Fcf2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fcf2 pre-rRNA processing, putative

Species:

Leishmania braziliensis

UniProt:

A4H4A5_LEIBR

TriTrypDb:

LbrM.05.0600 , LBRM2903_250009000

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.534
CLV_NRD_NRD_1	138	140	PF00675	0.272
CLV_NRD_NRD_1	195	197	PF00675	0.605
CLV_NRD_NRD_1	59	61	PF00675	0.481
CLV_NRD_NRD_1	68	70	PF00675	0.500
CLV_PCSK_FUR_1	134	138	PF00082	0.272
CLV_PCSK_FUR_1	196	200	PF00082	0.441
CLV_PCSK_FUR_1	65	69	PF00082	0.589
CLV_PCSK_KEX2_1	136	138	PF00082	0.272
CLV_PCSK_KEX2_1	190	192	PF00082	0.510
CLV_PCSK_KEX2_1	194	196	PF00082	0.498
CLV_PCSK_KEX2_1	198	200	PF00082	0.507
CLV_PCSK_KEX2_1	67	69	PF00082	0.542
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.272
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.510
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.498
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.507
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.575
CLV_PCSK_PC7_1	134	140	PF00082	0.272
CLV_PCSK_PC7_1	191	197	PF00082	0.423
CLV_PCSK_SKI1_1	39	43	PF00082	0.493
DEG_SPOP_SBC_1	40	44	PF00917	0.477
DOC_PP4_FxxP_1	102	105	PF00568	0.306
DOC_USP7_UBL2_3	163	167	PF12436	0.383
DOC_USP7_UBL2_3	186	190	PF12436	0.315
DOC_USP7_UBL2_3	194	198	PF12436	0.522
LIG_14-3-3_CanoR_1	13	19	PF00244	0.440
LIG_14-3-3_CanoR_1	138	144	PF00244	0.273
LIG_14-3-3_CanoR_1	22	27	PF00244	0.516
LIG_14-3-3_CanoR_1	51	55	PF00244	0.490
LIG_BRCT_BRCA1_1	43	47	PF00533	0.479
LIG_deltaCOP1_diTrp_1	145	154	PF00928	0.416
LIG_FHA_2	41	47	PF00498	0.538
LIG_LIR_Gen_1	120	129	PF02991	0.275
LIG_LIR_Nem_3	120	126	PF02991	0.275
LIG_PDZ_Class_3	197	202	PF00595	0.671
LIG_Pex14_2	143	147	PF04695	0.272
LIG_PTB_Apo_2	148	155	PF02174	0.416
LIG_SH2_STAT5	128	131	PF00017	0.332
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.272
MOD_CK1_1	16	22	PF00069	0.497
MOD_CK1_1	25	31	PF00069	0.639
MOD_CK2_1	84	90	PF00069	0.263
MOD_GlcNHglycan	18	21	PF01048	0.655
MOD_GlcNHglycan	43	46	PF01048	0.679
MOD_GlcNHglycan	48	51	PF01048	0.635
MOD_GlcNHglycan	86	89	PF01048	0.465
MOD_GSK3_1	157	164	PF00069	0.195
MOD_GSK3_1	190	197	PF00069	0.614
MOD_GSK3_1	22	29	PF00069	0.483
MOD_GSK3_1	46	53	PF00069	0.492
MOD_GSK3_1	9	16	PF00069	0.477
MOD_NEK2_1	14	19	PF00069	0.471
MOD_NEK2_1	24	29	PF00069	0.572
MOD_PIKK_1	7	13	PF00454	0.449
MOD_PIKK_1	73	79	PF00454	0.272
MOD_PKA_1	190	196	PF00069	0.512
MOD_PKA_2	190	196	PF00069	0.649
MOD_PKA_2	50	56	PF00069	0.495
MOD_PKB_1	137	145	PF00069	0.272
MOD_SUMO_rev_2	53	63	PF00179	0.492
MOD_SUMO_rev_2	66	74	PF00179	0.598
TRG_ENDOCYTIC_2	21	24	PF00928	0.431
TRG_ENDOCYTIC_2	99	102	PF00928	0.332
TRG_ER_diArg_1	137	139	PF00400	0.310
TRG_NLS_Bipartite_1	178	198	PF00514	0.311
TRG_NLS_Bipartite_1	67	86	PF00514	0.370
TRG_NLS_MonoCore_2	135	140	PF00514	0.272
TRG_NLS_MonoExtC_3	193	198	PF00514	0.532
TRG_NLS_MonoExtN_4	134	140	PF00514	0.272
TRG_NLS_MonoExtN_4	191	198	PF00514	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK2	Leptomonas seymouri	78%	100%
A0A0S4JBE6	Bodo saltans	51%	100%
A0A1X0P5L4	Trypanosomatidae	57%	100%
A0A3R7RI11	Trypanosoma rangeli	57%	100%
A0A3S7WYT4	Leishmania donovani	82%	100%
A4I180	Leishmania infantum	82%	100%
D0A5G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AXB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA58	Leishmania major	80%	100%
V5B7R5	Trypanosoma cruzi	56%	100%