FHA_1 172 178 PF00498 0.550
LIG_FHA_1 219 225 PF00498 0.695
LIG_FHA_1 27 33 PF00498 0.650
LIG_FHA_1 273 279 PF00498 0.606
LIG_FHA_1 287 293 PF00498 0.510
LIG_FHA_1 39 45 PF00498 0.482
LIG_FHA_1 413 419 PF00498 0.400
LIG_FHA_1 432 438 PF00498 0.493
LIG_FHA_1 449 455 PF00498 0.235
LIG_FHA_1 746 752 PF00498 0.675
LIG_FHA_2 531 537 PF00498 0.682
LIG_FHA_2 654 660 PF00498 0.691
LIG_HP1_1 30 34 PF01393 0.471
LIG_LIR_Apic_2 390 395 PF02991 0.466
LIG_LIR_Gen_1 136 145 PF02991 0.372
LIG_LIR_Gen_1 163 171 PF02991 0.684
LIG_LIR_Gen_1 301 310 PF02991 0.466
LIG_LIR_Gen_1 338 345 PF02991 0.495
LIG_LIR_Gen_1 394 405 PF02991 0.404
LIG_LIR_Gen_1 424 430 PF02991 0.653
LIG_LIR_Gen_1 510 519 PF02991 0.669
LIG_LIR_LC3C_4 275 278 PF02991 0.502
LIG_LIR_Nem_3 129 135 PF02991 0.437
LIG_LIR_Nem_3 136 140 PF02991 0.335
LIG_LIR_Nem_3 163 169 PF02991 0.608
LIG_LIR_Nem_3 261 265 PF02991 0.666
LIG_LIR_Nem_3 301 307 PF02991 0.416
LIG_LIR_Nem_3 393 399 PF02991 0.426
LIG_LIR_Nem_3 421 425 PF02991 0.461
LIG_LIR_Nem_3 439 444 PF02991 0.589
LIG_LIR_Nem_3 510 516 PF02991 0.666
LIG_PCNA_yPIPBox_3 160 169 PF02747 0.508
LIG_Pex14_1 128 132 PF04695 0.540
LIG_Pex14_2 135 139 PF04695 0.346
LIG_Pex14_2 351 355 PF04695 0.532
LIG_Pex14_2 419 423 PF04695 0.322
LIG_Pex14_2 512 516 PF04695 0.671
LIG_RPA_C_Fungi 442 454 PF08784 0.261
LIG_SH2_CRK 297 301 PF00017 0.411
LIG_SH2_CRK 304 308 PF00017 0.411
LIG_SH2_NCK_1 392 396 PF00017 0.577
LIG_SH2_STAP1 444 448 PF00017 0.463
LIG_SH2_STAT3 15 18 PF00017 0.838
LIG_SH2_STAT3 85 88 PF00017 0.720
LIG_SH2_STAT5 134 137 PF00017 0.592
LIG_SH2_STAT5 429 432 PF00017 0.472
LIG_SH2_STAT5 506 509 PF00017 0.581
LIG_SH2_STAT5 85 88 PF00017 0.720
LIG_SH3_2 235 240 PF14604 0.509
LIG_SH3_3 104 110 PF00018 0.672
LIG_SH3_3 115 121 PF00018 0.682
LIG_SH3_3 180 186 PF00018 0.374
LIG_SH3_3 189 195 PF00018 0.484
LIG_SH3_3 232 238 PF00018 0.560
LIG_SH3_3 493 499 PF00018 0.620
LIG_SH3_3 701 707 PF00018 0.746
LIG_SH3_3 748 754 PF00018 0.849
LIG_SUMO_SIM_anti_2 298 304 PF11976 0.355
LIG_SUMO_SIM_anti_2 451 456 PF11976 0.513
LIG_SUMO_SIM_anti_2 469 475 PF11976 0.216
LIG_SUMO_SIM_par_1 450 456 PF11976 0.377
LIG_SUMO_SIM_par_1 651 656 PF11976 0.588
LIG_TRAF2_1 121 124 PF00917 0.616
LIG_TYR_ITIM 302 307 PF00017 0.411
LIG_WRC_WIRS_1 259 264 PF05994 0.584
LIG_WRC_WIRS_1 419 424 PF05994 0.379
