Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4A4_LEIBR

TriTrypDb:

LbrM.05.0590 , LBRM2903_250009100

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	267	269	PF00675	0.462
CLV_NRD_NRD_1	409	411	PF00675	0.615
CLV_NRD_NRD_1	415	417	PF00675	0.561
CLV_NRD_NRD_1	441	443	PF00675	0.458
CLV_NRD_NRD_1	456	458	PF00675	0.418
CLV_NRD_NRD_1	464	466	PF00675	0.488
CLV_NRD_NRD_1	539	541	PF00675	0.625
CLV_NRD_NRD_1	626	628	PF00675	0.500
CLV_NRD_NRD_1	672	674	PF00675	0.643
CLV_NRD_NRD_1	749	751	PF00675	0.556
CLV_NRD_NRD_1	856	858	PF00675	0.417
CLV_PCSK_KEX2_1	415	417	PF00082	0.507
CLV_PCSK_KEX2_1	441	443	PF00082	0.417
CLV_PCSK_KEX2_1	515	517	PF00082	0.479
CLV_PCSK_KEX2_1	539	541	PF00082	0.625
CLV_PCSK_KEX2_1	626	628	PF00082	0.421
CLV_PCSK_KEX2_1	672	674	PF00082	0.531
CLV_PCSK_KEX2_1	749	751	PF00082	0.556
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.469
CLV_PCSK_SKI1_1	254	258	PF00082	0.477
CLV_PCSK_SKI1_1	269	273	PF00082	0.378
CLV_PCSK_SKI1_1	338	342	PF00082	0.457
CLV_PCSK_SKI1_1	354	358	PF00082	0.464
CLV_PCSK_SKI1_1	388	392	PF00082	0.499
CLV_PCSK_SKI1_1	399	403	PF00082	0.484
CLV_PCSK_SKI1_1	415	419	PF00082	0.416
CLV_PCSK_SKI1_1	475	479	PF00082	0.424
CLV_PCSK_SKI1_1	511	515	PF00082	0.373
CLV_PCSK_SKI1_1	627	631	PF00082	0.483
CLV_PCSK_SKI1_1	650	654	PF00082	0.497
CLV_PCSK_SKI1_1	742	746	PF00082	0.598
DEG_APCC_KENBOX_2	427	431	PF00400	0.489
DEG_SCF_FBW7_1	185	190	PF00400	0.527
DEG_SPOP_SBC_1	144	148	PF00917	0.510
DEG_SPOP_SBC_1	167	171	PF00917	0.786
DEG_SPOP_SBC_1	543	547	PF00917	0.500
DOC_CKS1_1	816	821	PF01111	0.614
DOC_CYCLIN_RxL_1	251	259	PF00134	0.466
DOC_MAPK_DCC_7	672	680	PF00069	0.485
DOC_MAPK_gen_1	647	655	PF00069	0.496
DOC_MAPK_gen_1	672	680	PF00069	0.566
DOC_MAPK_MEF2A_6	672	680	PF00069	0.485
DOC_PP1_RVXF_1	521	528	PF00149	0.471
DOC_USP7_MATH_1	106	110	PF00917	0.654
DOC_USP7_MATH_1	118	122	PF00917	0.663
DOC_USP7_MATH_1	130	134	PF00917	0.593
DOC_USP7_MATH_1	198	202	PF00917	0.590
DOC_USP7_MATH_1	204	208	PF00917	0.650
DOC_USP7_MATH_1	213	217	PF00917	0.684
DOC_USP7_MATH_1	278	282	PF00917	0.598
DOC_USP7_MATH_1	367	371	PF00917	0.569
DOC_USP7_MATH_1	549	553	PF00917	0.638
DOC_USP7_MATH_1	591	595	PF00917	0.667
DOC_USP7_MATH_1	681	685	PF00917	0.663
DOC_USP7_UBL2_3	511	515	PF12436	0.474
DOC_WW_Pin1_4	111	116	PF00397	0.698
DOC_WW_Pin1_4	120	125	PF00397	0.527
DOC_WW_Pin1_4	163	168	PF00397	0.540
DOC_WW_Pin1_4	183	188	PF00397	0.662
DOC_WW_Pin1_4	206	211	PF00397	0.658
DOC_WW_Pin1_4	285	290	PF00397	0.613
DOC_WW_Pin1_4	567	572	PF00397	0.725
DOC_WW_Pin1_4	589	594	PF00397	0.774
DOC_WW_Pin1_4	671	676	PF00397	0.458
DOC_WW_Pin1_4	78	83	PF00397	0.530
DOC_WW_Pin1_4	815	820	PF00397	0.608
LIG_14-3-3_CanoR_1	111	115	PF00244	0.584
LIG_14-3-3_CanoR_1	244	250	PF00244	0.399
LIG_14-3-3_CanoR_1	354	364	PF00244	0.419
LIG_14-3-3_CanoR_1	379	386	PF00244	0.554
LIG_14-3-3_CanoR_1	650	656	PF00244	0.527
LIG_14-3-3_CanoR_1	695	705	PF00244	0.508
LIG_14-3-3_CanoR_1	742	751	PF00244	0.586
LIG_14-3-3_CanoR_1	772	777	PF00244	0.503
LIG_14-3-3_CanoR_1	803	809	PF00244	0.495
LIG_14-3-3_CanoR_1	86	93	PF00244	0.440
LIG_Actin_WH2_2	419	436	PF00022	0.488
LIG_Actin_WH2_2	460	477	PF00022	0.428
LIG_Actin_WH2_2	500	517	PF00022	0.332
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_Dynein_DLC8_1	242	248	PF01221	0.384
LIG_FHA_1	154	160	PF00498	0.661
LIG_FHA_1	168	174	PF00498	0.638
LIG_FHA_1	184	190	PF00498	0.498
LIG_FHA_1	230	236	PF00498	0.455
LIG_FHA_1	31	37	PF00498	0.639
LIG_FHA_1	355	361	PF00498	0.429
LIG_FHA_1	400	406	PF00498	0.460
LIG_FHA_1	469	475	PF00498	0.345
LIG_FHA_1	508	514	PF00498	0.356
LIG_FHA_1	59	65	PF00498	0.534
LIG_FHA_1	605	611	PF00498	0.577
LIG_FHA_1	637	643	PF00498	0.387
LIG_FHA_1	662	668	PF00498	0.531
LIG_FHA_1	69	75	PF00498	0.548
LIG_FHA_1	705	711	PF00498	0.495
LIG_FHA_1	731	737	PF00498	0.672
LIG_FHA_1	782	788	PF00498	0.493
LIG_FHA_2	23	29	PF00498	0.762
LIG_FHA_2	237	243	PF00498	0.546
LIG_FHA_2	344	350	PF00498	0.421
LIG_FHA_2	379	385	PF00498	0.573
LIG_FHA_2	40	46	PF00498	0.413
LIG_FHA_2	711	717	PF00498	0.516
LIG_FHA_2	743	749	PF00498	0.580
LIG_FHA_2	773	779	PF00498	0.504
LIG_FHA_2	783	789	PF00498	0.431
LIG_LIR_Gen_1	758	764	PF02991	0.521
LIG_LIR_Gen_1	85	95	PF02991	0.579
LIG_LIR_Nem_3	758	762	PF02991	0.535
LIG_LIR_Nem_3	85	90	PF02991	0.577
LIG_NRBOX	351	357	PF00104	0.454
LIG_NRBOX	833	839	PF00104	0.515
LIG_PTAP_UEV_1	592	597	PF05743	0.519
LIG_Rb_LxCxE_1	42	61	PF01857	0.499
LIG_SH2_CRK	87	91	PF00017	0.587
LIG_SH2_STAP1	32	36	PF00017	0.635
LIG_SH2_STAT3	440	443	PF00017	0.481
LIG_SH2_STAT5	32	35	PF00017	0.642
LIG_SH3_3	112	118	PF00018	0.766
LIG_SH3_3	121	127	PF00018	0.600
LIG_SH3_3	34	40	PF00018	0.568
LIG_SH3_3	556	562	PF00018	0.632
LIG_SH3_3	568	574	PF00018	0.729
LIG_SH3_3	590	596	PF00018	0.625
LIG_SH3_3	675	681	PF00018	0.686
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.349
LIG_SUMO_SIM_par_1	495	500	PF11976	0.477
LIG_TRAF2_1	775	778	PF00917	0.502
LIG_TRAF2_2	741	746	PF00917	0.595
LIG_UBA3_1	642	647	PF00899	0.525
LIG_WW_3	739	743	PF00397	0.506
MOD_CDK_SPxK_1	78	84	PF00069	0.469
MOD_CK1_1	101	107	PF00069	0.649
MOD_CK1_1	120	126	PF00069	0.665
MOD_CK1_1	166	172	PF00069	0.620
MOD_CK1_1	199	205	PF00069	0.642
MOD_CK1_1	2	8	PF00069	0.707
MOD_CK1_1	238	244	PF00069	0.524
MOD_CK1_1	31	37	PF00069	0.781
MOD_CK1_1	332	338	PF00069	0.441
MOD_CK1_1	547	553	PF00069	0.807
MOD_CK1_1	572	578	PF00069	0.621
MOD_CK1_1	594	600	PF00069	0.557
MOD_CK1_1	674	680	PF00069	0.666
MOD_CK1_1	693	699	PF00069	0.623
MOD_CK1_1	732	738	PF00069	0.533
MOD_CK1_1	820	826	PF00069	0.514
MOD_CK1_1	88	94	PF00069	0.478
MOD_CK2_1	22	28	PF00069	0.752
MOD_CK2_1	236	242	PF00069	0.527
MOD_CK2_1	343	349	PF00069	0.503
MOD_CK2_1	365	371	PF00069	0.625
MOD_CK2_1	378	384	PF00069	0.578
MOD_CK2_1	39	45	PF00069	0.484
MOD_CK2_1	444	450	PF00069	0.460
MOD_CK2_1	453	459	PF00069	0.482
MOD_CK2_1	573	579	PF00069	0.671
MOD_CK2_1	710	716	PF00069	0.649
MOD_CK2_1	742	748	PF00069	0.586
MOD_CK2_1	772	778	PF00069	0.412
MOD_CK2_1	782	788	PF00069	0.434
MOD_DYRK1A_RPxSP_1	111	115	PF00069	0.541
MOD_GlcNHglycan	120	123	PF01048	0.656
MOD_GlcNHglycan	160	163	PF01048	0.590
MOD_GlcNHglycan	181	184	PF01048	0.653
MOD_GlcNHglycan	198	201	PF01048	0.660
MOD_GlcNHglycan	290	293	PF01048	0.440
MOD_GlcNHglycan	318	321	PF01048	0.493
MOD_GlcNHglycan	365	368	PF01048	0.584
MOD_GlcNHglycan	435	438	PF01048	0.469
MOD_GlcNHglycan	475	478	PF01048	0.345
MOD_GlcNHglycan	547	550	PF01048	0.546
MOD_GlcNHglycan	567	570	PF01048	0.507
MOD_GlcNHglycan	593	596	PF01048	0.555
MOD_GlcNHglycan	699	702	PF01048	0.623
MOD_GlcNHglycan	736	739	PF01048	0.760
MOD_GlcNHglycan	819	822	PF01048	0.538
MOD_GlcNHglycan	87	90	PF01048	0.612
MOD_GSK3_1	101	108	PF00069	0.623
MOD_GSK3_1	144	151	PF00069	0.563
MOD_GSK3_1	163	170	PF00069	0.642
MOD_GSK3_1	179	186	PF00069	0.696
MOD_GSK3_1	196	203	PF00069	0.706
MOD_GSK3_1	2	9	PF00069	0.689
MOD_GSK3_1	205	212	PF00069	0.796
MOD_GSK3_1	234	241	PF00069	0.524
MOD_GSK3_1	272	279	PF00069	0.607
MOD_GSK3_1	28	35	PF00069	0.602
MOD_GSK3_1	363	370	PF00069	0.502
MOD_GSK3_1	399	406	PF00069	0.461
MOD_GSK3_1	543	550	PF00069	0.578
MOD_GSK3_1	561	568	PF00069	0.620
MOD_GSK3_1	569	576	PF00069	0.656
MOD_GSK3_1	591	598	PF00069	0.600
MOD_GSK3_1	689	696	PF00069	0.648
MOD_GSK3_1	730	737	PF00069	0.543
MOD_GSK3_1	74	81	PF00069	0.562
MOD_N-GLC_1	101	106	PF02516	0.503
MOD_N-GLC_1	273	278	PF02516	0.473
MOD_N-GLC_1	444	449	PF02516	0.397
MOD_N-GLC_1	6	11	PF02516	0.518
MOD_N-GLC_1	803	808	PF02516	0.521
MOD_NEK2_1	105	110	PF00069	0.716
MOD_NEK2_1	205	210	PF00069	0.588
MOD_NEK2_1	229	234	PF00069	0.531
MOD_NEK2_1	235	240	PF00069	0.515
MOD_NEK2_1	243	248	PF00069	0.478
MOD_NEK2_1	256	261	PF00069	0.417
MOD_NEK2_1	355	360	PF00069	0.538
MOD_NEK2_1	433	438	PF00069	0.413
MOD_NEK2_1	451	456	PF00069	0.426
MOD_NEK2_1	497	502	PF00069	0.478
MOD_NEK2_1	74	79	PF00069	0.704
MOD_NEK2_1	838	843	PF00069	0.496
MOD_NEK2_2	106	111	PF00069	0.545
MOD_PIKK_1	229	235	PF00454	0.524
MOD_PIKK_1	236	242	PF00454	0.512
MOD_PIKK_1	243	249	PF00454	0.541
MOD_PIKK_1	322	328	PF00454	0.374
MOD_PIKK_1	532	538	PF00454	0.558
MOD_PIKK_1	636	642	PF00454	0.590
MOD_PIKK_1	653	659	PF00454	0.500
MOD_PKA_1	410	416	PF00069	0.364
MOD_PKA_2	110	116	PF00069	0.597
MOD_PKA_2	243	249	PF00069	0.383
MOD_PKA_2	329	335	PF00069	0.430
MOD_PKA_2	378	384	PF00069	0.578
MOD_PKA_2	468	474	PF00069	0.347
MOD_PKA_2	694	700	PF00069	0.709
MOD_PKA_2	771	777	PF00069	0.508
MOD_PKA_2	85	91	PF00069	0.715
MOD_PKB_1	314	322	PF00069	0.506
MOD_Plk_1	101	107	PF00069	0.525
MOD_Plk_1	322	328	PF00069	0.443
MOD_Plk_1	451	457	PF00069	0.355
MOD_Plk_1	6	12	PF00069	0.518
MOD_Plk_1	661	667	PF00069	0.539
MOD_Plk_1	803	809	PF00069	0.525
MOD_Plk_4	32	38	PF00069	0.733
MOD_Plk_4	595	601	PF00069	0.597
MOD_Plk_4	705	711	PF00069	0.576
MOD_Plk_4	782	788	PF00069	0.619
MOD_ProDKin_1	111	117	PF00069	0.698
MOD_ProDKin_1	120	126	PF00069	0.527
MOD_ProDKin_1	163	169	PF00069	0.539
MOD_ProDKin_1	183	189	PF00069	0.664
MOD_ProDKin_1	206	212	PF00069	0.656
MOD_ProDKin_1	285	291	PF00069	0.607
MOD_ProDKin_1	567	573	PF00069	0.718
MOD_ProDKin_1	589	595	PF00069	0.772
MOD_ProDKin_1	671	677	PF00069	0.466
MOD_ProDKin_1	78	84	PF00069	0.535
MOD_ProDKin_1	815	821	PF00069	0.609
MOD_SUMO_for_1	417	420	PF00179	0.502
MOD_SUMO_for_1	797	800	PF00179	0.465
MOD_SUMO_for_1	844	847	PF00179	0.506
MOD_SUMO_rev_2	429	436	PF00179	0.479
MOD_SUMO_rev_2	614	623	PF00179	0.486
TRG_DiLeu_BaEn_1	638	643	PF01217	0.680
TRG_DiLeu_BaEn_1	662	667	PF01217	0.543
TRG_DiLeu_BaEn_1	70	75	PF01217	0.437
TRG_DiLeu_BaEn_1	765	770	PF01217	0.451
TRG_DiLeu_BaEn_4	778	784	PF01217	0.502
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.452
TRG_DiLeu_LyEn_5	662	667	PF01217	0.543
TRG_ENDOCYTIC_2	87	90	PF00928	0.586
TRG_ER_diArg_1	222	225	PF00400	0.559
TRG_ER_diArg_1	440	442	PF00400	0.426
TRG_ER_diArg_1	626	628	PF00400	0.421
TRG_ER_diArg_1	749	751	PF00400	0.556
TRG_NES_CRM1_1	389	403	PF08389	0.352
TRG_NES_CRM1_1	618	632	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	516	521	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y9	Leptomonas seymouri	47%	96%
A0A3S7WYS7	Leishmania donovani	66%	100%
A4I181	Leishmania infantum	67%	100%
E9AXB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QA57	Leishmania major	64%	97%
V5B7N4	Trypanosoma cruzi	24%	100%