DUF1308 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1308), putative

Species:

Leishmania braziliensis

UniProt:

A4H4A7_LEIBR

TriTrypDb:

LbrM.05.0620 , LBRM2903_250008800

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.469
CLV_NRD_NRD_1	330	332	PF00675	0.406
CLV_NRD_NRD_1	347	349	PF00675	0.419
CLV_NRD_NRD_1	440	442	PF00675	0.421
CLV_NRD_NRD_1	580	582	PF00675	0.331
CLV_NRD_NRD_1	730	732	PF00675	0.479
CLV_PCSK_KEX2_1	323	325	PF00082	0.421
CLV_PCSK_KEX2_1	330	332	PF00082	0.372
CLV_PCSK_KEX2_1	580	582	PF00082	0.552
CLV_PCSK_KEX2_1	730	732	PF00082	0.477
CLV_PCSK_KEX2_1	75	77	PF00082	0.532
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.468
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.532
CLV_PCSK_SKI1_1	155	159	PF00082	0.418
CLV_PCSK_SKI1_1	232	236	PF00082	0.453
CLV_PCSK_SKI1_1	284	288	PF00082	0.409
CLV_PCSK_SKI1_1	348	352	PF00082	0.307
CLV_PCSK_SKI1_1	475	479	PF00082	0.403
CLV_PCSK_SKI1_1	595	599	PF00082	0.377
CLV_PCSK_SKI1_1	679	683	PF00082	0.295
CLV_PCSK_SKI1_1	718	722	PF00082	0.354
DEG_Nend_UBRbox_3	1	3	PF02207	0.490
DEG_SPOP_SBC_1	190	194	PF00917	0.555
DEG_SPOP_SBC_1	47	51	PF00917	0.562
DEG_SPOP_SBC_1	641	645	PF00917	0.524
DEG_SPOP_SBC_1	88	92	PF00917	0.541
DOC_CKS1_1	367	372	PF01111	0.488
DOC_CYCLIN_RxL_1	289	299	PF00134	0.447
DOC_CYCLIN_RxL_1	609	618	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.294
DOC_MAPK_DCC_7	511	520	PF00069	0.305
DOC_MAPK_gen_1	230	239	PF00069	0.443
DOC_MAPK_gen_1	330	337	PF00069	0.381
DOC_MAPK_gen_1	609	619	PF00069	0.348
DOC_MAPK_gen_1	669	676	PF00069	0.216
DOC_MAPK_MEF2A_6	232	241	PF00069	0.451
DOC_MAPK_MEF2A_6	268	277	PF00069	0.423
DOC_MAPK_MEF2A_6	330	339	PF00069	0.383
DOC_MAPK_RevD_3	333	349	PF00069	0.273
DOC_PP1_RVXF_1	509	515	PF00149	0.304
DOC_PP2B_LxvP_1	199	202	PF13499	0.502
DOC_PP2B_LxvP_1	340	343	PF13499	0.416
DOC_PP2B_LxvP_1	506	509	PF13499	0.433
DOC_USP7_MATH_1	240	244	PF00917	0.387
DOC_USP7_MATH_1	352	356	PF00917	0.332
DOC_USP7_MATH_1	47	51	PF00917	0.809
DOC_USP7_MATH_1	530	534	PF00917	0.599
DOC_USP7_MATH_1	651	655	PF00917	0.544
DOC_USP7_MATH_1	716	720	PF00917	0.354
DOC_USP7_UBL2_3	151	155	PF12436	0.586
DOC_WW_Pin1_4	192	197	PF00397	0.559
DOC_WW_Pin1_4	306	311	PF00397	0.439
DOC_WW_Pin1_4	329	334	PF00397	0.298
DOC_WW_Pin1_4	366	371	PF00397	0.660
DOC_WW_Pin1_4	394	399	PF00397	0.541
DOC_WW_Pin1_4	487	492	PF00397	0.498
DOC_WW_Pin1_4	545	550	PF00397	0.505
DOC_WW_Pin1_4	653	658	PF00397	0.505
DOC_WW_Pin1_4	733	738	PF00397	0.399
DOC_WW_Pin1_4	91	96	PF00397	0.488
LIG_14-3-3_CanoR_1	615	620	PF00244	0.354
LIG_14-3-3_CanoR_1	671	677	PF00244	0.243
LIG_14-3-3_CanoR_1	718	726	PF00244	0.354
LIG_Actin_WH2_2	610	628	PF00022	0.425
LIG_CSL_BTD_1	389	392	PF09270	0.451
LIG_EVH1_2	202	206	PF00568	0.471
LIG_EVH1_2	658	662	PF00568	0.434
LIG_FHA_1	186	192	PF00498	0.466
LIG_FHA_1	310	316	PF00498	0.415
LIG_FHA_1	330	336	PF00498	0.246
LIG_FHA_1	403	409	PF00498	0.238
LIG_FHA_1	546	552	PF00498	0.664