LIG_WRC_WIRS_1 437 442 PF05994 0.474
MOD_CDK_SPK_2 114 119 PF00069 0.788
MOD_CDK_SPK_2 374 379 PF00069 0.528
MOD_CDK_SPxK_1 114 120 PF00069 0.752
MOD_CDK_SPxxK_3 597 604 PF00069 0.568
MOD_CK1_1 22 28 PF00069 0.828
MOD_CK1_1 281 287 PF00069 0.495
MOD_CK1_1 298 304 PF00069 0.390
MOD_CK1_1 325 331 PF00069 0.679
MOD_CK1_1 4 10 PF00069 0.830
MOD_CK1_1 407 413 PF00069 0.411
MOD_CK1_1 421 427 PF00069 0.468
MOD_CK1_1 45 51 PF00069 0.796
MOD_CK1_1 83 89 PF00069 0.700
MOD_CK2_1 172 178 PF00069 0.523
MOD_CK2_1 384 390 PF00069 0.452
MOD_CK2_1 653 659 PF00069 0.686
MOD_CK2_1 664 670 PF00069 0.682
MOD_GlcNHglycan 10 13 PF01048 0.835
MOD_GlcNHglycan 174 177 PF01048 0.348
MOD_GlcNHglycan 211 214 PF01048 0.674
MOD_GlcNHglycan 24 27 PF01048 0.810
MOD_GlcNHglycan 386 389 PF01048 0.489
MOD_GlcNHglycan 406 409 PF01048 0.436
MOD_GlcNHglycan 44 47 PF01048 0.739
MOD_GlcNHglycan 53 56 PF01048 0.759
MOD_GlcNHglycan 666 669 PF01048 0.728
MOD_GlcNHglycan 766 769 PF01048 0.611
MOD_GSK3_1 207 214 PF00069 0.771
MOD_GSK3_1 22 29 PF00069 0.830
MOD_GSK3_1 312 319 PF00069 0.530
MOD_GSK3_1 324 331 PF00069 0.608
MOD_GSK3_1 38 45 PF00069 0.537
MOD_GSK3_1 4 11 PF00069 0.831
MOD_GSK3_1 653 660 PF00069 0.726
MOD_GSK3_1 678 685 PF00069 0.809
MOD_GSK3_1 686 693 PF00069 0.722
MOD_GSK3_1 732 739 PF00069 0.763
MOD_GSK3_1 95 102 PF00069 0.656
MOD_LATS_1 682 688 PF00433 0.856
MOD_LATS_1 734 740 PF00433 0.752
MOD_N-GLC_1 172 177 PF02516 0.618
MOD_N-GLC_1 188 193 PF02516 0.423
MOD_N-GLC_1 448 453 PF02516 0.290
MOD_N-GLC_1 670 675 PF02516 0.822
MOD_NEK2_1 1 6 PF00069 0.841
MOD_NEK2_1 135 140 PF00069 0.411
MOD_NEK2_1 211 216 PF00069 0.723
MOD_NEK2_1 258 263 PF00069 0.580
MOD_NEK2_1 295 300 PF00069 0.411
MOD_NEK2_1 412 417 PF00069 0.411
MOD_NEK2_1 418 423 PF00069 0.411
MOD_NEK2_1 448 453 PF00069 0.448
MOD_NEK2_1 522 527 PF00069 0.594
MOD_NEK2_1 567 572 PF00069 0.731
MOD_NEK2_1 596 601 PF00069 0.704
MOD_NEK2_1 658 663 PF00069 0.818
MOD_NEK2_1 664 669 PF00069 0.708
MOD_NEK2_1 80 85 PF00069 0.557
MOD_NEK2_2 127 132 PF00069 0.589
MOD_PIKK_1 251 257 PF00454 0.409
MOD_PIKK_1 552 558 PF00454 0.651
MOD_PIKK_1 562 568 PF00454 0.613
MOD_PIKK_1 86 92 PF00454 0.727
MOD_PIKK_1 95 101 PF00454 0.616
MOD_PK_1 199 205 PF00069 0.512
MOD_PKA_1 678 684 PF00069 0.848
MOD_PKA_2 286 292 PF00069 0.408
