PH domain-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4A8_LEIBR

TriTrypDb:

LbrM.05.0630 , LBRM2903_050011000

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.610
CLV_PCSK_FUR_1	222	226	PF00082	0.575
CLV_PCSK_KEX2_1	213	215	PF00082	0.573
CLV_PCSK_KEX2_1	221	223	PF00082	0.563
CLV_PCSK_KEX2_1	224	226	PF00082	0.559
CLV_PCSK_KEX2_1	34	36	PF00082	0.449
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.615
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.551
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.449
CLV_PCSK_SKI1_1	160	164	PF00082	0.481
CLV_PCSK_SKI1_1	18	22	PF00082	0.594
CLV_PCSK_SKI1_1	380	384	PF00082	0.464
CLV_PCSK_SKI1_1	54	58	PF00082	0.523
CLV_Separin_Metazoa	168	172	PF03568	0.595
DOC_CYCLIN_RxL_1	157	164	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.506
DOC_MAPK_DCC_7	308	317	PF00069	0.459
DOC_MAPK_gen_1	264	271	PF00069	0.432
DOC_MAPK_gen_1	57	65	PF00069	0.606
DOC_MAPK_MEF2A_6	264	273	PF00069	0.400
DOC_MAPK_MEF2A_6	308	317	PF00069	0.459
DOC_MAPK_MEF2A_6	353	361	PF00069	0.586
DOC_PP1_RVXF_1	358	364	PF00149	0.411
DOC_PP2B_LxvP_1	385	388	PF13499	0.567
DOC_USP7_MATH_1	121	125	PF00917	0.438
DOC_USP7_MATH_1	95	99	PF00917	0.535
DOC_USP7_UBL2_3	21	25	PF12436	0.680
DOC_WW_Pin1_4	400	405	PF00397	0.476
DOC_WW_Pin1_4	56	61	PF00397	0.527
LIG_14-3-3_CanoR_1	224	231	PF00244	0.570
LIG_14-3-3_CanoR_1	295	303	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.538
LIG_BRCT_BRCA1_1	296	300	PF00533	0.448
LIG_deltaCOP1_diTrp_1	177	183	PF00928	0.431
LIG_deltaCOP1_diTrp_1	230	235	PF00928	0.561
LIG_deltaCOP1_diTrp_1	354	363	PF00928	0.427
LIG_FHA_1	10	16	PF00498	0.737
LIG_FHA_1	257	263	PF00498	0.440
LIG_FHA_1	277	283	PF00498	0.472
LIG_FHA_1	40	46	PF00498	0.457
LIG_FHA_2	107	113	PF00498	0.537
LIG_FHA_2	202	208	PF00498	0.586
LIG_FHA_2	241	247	PF00498	0.571
LIG_FHA_2	369	375	PF00498	0.512
LIG_HCF-1_HBM_1	125	128	PF13415	0.326
LIG_Integrin_RGD_1	171	173	PF01839	0.629
LIG_LIR_Gen_1	111	121	PF02991	0.432
LIG_LIR_Gen_1	258	267	PF02991	0.388
LIG_LIR_Gen_1	297	306	PF02991	0.452
LIG_LIR_Gen_1	354	363	PF02991	0.427
LIG_LIR_Nem_3	111	117	PF02991	0.444
LIG_LIR_Nem_3	258	263	PF02991	0.391
LIG_LIR_Nem_3	354	359	PF02991	0.439
LIG_LIR_Nem_3	406	412	PF02991	0.588
LIG_PALB2_WD40_1	146	154	PF16756	0.451
LIG_Pex14_1	179	183	PF04695	0.439
LIG_Pex14_1	231	235	PF04695	0.563
LIG_SH2_STAP1	319	323	PF00017	0.506
LIG_SH2_STAP1	32	36	PF00017	0.533
LIG_SH2_STAT3	128	131	PF00017	0.334
LIG_SH2_STAT5	253	256	PF00017	0.502
LIG_SH3_3	115	121	PF00018	0.308
LIG_SH3_3	251	257	PF00018	0.499
LIG_SH3_3	279	285	PF00018	0.447
LIG_TRAF2_1	109	112	PF00917	0.622
LIG_TRAF2_1	204	207	PF00917	0.561
LIG_TRAF2_1	371	374	PF00917	0.477
LIG_UBA3_1	262	266	PF00899	0.410
LIG_UBA3_1	303	310	PF00899	0.451
LIG_WW_3	157	161	PF00397	0.423
MOD_CK1_1	134	140	PF00069	0.347
MOD_CK1_1	161	167	PF00069	0.477
MOD_CK1_1	199	205	PF00069	0.640
MOD_CK1_1	2	8	PF00069	0.684
MOD_CK1_1	76	82	PF00069	0.619
MOD_CK1_1	87	93	PF00069	0.661
MOD_CK2_1	106	112	PF00069	0.565
MOD_CK2_1	201	207	PF00069	0.573
MOD_CK2_1	240	246	PF00069	0.574
MOD_CK2_1	368	374	PF00069	0.520
MOD_CK2_1	87	93	PF00069	0.768
MOD_GlcNHglycan	163	166	PF01048	0.415
MOD_GlcNHglycan	2	5	PF01048	0.741
MOD_GlcNHglycan	66	69	PF01048	0.661
MOD_GlcNHglycan	75	78	PF01048	0.670
MOD_GlcNHglycan	87	90	PF01048	0.713
MOD_GSK3_1	19	26	PF00069	0.636
MOD_GSK3_1	317	324	PF00069	0.514
MOD_GSK3_1	388	395	PF00069	0.588
MOD_GSK3_1	48	55	PF00069	0.534
MOD_GSK3_1	75	82	PF00069	0.714
MOD_GSK3_1	83	90	PF00069	0.778
MOD_N-GLC_1	317	322	PF02516	0.497
MOD_N-GLC_1	393	398	PF02516	0.585
MOD_NEK2_1	317	322	PF00069	0.445
MOD_NEK2_1	390	395	PF00069	0.621
MOD_NEK2_1	48	53	PF00069	0.496
MOD_PIKK_1	276	282	PF00454	0.486
MOD_PIKK_1	338	344	PF00454	0.439
MOD_PIKK_1	388	394	PF00454	0.601
MOD_PIKK_1	9	15	PF00454	0.516
MOD_PKA_1	224	230	PF00069	0.570
MOD_PKA_2	224	230	PF00069	0.570
MOD_PKA_2	294	300	PF00069	0.507
MOD_PKA_2	73	79	PF00069	0.686
MOD_PKB_1	222	230	PF00069	0.572
MOD_PKB_1	238	246	PF00069	0.580
MOD_Plk_1	112	118	PF00069	0.456
MOD_Plk_1	179	185	PF00069	0.482
MOD_Plk_1	317	323	PF00069	0.487
MOD_Plk_1	393	399	PF00069	0.600
MOD_Plk_4	134	140	PF00069	0.432
MOD_ProDKin_1	400	406	PF00069	0.476
MOD_ProDKin_1	56	62	PF00069	0.533
MOD_SUMO_for_1	212	215	PF00179	0.657
MOD_SUMO_for_1	255	258	PF00179	0.499
MOD_SUMO_for_1	352	355	PF00179	0.577
MOD_SUMO_rev_2	195	205	PF00179	0.596
MOD_SUMO_rev_2	215	223	PF00179	0.380
TRG_DiLeu_BaEn_3	111	117	PF01217	0.537
TRG_DiLeu_BaEn_4	354	360	PF01217	0.451
TRG_ENDOCYTIC_2	409	412	PF00928	0.607
TRG_ER_diArg_1	222	225	PF00400	0.573
TRG_NES_CRM1_1	358	372	PF08389	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT4	Leptomonas seymouri	82%	100%
A0A0S4IKX2	Bodo saltans	60%	100%
A0A1X0NJW6	Trypanosomatidae	64%	99%
A0A3S5H5I6	Leishmania donovani	90%	100%
A0A422ND56	Trypanosoma rangeli	62%	100%
A4HSH9	Leishmania infantum	91%	100%
C9ZUC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AKG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJE5	Leishmania major	89%	100%
V5AVB4	Trypanosoma cruzi	66%	100%