LIG_FHA_1	620	626	PF00498	0.476
LIG_FHA_2	112	118	PF00498	0.310
LIG_FHA_2	588	594	PF00498	0.332
LIG_FHA_2	661	667	PF00498	0.434
LIG_GBD_Chelix_1	108	116	PF00786	0.433
LIG_Integrin_RGD_1	632	634	PF01839	0.439
LIG_LIR_Apic_2	242	247	PF02991	0.422
LIG_LIR_Apic_2	388	393	PF02991	0.480
LIG_LIR_Apic_2	513	517	PF02991	0.443
LIG_LIR_Gen_1	309	319	PF02991	0.407
LIG_LIR_Gen_1	355	364	PF02991	0.310
LIG_LIR_Gen_1	588	598	PF02991	0.393
LIG_LIR_Gen_1	666	674	PF02991	0.347
LIG_LIR_Gen_1	97	106	PF02991	0.284
LIG_LIR_Nem_3	219	224	PF02991	0.398
LIG_LIR_Nem_3	235	241	PF02991	0.435
LIG_LIR_Nem_3	355	361	PF02991	0.312
LIG_LIR_Nem_3	388	394	PF02991	0.417
LIG_LIR_Nem_3	588	594	PF02991	0.342
LIG_LIR_Nem_3	663	667	PF02991	0.437
LIG_LIR_Nem_3	97	102	PF02991	0.320
LIG_NRBOX	101	107	PF00104	0.430
LIG_PALB2_WD40_1	386	394	PF16756	0.361
LIG_PDZ_Class_2	737	742	PF00595	0.427
LIG_SH2_CRK	221	225	PF00017	0.514
LIG_SH2_PTP2	238	241	PF00017	0.480
LIG_SH2_PTP2	244	247	PF00017	0.517
LIG_SH2_SRC	238	241	PF00017	0.458
LIG_SH2_SRC	417	420	PF00017	0.472
LIG_SH2_STAP1	423	427	PF00017	0.293
LIG_SH2_STAP1	465	469	PF00017	0.473
LIG_SH2_STAT3	726	729	PF00017	0.470
LIG_SH2_STAT5	113	116	PF00017	0.306
LIG_SH2_STAT5	238	241	PF00017	0.480
LIG_SH2_STAT5	244	247	PF00017	0.517
LIG_SH2_STAT5	417	420	PF00017	0.325
LIG_SH2_STAT5	465	468	PF00017	0.416
LIG_SH2_STAT5	667	670	PF00017	0.354
LIG_SH3_1	731	737	PF00018	0.482
LIG_SH3_3	124	130	PF00018	0.460
LIG_SH3_3	234	240	PF00018	0.432
LIG_SH3_3	242	248	PF00018	0.536
LIG_SH3_3	364	370	PF00018	0.637
LIG_SH3_3	654	660	PF00018	0.640
LIG_SH3_3	731	737	PF00018	0.482
LIG_SUMO_SIM_anti_2	274	279	PF11976	0.356
LIG_SUMO_SIM_par_1	312	320	PF11976	0.415
LIG_SUMO_SIM_par_1	392	397	PF11976	0.450
LIG_SUMO_SIM_par_1	404	413	PF11976	0.297
LIG_SUMO_SIM_par_1	615	623	PF11976	0.420
LIG_TRAF2_1	139	142	PF00917	0.550
LIG_TRAF2_1	590	593	PF00917	0.392
LIG_TYR_ITIM	665	670	PF00017	0.436
LIG_UBA3_1	314	323	PF00899	0.420
LIG_UBA3_1	506	511	PF00899	0.297
LIG_WRC_WIRS_1	661	666	PF05994	0.292
LIG_WW_1	130	133	PF00397	0.478
MOD_CDK_SPxxK_3	366	373	PF00069	0.487
MOD_CK1_1	134	140	PF00069	0.643
MOD_CK1_1	143	149	PF00069	0.565
MOD_CK1_1	29	35	PF00069	0.671
MOD_CK1_1	322	328	PF00069	0.318
MOD_CK1_1	386	392	PF00069	0.502
MOD_CK1_1	49	55	PF00069	0.634
MOD_CK1_1	573	579	PF00069	0.397
MOD_CK1_1	628	634	PF00069	0.492
MOD_CK1_1	652	658	PF00069	0.491
MOD_CK2_1	111	117	PF00069	0.448
MOD_CK2_1	20	26	PF00069	0.614
MOD_CK2_1	263	269	PF00069	0.679
MOD_CK2_1	357	363	PF00069	0.333
MOD_CK2_1	587	593	PF00069	0.332
MOD_CK2_1	660	666	PF00069	0.452
MOD_CK2_1	716	722	PF00069	0.354
MOD_GlcNHglycan	182	185	PF01048	0.465
MOD_GlcNHglycan	207	210	PF01048	0.317
MOD_GlcNHglycan	21	25	PF01048	0.712
MOD_GlcNHglycan	280	283	PF01048	0.478
MOD_GlcNHglycan	31	34	PF01048	0.679
MOD_GlcNHglycan	385	388	PF01048	0.565
MOD_GlcNHglycan	43	46	PF01048	0.744
MOD_GlcNHglycan	445	450	PF01048	0.315
MOD_GlcNHglycan	492	495	PF01048	0.603
MOD_GlcNHglycan	52	55	PF01048	0.784
MOD_GSK3_1	16	23	PF00069	0.669
MOD_GSK3_1	185	192	PF00069	0.497
MOD_GSK3_1	25	32	PF00069	0.662
MOD_GSK3_1	252	259	PF00069	0.643
MOD_GSK3_1	33	40	PF00069	0.713
MOD_GSK3_1	381	388	PF00069	0.549
MOD_GSK3_1	403	410	PF00069	0.367
MOD_GSK3_1	459	466	PF00069	0.441
MOD_GSK3_1	46	53	PF00069	0.667
MOD_GSK3_1	486	493	PF00069	0.500
MOD_GSK3_1	531	538	PF00069	0.717
MOD_GSK3_1	539	546	PF00069	0.699
MOD_GSK3_1	570	577	PF00069	0.544
MOD_GSK3_1	615	622	PF00069	0.432
MOD_GSK3_1	642	649	PF00069	0.817
MOD_GSK3_1	87	94	PF00069	0.597
MOD_NEK2_1	191	196	PF00069	0.448
MOD_NEK2_1	20	25	PF00069	0.738
MOD_NEK2_1	357	362	PF00069	0.287
MOD_NEK2_1	403	408	PF00069	0.309
MOD_NEK2_1	554	559	PF00069	0.444
MOD_NEK2_1	625	630	PF00069	0.320
MOD_NEK2_1	692	697	PF00069	0.464
MOD_NEK2_1	89	94	PF00069	0.508
MOD_NEK2_2	352	357	PF00069	0.287
MOD_NEK2_2	412	417	PF00069	0.380
MOD_NEK2_2	672	677	PF00069	0.354
MOD_OFUCOSY	321	326	PF10250	0.543
MOD_PIKK_1	131	137	PF00454	0.644
MOD_PIKK_1	381	387	PF00454	0.462
MOD_PIKK_1	410	416	PF00454	0.375
MOD_PK_1	615	621	PF00069	0.394
MOD_PKA_2	143	149	PF00069	0.586
MOD_PKA_2	263	269	PF00069	0.620
MOD_PKA_2	625	631	PF00069	0.508
MOD_PKA_2	646	652	PF00069	0.657
MOD_PKB_1	230	238	PF00069	0.440
MOD_Plk_1	16	22	PF00069	0.646
MOD_Plk_1	352	358	PF00069	0.497
MOD_Plk_1	403	409	PF00069	0.308
MOD_Plk_1	445	451	PF00069	0.318
MOD_Plk_1	554	560	PF00069	0.437
MOD_Plk_1	587	593	PF00069	0.332
MOD_Plk_1	620	626	PF00069	0.419
MOD_Plk_4	240	246	PF00069	0.410
MOD_Plk_4	352	358	PF00069	0.285
MOD_Plk_4	386	392	PF00069	0.514
MOD_Plk_4	555	561	PF00069	0.391
MOD_Plk_4	570	576	PF00069	0.553
MOD_Plk_4	615	621	PF00069	0.358
MOD_ProDKin_1	192	198	PF00069	0.557
MOD_ProDKin_1	306	312	PF00069	0.431
MOD_ProDKin_1	329	335	PF00069	0.294
MOD_ProDKin_1	366	372	PF00069	0.662
MOD_ProDKin_1	394	400	PF00069	0.528
MOD_ProDKin_1	487	493	PF00069	0.498
MOD_ProDKin_1	545	551	PF00069	0.501
MOD_ProDKin_1	653	659	PF00069	0.497
MOD_ProDKin_1	733	739	PF00069	0.404
MOD_ProDKin_1	91	97	PF00069	0.487
MOD_SUMO_rev_2	588	597	PF00179	0.402
MOD_SUMO_rev_2	719	725	PF00179	0.356
TRG_DiLeu_BaEn_1	556	561	PF01217	0.426
TRG_DiLeu_BaEn_1	562	567	PF01217	0.442
TRG_DiLeu_BaEn_3	592	598	PF01217	0.396
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.400
TRG_ENDOCYTIC_2	113	116	PF00928	0.366
TRG_ENDOCYTIC_2	221	224	PF00928	0.378
TRG_ENDOCYTIC_2	238	241	PF00928	0.310
TRG_ENDOCYTIC_2	5	8	PF00928	0.595
TRG_ENDOCYTIC_2	591	594	PF00928	0.393
TRG_ENDOCYTIC_2	667	670	PF00928	0.354
TRG_ER_diArg_1	164	167	PF00400	0.405
TRG_ER_diArg_1	580	582	PF00400	0.304
TRG_ER_diArg_1	629	632	PF00400	0.367
TRG_ER_diArg_1	668	671	PF00400	0.290
TRG_NES_CRM1_1	468	484	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW5	Leptomonas seymouri	46%	97%
A0A1X0P4J1	Trypanosomatidae	30%	100%
A0A3Q8IC76	Leishmania donovani	67%	99%
A4I178	Leishmania infantum	68%	99%
E9AXB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4QA60	Leishmania major	67%	100%