MOD_PKA_2 311 317 PF00069 0.609
MOD_PKA_2 430 436 PF00069 0.590
MOD_PKA_2 483 489 PF00069 0.581
MOD_PKA_2 641 647 PF00069 0.668
MOD_PKA_2 678 684 PF00069 0.848
MOD_PKA_2 68 74 PF00069 0.589
MOD_PKA_2 732 738 PF00069 0.763
MOD_PKA_2 754 760 PF00069 0.766
MOD_PKB_1 638 646 PF00069 0.759
MOD_PKB_1 676 684 PF00069 0.783
MOD_PKB_1 686 694 PF00069 0.704
MOD_Plk_1 1 7 PF00069 0.838
MOD_Plk_1 135 141 PF00069 0.353
MOD_Plk_1 172 178 PF00069 0.602
MOD_Plk_1 188 194 PF00069 0.408
MOD_Plk_1 218 224 PF00069 0.551
MOD_Plk_1 448 454 PF00069 0.513
MOD_Plk_1 658 664 PF00069 0.597
MOD_Plk_1 744 750 PF00069 0.622
MOD_Plk_1 99 105 PF00069 0.731
MOD_Plk_2-3 544 550 PF00069 0.682
MOD_Plk_4 127 133 PF00069 0.593
MOD_Plk_4 146 152 PF00069 0.411
MOD_Plk_4 272 278 PF00069 0.474
MOD_Plk_4 286 292 PF00069 0.353
MOD_Plk_4 295 301 PF00069 0.342
MOD_Plk_4 448 454 PF00069 0.388
MOD_Plk_4 567 573 PF00069 0.629
MOD_Plk_4 80 86 PF00069 0.738
MOD_ProDKin_1 114 120 PF00069 0.752
MOD_ProDKin_1 19 25 PF00069 0.609
MOD_ProDKin_1 26 32 PF00069 0.748
MOD_ProDKin_1 312 318 PF00069 0.744
MOD_ProDKin_1 330 336 PF00069 0.628
MOD_ProDKin_1 341 347 PF00069 0.619
MOD_ProDKin_1 374 380 PF00069 0.733
MOD_ProDKin_1 391 397 PF00069 0.545
MOD_ProDKin_1 597 603 PF00069 0.609
MOD_ProDKin_1 6 12 PF00069 0.832
MOD_ProDKin_1 619 625 PF00069 0.851
MOD_ProDKin_1 653 659 PF00069 0.583
MOD_ProDKin_1 70 76 PF00069 0.677
MOD_ProDKin_1 83 89 PF00069 0.627
MOD_SUMO_rev_2 515 522 PF00179 0.526
TRG_DiLeu_BaEn_1 469 474 PF01217 0.513
TRG_DiLeu_BaEn_1 771 776 PF01217 0.542
TRG_DiLeu_BaEn_2 218 224 PF01217 0.512
TRG_ENDOCYTIC_2 132 135 PF00928 0.609
TRG_ENDOCYTIC_2 297 300 PF00928 0.411
TRG_ENDOCYTIC_2 304 307 PF00928 0.411
TRG_ENDOCYTIC_2 397 400 PF00928 0.531
TRG_ER_diArg_1 118 120 PF00400 0.786
TRG_ER_diArg_1 220 223 PF00400 0.512
TRG_ER_diArg_1 446 448 PF00400 0.261
TRG_ER_diArg_1 638 640 PF00400 0.757
TRG_ER_diArg_1 676 679 PF00400 0.773
TRG_NLS_MonoCore_2 636 641 PF00514 0.856
TRG_NLS_MonoExtN_4 634 641 PF00514 0.856

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I288 Leptomonas seymouri 49% 90%
A0A3S7WP32 Leishmania donovani 67% 100%
A4HSI0 Leishmania infantum 67% 100%
E9AKG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 99%
Q4QJE4 Leishmania major 66% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS